Dr Irene Chassagnon
Postdoctoral Research Fellow
School of Chemistry and Molecular Biosciences
Affiliate Postdoc Research Fellow
Institute for Molecular Bioscience
+61 7 336 59175
Book Chapter
Chassagnon, Irene R., Piper, Sarah J. and Landsberg, Michael J. (2019). ABC toxins: self-assembling nanomachines for the targeted cellular delivery of bioactive proteins. In David L. Andrews, Gregory D. Scholes and Gary P. Wiederrecht (Ed.), Comprehensive nanoscience and nanotechnology 2nd ed. (pp. 279-298) London, United Kingdom: Academic Press. doi:10.1016/b978-0-12-803581-8.10513-2
Journal Articles
Cristofori-Armstrong, Ben, Saez, Natalie J., Chassagnon, Irène R., King, Glenn F. and Rash, Lachlan D. (2019) The modulation of acid-sensing ion channel 1 by PcTx1 is pH-, subtype- and species-dependent: importance of interactions at the channel subunit interface and potential for engineering selective analogues. Biochemical Pharmacology, 163 381-390. doi:10.1016/j.bcp.2019.03.004
Piper, Sarah J., Brillault, Lou, Rothnagel, Rosalba, Croll, Tristan I., Box, Joseph K., Chassagnon, Irene, Scherer, Sebastian, Goldie, Kenneth N, Jones, Sandra A, Schepers, Femke, Hartley-Tassell, Lauren, Ve, Thomas, Busby, Jason N, Dalziel, Julie E, Lott, J Shaun, Hankamer, Ben, Stahlberg, Henning, Hurst, Mark R H and Landsberg, Michael J (2019) Cryo-EM structures of the pore-forming A subunit from the Yersinia entomophaga ABC toxin. Nature Communications, 10 1: . doi:10.1038/s41467-019-09890-8
Chassagnon, Irene R., McCarthy, Claudia A., Chin, Yanni K.-Y., Pineda, Sandy S., Keramidas, Angelo, Mobli, Mehdi, Pham, Vi, De Silva, T. Michael, Lynch, Joseph W., Widdop, Robert E., Rash, Lachlan D. and King, Glenn F. (2017) Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a. Proceedings from the National Academy of Sciences of the United States of America, 114 14: 3750-3755. doi:10.1073/pnas.1614728114
McCarthy, Claudia A., Rash, Lachlan D., Chassagnon, Irene R., King, Glenn F. and Widdop, Robert E. (2015) PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a. Neuropharmacology, 99 650-657. doi:10.1016/j.neuropharm.2015.08.040
Saez, Natalie J., Deplazes, Evelyne, Cristofori-Armstrong, Ben, Chassagnon, Irene R., Lin, Xiaozhen, Mobli, Mehdi, Mark, Alan E., Rash, Lachlan D. and King, Glenn F. (2015) Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a. British Journal of Pharmacology, 172 20: 4985-4995. doi:10.1111/bph.13267
Saez, Natalie J., Mobli, Mehdi, Bieri, Michael, Chassagnon, Irene R., Malde, Alpeshkumar K., Gamsjaeger, Roland, Mark, Alan E., Gooley, Paul R., Rash. Lachlan D. and King, Glenn F. (2011) A dynamic pharmacophore drives the interaction between psalmotoxin-1 and the putative drug target acid-sensing ion channel 1a. Molecular Pharmacology, 80 5: 796-808. doi:10.1124/mol.111.072207
Thesis
Chassagnon, Irene (2017). Peptide modulators of ASIC1a: A putative drug target for the treatment of stroke PhD Thesis, Institute for Molecular Bioscience, The University of Queensland. doi:10.14264/uql.2017.708