Publications
Book Chapter
Mitić, Nataša, Miraula, Manfredi, Selleck, Christopher, Hadler, Kieran S., Uribe, Elena, Pedroso, M. M. and Schenk, G. (2014). Catalytic mechanisms of metallohydrolases containing two metal ions. Metal-containing enzymes. (pp. 49-81) edited by Christo Z. Christov. Waltham, MA, United States: Academic Press. doi: 10.1016/bs.apcsb.2014.07.002
Journal Articles
Wilson, Liam A., Melville, Jamie N., Pedroso, Marcelo M., Krco, Stefan, Hoelzl, Robert, Zaugg, Julian, Southam, Gordon, Virdis, Bernardino, Evans, Paul, Supper, Jenna, Harmer, Jeffrey R., Tyson, Gene, Clark, Alice, Schenk, Gerhard and Bernhardt, Paul V. (2024). Kinetic, electrochemical and spectral characterization of bacterial and archaeal rusticyanins; unexpected stability issues and consequences for applications in biotechnology. Journal of Inorganic Biochemistry, 256 112539, 1-10. doi: 10.1016/j.jinorgbio.2024.112539
Lv, Kemin, Cao, Xuefei, Pedroso, Marcelo Monteiro, Wu, Bin, Li, Jiahuang, He, Bingfang and Schenk, Gerhard (2024). Structure-guided engineering of branched-chain α-keto acid decarboxylase for improved 1,2,4-butanetriol production by in vitro synthetic enzymatic biosystem. International Journal of Biological Macromolecules, 255 128303, 1-12. doi: 10.1016/j.ijbiomac.2023.128303
Kurz, Julia L., Monteiro Pedroso, Marcelo, Richard, Emmanuelle, McGeary, Ross P. and Schenk, Gerhard (2023). Inhibitors for metallo-β-lactamases from the B1 and B3 subgroups provide an avenue to combat a major mechanism of antibiotic resistance. Bioorganic and Medicinal Chemistry Letters, 92 129387, 1-5. doi: 10.1016/j.bmcl.2023.129387
Krco, Stefan, Davis, Samuel J., Joshi, Pallav, Wilson, Liam A., Monteiro Pedroso, Marcelo, Douw, Andrew, Schofield, Christopher J., Hugenholtz, Philip, Schenk, Gerhard and Morris, Marc T. (2023). Structure, function, and evolution of metallo-β-lactamases from the B3 subgroup—emerging targets to combat antibiotic resistance. Frontiers in Chemistry, 11 1196073, 1196073. doi: 10.3389/fchem.2023.1196073
Rodriguez, Karen, Pedroso, Marcelo, Harris, Audrey, Garg, Shivani, Hine, Damian, Köpke, Michael, Schenk, Gerhard and Marcellin, Esteban (2023). Gas fermentation for microbial sustainable aviation fuel production. Microbiology Australia, 44 (1), 31-35. doi: 10.1071/ma23008
Wilson, Liam A., Pedroso, Marcelo M., Peralta, Rosely A., Gahan, Lawrence R. and Schenk, Gerhard (2023). Biomimetics for purple acid phosphatases: a historical perspective. Journal of Inorganic Biochemistry, 238 112061, 112061. doi: 10.1016/j.jinorgbio.2022.112061
Stroek, Rozanne, Wilson, Liam, Goracke, William, Kang, Taeuk, Vermue, Febe, Krco, Stefan, Mendels, Yonatan, Douw, Andrew, Morris, Marc, Knaven, Esmee G., Mitić, Nataša, Gutierrez, Maria C.R., Schenk, Elaine B., Clark, Alice, Garcia, David, Monteiro Pedroso, Marcelo and Schenk, Gerhard (2022). LAM-1 from Lysobacter antibioticus: a potent zinc-dependent activity that inactivates β-lactam antibiotics. Journal of Inorganic Biochemistry, 226 111637, 1-4. doi: 10.1016/j.jinorgbio.2021.111637
Wang, Lijuan, Cao, Kun, Pedroso, Marcelo Monteiro, Wu, Bin, Gao, Zhen, He, Bingfang and Schenk, Gerhard (2021). Sequence- and structure-guided improvement of the catalytic performance of a GH11 family xylanase from Bacillus subtilis. Journal of Biological Chemistry, 297 (5) 101262, 101262. doi: 10.1016/j.jbc.2021.101262
Wilson, Liam A., Knaven, Esmée G., Morris, Marc T., Monteiro Pedroso, Marcelo, Schofield, Christopher J., Brück, Thomas, Boden, Mikael, Waite, David W., Hugenholtz, Philip, Guddat, Luke and Schenk, Gerhard (2021). Kinetic and structural characterization of the first B3 metallo-β-lactamase with an active site glutamic acid. Antimicrobial Agents and Chemotherapy, 65 (10) e00936-21, e0093621. doi: 10.1128/aac.00936-21
Lv, Kemin, Yu, Zhimeng, Pedroso, Marcelo M., Wu, Bin, Gao, Zhen, He, Bingfang and Schenk, Gerhard (2021). Metal affinity immobilization of the processive endoglucanase EG5C-1 from Bacillus subtilis on a recyclable pH-responsive polymer. ACS Sustainable Chemistry and Engineering, 9 (23) acssuschemeng.1c02215, 7948-7959. doi: 10.1021/acssuschemeng.1c02215
Pedroso, Marcelo Monteiro, Hine, Damian, Hahn, Sebastian, Chmielewicz, Wioleta Monika, Diegel, Janika, Gahan, Lawrence and Schenk, Gerhard (2021). Pesticide degradation by immobilised metalloenzymes provides an attractive avenue for bioremediation. EFB Bioeconomy Journal, 1 100015, 1-8. doi: 10.1016/j.bioeco.2021.100015
Lv, Kemin, Shao, Wenyu, Pedroso, Marcelo Monteiro, Peng, Jiayu, Wu, Bin, Li, Jiahuang, He, Bingfang and Schenk, Gerhard (2021). Enhancing the catalytic activity of a GH5 processive endoglucanase from Bacillus subtilis BS-5 by site-directed mutagenesis. International Journal of Biological Macromolecules, 168, 442-452. doi: 10.1016/j.ijbiomac.2020.12.060
Selleck, Christopher, Pedroso, Marcelo Monteiro, Wilson, Liam, Krco, Stefan, Knaven, Esmée Gianna, Miraula, Manfredi, Mitić, Nataša, Larrabee, James A., Brück, Thomas, Clark, Alice, Guddat, Luke W. and Schenk, Gerhard (2020). Structure and mechanism of potent bifunctional β-lactam- and homoserine lactone-degrading enzymes from marine microorganisms. Scientific Reports, 10 (1) 12882, 12882. doi: 10.1038/s41598-020-68612-z
Ringel, Marion, Reinbold, Markus, Hirte, Max, Haack, Martina, Huber, Claudia, Eisenreich, Wolfgang, Masri, Mahmoud A., Schenk, Gerhard, Guddat, Luke W., Loll, Bernhard, Kerr, Russell, Garbe, Daniel and Brück, Thomas (2020). Towards a sustainable generation of pseudopterosin-type bioactives. Green Chemistry, 22 (18), 6033-6046. doi: 10.1039/d0gc01697g
Pedroso, Marcelo Monteiro, Waite, David W., Melse, Okke, Wilson, Liam, Mitić, Nataša, McGeary, Ross P., Antes, Iris, Guddat, Luke W., Hugenholtz, Philip and Schenk, Gerhard (2020). Broad spectrum antibiotic-degrading metallo-β-lactamases are phylogenetically diverse. Protein and Cell, 11 (8), 613-617. doi: 10.1007/s13238-020-00736-4
Wilson, Liam A., Garcia, David, Pedroso, Marcelo Monteiro, Schulz, Benjamin L., Guddat, Luke W. and Schenk, Gerhard (2020). Adaptation of a continuous, calorimetric kinetic assay to study the agmatinase-catalyzed hydrolytic reaction. Analytical Biochemistry, 595 113618, 113618. doi: 10.1016/j.ab.2020.113618
Mostert, A. Bernardus, Rienecker, Shermiyah B., Sheliakina, Margarita, Zierep, Paul, Hanson, Graeme R., Harmer, Jeffrey R., Schenk, Gerhard and Meredith, Paul (2020). Engineering proton conductivity in melanin using metal doping. Journal of Materials Chemistry B, 8 (35), 8050-8060. doi: 10.1039/d0tb01390k
Wu, Bin, Yu, Qi, Chang, Siyuan, Pedroso, Marcelo Monteiro, Gao, Zhen, He, Bingfang and Schenk, Gerhard (2019). Expansin assisted bio-affinity immobilization of endoxylanase from Bacillus subtilis onto corncob residue: characterization and efficient production of xylooligosaccharides. Food Chemistry, 282, 101-108. doi: 10.1016/j.foodchem.2019.01.004
Wu, Bin, Yu, Qi, Zheng, Shan, Pedroso, Marcelo Monteiro, Guddat, Luke W., He, Bingfang and Schenk, Gerhard (2019). Relative catalytic efficiencies and transcript levels of three D‐ and two L‐lactate dehydrogenases for optically pure D‐lactate production in Sporolactobacillus inulinus. MicrobiologyOpen, 8 (5) e00704, e00704. doi: 10.1002/mbo3.704
Wu, Bin, Zheng, Shan, Pedroso, Marcelo Monteiro, Guddat, Luke W., Chang, Siyuan, He, Bingfang and Schenk, Gerhard (2018). Processivity and enzymatic mechanism of a multifunctional family 5 endoglucanase from Bacillus subtilis BS-5 with potential applications in the saccharification of cellulosic substrates. Biotechnology for Biofuels, 11 (1) 20, 1-15. doi: 10.1186/s13068-018-1022-2
Pedroso, Marcelo Monteiro, Selleck, Christopher, Enculescu, Charmaine, Harmer, Jeffrey R., Mitic, Natasa, Craig, Whitney R., Helweh, Waleed, Hugenholtz, Philip, Tyson, Gene W., Tierney, David L., Larrabee, James A. and Schenk, Gerhard (2017). Characterization of a highly efficient antibiotic-degrading metallo-β-lactamase obtained from an uncultured member of a permafrost community. Metallomics, 9 (8), 1157-1168. doi: 10.1039/c7mt00195a
Pedroso, Marcelo M., Ely, Fernanda, Carpenter, Margaret C., Mitic, Natasa, Gahan, Lawrence R., Ollis, David L., Wilcox, Dean E. and Schenk, Gerhard (2017). Mechanistic insight from calorimetric measurements of the assembly of the binuclear metal active site of glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes. Biochemistry, 56 (26), 3328-3336. doi: 10.1021/acs.biochem.6b01200
Selleck, Christopher , Guddat, Luke W., Ollis, David L., Schenk, Gerhard and Pedroso, Marcelo Monteiro (2017). High resolution crystal structure of a fluoride-inhibited organophosphate-degrading metallohydrolase. Journal of Inorganic Biochemistry, 177, 287-290. doi: 10.1016/j.jinorgbio.2017.06.013
McGeary, Ross P., Tan, Daniel T. C., Selleck, Christopher, Monteiro Pedroso, Marcelo, Sidjabat, Hanna E. and Schenk, Gerhard (2017). Structure-activity relationship study and optimisation of 2-aminopyrrole-1-benzyl-4,5-diphenyl-1H-pyrrole-3-carbonitrile as a broad spectrum metallo-β-lactamase inhibitor. European Journal of Medicinal Chemistry, 137, 351-364. doi: 10.1016/j.ejmech.2017.05.061
Monteiro Pedroso, Marcelo, Selleck, Christopher, Bilyj, Jessica, Harmer, Jeffrey R. , Gahan, Lawrence R. , Mitić, Natasa, Standish, Alistair J. , Tierney, David L. , Larrabee, James A. and Schenk, Gerhard (2017). Reaction mechanism of the metallohydrolase CpsB from Streptococcus pneumoniae, a promising target for novel antimicrobial agents. Dalton Transactions, 46 (39), 13194-13201. doi: 10.1039/c7dt01350g
Selleck, Christopher, Clayton, Daniel, Gahan, Lawrence R., Mitic, Nataša, McGeary, Ross P., Pedroso, Marcelo Monteiro, Guddat, Luke W. and Schenk, Gerhard (2017). Visualization of the reaction trajectory and transition state in a hydrolytic reaction catalyzed by a metalloenzyme. Chemistry: A European Journal, 23 (20), 4778-4781. doi: 10.1002/chem.201700866
Hou, Chun-Feng D., Liu, Jian-wei, Collyer, Charles, Mitić, Natasha, Pedroso, Marcelo Monteiro, Schenk, Gerhard and Ollis, David L. (2017). Insights into an evolutionary strategy leading to antibiotic resistance. Scientific Reports, 7 (1) 40357, 40357.1-40357.13. doi: 10.1038/srep40357
Selleck, Christopher, Larrabee James A., Harmer, Jeffrey, Guddat, Luke W., Mitić, Natasa, Helweh, Waleed, Ollis, David L., Craig, Whitney R., Tierney, David L., Monteiro Pedroso, Marcelo and Schenk, Gerhard (2016). AIM-1: an antibiotic-degrading metallohydrolase that displays mechanistic flexibility. Chemistry, 22 (49), 17704-17714. doi: 10.1002/chem.201602762
Shannon, A. E., Pedroso, M. M., Chappell, K. J., Watterson, D., Liebscher, S., Kok, W. M., Fairlie, D. P., Schenk, G. and Young, P. R. (2016). Product release is rate-limiting for catalytic processing by the Dengue virus protease. Scientific Reports, 6 (1) 37539, 37539. doi: 10.1038/srep37539
Schenk, Gerhard, Mateen, Irsa, Ng, Tee-Kheang, Pedroso, Marcelo M., Mitic, Natasa, Jafelicci, Miguel, Marques, Rodrigo F. C., Gahan, Lawrence R. and Ollis, David L. (2016). Organophosphate-degrading metallohydrolases: structure and function of potent catalysts for applications in bioremediation. Coordination Chemistry Reviews, 317, 122-131. doi: 10.1016/j.ccr.2016.03.006
Tadrowski, Sonya, Pedroso, Marcelo M., Sieber, Volker, Larrabee, James A., Guddat, Luke W. and Schenk, Gerhard (2016). Metal ions play an essential catalytic role in the mechanism of ketol-acid reductoisomerase. Chemistry, 22 (22), 7427-7436. doi: 10.1002/chem.201600620
Pedroso, Marcelo M., Larrabee, James A., Ely, Fernanda, Gwee, Shuhui E., Mitic, Natasa, Ollis, David L., Gahan, Lawrence R. and Schenk, Gerhard (2016). CaII binding regulates and dominates the reactivity of a transition-metal-ion-dependent diesterase from Mycobacterium tuberculosis. Chemistry - A European Journal, 22 (3), 999-1009. doi: 10.1002/chem.201504001
Pedroso, Marcelo M., Ely, Fernanda, Mitic, Natasa, Carpenter, Margaret C., Gahan, Lawrence R., Wilcox, Dean E., Larrabee, James L., Ollis, David L. and Schenk, Gerhard (2014). Comparative investigation of the reaction mechanisms of the organophosphate-degrading phosphotriesterases from Agrobacterium radiobacter (OpdA) and Pseudomonas diminuta (OPH).. Journal of Biological Inorganic Chemistry, 19 (8), 1263-1275. doi: 10.1007/s00775-014-1183-9
Guilfoyle, Amy P., Deshpande, Chandrika N., Vincent, Kimberley, Pedroso, Marcelo M., Schenk, Gerhard, Maher, Megan J. and Jormakka, Mika (2014). Structural and functional analysis of a FeoB A143S G5 loop mutant explains the accelerated GDP release rate. FEBS Journal, 281 (9), 2254-2265. doi: 10.1111/febs.12779
Pedroso, Marcelo M., Ely, Fernanda, Lonhienne, Thierry, Gahan, Lawrence R., Ollis, David L., Guddat, Luke W. and Schenk, Gerhard (2014). Determination of the catalytic activity of binuclear metallohydrolases using isothermal titration calorimetry. Journal of Biological Inorganic Chemistry, 19 (3), 389-398. doi: 10.1007/s00775-013-1079-0
Ely, Fernanda, Pedroso, Marcelo M., Gahan, Lawrence R., Ollis, David L., Guddat, Luke W. and Schenk, Gerhard (2012). Phosphate-bound structure of an organophosphate-degrading enzyme from Agrobacterium radiobacter. Journal of Inorganic Biochemistry, 106 (1), 19-22. doi: 10.1016/j.jinorgbio.2011.09.015
dos Santos Nunes, Marta Regina, Martinelli, Marcia and Pedroso, Marcelo Monteiro (2008). Epoxidacao do oleo de mamona e derivados empregando o sistema catalitico VO(acac)(2)/TBHP. Quimica Nova, 31 (4), 818-821. doi: 10.1590/S0100-40422008000400021
Conference Paper
Pedroso, M., Ely, F., Gahan, L. R., Schenk, G., Ollis, D. L. and Larrabee, J. A. (2014). Kinetics and Structural Analysis of Rv0805 from Mycobacterium tuberculosis. 16th International Conference on Biological Inorganic Chemistry (ICBIC), Grenoble France, 22-26 July 2013. Heidelberg, Germany: Springer. doi: 10.1007/s00775-014-1095-8
Newspaper Article
Monteiro Pedroso, Marcelo (2020, 08 05). Marine environments harbor a large reservoir of antibiotic-degrading activities Nature Research Microbiology: Behind the Paper
Thesis
Pedroso, Marcelo (2013). Organophosphate Hydrolases and their Mechanistic Flexibility: A Thermodynamic and Kinetic Study. PhD Thesis, School of Chemistry and Molecular Bioscience, The University of Queensland.