Enzyme approach to killing drug-resistant fungal infection

24 Jul 2017
Crystal structure at 2.1 Å resolution of the target enzyme, ADS lyase. The inset shows detailed structure of the active site.

The development of new drugs to fight a common fungal pathogen which kills half a million people globally each year is a step closer thanks to a University of Queensland-led study.

UQ PhD student Jessica Chitty of the Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, said the study targeted the fungus Cryptococcus neoformans, which had shown signs of becoming resistant to current medications.

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