Dr Mathew Jones
Senior Lecturer
School of Chemistry and Molecular Biosciences
+61 7 336 54878
Room 126A, Molecular Biosciences Building (76)
Book Chapters
Jones, Mathew J. K. and Jallepalli, Prasad V. (2016). Engineering and functional analysis of mitotic kinases through chemical genetics. The Mitotic Spindle. (pp. 349-363) New York, NY United States: Humana Press. doi: 10.1007/978-1-4939-3542-0_22
Pagan, Julia, Bolderson, Emma, Jones, Mathew and Khanna, Kum Kum (2009). Chromatin modifications involved in the DNA damage response to double strand breaks. DNA damage response: implications on cancer formation and treatment. (pp. 109-131) edited by Kum Kum Khanna and Yosef Shiloh. New York, NY, United States: Springer. doi: 10.1007/978-90-481-2561-6_6
Journal Articles
Zhu, Tianyi, Tan, Jing Zhi Anson, Zhang, Lingrui, Huang, He, Das, Sooraj S., Cheng, Flora, Padmanabhan, Pranesh, Jones, Mathew J. K., Lee, Mihwa, Lee, Albert, Widagdo, Jocelyn and Anggono, Victor (2025). FTO suppresses DNA repair by inhibiting PARP1. Nature Communications, 16 (1) 2925, 2925. doi: 10.1038/s41467-025-58309-0
Giles, Katherine A., Taberlay, Phillippa C., Cesare, Anthony J. and Jones, Mathew J. K. (2025). Roles for the 3D genome in the cell cycle, DNA replication, and double strand break repair. Frontiers in Cell and Developmental Biology, 13 1548946, 13. doi: 10.3389/fcell.2025.1548946
Totañes, Francis Isidore Garcia, Chapman, Sarah E, Rai, Subash Kumar, Jones, Mathew J K, Boemo, Michael A and Merrick, Catherine J (2025). DNA replication dynamics are associated with genome composition in Plasmodium species. Nucleic Acids Research, 53 (4) gkaf111. doi: 10.1093/nar/gkaf111
Vora, Shivam, Chatterjee, Saptarshi, Andrew, Ariel, Kumar, Ramyashree Prasanna, Proctor, Martina, Zeng, Zhen, Bhatt, Rituparna, Nazareth, Deborah, Fernando, Madushan, Jones, Mathew J. K., He, Yaowu, Hooper, John D., McMillan, Nigel A. J., Urosevic, Jelena, Saeh, Jamal, Travers, Jon, Cimini, Daniela, Chen, Jing and Gabrielli, Brian (2025). Aurora B inhibition induces hyper-polyploidy and loss of long-term proliferative potential in RB and p53 defective cells. Cell Death & Disease, 16 (1) 7, 7-1. doi: 10.1038/s41419-024-07329-7
Vora, Shivam, Andrew, Ariel, Kumar, Ramyashree Prasanna, Nazareth, Deborah, Bonfim-Melo, Alexis, Lim, Yoon, Ong, Xin Yee, Fernando, Madushan, He, Yaowu, Hooper, John D., McMillan, Nigel A. J., Urosevic, Jelena, Travers, Jon, Saeh, Jamal, Kumar, Sharad, Jones, Mathew J. K. and Gabrielli, Brian (2024). Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition. Cell Death & Disease, 15 (11) 810, 810. doi: 10.1038/s41419-024-07204-5
Nguyen-Dien, Giang Thanh, Townsend, Brendan, Kulkarni, Prajakta Gosavi, Kozul, Keri-Lyn, Ooi, Soo Siang, Eldershaw, Denaye N, Weeratunga, Saroja, Liu, Meihan, Jones, Mathew JK, Millard, S Sean, Ng, Dominic CH, Pagano, Michele, Bonfim-Melo, Alexis, Schneider, Tobias, Komander, David, Lazarou, Michael, Collins, Brett M and Pagan, Julia K (2024). PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4. EMBO Reports, 25 (8), 3324-3347. doi: 10.1038/s44319-024-00181-y
Nguyen‐Dien, Giang Thanh, Kozul, Keri‐Lyn, Cui, Yi, Townsend, Brendan, Kulkarni, Prajakta Gosavi, Ooi, Soo Siang, Marzio, Antonio, Carrodus, Nissa, Zuryn, Steven, Pagano, Michele, Parton, Robert G, Lazarou, Michael, Millard, S Sean, Taylor, Robert W, Collins, Brett M, Jones, Mathew JK and Pagan, Julia K (2023). FBXL4
suppresses mitophagy by restricting the accumulation of
NIX
and
BNIP3
mitophagy receptors. The EMBO Journal, 42 (13) e112767, e112767. doi: 10.15252/embj.2022112767
Bonfim-Melo, Alexis, Noordstra, Ivar, Gupta, Shafali, Chan, Amy H., Jones, Mathew J.K., Schroder, Kate and Yap, Alpha S. (2022). Rapid lamellipodial responses by neighbor cells drive epithelial sealing in response to pyroptotic cell death. Cell Reports, 38 (5) 110316, 110316. doi: 10.1016/j.celrep.2022.110316
Rashidieh, Behnam, Molakarimi, Maryam, Mohseni, Ammar, Tria, Simon Manuel, Truong, Hein, Srihari, Sriganesh, Adams, Rachael C., Jones, Mathew, Duijf, Pascal H. G., Kalimutho, Murugan and Khanna, Kum Kum (2021). Targeting BRF2 in cancer using repurposed drugs. Cancers, 13 (15) 3778, 1-28. doi: 10.3390/cancers13153778
Jones, Mathew J. K., Gelot, Camille, Munk, Stephanie, Koren, Amnon, Kawasoe, Yoshitaka, George, Kelly A, Santos, Ruth E, Olsen, Jesper V, McCarroll, Steven A, Frattini, Mark G, Takahashi, Tatsuro S and Jallepalli, Prasad V (2021). Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication. Molecular Cell, 81 (3), 426-441.e8. doi: 10.1016/j.molcel.2021.01.004
Nazareth, Deborah, Jones, Matthew J.K. and Gabrielli, Brian (2019). Everything in moderation: lessons learned by exploiting moderate replication stress in cancer. Cancers, 11 (9) 1320, 1320. doi: 10.3390/cancers11091320
Coleman, Kate E., Békés, Miklós, Chapman, Jessica R., Crist, Sarah B., Jones, Mathew J.K., Ueberheide, Beatrix M. and Huang, Tony T. (2017). SENP8 limits aberrant neddylation of nedd8 pathway components to promote cullin-RING ubiquitin ligase function. eLife, 6 e24325. doi: 10.7554/eLife.24325
Maciejowski, John, Drechsler, Hauke, Grundner-Culemann, Kathrin, Ballister, Edward R., Rodriguez-Rodriguez, Jose-Antonio, Rodriguez-Bravo, Veronica, Jones, Mathew J.K., Foley, Emily, Lampson, Michael A., Daub, Henrik, McAinsh, Andrew D. and Jallepalli, Prasad V. (2017). Mps1 regulates kinetochore-microtubule attachment stability via the Ska complex to ensure error-free chromosome segregation. Developmental Cell, 41 (2), 143-156.e6. doi: 10.1016/j.devcel.2017.03.025
Rahman, Sadia, Jones, Mathew J.K. and Jallepalli, Prasad V. (2015). Cohesin recruits the Esco1 acetyltransferase genome wide to repress transcription and promote cohesion in somatic cells. Proceedings of the National Academy of Sciences of the United States of America, 112 (36), 11270-11275. doi: 10.1073/pnas.1505323112
Gitlin, Alexander D., Mayer, Christian T., Oliveira, Thiago Y., Shulman, Ziv, Jones, Mathew J. K., Koren, Amnon and Nussenzweig, Michel C. (2015). T cell help controls the speed of the cell cycle in germinal center B cells. Science, 349 (6248), 643-646. doi: 10.1126/science.aac4919
Chen, Yu-Hung, Jones, Mathew J.K., Yin, Yandong, Crist, Sarah B., Colnaghi, Luca, Sims, Robert J., Rothenberg, Eli, Jallepalli, Prasad V. and Huang, Tony T. (2015). ATR-mediated phosphorylation of FANCI regulates dormant origin firing in response to replication stress. Molecular Cell, 58 (2), 323-338. doi: 10.1016/j.molcel.2015.02.031
Pagan, Julia K., Marzio, Antonio, Jones, Mathew J. K., Saraf, Anita, Jallepalli, Prasad V., Florens, Laurence, Washburn, Michael P. and Pagano, Michele (2015). Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing. Nature Cell Biology, 17 (1), 31-43. doi: 10.1038/ncb3076
Grabocka, Elda, Pylayeva-Gupta, Yuliya, Jones, Mathew J.K., Lubkov, Veronica, Yemanaberhan, Eyoel, Taylor, Laura, Jeng, HaoHsuan and Bar-Sagi, Dafna (2014). Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response. Cancer Cell, 25 (2), 243-256. doi: 10.1016/j.ccr.2014.01.005
Békés, Miklós, Okamoto, Keiji, Crist, Sarah B., Jones, Mathew J., Chapman, Jessica R., Brasher, Bradley B., Melandri, Francesco D., Ueberheide, Beatrix M., LazzeriniDenchi, Eros and Huang, Tony T. (2013). DUB-resistant ubiquitin to survey ubiquitination switches in mammalian cells. Cell Reports, 5 (3), 826-838. doi: 10.1016/j.celrep.2013.10.008
Jones, Mathew J. K. and Huang, Tony T. (2012). The Fanconi anemia pathway in replication stress and DNA crosslink repair. Cellular and Molecular Life Sciences, 69 (23), 3963-3974. doi: 10.1007/s00018-012-1051-0
Jones, Mathew J.K. and Jallepalli, Prasad V. (2012). Chromothripsis: chromosomes in crisis. Developmental Cell, 23 (5), 908-917. doi: 10.1016/j.devcel.2012.10.010
Jones, Mathew J. K., Colnaghi, Luca and Huang, Tony T. (2012). Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability. The EMBO Journal, 31 (4), 908-918. doi: 10.1038/emboj.2011.457
Cotto-Rios, Xiomaris M., Jones, Mathew J.K. and Huang, Tony T. (2011). Insights into phosphorylation-dependent mechanisms regulating USP1 protein stability during the cell cycle. Cell Cycle, 10 (23), 4009-4016. doi: 10.4161/cc.10.23.18501
Cotto-Rios, Xiomaris M., Jones, Mathew J.K., Busino, Luca, Pagano, Michele and Huang, Tony T. (2011). APC/C Cdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage. Journal of Cell Biology, 194 (2), 177-186. doi: 10.1083/jcb.201101062
Colnaghi, Luca, Jones, Mathew J. K., Cotto-Rios, Xiomaris M., Schindler, Detlev, Hanenberg, Helmut and Huang, Tony T. (2011). Patient-derived C-terminal mutation of FANCI causes protein mislocalization and reveals putative EDGE motif function in DNA repair. Blood, 117 (7), 2247-2256. doi: 10.1182/blood-2010-07-295758
Pagan, Julia K., Arnold, Jeremy, Hanchard, Kim J., Kumar, Raman, Bruno, Tiziana, Jones, Mathew J.K., Richard, Derek J., Forrest, Alistair, Spurdle, Amanda, Verdin, Eric, Crossley, Merlin, Fanciulli, Maurizio, Chenevix-Trench, Georgia, Young, David B. and Khanna, Kum Kum (2007). A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP. Journal of Biological Chemistry, 282 (20), 15248-15257. doi: 10.1074/jbc.M700246200