Dr Mariusz Skwarczynski
Postdoctoral Research Fellow
School of Chemistry and Molecular Biosciences
+61 7 334 69894
Primary research interest
Development of vaccines and immunostimulators
About me
I have a Master/Engineer degree in Biotechnology and a PhD in Chemistry from Wroclaw University of Technology, Poland. I did my initial postdoctoral training at Tokushima Bunri University (Japan), and then I was awarded with Japan Society for the Promotion of Science Postdoctoral Fellowship to work in the laboratory of Professor Yoshiaki Kiso at Kyoto Pharmaceutical University (Japan) to study prodrugs of paclitaxel. I also co-developed an epimerization-free method for the synthesis of novel building blocks (isodipeptides) for solid-phase peptide synthesis and these units have been commercialized by Merck-Novabiochem. I moved to Australia to work in Prof. Istvan Toth’s group in 2008 and I was appointed as a Strategic Fund Research Fellow by The University of Queensland in 2010 to work on the vaccine delivery systems. I serve on several editorial boards, including Frontiers in Pharmacology as an Associate Editor and Vaccines as a Regional Editor of Australia. Finally, I was just recently awarded with Higher Education Academy (HEA) Fellowship (2023).
Research focus and collaborations
My research interest is related mostly to vaccine development, which involves organic and medicinal chemistry, peptide and macromolecule synthesis, self-assembly, and other techniques involved in nanoparticle formation, as well as liposomal and polymer-based delivery systems. My work focuses on vaccine and antibiotic design, their characterisation, and in vitro and in vivo evaluation.
I am involved in a wide range of collaborative research projects, both nationally and internationally, to develop vaccines against GAS, HIV, hookworm infections, malaria, tuberculosis, cancer (mainly HPV-related), and fertility control vaccines along with antibiotics against multidrug-resistant bacteria. This collaborative work involved such universities as Griffith University (Gold Coast), James Cook University (Cairns), Royal Melbourne Institute of Technology (Melbourne), and Translation Research Institute (Brisbane); Istituto Zooprofilattico Sperimentale del Mezzogiorno (Italy), Lodz University of Technology (Poland), National University of Malaysia (Malaysia), and Washington University School of Medicine (USA).
Funded projects
2024-2027 NHMRC Ideas Grant - A nanovaccine against Invasive Group A Streptococcus and Rheumatic Heart Disease ($608,061)
2024-2027 NHRMC Ideas Grant - Paving the way for a Clinical Vaccine Candidate against Hookworm Infection ($855,524)
2024-2025 Australia’s Economic Accelerator Launch Program - Single-shot anti-fertility vaccine in pigs. ($471,683)
2021-2024 Meat & Livestock Australia Limited - A single-shot fertility vaccine in cattle. ($850,733)
2021-2024 ARC Discovery Project - Poly(amino acids) as immune stimulators. ($425,000)
2020-2021 NHMRC Development grant - Hookworm peptide therapeutic for oral treatment of IBD. ($732,700)
2011-2014 NHMRC Project grant - A self-assembling and self-adjuvanting nanoparticular therapeutic vaccine against cervical cancer. ($374,208)
Teaching interests
Medicinal chemistry, vaccine and drug development
Achievements and awards
I was ranked third in the world in the Subunit Vaccines field (2012-2022). Expertscape's PubMed-based scheme labelled me as a "World Expert" and placed me in the top 0.1% of scholars writing about Subunit Vaccines over the past 10 years: “The expertise of Mariusz Skwarczynski ranks in the Top 0.022% of 18,308 published authors worldwide on Subunit Vaccines from 2012 through 2022 (3rd in the world).” https://expertscape.com/ex/vaccines%2C+subunit
I was listed among World’s Top 1% Scientists by Stanford University (2022 ranking, all science fields) for its activity in 2021 and among World’s Top 2% Scientists in whole carrier ranking (years 1788-2021). https://elsevier.digitalcommonsdata.com/datasets/btchxktzyw
Featured publications
1. Koirala, P.; Chen, S.-P. R.; Boer, J. C.; Khalil, Z. G.; Deceneux, C.; Goodchild, G.; Lu, L.; Faruck, M. O.; Shalash, A. O.; Bashiri, S.; Capon, R. J.; Hussein, W. M.; Monteiro, M. J.; Plebanski, M.; Toth, I.; Skwarczynski, M. Polymeric Nanoparticles as a Self-Adjuvanting Peptide Vaccine Delivery System: The Role of Shape. Adv. Funct. Mater. 2023, 2209304. (Impact Factor = 19.924)
2. Shalash, A. O.; Becker, L.; Yang, J.; Giacomin, P.; Pearson, M.; Hussein, Loukas, A.; Toth, I.; Skwarczynski, M. Development of a Peptide Vaccine against Hookworm Infection: Immunogenicity, Efficacy, and Immune Correlates of Protection, J. Allergy Clin. Immunol. 2022, 150, 157-169.e10. (Impact Factor = 14.290)
3. Alharbi, N; Skwarczynski, M.; Toth, I. The Influence of Component Structural Arrangement on Peptide Vaccine Immunogenicity. Biotechnology Advances, 2022, 60, 107029. (Impact Factor = 17.681)
4. Nahar, U. J.; Toth, I.; Skwarczynski, M. Mannose in vaccine delivery. J. Control. Release 2022, 351, 284-300. (Impact Factor = 11.467)
5. Azuar A, Li Z, Shibu MA, Zhao L, Luo Y, Shalash AO, Khalil ZG, Capon RJ, Hussein WM, Toth I, Skwarczynski, M. Poly(hydrophobic amino acid)-based self-adjuvanting nanoparticles for Group A Streptococcus vaccine delivery. J. Med. Chem., 2021, 64, 2648-2658. (Impact Factor = 8.039)
6. Al-Nazal, H. A.; Cooper, E.; Ho, M. F.; Eskandari, S.; Majam, V. F.; Giddam, A. K.; Hussein, W. M.; Islam, M. T.; Skwarczynski, M.; Toth, I.; Kumar, S.; Zaid, A.; Batzloff, M.; Stanisic, D. I.; Good M. F. Pre-clinical evaluation of a whole-parasite vaccine to control human babesiosis. Cell Host Microbe, 2021, 29, 894-903. (Impact Factor = 31.316)
7. Shalash, A. O; Hussein, W. M.; Skwarczynski, M.; Toth, I. Key considerations for the development of safe and effective SARS-CoV-2 subunit vaccine: A peptide-based vaccine alternative. Advanced Science, 2021, 2100985. doi: 10.1002/advs.202100985 (Impact Factor = 17.521)
8. Bartlett, S.; Eichenberger, R. M.; Nevagi, R. J.; Ghaffar, K. A.; Marasini, N.; Dai, Y.; Loukas, A.; Toth, I.; Skwarczynski, M. Lipopeptide-based oral vaccine against hookworm infection. J. Infect. Dis. 2020, 221, 934–942. (Impact Factor = 7.759)
9. Skwarczynski, M.; Zhao, G.; Boer, J. C.; Ozberk, V.; Azuar, A.; Cruz, J. G.; Giddam, A. K.; Khalil, Z. G.; Pandey, M.; Shibu, M. A.; Hussein, W. M.; Nevagi, R. J.; Batzloff, M. R.; Wells, J. W.; Capon, R. J.; Plebanski, M.; Good, M. F.; Toth I. Poly(amino acids) as a Potent Self-adjuvanting Delivery System for Peptide-based Nanovaccines Science Advances 2020, 6, eaax2285. (Impact Factor = 14.957)
10. Azuar, A.; Zhao, L.; Hei, T. T.; Nevagi, R. J.; Bartlett, S.; Hussein, W. M.; Khalil, Z. G.; Capon, R. J.; Toth I.; Skwarczynski, M. Cholic Acid-based Delivery System for Vaccine Candidates against Group A Streptococcus. ACS Med. Chem. Lett., 2019, 10, 1253-1259. (Impact Factor = 4.632)
Researcher biography
Mariusz Skwarczynski completed his Ph.D. in Chemistry in 1999 at Wroclaw University of Technology (Poland). His postdoctoral training began at Tokushima Bunri University (Japan) under the direction of late Professor M. Nishizawa, where he studied the biomimetic total synthesis of anticancer agent paclitaxel. He then joined the laboratory of Professor Yoshiaki Kiso at Kyoto Pharmaceutical University (Japan) to study prodrugs of paclitaxel. In 2004 he was awarded with Japanese fellowship (Japan Society for the Promotion of Science postdoctoral fellowship) and research grant to conduct further research on paclitaxel. He developed novel classes of paclitaxel prodrugs: isotaxoids and phototaxels. He also co-developed an epimerization-free method for the synthesis of novel building blocks (isodipeptides) for solid phase peptide synthesis and these units have been commercialized by Merck-Novabiochem.
In 2008 he joined Professor Istvan Toth group at University of Queensland (Australia) to work on vaccine delivery strategies. Since then, he research is mainly focused on nanotechnology-based peptide vaccine delivery approaches. In 2010 he was awarded with University of Queensland Strategic Fund Research Fellowship. In Australia, he is involved in a wide range of collaborative research projects, both nationally and internationally, to develop vaccines against GAS, HIV, hookworm infections, malaria and cancer, along with antibiotics against multidrug resistant bacteria.
Book Chapters
Koirala, Prashamsa, Bashiri, Sahra, Toth, Istvan and Skwarczynski, Mariusz (2022). Current Prospects in Peptide-Based Subunit Nanovaccines. Methods in Molecular Biology. (pp. 309-338) New York, NY: Humana Press Inc.. doi: 10.1007/978-1-0716-1892-9_16
Firdaus, Farrhana Ziana, Skwarczynski, Mariusz and Toth, Istvan (2022). Developments in vaccine adjuvants. Vaccine Design: Methods and Protocols, Volume 3: Resources for Vaccine Development. (pp. 145-178) edited by Sunil Thomas. New York, United States: Humana Press. doi: 10.1007/978-1-0716-1892-9_8
Zhao, Lili, Bashiri, Sahra, Toth, Istvan and Skwarczynski, Mariusz (2022). Preparation of Trimethyl Chitosan-Based Polyelectrolyte Complexes for Peptide Subunit Vaccine Delivery. Methods in Molecular Biology. (pp. 141-149) New York, NY: Humana Press Inc.. doi: 10.1007/978-1-0716-1900-1_9
Yang, Jieru, Azuar, Armira, Toth, Istvan and Skwarczynski, Mariusz (2022). Liposomes for the delivery of lipopeptide vaccines. Methods in Molecular Biology. (pp. 295-307) New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-1892-9_15
Faruck, Mohammad Omer, Skwarczynski, Mariusz and Toth, Istvan (2022). Polymer–Peptide Conjugate Vaccine for Oral Immunization. Methods in Molecular Biology. (pp. 35-44) New York, NY: Humana Press Inc.. doi: 10.1007/978-1-0716-1892-9_3
Hussein, Waleed M., Skwarczynski, Mariusz and Toth, Istvan (2021). Double conjugation using mercapto-acryloyl and alkyne-azide reactions for the synthesis of branched multiantigenic vaccine candidates. Peptide conjugation: methods and protocols. (pp. 141-150) New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-1617-8_13
Hussein, Waleed M., Toth, Istvan and Skwarczynski, Mariusz (2021). Peptide-Polymer Conjugation Via Copper-Catalyzed Alkyne-Azide 1,3-Dipolar Cycloaddition. Methods in Molecular Biology. (pp. 1-7) New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-1617-8_1
Hussein, Waleed M., Skwarczynski, Mariusz and Toth, Istvan (2020). Preface. Peptide synthesis: methods and protocols. (pp. v-v) edited by Waleed M. Hussein, Mariusz Skwarczynski and Istvan Toth. New York, NY, United States: Springer.
Hussein, Waleed M., Skwarczynski, Mariusz and Toth, Istvan (2020). An isodipeptide building block for microwave-assisted solid-phase synthesis of difficult sequence-containing peptides. Peptide synthesis: methods and protocols. (pp. 139-150) edited by Waleed M. Hussein, Mariusz Skwarczynski and Istvan Toth. New York, NY, United States: Springer. doi: 10.1007/978-1-0716-0227-0_9
Nevagi, Reshma J., Toth, Istvan and Skwarczynski, Mariusz (2018). Peptide-based vaccines. Peptide applications in biomedicine, biotechnology and bioengineering. (pp. 327-358) edited by Sotirios Koutsopoulos. Duxford, United Kingdom: Woodhead Publishing (Elsevier). doi: 10.1016/B978-0-08-100736-5.00012-0
Marasini, N., Ghaffar, K.A., Skwarczynski, M. and Toth, I. (2017). Liposomes as a vaccine delivery system. Micro and Nanotechnology in Vaccine Development. (pp. 221-239) edited by Mariusz Skwarczynski and Istvan Toth. Kidlington, Oxford, United Kingdom: Elsevier. doi: 10.1016/B978-0-323-39981-4.00012-9
Skwarczynski, Mariusz and Toth, Istvan (2017). Micro- and Nanotechnology in Vaccine Development - Introduction. Micro- and Nanotechnology in Vaccine Development . (pp. XVII-XVIII) edited by Skwarczynski, M. and Toth, I.. Kidlington, Oxford, United Kingdom: Elsevier Science.
Skwarczynski, Mariusz and Toth, Istvan (2016). Introduction. Micro and nanotechnology in vaccine development: micro and nano technologies. (pp. xvii-xviii) edited by Mariusz Skwarczynski and Istvan Toth. Oxford, United Kingdom: Elsevier. doi: 10.1016/B978-0-323-39981-4.00027-0
Ahmad Fuaad, Abdullah A. H., Skwarczynski, Mariusz and Toth, Istvan (2016). The use of microwave-assisted solid-phase peptide synthesis and click chemistry for the synthesis of vaccine candidates against hookworm infection. Vaccine design: methods and protocols: volume 1: vaccines for human diseases. (pp. 639-653) edited by Thomas, Sunil. New York, NY United States: Springer New York. doi: 10.1007/978-1-4939-3387-7_36
Skwarczynskim, Mariusz, Zaman, Mehfuz and Toth, Istvan (2013). Lipo-peptides/saccharides in peptide vaccine delivery. Handbook of biologically active peptides. (pp. 571-579) edited by Abba J. Kastin. Amsterdam, Netherlands: Academic Press/Elsevier. doi: 10.1016/B978-0-12-385095-9.00078-6
Ziora, Zyta, Skwarczynski, Mariusz and Kiso, Yoshiaki (2011). Medicinal chemistry of a-hydroxy-b-amino acids. Amino Acids, Peptides and Proteins in Organic Chemistry: Volume 4 - Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis. (pp. 189-234) edited by Andrew B. Hughes. Weinheim, Germany: Wiley-VCH. doi: 10.1002/9783527631827.ch6
Skwarczynski, Mariusz and Toth, Istvan (2011). Lipid core peptide system for self-adjuvanting synthetic vaccine delivery. Bioconjugation protocols: Strategies and methods. (pp. 297-308) edited by Sonny S. S. Mark. New York , U.S.A: Humana Press. doi: 10.1007/978-1-61779-151-2_18
Zaman, Mehfuz, Skwarczynski, Marius and Toth, Istvan (2010). Toll-like receptor 2 mediated dendritic cell activation: Key target for lipopeptide vaccines design. Dendritic Cells: Types, Life Cycles and Biological Functions. (pp. 63-80) edited by Lorraine C. Welles. New York, NY, U.S.A.: Nova Science Publishers.
Journal Articles
Alharbi, Nedaa, Shalash, Ahmed O., Koirala, Prashamsa, Boer, Jennifer C., Hussein, Waleed M., Khalil, Zeinab G., Capon, Robert J., Plebanski, Magdalena, Toth, Istvan and Skwarczynski, Mariusz (2024). Cholesterol as an inbuilt immunoadjuvant for a lipopeptide vaccine against group A Streptococcus infection. Journal of Colloid and Interface Science, 663, 43-52. doi: 10.1016/j.jcis.2024.02.134
Lu, Lantian, Kong, Wei Yang, Zhang, Jiahui, Firdaus, Farrhana, Wells, James W., Stephenson, Rachel J., Toth, Istvan, Skwarczynski, Mariusz and Cruz, Jazmina L. Gonzalez (2024). Utilizing murine dendritic cell line DC2.4 to evaluate the immunogenicity of subunit vaccines in vitro. Frontiers in Immunology, 15 ARTN 1298721, 1-13. doi: 10.3389/fimmu.2024.1298721
Koirala, Prashamsa, Shalash, Ahmed O., Chen, Sung-Po R., Faruck, Mohammad O., Wang, Jingwen, Hussein, Waleed M., Khalil, Zeinab G., Capon, Robert J., Monteiro, Michael J., Toth, Istvan and Skwarczynski, Mariusz (2024). Polymeric nanoparticles as oral and intranasal peptide vaccine delivery systems: the role of shape and conjugation. Vaccines, 12 (2) 198, 1-14. doi: 10.3390/vaccines12020198
Jin, Shengbin, Zhang, Jiahui, Nahar, Ummey J., Huang, Wenbin, Alharbi, Nedaa A., Shalash, Ahmed O., Koirala, Prashamsa, Yang, Jieru, Kiong, Jolynn J. E., Khalil, Zeinab G., Capon, Robert J., Stephenson, Rachel J., Skwarczynski, Mariusz, Toth, Istvan and Hussein, Waleed M. (2023). Activity relationship of poly(ethylenimine)-based liposomes as group A Streptococcus vaccine delivery systems. ACS Infectious Diseases, 9 (8), 1570-1581. doi: 10.1021/acsinfecdis.3c00159
Duong, Viet Tram, Skwarczynski, Mariusz and Toth, Istvan (2023). Towards the development of subunit vaccines against tuberculosis: The key role of adjuvant. Tuberculosis, 139 102307, 1-15. doi: 10.1016/j.tube.2023.102307
Duong, Viet Tram, Koirala, Prashamsa, Chen, Sung-Po R., Monteiro, Michael J., Skwarczynski, Mariusz and Toth, Istvan (2023). Multiepitope subunit peptide-based nanovaccine against porcine circovirus type 2 (PCV2) elicited high antibody titers in vaccinated mice. Molecules, 28 (5) 2248, 1-15. doi: 10.3390/molecules28052248
Firdaus, Farrhana Z., Bartlett, Stacey, Hussein, Waleed M., Lu, Lantian, Wright, Quentin, Huang, Wenbin, Nahar, Ummey J., Yang, Jieru, Khongkow, Mattaka, Veitch, Margaret, Koirala, Prashamsa, Ruktanonchai, Uracha R., Monteiro, Michael J., Gonzalez Cruz, Jazmina L., Stephenson, Rachel J., Wells, James W., Toth, Istvan and Skwarczynski, Mariusz (2023). Liposomal formulations of a polyleucine–antigen conjugate as therapeutic vaccines against cervical cancer. Pharmaceutics, 15 (2) 602, 1-15. doi: 10.3390/pharmaceutics15020602
Yang, Jieru, Boer, Jennifer C., Khongkow, Mattaka, Phunpee, Sarunya, Khalil, Zeinab G., Bashiri, Sahra, Deceneux, Cyril, Goodchild, Georgia, Hussein, Waleed M., Capon, Robert J., Ruktanonchai, Uracha, Plebanski, Magdalena, Toth, Istvan and Skwarczynski, Mariusz (2023). The development of surface-modified liposomes as an intranasal delivery system for group A Streptococcus vaccines. Vaccines, 11 (2) 305. doi: 10.3390/vaccines11020305
Szerlauth, Adel, Varga, Árpád, Madácsy, Tamara, Sebők, Dániel, Bashiri, Sahra, Skwarczynski, Mariusz, Toth, Istvan, Maléth, József and Szilagyi, Istvan (2023). Confinement of triple-enzyme-involved antioxidant cascade in two-dimensional nanostructure. ACS Materials Letters, 5 (2), 565-573. doi: 10.1021/acsmaterialslett.2c00580
Koirala, Prashamsa, Chen, Sung‐Po R., Boer, Jennifer C., Khalil, Zeinab G., Deceneux, Cyril, Goodchild, Georgia, Lu, Lantian, Faruck, Mohammad Omer, Shalash, Ahmed O., Bashiri, Sahra, Capon, Robert J., Hussein, Waleed M., Monteiro, Michael J., Plebanski, Magdalena, Toth, Istvan and Skwarczynski, Mariusz (2023). Polymeric nanoparticles as a self‐adjuvanting peptide vaccine delivery system: the role of shape. Advanced Functional Materials, 33 (12) 2209304, 2209304. doi: 10.1002/adfm.202209304
Skwarczynski, Mariusz, Zhao, Guangzu, Ozberk, Victoria, Giddam, Ashwini Kumar, Khalil, Zeinab G., Pandey, Manisha, Hussein, Waleed M., Nevagi, Reshma J., Batzloff, Michael R., Capon, Robert J., Good, Michael F. and Toth, Istvan (2023). Polyphenylalanine as a self-adjuvanting delivery system for peptide-based vaccines: the role of peptide conformation. Australian Journal of Chemistry, 76 (8), 429-436. doi: 10.1071/ch22167
Nahar, Ummey Jannatun, Toth, Istvan and Skwarczynski, Mariusz (2022). Mannose in vaccine delivery. Journal of Controlled Release, 351, 284-300. doi: 10.1016/j.jconrel.2022.09.038
Alharbi, Nedaa, Skwarczynski, Mariusz and Toth, Istvan (2022). The influence of component structural arrangement on peptide vaccine immunogenicity. Biotechnology Advances, 60 108029, 1-24. doi: 10.1016/j.biotechadv.2022.108029
Kiong, Jolynn, Nahar, Ummey Jannatun, Jin, Shengbin, Shalash, Ahmed O., Zhang, Jiahui, Koirala, Prashamsa, Khalil, Zeinab G., Capon, Robert J., Skwarczynski, Mariusz, Toth, Istvan and Hussein, Waleed M. (2022). Development of multilayer nanoparticles for the delivery of peptide-based subunit vaccine against group a Streptococcus. Pharmaceutics, 14 (10) 2151, 1-12. doi: 10.3390/pharmaceutics14102151
Shalash, Ahmed O., Skwarczynski, Mariusz and Toth, Istvan (2022). Perspectives in the vaccine development against Opisthorchis viverrini liver fluke. MedComm – Biomaterials and Applications, 1 (2) e21, 1-8. doi: 10.1002/mba2.21
Azuar, Armira, Madge, Harrison Y. R., Boer, Jennifer C., Gonzalez Cruz, Jazmina L., Wang, Jingwen, Khalil, Zeinab G., Deceneux, Cyril, Goodchild, Georgia, Yang, Jieru, Koirala, Prashamsa, Hussein, Waleed M., Capon, Robert J., Plebanski, Magdalena, Toth, Istvan and Skwarczynski, Mariusz (2022). Poly(hydrophobic amino acids) and liposomes for delivery of vaccine against Group A Streptococcus. Vaccines, 10 (8) 1212, 1-14. doi: 10.3390/vaccines10081212
Shalash, Ahmed O., Becker, Luke, Yang, Jieru, Giacomin, Paul, Pearson, Mark, Hussein, Waleed M., Loukas, Alex, Toth, Istvan and Skwarczynski, Mariusz (2022). Development of a peptide vaccine against hookworm infection: immunogenicity, efficacy, and immune correlates of protection. Journal of Allergy and Clinical Immunology, 150 (1), 157-169.e10. doi: 10.1016/j.jaci.2022.02.020
Shalash, Ahmed O., Toth, Istvan and Skwarczynski, Mariusz (2022). The potential of developing a protective peptide‐based vaccines against SARS‐CoV‐2. Drug Development Research, 83 (6), 1251-1256. doi: 10.1002/ddr.21969
Apostolopoulos, Vasso, Bojarska, Joanna, Chai, Tsun-Thai, Feehan, Jack, Kaczmarek, Krzysztof, Matsoukas, John M., Paredes Lopez, Octavio, Saviano, Michele, Skwarczynski, Mariusz, Smith-Carpenter, Jillian, Venanzi, Mariano, Wolf, Wojciech M., Zielenkiewicz, Piotr and Ziora, Zyta M. (2022). New Advances in Short Peptides: Looking Forward. Molecules, 27 (11) 3635, 3635. doi: 10.3390/molecules27113635
Shalash, Ahmed O., Azuar, Armira, Madge, Harrison Y. R., Modhiran, Naphak, Amarilla, Alberto A., Liang, Benjamin, Khromykh, Alexander A., Hussein, Waleed M., Chappell, Keith J., Watterson, Daniel, Young, Paul R., Skwarczynski, Mariusz and Toth, Istvan (2022). Peptide-based vaccine against SARS-CoV-2: peptide antigen discovery and screening of adjuvant systems. Pharmaceutics, 14 (4) 856, 856. doi: 10.3390/pharmaceutics14040856
Skwarczynski, Mariusz, Bashiri, Sahra, Yuan, Ye, Ziora, Zyta M., Nabil, Osama, Masuda, Keita, Khongkow, Mattaka, Rimsueb, Natchanon, Cabral, Horacio, Ruktanonchai, Uracha, Blaskovich, Mark A. T. and Toth, Istvan (2022). Antimicrobial activity enhancers: towards smart delivery of antimicrobial agents. Antibiotics, 11 (3) 412, 412. doi: 10.3390/antibiotics11030412
Islam, Md. Tanjir, Ho, Mei-Fong, Nahar, Ummey J., Shalash, Ahmed O., Koirala, Prashamsa, Hussein, Waleed M., Stanisic, Danielle I., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2022). Investigation of liposomal self-adjuvanting peptide epitopes derived from conserved blood-stage Plasmodium antigens. PLoS One, 17 (3) e0264961, e0264961. doi: 10.1371/journal.pone.0264961
Skwarczynski, Mariusz (2022). Editorial: Advances in vaccine delivery: Adjuvants, carriers, formulations, and routes. Frontiers in Pharmacology, 13 857792, 857792. doi: 10.3389/fphar.2022.857792
Zhang, Jiahui, Fan, Jingyi, Skwarczynski, Mariusz, Stephenson, Rachel J, Toth, Istvan and Hussein, Waleed M (2022). Peptide-based nanovaccines in the treatment of cervical cancer: a review of recent advances. International Journal of Nanomedicine, 17, 869-900. doi: 10.2147/ijn.s269986
Marasini, Nirmal, Er, Gerald, Fu, Changkui, Subasic, Christopher N., Ibrahim, Jibriil, Skwarczynski, Mariusz, Toth, Istvan, Whittaker, Andrew K. and Kaminskas, Lisa M. (2022). Development of a hyperbranched polymer-based methotrexate nanomedicine for rheumatoid arthritis. Acta Biomaterialia, 142, 298-307. doi: 10.1016/j.actbio.2022.01.054
Shalash, Ahmed O., Azuar, Armira, Madge, Harrison Y. R., Modhiran, Naphak, Amarilla, Alberto A., Liang, Benjamin, Khromykh, Alexander A., Watterson, Daniel, Young, Paul R., Toth, Istvan and Skwarczynski, Mariusz (2021). Detection and quantification of SARS-CoV-2 receptor binding domain neutralization by a sensitive competitive ELISA assay. Vaccines, 9 (12) 1493, 1-21. doi: 10.3390/vaccines9121493
Shalash, Ahmed O., Hussein, Waleed M., Skwarczynski, Mariusz and Toth, Istvan (2021). Hookworm infection: toward development of safe and effective peptide vaccines. Journal of Allergy and Clinical Immunology, 148 (6), 1394-1419.e6. doi: 10.1016/j.jaci.2021.10.013
Stanisic, Danielle I., Ho, Mei-Fong, Nevagi, Reshma, Cooper, Emily, Walton, Maddison, Islam, Md Tanjir, Hussein, Waleed M., Skwarczynski, Mariusz, Toth, Istvan and Good, Michael F. (2021). Development and evaluation of a cryopreserved whole-parasite vaccine in a rodent model of blood-stage malaria. mBio, 12 (5) e02657-21, e0265721. doi: 10.1128/mBio.02657-21
Bojarska, Joanna, Mieczkowski, Adam, Ziora, Zyta, Skwarczynski, Mariusz, Toth, Istvan, Shalash, Ahmed O., Parang, Keykavous, El-Mowafi, Shaima A., Mohammed, Eman H. M., Elnagdy, Sherif, AlKhazindar, Maha and Wolf, Wojciech M. (2021). Cyclic dipeptides: the biological and structural landscape with special focus on the anti-cancer proline-based scaffold. Biomolecules, 11 (10) 1515, 1515. doi: 10.3390/biom11101515
Shalash, Ahmed O., Becker, Luke, Yang, Jieru, Giacomin, Paul, Pearson, Mark, Hussein, Waleed M., Loukas, Alex, Skwarczynski, Mariusz and Toth, Istvan (2021). Oral peptide vaccine against hookworm infection: correlation of antibody titers with protective efficacy. Vaccines, 9 (9) 1034, 1034. doi: 10.3390/vaccines9091034
Azuar, Armira, Shibu, Mohini A., Adilbish, Nomin, Marasini, Nirmal, Hung, Hong, Yang, Jieru, Luo, Yacheng, Khalil, Zeinab G., Capon, Robert J., Hussein, Waleed M., Toth, Istvan and Skwarczynski, Mariusz (2021). Poly(hydrophobic amino acid) conjugates for the delivery of multiepitope vaccine against Group A Streptococcus. Bioconjugate Chemistry, 32 (11) acs.bioconjchem.1c00333, 2307-2317. doi: 10.1021/acs.bioconjchem.1c00333
Faruck, Mohammad O., Koirala, Prashamsa, Yang, Jieru, D’Occhio, Michael J., Skwarczynski, Mariusz and Toth, Istvan (2021). Polyacrylate-GnRH peptide conjugate as an oral contraceptive vaccine candidate. Pharmaceutics, 13 (7) 1081, 1-15. doi: 10.3390/pharmaceutics13071081
Shalash, Ahmed O., Hussein, Waleed M., Skwarczynski, Mariusz and Toth, Istvan (2021). Key considerations for the development of safe and effective SARS‐CoV‐2 subunit vaccine: a peptide‐based vaccine alternative. Advanced Science, 8 (16) 2100985, 1-35. doi: 10.1002/advs.202100985
Al-Nazal, Hanan A., Cooper, Emily, Ho, Mei Fong, Eskandari, Sharareh, Majam, Victoria, Giddam, Ashwini Kumar, Hussein, Waleed M., Islam, Md Tanjir, Skwarczynski, Mariusz, Toth, Istvan, Kumar, Sanjai, Zaid, Ali, Batzloff, Michael, Stanisic, Danielle I. and Good, Michael F. (2021). Pre-clinical evaluation of a whole-parasite vaccine to control human babesiosis. Cell Host and Microbe, 29 (6), 894-903. doi: 10.1016/j.chom.2021.04.008
Lu, Lantian, Duong, Viet Tram, Shalash, Ahmed O., Skwarczynski, Mariusz and Toth, Istvan (2021). Chemical conjugation strategies for the development of protein-based subunit nanovaccines. Vaccines, 9 (6) 563, 1-24. doi: 10.3390/vaccines9060563
Yang, Jieru, Firdaus, Farrhana, Azuar, Armira, Khalil, Zeinab G., Marasini, Nirmal, Capon, Robert J., Hussein, Waleed M., Toth, Istvan and Skwarczynski, Mariusz (2021). Cell-penetrating peptides-based liposomal delivery system enhanced immunogenicity of peptide-based vaccine against group A streptococcus. Vaccines, 9 (5) 499, 499. doi: 10.3390/vaccines9050499
Azuar, Armira, Li, Zhuoqing, Shibu, Mohini A., Zhao, Lili, Luo, Yacheng, Shalash, Ahmed O., Khalil, Zeinab G., Capon, Robert J., Hussein, Waleed M., Toth, Istvan and Skwarczynski, Mariusz (2021). Poly(hydrophobic amino acid)-based self-adjuvanting nanoparticles for Group A Streptococcus vaccine delivery. Journal of Medicinal Chemistry, 64 (5) acs.jmedchem.0c01660, 2648-2658. doi: 10.1021/acs.jmedchem.0c01660
Apostolopoulos, Vasso, Bojarska, Joanna, Chai, Tsun-Thai, Elnagdy, Sherif, Kaczmarek, Krzysztof, Matsoukas, John, New, Roger, Parang, Keykavous, Lopez, Octavio Paredes, Parhiz, Hamideh, Perera, Conrad O., Pickholz, Monica, Remko, Milan, Saviano, Michele, Skwarczynski, Mariusz, Tang, Yefeng, Wolf, Wojciech M., Yoshiya, Taku, Zabrocki, Janusz, Zielenkiewicz, Piotr, AlKhazindar, Maha, Barriga, Vanessa, Kelaidonis, Konstantinos, Sarasia, Elham Mousavinezhad and Toth, Istvan (2021). A global review on short peptides: frontiers and perspectives. Molecules, 26 (2) 430, 430. doi: 10.3390/molecules26020430
Pandey, Manisha, Ozberk, Victoria, Eskandari, Sharareh, Shalash, Ahmed O., Joyce, Michael A., Saffran, Holly A., Day, Christopher J., Lepletier, Ailin, Spillings, Belinda L., Mills, Jamie-Lee, Calcutt, Ainslie, Fan, Fan, Williams, James T., Stanisic, Danielle I., Hattingh, Laetitia, Gerrard, John, Skwarczynski, Mariusz, Mak, Johnson, Jennings, Michael P., Toth, Istvan, Tyrrell, D. Lorne and Good, Michael F. (2021). Antibodies to neutralising epitopes synergistically block the interaction of the receptor-binding domain of SARS-CoV-2 to ACE 2. Clinical and Translational Immunology, 10 (3) e1260, e1260. doi: 10.1002/cti2.1260
Zhao, Guangzu, Azuar, Armira, Toth, Istvan and Skwarczynski, Mariusz (2021). A potent vaccine delivery system. Bio-protocol, 11 (7) e3973, e3973. doi: 10.21769/bioprotoc.3973
Zhao, Lili, Yang, Jieru, Nahar, Ummey Jannatun, Khalil, Zeinab G., Capon, Robert J., Hussein, Waleed M., Skwarczynski, Mariusz and Toth, Istvan (2020). A dual-adjuvanting strategy for peptide-based subunit vaccines against group A Streptococcus: lipidation and polyelectrolyte complexes. Bioorganic and Medicinal Chemistry, 28 (24) 115823, 115823. doi: 10.1016/j.bmc.2020.115823
Bashiri, Sahra, Koirala, Prashamsa, Toth, Istvan and Skwarczynski, Mariusz (2020). Carbohydrate immune adjuvants in subunit vaccines. Pharmaceutics, 12 (10) 965, 965-33. doi: 10.3390/pharmaceutics12100965
Skwarczynski, Mariusz, Chandrudu, Saranya, Rigau-Planella, Berta, Islam, Md. Tanjir, Cheong, Yee S., Liu, Genan, Wang, Xiumin, Toth, Istvan and Hussein, Waleed M. (2020). Progress in the development of subunit vaccines against malaria. Vaccines, 8 (3) 373, 1-19. doi: 10.3390/vaccines8030373
Zhao, Lili, Jin, Wanli, Cruz, Jazmina Gonzalez, Marasini, Nirmal, Khalil, Zeinab G., Capon, Robert J., Hussein, Waleed M., Skwarczynski, Mariusz and Toth, Istvan (2020). Development of polyelectrolyte complexes for the delivery of peptide-based subunit vaccines against group A streptococcus. Nanomaterials, 10 (5) 823, 823. doi: 10.3390/nano10050823
Bartlett, Stacey, Eichenberger, Ramon M., Nevagi, Reshma J., Ghaffar, Khairunnisa Abdul, Marasini, Nirmal, Dai, Yang, Loukas, Alex, Toth, Istvan and Skwarczynski, Mariusz (2020). Lipopeptide-based oral vaccine against hookworm infection. The Journal of Infectious Diseases, 221 (6), 934-942. doi: 10.1093/infdis/jiz528
Skwarczynski, Mariusz and Toth, Istvan (2020). Non-invasive mucosal vaccine delivery: advantages, challenges and the future. Expert Opinion on Drug Delivery, 17 (4), 1-3. doi: 10.1080/17425247.2020.1731468
Bartlett, Stacey, Skwarczynski, Mariusz, Xie, Xin, Toth, Istvan, Loukas, Alex and Eichenberger, Ramon M. (2020). Development of natural and unnatural amino acid delivery systems against hookworm infection. Precision Nanomedicine, 3 (1), 471-482. doi: 10.33218/prnano3(1).191210.1
Skwarczynski, Mariusz, Zhao, Guangzu, Boer, Jennifer C., Ozberk, Victoria, Azuar, Armira, Gonzalez Cruz, Jazmina, Kumar Giddam, Ashwini, Khalil, Zeinab G., Pandey, Manisha, Shibu, Mohini A., Hussein, Waleed M., Nevagi, Reshma J., Batzloff, Michael R., Wells, James W., Capon, Robert J., Plebanski, Magdalena, Good, Michael F. and Toth, Istvan (2020). Poly(amino acids) as a potent self-adjuvanting delivery system for peptide-based nanovaccines. Science Advances, 6 (5) eaax2285, eaax2285. doi: 10.1126/sciadv.aax2285
Faruck, Mohammad Omer, Zhao, Lili, Hussein, Waleed M., Khalil, Zeinab G., Capon, Robert J., Skwarczynski, Mariusz and Toth, Istvan (2020). Polyacrylate–peptide antigen conjugate as a single-dose oral vaccine against Group A Streptococcus. Vaccines, 8 (1) 23, 1-10. doi: 10.3390/vaccines8010023
Bartlett, Stacey, Skwarczynski, Mariusz and Toth, Istvan (2020). Lipids as activators of innate immunity in peptide vaccine delivery. Current Medicinal Chemistry, 25 (17), 2887-2901. doi: 10.2174/0929867325666181026100849
Dai, Chuankai, Stephenson, Rachel J., Skwarczynski, Mariusz and Toth, Istvan (2020). Application of Fmoc-SPPS, thiol-maleimide conjugation, and copper(I)-catalyzed alkyne-azide cycloaddition "click" reaction in the synthesis of a complex peptide-based vaccine candidate against Group A Streptococcus. Methods in Molecular Biology, 2103, 13-27. doi: 10.1007/978-1-0716-0227-0_2
Ssemaganda, Aloysious, Giddam, Ashwini Kumar, Low, Leanne M., Liu, Xue Q., Ho, Mei-Fong, Zaman, Mehfuz, Hussein, Waleed M., Skwarczynski, Mariusz, Toth, Istvan, Stanisic, Danielle I. and Good, Michael F. (2019). Mannosylated liposomes formulated with whole parasite P. falciparum blood-stage antigens are highly immunogenic in mice. Vaccine, 38 (6), 1494-1504. doi: 10.1016/j.vaccine.2019.11.063
Zhao, Lili, Skwarczynski, Mariusz and Toth, Istvan (2019). Polyelectrolyte-based platforms for the delivery of peptides and proteins. ACS Biomaterials Science & Engineering, 5 (10) acsbiomaterials.9b01135, 4937-4950. doi: 10.1021/acsbiomaterials.9b01135
Skwarczynski, Mariusz and Toth, Istvan (2019). Cell-penetrating peptides in vaccine delivery: facts, challenges and perspectives. Therapeutic Delivery, 10 (8), 465-467. doi: 10.4155/tde-2019-0042
Azuar, Armira, Zhao, Lili, Hei, Tsui Ting, Nevagi, Reshma J., Bartlett, Stacey, Hussein, Waleed M., Khalil, Zeinab G., Capon, Robert J., Toth, Istvan and Skwarczynski, Mariusz (2019). Cholic acid-based delivery system for vaccine candidates against Group A Streptococcus. ACS Medicinal Chemistry Letters, 10 (9) acsmedchemlett.9b00239, 1253-1259. doi: 10.1021/acsmedchemlett.9b00239
Nevagi, Reshma J., Dai, Wei, Khalil, Zeinab G., Hussein, Waleed M., Capon, Robert J., Skwarczynski, Mariusz and Toth, Istvan (2019). Self-assembly of trimethyl chitosan and poly(anionic amino acid)-peptide antigen conjugate to produce a potent self-adjuvanting nanovaccine delivery system. Bioorganic and Medicinal Chemistry, 27 (14), 3082-3088. doi: 10.1016/j.bmc.2019.05.033
Azuar, Armira, Jin, Wanli , Mukaida, Saori, Hussein, Waleed , Toth, Istvan and Skwarczynski, Mariusz (2019). Recent advances in the development of peptide vaccines and their delivery systems against Group A Streptococcus. Vaccines, 7 (3) 58, 58. doi: 10.3390/vaccines7030058
Nevagi, Reshma J., Dai, Wei, Khalil, Zeinab G., Hussein, Waleed M., Capon, Robert J., Skwarczynski, Mariusz and Toth, Istvan (2019). Structure-activity relationship of group A streptococcus lipopeptide vaccine candidates in trimethyl chitosan-based self-adjuvanting delivery system. European Journal of Medicinal Chemistry, 179, 100-108. doi: 10.1016/j.ejmech.2019.06.047
Nevagi, Reshma J., Skwarczynski, Mariusz and Toth, Istvan (2019). Polymers for subunit vaccine delivery. European Polymer Journal, 114, 397-410. doi: 10.1016/j.eurpolymj.2019.03.009
Ssemaganda, Aloysious, Giddam, Ashwini Kumar, Zaman, Mehfuz, Skwarczynski, Mariusz, Toth, Istvan, Stanisic, Danielle I. and Good, Michael F. (2019). Induction of Plasmodium-specific immune responses using liposome-based vaccines. Frontiers in Immunology, 10 135, 135. doi: 10.3389/fimmu.2019.00135
Toth, Istvan and Skwarczynski, Mariusz (2019). Drug delivery Asia. Current Drug Delivery, 16 (7), 586-587. doi: 10.2174/156720181607190917091556
Yang, Jieru, Luo, Yacheng, Shibu, Mohini Anjna, Toth, Istvan and Skwarczynski, Mariusz (2019). Cell-penetrating peptides: efficient vectors for vaccine delivery. Current Drug Delivery, 16 (5), 430-443. doi: 10.2174/1567201816666190123120915
Khongkow, Mattaka, Liu, Tzu-yu, Bartlett, Stacey, Hussein, Waleed M., Nevagi, Reshma, Jia, Zhongfan, Monteiro, Michael J., Wells, James, Ruktanonchai, Uracha Rungsardthong, Skwarczynski, Mariusz and Toth, Istvan (2018). Liposomal formulation of polyacrylate-peptide conjugate as a new vaccine candidate against cervical cancer. Precision Nanomedicine, 1 (3), 183-193. doi: 10.33218/prnano1(3).181003.1
Hussein, Waleed M., Choi, Phil M., Zhang, Cheng, Sierecki, Emma, Johnston, Wayne, Jia, Zhongfan, Monteiro, Michael J., Skwarczynski, Mariusz, Gambin, Yann and Toth, Istvan (2018). Investigating the affinity of poly tert-butyl acrylate toward Toll-Like Receptor 2. AIMS Allergy and Immunology, 2 (3), 141-147. doi: 10.3934/allergy.2018.3.141
Nevagi, Reshma J., Khalil, Zeinab G., Hussein, Waleed M., Powell, Jessica, Batzloff, Michael R., Capon, Robert J., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2018). Polyglutamic acid-trimethyl chitosan-based intranasal peptide nano-vaccine induces potent immune responses against group A streptococcus. Acta Biomaterialia, 80, 278-287. doi: 10.1016/j.actbio.2018.09.037
Jaberolansar, Noushin, Chappell, Keith J., Watterson, Daniel, Bermingham, Imogen M., Toth, Istvan, Young, Paul R. and Skwarczynski, Mariusz (2017). Induction of high titred, non-neutralising antibodies by self-adjuvanting peptide epitopes derived from the respiratory syncytial virus fusion protein. Scientific Reports, 7 (1) 11130, 11130. doi: 10.1038/s41598-017-10415-w
Schulze, Kai, Ebensen, Thomas, Chandrudu, Saranya, Skwarczynski, Mariusz, Toth, Istvan, Olive, Colleen and Guzman, Carlos A (2017). Bivalent mucosal peptide vaccines administered using the LCP carrier system stimulate protective immune responses against Streptococcus pyogenes infection. Nanomedicine : nanotechnology, biology, and medicine, 13 (8), 2463-2474. doi: 10.1016/j.nano.2017.08.015
Zhao, Guangzu, Chandrudu, Saranya, Skwarczynski, Mariusz and Toth, Istvan (2017). The application of self-assembled nanostructures in peptide-based subunit vaccine development. European Polymer Journal, 93, 670-681. doi: 10.1016/j.eurpolymj.2017.02.014
Marasini, Nirmal, Ghaffar, Khairunnisa Abdul, Giddam, Ashwini Kumar, Batzloff, Michael R., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2017). Highly immunogenic trimethyl chitosan-based delivery system for intranasal lipopeptide vaccines against group A streptococcus. Current Drug Delivery, 14 (5), 701-708. doi: 10.2174/1567201813666160721141322
Skwarczynski, Mariusz and Toth, Istvan (2017). Development and delivery of a peptide-based vaccine against group A Streptococcus. Infectious Diseases Hub.
Hussein, Waleed M., Mukaida, Saori, Liu, Tzu-Yu, Toth, Istvan and Skwarczynski, Mariusz (2017). Fluorinated lipids conjugated to peptide antigens do not induce immune responses against cervical cancer. Vaccination Research Open Journal, 1 (1), 39-44. doi: 10.17140/VROJ-1-107
Marasini, Nirmal, Skwarczynski, Mariusz and Toth, Istvan (2017). Intranasal delivery of nanoparticle-based vaccines. Therapeutic Delivery, 8 (3), 151-167. doi: 10.4155/tde-2016-0068
Hussein, Waleed M., Mukaida, Saori, Azmi, Fazren, Bartlett, Stacey, Olivier, Celine, Batzloff, Michael R., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2017). Comparison of fluorinated and nonfluorinated lipids in self-adjuvanting delivery systems for peptide-based vaccines. ACS Medicinal Chemistry Letters, 8 (2), 227-232. doi: 10.1021/acsmedchemlett.6b00453
Marasini, Nirmal, Giddam, Ashwini Kumar, Batzloff, Michael R. , Good, Michael F. , Skwarczynski, Mariusz and Toth, Istvan (2017). Poly-L-lysine-coated nanoparticles are ineffective in inducing mucosal immunity against group a streptococcus. Biochemical Compounds, 5 (1), 1.1-1.6. doi: 10.7243/2052-9341-5-1
Skwarczynski, Mariusz (2017). Inulin: a new adjuvant with unknown mode of action. EBioMedicine, 15, 8-9. doi: 10.1016/j.ebiom.2016.11.019
Ghaffar, Khairunnisa Abdul, Marasini, Nirmal, Giddam, Ashwini Kumar, Batzloff, Michael R., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2017). The role of size in development of mucosal liposome-lipopeptide vaccine candidates against group A streptococcus. Medicinal Chemistry, 13 (1), 22-27. doi: 10.2174/1573406412666160720093138
Skwarczynski, Mariusz (2017). Meet our editorial board member. Medicinal Chemistry, 13 (1), 2-2. doi: 10.2174/157340641301161222205112
Hussein, Waleed, Choi, Phil, Zhang, Cheng, Su, Mei, Sierecki, Emma, Johnston, Wayne, Fagan, Vincent, Alexandrov, Kirill, Skwarczynski, Mariusz, Gambin, Yann, Toth, Istvan and Simerska, P. (2017). Evaluation of lipopeptides as toll-like receptor 2 ligands. Current Drug Delivery, 14 (7), 935-943. doi: 10.2174/1567201813666160804114107
Azmi, Fazren, Skwarczynski, Mariusz and Toth, Istvan (2016). Towards the development of synthetic antibiotics: designs inspired by natural antimicrobial peptides. Current Medicinal Chemistry, 23 (41), 4610-4624. doi: 10.2174/0929867323666160825162435
Marasini, Nirmal, Giddam, Ashwini K., Khalil, Zeinab G., Hussein, Waleed M., Capon, Robert J., Batzloff, Michael R., Good, Michael F., Toth, Istvan and Skwarczynski, Mariusz (2016). Double adjuvanting strategy for peptide-based vaccines: trimethyl chitosan nanoparticles for lipopeptide delivery. Nanomedicine, 11 (24), 3223-3235. doi: 10.2217/nnm-2016-0291
Marasini, Nirmal, Khalil, Zeinab G., Giddam, Ashwini K., Abdul Ghaffar, Khairunnisa, Hussein, Waleed M., Capon, Robert J., Batzloff, Michael R., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2016). Lipid core peptide/poly(lactic-co-glycolic acid) as a highly potent intranasal vaccine delivery system against Group A streptococcus. International Journal of Pharmaceutics, 513 (1-2), 410-420. doi: 10.1016/j.ijpharm.2016.09.057
Skwarczynski, Mariusz (2016). Meet our editorial board member. Current Drug Delivery, 13 (7), 1003-1003. doi: 10.2174/156720181307161018173422
Giddam, Ashwini Kumar, Reiman, Jennifer M., Zaman, Mehfuz, Skwarczynski, Mariusz, Toth, Istvan and Good, Michael F. (2016). A semi-synthetic whole parasite vaccine designed to protect against blood stage malaria. Acta Biomaterialia, 44, 295-303. doi: 10.1016/j.actbio.2016.08.020
Hussein, Waleed M., Liu, Tzu-Yu, Jia, Zhongfan, McMillan, Nigel A. J., Monteiro, Michael J., Toth, Istvan and Skwarczynski, Mariusz (2016). Multiantigenic peptide-polymer conjugates as therapeutic vaccines against cervical cancer. Bioorganic and Medicinal Chemistry, 24 (18), 4372-4380. doi: 10.1016/j.bmc.2016.07.036
Chandrudu, Saranya, Bartlett, Stacey, Khalil, Zeinab G., Jia, Zhongfan, Hussein, Waleed M., Capon, Robert J., Batzloff, Michael R., Good, Michael F., Monteiro, Michael J., Skwarczynski, Mariusz and Toth, Istvan (2016). Linear and branched polyacrylates as a delivery platform for peptide-based vaccines. Therapeutic Delivery, 7 (9), 601-609. doi: 10.4155/tde-2016-0037
Azmi, Fazren, Elliott, Alysha G., Marasini, Nirmal, Ramu, Soumya, Ziora, Zyta, Kavanagh, Angela M., Blaskovich, Mark A. T., Cooper, Matthew A., Skwarczynski, Mariusz and Toth, Istvan (2016). Short cationic lipopeptides as effective antibacterial agents: design, physicochemical properties and biological evaluation. Bioorganic and Medicinal Chemistry, 24 (10), 2235-2241. doi: 10.1016/j.bmc.2016.03.053
Marasini, Nirmal, Giddam, Ashwini K., Ghaffar, Khairunnisa A., Batzloff, Michael R., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2016). Multilayer engineered nanoliposomes as a novel tool for oral delivery of lipopeptide-based vaccines against group A Streptococcus. Nanomedicine, 11 (10), 1223-1236. doi: 10.2217/nnm.16.36
Ghaffar, Khairunnisa Abdul, Marasini, Nirmal, Giddam, Ashwini K., Batzloff, Michael, Good, Michael, Skwarczynski, Mariusz and Toth, Istvan (2016). Liposome-based intranasal Delivery of lipopeptide vaccine candidates against Group A Streptococcus. Acta Biomaterialia, 41, 161-168. doi: 10.1016/j.actbio.2016.04.012
Skwarczynski, Mariusz and Toth, Istvan (2016). Peptide-based synthetic vaccines. Chemical Science, 7 (2), 842-854. doi: 10.1039/c5sc03892h
Hussein, Waleed M., Liu, Tzu-Yu, Maruthayanar, Pirashanthini, Mukaida, Saori, Moyle, Peter M., Wells, James W., Toth, Istvan and Skwarczynski, Mariusz (2016). Double conjugation strategy to incorporate lipid adjuvants into multiantigenic vaccines. Chemical Science, 7 (3), 2308-2321. doi: 10.1039/C5SC03859F
Chandrudu, Saranya, Skwarczynski, Mariusz, Pattinson, David, Apte, Simon H., Doolan, Denise L. and Toth, Istvan (2016). Synthesis and immunological evaluation of peptide-based vaccine candidates against malaria. Biochemical Compounds, 4 (1). doi: 10.7243/2052-9341-4-1
Chan, Amy, Hussein, Waleed M., Ghaffar, Khairunnisa Abdul, Marasini, Nirmal, Mostafa, Ahmed, Eskandari, Sharareh, Batzloff, Michael R., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2016). Structure-activity relationship of lipid core peptide-based Group A Streptococcus vaccine candidates. Bioorganic and Medicinal Chemistry, 24 (14), 3095-3101. doi: 10.1016/j.bmc.2016.03.063
Moyle, Peter M., Dai, Wei, Liu, Tzu-Yu, Hussein, Waleed M., Maruthayanar, Pirashanthini, Wells, James W., McMillan, Nigel A. J., Skwarczynski, Mariusz and Toth, Istvan (2015). Combined synthetic and recombinant techniques for the development of lipoprotein-based, self-adjuvanting vaccines targeting human papillomavirus type-16 associated tumors. Bioorganic and Medicinal Chemistry Letters, 25 (23), 5570-5575. doi: 10.1016/j.bmcl.2015.10.049
Jaberolansar, Noushin, Toth, Istvan, Young, Paul R. and Skwarczynski, Mariusz (2015). Recent advances in the development of subunit-based RSV vaccines.. Expert Review of Vaccines, 15 (1), 53-68. doi: 10.1586/14760584.2016.1105134
Cupri, Sarha, Graziano, Adriana C. E., Cardile, Venera, Skwarczynski, Mariusz, Toth, Istvan and Pignatello, Rosario (2015). A study on the encapsulation of an occludin lipophilic derivative in liposomal carriers. Journal of Liposome Research, 25 (4), 287-293. doi: 10.3109/08982104.2014.992025
Fuaad, Abdullah A. H. Ahmad, Pearson, Mark S., Pickering, Darren A., Becker, Luke, Zhao, Guangzu, Loukas, Alex C., Skwarczynski, Mariusz and Toth, Istvan (2015). Lipopeptide nanoparticles: development of vaccines against hookworm parasite. ChemMedChem, 10 (10), 1647-1654. doi: 10.1002/cmdc.201500227
Fuaad, Abdullah A. H. Ahmad, Pearson, Mark S., Pickering, Darren A., Becker, Luke, Zhao, Guangzu, Loukas, Alex C., Skwarczynski, Mariusz and Toth, Istvan (2015). Back Cover: Lipopeptide Nanoparticles: Development of Vaccines against Hookworm Parasite (ChemMedChem 10/2015). ChemMedChem, 10 (10), 1768-1768. doi: 10.1002/cmdc.201500390
Ghaffar, Khairunnisa Abdul, Hussein, Waleed M., Khalil, Zeinab G., Capon, Robert J., Skwarczynski, Mariusz and Toth, Istvan (2015). Levofloxacin and indolicidin for combination antimicrobial therapy. Current Drug Delivery, 12 (1), 108-114. doi: 10.2174/1567201811666140910094050
Ahmad Fuaad, Abdullah A. H., Roubille, Romain, Pearson, Mark S., Pickering, Darren A., Loukas, Alex C., Skwarczynski, Mariusz and Toth, Istvan (2015). The use of a conformational cathepsin D-derived epitope for vaccine development against Schistosoma mansoni. Bioorganic and Medicinal Chemistry, 23 (6), 1307-1312. doi: 10.1016/j.bmc.2015.01.033
Liu, Tzu-Yu, Hussein, Waleed M., Giddam, Ashwini Kumar, Jia, Zhongfan, Reiman, Jennifer M., Zaman, Mehfuz, McMillan, Nigel A. J., Good, Michael F., Monteiro, Michael J., Toth, Istvan and Skwarczynski, Mariusz (2015). Polyacrylate-based delivery system for self-adjuvanting anticancer peptide vaccine. Journal of Medicinal Chemistry, 58 (2), 888-896. doi: 10.1021/jm501514h
Skwarczynski, Mariusz, Boyd, Ben J and Toth, Istvan (2015). Drug delivery Australia. Current Drug Delivery, 12 (1), 2-2. doi: 10.2174/156720181201150310141415
Azmi, Fazren, Elliott, Alysha G., Khalil, Zeinab G., Hussein, Waleed M., Kavanagh, Angela, Huang, Johnny X., Quezada, Michelle, Blaskovich, Mark A. T., Capon, Robert J., Cooper, Matthew A., Skwarczynski, Mariusz and Toth, Istvan (2015). Self-assembling lipopeptides with a potent activity against Gram-positive bacteria, including multidrug resistant strains. Nanomedicine, 10 (22), 3359-3371. doi: 10.2217/nnm.15.137
Liu, Tzu-Yu, Giddam, Ashwini Kumar, Hussein, Waleed M., Jia, Zhongfan, McMillan, Nigel A. J., Monteiro, Michael J., Toth, Istvan and Skwarczynski, Mariusz (2015). Self-adjuvanting therapeutic peptide-based vaccine induce CD8+ cytotoxic T lymphocyte responses in a murine human papillomavirus tumor model. Current Drug Delivery, 12 (1), 3-8. doi: 10.2174/1567201811666141001155729
Zaman, Mehfuz, Chandrudu, Saranya, Giddam, Ashwini K., Reiman, Jennifer, Skwarczynski, Mariusz, McPhun, Virginia, Moyle, Peter M., Batzloff, Michael R., Good, Michael F. and Toth, Istvan (2014). Group A Streptococcal vaccine candidate: contribution of epitope to size, antigen presenting cell interaction and immunogenicity. Nanomedicine, 9 (17), 2613-2624. doi: 10.2217/NNM.14.190
Skwarczynski, Mariusz and Toth, Istvan (2014). Recent advances in peptide-based subunit nanovaccines. Nanomedicine, 9 (17), 2657-2669. doi: 10.2217/nnm.14.187
Azmi, Fazren, Ahmad Fuaad, Abdullah Al Hadi, Giddam, Ashwini Kumar, Batzloff, Michael R., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2014). Self-adjuvanting vaccine against group A streptococcus: application of fibrillized peptide and immunostimulatory lipid as adjuvant. Bioorganic and Medicinal Chemistry, 22 (22), 6401-6408. doi: 10.1016/j.bmc.2014.09.042
Marasini, Nirmal, Skwarczynski, Mariusz and Toth, Istvan (2014). Oral delivery of nanoparticle-based vaccines. Expert Review of Vaccines, Early Online (11), 1361-1376. doi: 10.1586/14760584.2014.936852
Ghaffar, Khairunnisa Abdul, Giddam, Ashwini Kumar, Zaman, Mehfuz, Skwarczynski, Mariusz and Toth, Istvan (2014). Liposomes as Nanovaccine Delivery Systems. Current Topics in Medicinal Chemistry, 14 (9), 1194-1208. doi: 10.2174/1568026614666140329232757
Hussein, Waleed M., Liu, Tzu-Yu, Skwarczynski, Mariusz and Toth, Istvan (2014). Toll-like receptor agonists: a patent review (2011 - 2013). Expert Opinion on Therapeutic Patents, 24 (4), 453-470. doi: 10.1517/13543776.2014.880691
Azmi, Fazren, Fuaad, Abdullah Al Hadi Ahmad, Skwarczynski, Mariusz and Toth, Istvan (2014). Recent progress in adjuvant discovery for peptide-based subunit vaccines. Human Vaccines and Immunotherapeutics, 10 (3), 778-796. doi: 10.4161/hv.27332
Ahmad Fuaad, Abdullah A. H., Jia, Zhongfan, Hartas, Jon, Ziora, Zyta M., Lin, I-Chun, Moyle, Peter M., Batzloff, Michael R., Good, Michael F., Monteiro, Michael J., Skwarczynski, Mariusz and Toth, Istvan (2014). Polymer–peptide hybrids as a highly immunogenic single-dose nanovaccine. Nanomedicine, 9 (1), 35-43. doi: 10.2217/NNM.13.7
Dougall, Annette M., Skwarczynski, Mariusz, Khoshnejad, Makan, Chandrudu, Saranya, Daly, Norelle L., Toth, Istvan and Loukas, Alex (2014). Lipid core peptide targeting the cathepsin D hemoglobinase of Schistosoma mansoni as a component of a schistosomiasis vaccine. Human Vaccines and Immunotherapeutics, 10 (2), 399-409. doi: 10.4161/hv.27057
Toth, Istvan and Skwarczynski, Mariusz (2014). The immune system likes nanotechnology. Nanomedicine, 9 (17), 2607-2609. doi: 10.2217/nnm.14.199
Liu, Tzu-Yu, Fuaad, Abdullah Al-Hadi Ahmad, Toth, Istvan and Skwarczynski, Mariusz (2014). Self-assembled peptide-polymer conjugates as vaccines. Chimica Oggi - Chemistry Today, 32 (2 (Supplement)), 18-22.
Toth, Istvan, Zaman, Mehfuz and Skwarczynski, Mariusz (2013). Feherje alapu vedooltasok nanotechnologiaval. Termézet Világa, 144 (11), 504-508.
Liu, Tzu-Yu, Hussein, Waleed M., Jia, Zhongfan, Ziora, Zyta M., McMillan, Nigel A. J., Monteiro, Michael J., Toth, Istvan and Skwarczynski, Mariusz (2013). Self-adjuvanting polymer-peptide conjugates as therapeutic vaccine candidates against cervical cancer. Biomacromolecules, 14 (8), 2798-2806. doi: 10.1021/bm400626w
Skwarczynski, Mariusz, Kowapradit, Jariya, Ziora, Zyta Maria and Toth, Istvan (2013). pH-Triggered peptide self-assembly into fibrils: a potential peptide-based subunit vaccine delivery platform. Biochemical Compounds, 1. doi: 10.7243/2052-9341-1-2
Skwarczynski, Mariusz, Kamaruzaman, Khairul A., Srinivasan, Saranya, Zaman, Mehfuz, Lin, I-Chun, Batzloff, Michael R., Good, Michael F. and Toth, Istvan (2013). M-protein-derived conformational peptide epitope vaccine candidate against Group A Streptococcus. Current Drug Delivery, 10 (1), 39-45. doi: 10.2174/1567201811310010007
Giddam, Ashwini Kumar, Zaman, Mehfuz, Skwarczynski, Mariusz and Toth, Istvan (2013). Liposome-based delivery system for vaccine candidates: constructing an effective formulation (vol 7, pg 1877, 2012). Nanomedicine, 8 (2), 312-312. doi: 10.2217/nnm.13.0
Hussein, Waleed M., Liu, Tzu-Yu, Toth, Istvan and Skwarczynski, Mariusz (2013). Microwave-assisted synthesis of difficult sequence-containing peptides using the isopeptide method. Organic and Biomolecular Chemistry, 11 (14), 2370-2376. doi: 10.1039/c3ob00030c
Ahmad Fuaad, Abdullah A. H., Azmi, Fazren, Skwarczynski, Mariusz and Toth, Istvan (2013). Peptide conjugation via CuAAC 'click' chemistry. Molecules, 18 (11), 13148-13174. doi: 10.3390/molecules181113148
Giddam, Ashwin Kumar, Zaman, Mehfuz, Skwarczynski, Mariusz and Toth, Istvan (2012). Liposome-based delivery system for vaccine candidates: constructing an effective formulation. Nanomedicine, 7 (12), 1877-1893. doi: 10.2217/nnm.12.157
Skwarczynski, Mariusz, Dougall, Annette M., Khoshnejad, Makan, Chandrudu, Saranya, Pearson, Mark S., Loukas, Alex and Toth, Istvan (2012). Peptide-Based Subunit Vaccine against Hookworm Infection. PLoS One, 7 (10 Article #e46870) e46870, e46870. doi: 10.1371/journal.pone.0046870
Apte, Simon H., Groves, Penny L., Skwarczynski, Mariusz, Fujita, Yoshio, Chang, Chenghung, Toth, Istvan and Doolan, Denise L. (2012). Vaccination with lipid core peptides fails to induce epitope-specific T cell responses but confers non-specific protective immunity in a malaria model.. PLoS One, 7 (8 Article. No.e40928) e40928, e40928. doi: 10.1371/journal.pone.0040928
Liu, Tzu-Yu, Hussein, Waleed M., Toth, Istvan and Skwarczynski, Mariusz (2012). Advances in peptide-based Human papillomavirus therapeutic vaccines. Current Topics in Medicinal Chemistry, 12 (14), 1581-1592. doi: 10.2174/156802612802652402
Ziora, Zyta, Skwarczynski, Mariusz and Kiso, Yoshiaki (2012). ChemInform Abstract: Medicinal Chemistry of α-Hydroxy-β-amino Acids. ChemInform, 43 (25), no-no. doi: 10.1002/chin.201225259
Ziora, Zyta M., Wimmer, Norbert, New, Roger, Skwarczynski, Mariusz and Toth, Istvan (2012). Lipopeptides for the fragment-based pharmaceutics design. International Journal of Organic Chemistry, 2 (01), 75-81. doi: 10.4236/ijoc.2012.21013
Skwarczynski, Mariusz, Parhiz, Bibi Hamideh, Soltani, Fatemeh, Srinivasan, Saranya, Kamaruzaman, Khairul A., Lin, I-Chun and Toth, Istvan (2012). Lipid peptide core nanoparticles as multivalent vaccine candidates against Streptococcus pyogenes. Australian Journal of Chemistry, 65 (1), 35-39. doi: 10.1071/CH11292
Ziora, Zyta M., Wimmer, Norbert, New, Roger, Skwarczynski, Mariusz and Toth, Istvan (2011). Synthesis of glycolipopeptidic building blocks for carbohydrate receptor discovery. Carbohydrate Research, 346 (12), 1439-1444. doi: 10.1016/j.carres.2011.03.019
Skwarczynski, Mariusz and Toth, Istvan (2011). Peptide-based subunit nanovaccines. Current Drug Delivery, 8 (3), 282-289. doi: 10.2174/156720111795256192
Zaman, Mehfuz, Skwarczynski, Mariusz, Malcolm, Jessica M., Urbani, Carl N., Jia, Zhongfan, Batzloff, Michael R., Good, Michael F., Monteiro, Michael J. and Toth, Istvan (2011). Self-adjuvanting polyacrylic nanoparticulate delivery system for Group A streptococcus (GAS) vaccine. Nanomedicine: Nanotechnology, Biology and Medicine, 7 (2), 168-173. doi: 10.1016/j.nano.2010.10.002
Skwarczynski, Mariusz, Ahmad Fuaad, Abdullah A. H., Rustanti, Lina, Ziora, Zyta M., Aqil, Mohammed, Batzloff, Michael R., Good, Michael F. and Toth, Istvan (2011). Group A streptococcal vaccine candidates based on the conserved conformational epitope from M protein. Drug Delivery Letters, 1 (1), 2-8. doi: 10.2174/2210304X11101010002
Wilke, DV, Jimenez, PC, Araujo, RM, da Silva, WMB, Pessoa, ODL, Silveira, ER, Pessoa, C, de Moraes, MO, Skwarczynski, M, Simerska, P, Toth, I and Costa-Lotufo, LV (2011). Pro-apoptotic activity of lipidic alpha-amino acids isolated from Protopalythoa variabilis (vol 18, pg 7997, 2010). Bioorganic and Medicinal Chemistry, 19 (3), 1366-1366. doi: 10.1016/j.bmc.2010.12.041
Wilke, Diego Veras, Jimenez, Paula Christine, Araújo, Renata Mendonça, da Silva, Wildson Max Barbosa, Pessoa, Otília Deusdênia Loiola, Silveira, Edilberto Roch, Pessoa, Claudia, de Moraes, Manoel Odorico, Skwarczynski, Mariusz, Simerska, Paul, Toth, Istvan and Costa-Lotufo, Letícia Veras (2010). Pro-apoptotic activity of lipidic α-amino acids isolated from Protopalythoa variabilis. Bioorganic and Medicinal Chemistry, 18 (22), 7997-8004. doi: 10.1016/j.bmc.2010.09.027
Skwarczynski, Mariusz, Zaman, Mehfuz, Urbani, Carl N., Lin, I-Chun, Jia, Zhongfan, Batzloff, Michael R., Good, Michael F., Monteiro, Michael J. and Toth, Istvan (2010). Polyacrylate dendrimer nanoparticles: a self-adjuvanting vaccine delivery system. Angewandte Chemie, 122 (33), 5878-5881. doi: 10.1002/ange.201002221
Skwarczynski, Mariusz, Zaman, Mehfuz, Urbani, Carl N., Lin, I-Chun, Jia, Zhongfan, Batzloff, Michael R., Good, Michael F., Monteiro, Michael J. and Toth, Istvan (2010). Polyacrylate dendrimer nanoparticles: A self-adjuvanting vaccine delivery system. Angewandte Chemie (International Edition), 49 (33), 5742-5745. doi: 10.1002/anie.201002221
Skwarczynski, Mariusz, Ziora, Zyta M., Coles, Daniel J., Lin, I-Chun and Toth, Istvan (2010). Thymine, adenine and lipoamino acid based gene delivery systems. Chemical Communications, 46 (18), 3140-3142. doi: 10.1039/b924371b
Zhong, Wei, Skwarczynski, Mariusz and Toth, Istvan (2009). Development of conformational mimetics of conserved Streptococcus pyogenes minimal epitope as vaccine candidates. Current Drug Delivery, 6 (5), 520-527. doi: 10.2174/156720109789941650
Zhong, Wei, Skwarczynski, Mariusz, Simerska, Pavla, Good, Michael F. and Toth, Istvan (2009). Development of highly pure alpha-helical lipoglycopeptides as self-adjuvanting vaccines. Tetrahedron, 65 (17), 3459-3464. doi: 10.1016/j.tet.2009.02.060
Taniguchi, Atsuhiko, Sohma, Youhei, Skwarczynski, Mariusz, Okada, Takuma, Ikeda, Keisuke, Prakash, Halan, Mukai, Hidehito, Kimura, Tooru, Hayashi, Yoshio, Hirota, Shun, Matsuzaki, Katsumi and Kiso, Yoshiaki (2009). Click peptide by use of the O-acyl isopeptide method: Production of Amyloid Beta peptide from water-soluble analogue. Peptide Science, 397-400.
Zhong, Wei, Skwarczynski, Mariusz and Toth, Istvan (2009). Lipid core peptide system for gene, drug, and vaccine delivery. Australian Journal of Chemistry, 62 (9), 956-967. doi: 10.1071/CH09149
Hayashi, Yoshio, Yamazaki, Yuri, Skwarczynski, Mariusz, Sohma, Youhei, Taniguchi, Atsuhiko, Noguchi, Mayo, Kimura, Tooru, Neuteboom, Saskia, Potts, Barbara, Lloyd, G. Kenneth and Kiso, Yoshiaki (2009). Application of intramolecular migration reaction in peptide chemistry to chemical biology, chemical pharmaceutics and medicinal chemistry. Advances in Experimental Medicine and Biology, 611, 513-514. doi: 10.1007/978-0-387-73657-0_223
Zhong, Wei, Skwarczynski, Mariusz, Fujita, Yoshio, Simerska, Pavla, Good, Michael F. and Toth, Istvan (2009). Design and synthesis of lipopeptide-carbohydrate assembled multivalent vaccine candidates using native chemical ligation. Australian Journal of Chemistry, 62 (9), 993-999. doi: 10.1071/CH09065
Taniguchi, Atsuhiko, Skwarczynski, Mariusz, Sohma, Youhei, Okada, Takuma, Ikeda, Keisuke, Prakash, Halan, Mukai, Hidehito, Hayashi, Yoshio, Kimura, Tooru, Hirota, Shun, Matsuzaki, Katsumi and Kiso, Yoshiaki (2008). Controlled production of amyloid beta peptide from a photo-triggered, water-soluble precursor "click peptide". ChemBioChem, 9 (18), 3055-3065. doi: 10.1002/cbic.200800503
Noguchi, Mayo, Skwarczynski, Mariusz, Prakash, Halan, Hirota, Shun, Kimura, Tooru, Hayashi, Yoshio and Kiso, Yoshiaki (2008). Development of novel water-soluble photocleavable protective group and its application for design of photoresponsive paclitaxel prodrugs. Bioorganic and Medicinal Chemistry, 16 (10), 5389-5397. doi: 10.1016/j.bmc.2008.04.022
Skwarczynski, Mariusz and Kiso, Yoshiaki (2007). Application of the O-N intramolecular acyl migration reaction in medicinal chemistry. Current Medicinal Chemistry, 14 (26), 2813-2823. doi: 10.2174/092986707782360123
Abe, Naoko, Fukao, Fukue, Hayashi, Yoshio, Ito, Nui, Kimura, Tooru, Kiso, Yoshiaki, Nakamura, Setsuko, Skwarczynski, Mariusz, Sohma, Youhei, Taniguchi, Atsuhiko and Yoshiya, Taku (2007). The synthesis of bioactive peptides based on O-Acyl Isopeptide Method: Application of O-acyl isodipeptide units. Peptide Science: Proceedings of the Japanese Peptide Symposium, 44, 187-190.
Yoshiya, Taku, Taniguchi, Atsuhiko, Sohma, Youhei, Fukao, Fukue, Nakamura, Setsuko, Abe, Naoko, Ito, Nui, Skwarczynski, Mariusz, Kimura, Tooru, Hayashi, Yoshio and Kiso, Yoshiaki (2007). "O-acyl isopeptide method" for peptide synthesis: Synthesis of forty kinds of "O-acyl isodipeptide unit" Boc-Ser/Thr(Fmoc-Xaa)-OH. Organic and Biomolecular Chemistry, 5 (11), 1720-1730. doi: 10.1039/b702284k
Skwarczynski, Mariusz, Hayashi, Yoshio and Kiso, Yoshiaki (2006). Paclitaxel prodrugs: Toward smarter delivery of anticancer agents. J. Med. Chem., 49 (25), 7253-7269. doi: 10.1021/jm0602155
Sohma, Youhei, Taniguchi, Atsuhiko, Yoshiya, Taku, Chiyomori, Yousuke, Fukao, Fukue, Nakamura, Setsuko, Skwarczynski, Mariusz, Okada, Takuma, Ikeda, Keisuke, Hayashi, Yoshio, Kimura, Tooru, Hirota, Shun, Matsuzaki, Katsumi and Kiso, Yoshiaki (2006). 'Click peptide': A novel 'O-acyl isopeptide method' for peptide synthesis and chemical biology-oriented synthesis of amyloid beta peptide analogues. Journal of Peptide Science, 12 (12), 823-828. doi: 10.1002/psc.817
Skwarczynski, M., Noguchi, M., Sohma, Y., Kimura, T., Hayashi, Y. and Kiso, Y. (2006). Application of intramolecular carbonate-carbamate migration. Chimica Oggi, 24 (6), 30-32.
Skwarczynski, Mariusz, Noguchi, Mayo, Hirota. Shun, Sohma, Youhei, Kimura, Tooru, Hayashi, Yoshio and Kiso, Yoshiaki (2006). Development of first photoresponsive prodrug of paclitaxel. Bioorganic and Medicinal Chemistry Letters, 16 (17), 4492-4496. doi: 10.1016/j.bmcl.2006.06.030
Sohma, Youhei, Taniguchi, Atsuhiko, Skwarczynski, Mariusz, Yoshiya, Taku, Fukao, Fukue, Kimura, Tooru, Hayashi, Yoshio and Kiso, Yoshiaki (2006). 'O-Acyl isopeptide method' for the efficient synthesis of difficult sequence-containing peptides: Use of 'O-acyl isodipeptide unit'. Tetrahedron Letters, 47 (18), 3013-3017. doi: 10.1016/j.tetlet.2006.03.017
Skwarczynski, Mariusz, Sohma, Youhei, Noguchi, Mayo, Kimura, Tooru, Hayashi, Yoshio and Kiso, Yoshiaki (2006). O-N intramolecular alkoxycarbonyl migration of typical protective groups in hydroxyamino acids. Journal of Organic Chemistry, 71 (6), 2542-2545. doi: 10.1021/jo0525579
Skwarczynski, Mariusz, Sohma, Youhei, Noguchi, Mayo, Kimura, Maiko, Hayashi, Yoshio, Hamada, Yoshio, Kimura, Tooru and Kiso, Yoshiaki (2005). No auxiliary, no byproduct strategy for water-soluble prodrugs of taxoids: Scope and limitation of O-N intramolecular acyl and acyloxy migration reactions. Journal of Medicinal Chemistry, 48 (7), 2655-2666. doi: 10.1021/jm049344g
Skwarczynski, M, Sohma, Y, Kimura, M, Hayashi, Y, Kimura, T and Kiso, Y (2003). O-N intramolecular acyl migration strategy in water-soluble prodrugs of taxoids. Bioorganic & Medicinal Chemistry Letters, 13 (24), 4441-4444. doi: 10.1016/j.bmcl.2003.09.020
Hayashi, Y, Skwarczynski, M, Hamada, Y, Sohma, Y, Kimura, T and Kiso, Y (2003). A novel approach of water-soluble paclitaxel prodrug with no auxiliary and no byproduct: Design and synthesis of isotaxel. Journal of Medicinal Chemistry, 46 (18), 3782-3784. doi: 10.1021/jm034112n
Nishizawa, M, Yadav, VK, Skwarczynski, M, Takao, H, Imagawa, H and Sugihara, T (2003). Mercuric triflate catalyzed hydroxylative carbocyclization of 1,6-enynes. Organic Letters, 5 (10), 1609-1611. doi: 10.1021/ol034201u
Nishizawa, M, Skwarczynski, M, Imagawa, H and Sugihara, T (2002). Mercuric triflate-TMU catalyzed hydration of terminal alkyne to give methyl ketone under mild conditions. Chemistry Letters, 31 (1), 12-13. doi: 10.1246/cl.2002.12
Skwarczynski, M, Lejczak, B and Kafarski, P (1999). Enantioselective hydrolysis of 1-butyryloxyalkylphosphonates by lipolytic microorganisms: Pseudomonas fluorescens and Penicillium citrinum. Chirality, 11 (2), 109-114. doi: 10.1002/(SICI)1520-636X(1999)11:2<109::AID-CHIR5>3.0.CO;2-T
Zymanczykduda, E, Skwarczynski, M, Lejczak, B and Kafarski, P (1996). Accurate assay of enantiopurity of 1-hydroxy- and 2-hydroxyalkylphosphonate esters. Tetrahedron-Asymmetry, 7 (5), 1277-1280. doi: 10.1016/0957-4166(96)00143-7
Lejczak, Barbara, Haliniarz, Ewa, Skwarczynski, Mariusz and Kafarski, Pawel (1996). The Use of Lypolitic Microorganisms Pseudomonas fluorescens and Penicillium citrinum for the Preparation of Optically Active 1 -Hydroxyalkylphosphonates. Phosphorus, Sulfur, and Silicon and the Related Elements, 111 (1), 86-86. doi: 10.1080/10426509608054715
Skwarczynski, M and Kafarski, P (1995). Alkylation of Potassium 1-(n-Benzyloxycarbonylamino)alkylphosphonates and Phosphinates in the Presence of 18-Crown-6. Synthetic Communications, 25 (22), 3565-3571. doi: 10.1080/00397919508015491
Conference Papers
Nevagi, Reshma Jayprakash, Dai, Wei, Khalil, Zeinab, Hussein, Waleed, Capon, Robert, Skwarczynski, Mariusz and Toth, Istvan (2019). Development of polymer-based nanoparticulate intranasal lipopeptide vaccine constructs against group A streptococcus. National Meeting of the American Chemical Society (ACS), Orlando, FL, United States, 31 March - 4 April, 2019. Washington, DC, United States: American Chemical Society.
Skwarczynski, Mariusz, Liu, Tzu-Yu, Hussein, Waleed M., Jia, Zhongfan, Ziora, Zyta M., McMillan, Nigel A. J., Monteiro, Michael J. and Toth, Istvan (2014). Synthesis of therapeutic vaccine against cervical cancer. 4th Asia-Pacific International Peptide Symposium in conjunction with 50th Japanese Peptide Symposium, Osaka, Japan, 6-8 November 2013. Osaka, Japan: Japanese Peptide Society.
Skwarczynski, M., Fuaad, A. A. H. A., Zaman, M., Jia, Z., Kowapradit, J., Rustanti, L., Ziora, Z. M., Monteiro, M. L. J., Batzloff, M. R., Goodc, M. F. and Toth, I. (2012). Nanoparticles-based peptide subunit vaccines against group A Streptococcus. 32nd European Peptide Symposium, Athens, Greece, 2-7 September 2012. Chichester, West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.2448
Toth, Istvan, Simerska, Pavla and Skwarczynsky, Mariusz (2011). Dendritic delivery systems for peptide vaccines. 1st European Conference of Microbiology and Immunology, Budapest, Hungary, 12-14 May 2011. Budapest, Hungary: Akademiai Kiado. doi: 10.1556/EuJMI.1.2011.2.1
Suehisa, Y., Noguchi, M., Skwarczynski, M., Yamamoto, A., Kiso, Y., Hayashi, Y. and Fujita, T. (2007). Synthesis of a Novel Water-Soluble Paclitaxel Prodrug, Arginine-Isotaxel, and its Physicochemical and Caco-2 Transport Properties. 8th Annual Meeting of the International Society for Study of Xenobiotics, Sendai, Japan, 9-12 October 2007. PHILADELPHIA: Informa Healthcare.
Noguchi, Mayo, Skwarczynski, Mariusz, Prakash, Halan, Hirota, Shun, Kimura, Tooru, Hayashi, Yoshio and Kiso, Yoshiaki (2007). Development of new photoresponsive paclitaxel prodrug. 第４４回 ペプチド討論会 (44th Japanese Peptide Symposium), Toyama, Toyama Prefecture, Japan, 7-9 November 2007. Osaka, Japan: Protein Research Foundation.
Sohma, Y, Hayashi, Y, Skwarczynski, M, Hamada, Y, Sasaki, M, Kimura, T and Kiso, Y (2004). O-N intramolecular acyl migration reaction in the development of prodrugs and the synthesis of difficult sequence-containing bioactive peptides. 9th Naples Workshop on Bioactive Peptides, Naples Italy, May 08-11, 2004. MALDEN: WILEY-BLACKWELL. doi: 10.1002/bip.20136
Lejczak, B, Haliniarz, E, Skwarczynski, M and Kafarski, P (1996). The use of lypolitic microorganisms Pseudomonas fluorescens and Penicillium citrinum for the preparation of optically active 1-hydroxyalkylphosphonates. 13th International Conference on Phosphorus Chemistry (XIIITH ICPC), Jerusalem Israel, Jul 16-21, 1995. READING: GORDON BREACH SCI PUBL LTD.
Patents
Cobos, C., Daly, N., Loukas, A., Bansal, P., Toth, I. and Skwarczynski, M. (2022). New peptide comprising specified amino acid sequence useful for treating or preventing inflammatory or autoimmune condition including inflammatory bowel disease, asthma, rheumatoid arthritis and celiac disease. . WO2022120423.
producer (2021). Self-assembling, self-adjuvanting system for delivery of vaccines . PCT/AU2021/050012.