School of Chemistry and Molecular Biosciences

Dr Simon Worrall

BSc (Hons) (St Andrews) Biochemistry, PhD (Nottingham) Biochemistry
Senior Lecturer
School of Chemistry and Molecular Biosciences
+61 7 336 54626
Molecular Biosciences Building (76), Room 453
View researcher profile

Primary research interest

Mechanisms of drug-induced liver damage

Additional role

Director of Postgraduate Coursework in Molecular Biology

About me

I started my research career as Science and Engineering Research Council (now Science and Engineering Research Board)-funded Ph.D. scholar in the Biochemistry Department at the Queen’s Medical Centre at the University of Nottingham, UK, working on the purification of the D2-dopamine receptor from bovine brain.  I then moved to Australia and found a position as a Research officer at the Department of Biochemistry at The University of Queensland working on acetaldehyde modification of proteins in alcohol abuse.

The role of protein modification in the toxicity of ethanol and other compounds such as clinical drugs, together with associated immune phenomena, has been my major research focus since that time.  In 1992, I received a Postdoctoral Research fellowship from The University of Queensland to continue my work in the Department of Biochemistry. Later, in 1994 I received an NHMRC grant to continue my work on ethanol toxicity.  In 1996 I was appointed as an Associate Lecturer in Biochemistry; in 1999 I was promoted to Lecturer, and in 2010 to Senior Lecturer.  I was also appointed Director of Molecular Biology postgraduate Coursework programs in 2007.  Part of my role as director of Postgraduate Coursework in Molecular Biology is to place and mentor up to 20 students each semester in research projects in various laboratories throughout the university, including my own. I have also successfully graduated 10 honours students and 6 doctoral students.

Research focus and collaborations

Mechanisms of Drug-Induced Tissue Injury: liver, muscle, heart and brain injury have long been associated with the abuse and clinical use of drugs.

My predominant research interest focuses on ethanol, the most commonly abused drug in Western societies.  Ethanol is widely tolerated but induces a wide variety of tissue injury in a small number of individuals. Thus, my main research focus is the investigation of immunological and genetic phenomena associated with this alcohol-induced tissue injury.

My main areas of research are focussed on providing the answers to the following questions:

  • Does ethanol alter hepatic gene expression to cause liver damage?
  • Does ethanol alter hepatocyte sensitivity to cytokines leading to cell death?
  • Is protein modification by ethanol metabolites involved in the aetiology of:
  • alcoholic liver disease? (with Dean Tuma and Geoffrey Thiele, USA)
  • alcoholic skeletal and cardiac myopathy? (with Victor Preedy, UK, and Onni Niemela, Finland)
  • alcoholic brain injury? (with Peter Dodd, UQ)
  • foetal alcohol syndrome? (with Vincent Sapin, France)
  • Are there alcohol metabolism-related molecular markers for the severity of alcoholic cerebellar degeneration and Alzheimer’s disease? (with Peter Dodd, UQ)

Teaching interests

My teaching is split into three main areas:

  • Teaching to health professions students: BIOL1007 - Molecular & Cellular Biology for Physiotherapists; BIOC1011 – Molecular basis of life (Vet Sci); DENT2054 - Foundation Biological Sciences for Dentistry; MEDI1000 - Fundations of Medical Practice
  • Teaching to science students:  BIOL3230 - Endocrinology & Metabolism
  • Teaching to postgraduate coursework students:  BIOC6014 - Literature Review in Molecular Biology A;BIOC7000 - Major Research Project & Seminar; BIOC7003 - Major Research Project & Seminar; BIOC7009 - Research Proposal; BIOC7010 - Research Project A; BIOC7011 - Research Project B; BIOC7014 - Literature Review in Molecular Biology B; BIOC7021 - Advanced Research Project & Seminar; BIOC7022 - Advanced Research Project & Seminar; BIOC7023 - Advanced Research Project & Seminar; BIOC8000 - Advanced Genomics & Bioinformatics

Achievements and awards 

  • 1992-1993: University of Queensland Postdoctoral Research Fellowship
  • 1997- present:  Visiting Professor at Omaha Veterans’ Administration Hospital Research Division, the University of Nebraska (Omaha)
  • 2000-2005: Editorial Board of Journal of Studies on Alcohol

Featured publications

Researcher biography

Mechanisms of drug-induced liver damage.

Liver disease has long been associated with the abuse and clinical use of drugs. My research interests focus on ethanol, perhaps the most commonly abused drug, and the widely used non-steroidal anti-inflammatory drugs (NSAIDS). Both NSAIDS and ethanol are widely tolerated but induce liver disease in a small number of individuals.

Research projects listed below investigate immunological and genetic phenomena associated with drug-induced liver disease.

  • Does ethanol alter hepatic gene expression to cause liver damage?
  • Does ethanol alter hepatocyte sensitivity to cytokines leading to cell death?
  • Is protein modification by ethanol metabolites involved in the aetiology of alcoholic liver disease?
  • Do keratin 8 or 18 mutants sensitise the liver to toxins?
  • Is an aberrant immune response involved in NSAID adverse reactions?
  • What is the mechanism of toxicity of the Bracken fern toxin ptaquiloside?

Publications

Book (1)
Book Chapters (7)
Journal Articles (51)
Conference Papers (35)

Book

Batmanian, Laura, Ridge, Justin and Worrall, Simon (2011). Biochemistry for health professionals. Chatswood, NSW, Australia: Elsevier Australia.

Book Chapters

Worrall, Simon (2013). The effect of diet on protein modification by ethanol metabolites. Alcohol, nutrition, and health consequences. (pp. 111-130) edited by Ronald Ross Watson, Victor R. Preedy and Sherma Zibadi. New York, NY, United States: Springer. doi: 10.1007/978-1-62703-047-2_9
Worrall, S. and Thiele, G.M. (2005). Modification of proteins by reactive ethanol metabolites: Adduct structure, functional and pathological consequences. Comprehensive Handbook of Alcohol Related Pathology Vol. 3. (pp. 1209-1222) edited by V.R. Preedy and R.R. Watson. Great Britain: Elsevier. doi: 10.1016/B978-012564370-2/50094-5
Worrall, S. (2004). The effect of diet on protein modification by ethanol metabolites in tissues damaged in chronic alcohol abuse. Nutrition and Alcohol: Linking Nutrient Interactions and Dietary Intake. (pp. 219-248) edited by R. R. Watson and V. R. Preedy. Florida: CRC Press. doi: 10.1201/9780203507636.ch13
Preedy, V. R., Dunn, M. J., Hunter, R., Mantle, D., Worrall, S. and Richardson, P. J. (2002). Alcohol and heart muscle proteins: With special reference to measurement of protein synthesis in vivo. Alcohol and Heart Disease. (pp. 197-211) CRC Press.
Worrall, S. (2001). Proteins modified by direct and indirect ethanol metabolites, and their associated antibodies, as markers of alcohol intake. New and Upcoming Markers of Alcohol Consumption. (pp. 94-110) edited by FM Wurst. Germany: Springer Verlag.
Dunn, M. J., Patel, V. B., Preedy, V. R., Richardson, P. and Worrall, S. (2001). Alcohol and the heart in humans and animal models. Alcohol and Coffee Use in the Aging. (pp. 41-56) edited by Ronald R Watson. USA: CRC Press LLC. doi: 10.1201/9781420038941.ch3
Preedy, Victor, Peters, Timothy, Adachi, Junko, Ahmed, Sohail, Mantle, David, Niemela, Onni, Parkkila, Seppo and Worrall, Simon (2001). Pathogenic Mechanisms in Alcoholic Myopathy. Alcohol in Health and Disease. (pp. 243-259) Boca Raton, FL United States: CRC Press. doi: 10.3109/9780203902172

Journal Articles

Thomaz, Fernanda Santos, Tan, Yuen P., Williams, Craig M., Ward, Leigh C., Worrall, Simon and Panchal, Sunil K. (2022). Wasabi (Eutrema japonicum) reduces obesity and blood pressure in diet-induced metabolic syndrome in rats. Foods, 11 (21) 3435, 1-12. doi: 10.3390/foods11213435
White, Hayden, Heffernan, Aaron J., Worrall, Simon, Grunsfeld, Alexander and Thomas, Matt (2021). A systematic review of intravenous β-hydroxybutyrate use in humans – a promising future therapy?. Frontiers in Medicine, 8 740374, 740374. doi: 10.3389/fmed.2021.740374
Thomaz, Fernanda S., Altemani, Faisal, Panchal, Sunil K., Worrall, Simon and Dekker Nitert, Marloes (2020). The influence of wasabi on the gut microbiota of high-carbohydrate, high-fat diet-induced hypertensive Wistar rats. Journal of Human Hypertension, 35 (2), 170-180. doi: 10.1038/s41371-020-0359-8
Thomaz, Fernanda S., Tomsett, Kate I., Panchal, Sunil K., Worrall, Simon and Dekker Nitert, Marloes (2020). Wasabi supplementation alters the composition of the gut microbiota of diet-induced obese rats. Journal of Functional Foods, 67 103868, 103868. doi: 10.1016/j.jff.2020.103868
Chakravarthy, Madhuri, AlShamaileh, Hadi, Huang, He, Tannenberg, Rudi K., Chen, Suxiang, Worrall, Simon, Dodd, Peter R. and Veedu, Rakesh N. (2018). Development of DNA aptamers targeting low-molecular-weight amyloid-β peptide aggregates in vitro. Chemical Communications, 54 (36), 4593-4596. doi: 10.1039/c8cc02256a
Toselli, Francesca, Depaz, Iris M. Booth, Worrall, Simon, Etheridge, Naomi, Dodd, Peter R., Wilce, Peter A. and Gillam, Elizabeth M. J. (2015). Expression of CYP2E1 and CYP2U1 proteins in amygdala and prefrontal cortex: influence of alcoholism and smoking. Alcoholism: Clinical and Experimental Research, 39 (5), 790-797. doi: 10.1111/acer.12697
White, Hayden, Venkatesh, Balasubramanian, Jones, Mark, Worrall, Simon, Chuah, Teong and Ordonez, Jenny (2013). Effect of a hypertonic balanced ketone solution on plasma, CSF and brain beta-hydroxybutyrate levels and acid-base status. Intensive Care Medicine, 39 (4), 727-733. doi: 10.1007/s00134-012-2790-y
Partadiredja, G., Worrall, S. and Bedi, K. S. (2009). Early life undernutrition alters the level of reduced glutathione but not the activity levels of reactive oxygen species enzymes or lipid peroxidation in the mouse forebrain. Brain Research, 1285, 22-29. doi: 10.1016/j.brainres.2009.06.010
Partadiredja, G., Worrall, S., Simpson, R. and Bedi, K. S. (2008). Pre-weaning undernutrition alters the expression levels of reactive oxygen species enzymes but not their activity levels or lipid peroxidation in the rat brain. Brain Research, 1222, 69-78. doi: 10.1016/j.brainres.2008.05.046
Patel, Vinood B., Worrall, Simon, Emery, Peter W. and Preedy, Victor R. (2005). Protein adduct species in muscle and liver of rats following acute ethanol administration. Alcohol and Alcoholism, 40 (6), 485-493. doi: 10.1093/alcalc/agh196
Niemela, O., Parkkila, S., Worrall, S., Emery, P. W. and Preedy, V. R. (2003). Generation of aldehyde-derived protein modifications in ethanol-exposed heart. Alcoholism-clinical And Experimental Research, 27 (12), 1987-1992. doi: 10.1097/01.ALC.0000099260.58926.F2
Preedy, Victor R., Adachi, Junko, Asano, Migiwa, Koll, Michael, Mantle, David, Niemela, Onni, Parkkila, Seppo, Paice, Alistair G., Peters, Timothy, Rajendram, Rajkumar, Seitz, Helmut, Ueno, Yasuhiro and Worrall, Simon (2002). Free radicals in alcoholic myopathy: Indices of damage and preventive studies. Free Radical Biology And Medicine, 32 (8), 683-687. doi: 10.1016/S0891-5849(01)00794-8
Riley, N. E., Li, J., Worrall, S., Rothnagel, J. A., Swagell, C., van Leeuwen, F. W. and French, S. W. (2002). The Mallory body as an aggresome: In vitro studies. Experimental and Molecular Pathology, 72 (1), 17-23. doi: 10.1006/exmp.2001.2413
Worrall, S., Niemela, O., Parkkila, S., Peters, T. J. and Preedy, V. R. (2001). Protein adducts in type I and type II fibre predominant muscles of the ethanol-fed rat: preferential localisation in the sarcolemmal and subsarcolemmal region. European Journal of Clinical Investigation, 31 (8), 723-730. doi: 10.1046/j.1365-2362.2001.00848.x
Thiele, Geoffrey M., Worrall, Simon, Tuma, Dean J., Klassen, Lynell W., Wyatt, Todd A. and Nagata, Naruhiko (2001). The chemistry and biological effects of malondialdehyde-acetaldehyde adducts. Alcoholism-clinical And Experimental Research, 25 (Supp 1), 218S-224S. doi: 10.1111/j.1530-0277.2001.tb02399.x
Preedy, Victor R., Adachi, Junko, Peters, Timothy J., Worrall, Simon, Parkkila, Seppo, Niemela, Onni, Asamo, Migiwa, Ueno, Yasuhino, Takeda, Kunihiko, Yamauchi, Masayoshi, Sakamoto, Kazuhiko, Takagi, Masaru, Nakajima, Hisato and Toda, Gotaro (2001). Recent advances in the pathology of alcoholic myopathy. Alcoholism-clinical And Experimental Research, 25 (Supp 1), 54S-59S. doi: 10.1111/j.1530-0277.2001.tb02374.x
Tuma, Dean J., Kearley, Mark L., Thiele, Geoffrey M., Worrall, Simon, Haver, Alvin, Klassen, Lynell W. and Sorrell, Michael F. (2001). Elucidation of reaction scheme describing malondialdehyde-acetaldehyde-protein adduct formation. Chemical Research In Toxicology, 14 (7), 822-832. doi: 10.1021/tx000222a
Worrall, S. and Thiele, G.M. (2001). Protein modification in ethanol toxicity. Adverse Drug Reactions and Toxicological Reviews, 20 (3), 133-159.
Worrall, Simon, Richardson, Peter J. and Preedy, Victor R. (2000). Experimental heart muscle damage in alcohol feeding is associated with increased amounts of reduced-and unreduced-acetaldehyde and malondialdehyde-acetaldehyde protein adducts. Addiction Biology, 5 (4), 421-427. doi: 10.1111/j.1369-1600.2000.tb00211.x
Worrall, S, de Jersey, J and Wilce, PA (2000). Comparison of the formation of proteins modified by direct and indirect ethanol metabolites in the liver and blood of rats fed the lieber-decarli liquid diet. Alcoholism and Alcoholism, 35 (2), 164-170. doi: 10.1093/alcalc/35.2.164
Ruaux, C., Pennington, H., Worrall, S. and Atwell, R. B. (1999). Tumor necrosis factor-a at presentation in 60 cases of spontaneous canine acute pancreatitis. Veterinary Immunology and Immunopathology, 72 (3-4), 369-376. doi: 10.1016/S0165-2427(99)00108-7
Shahin, M, Moore, MR, Worrall, S, Smith, BL, Seawright, AA and Prakash, AS (1998). H-ras activation is an early event in the ptaquiloside-induced carcinogenesis: Comparison of acute and chronic toxicity in rats (vol 250, pg 491, 1998). Biochemical and Biophysical Research Communications, 251 (2), 668-668. doi: 10.1006/bbrc.1998.9424
Bailey, MJ, Worrall, S, de Jersey, J and Dickinson, RG (1998). Zomepirac acyl glucuronide covalently modifies tubulin in vitro and in vivo and inhibits its assembly in an in vitro system. Chemico-Biological Interactions, 115 (2), 153-166. doi: 10.1016/S0009-2797(98)00071-4
Shahin, Mahmood, Smith, Barry L., Worral, Simon, Moore, Michael R., Seawright, Alan A. and Prakash, Arungundrum S. (1998). Bracken fern carcinogenesis: Multiple intravenous doses of activated ptaquiloside induce DNA adducts, monocytosis, increased TNF alpha levels, and mammary gland carcinoma in rats. Biochemical And Biophysical Research Communications, 244 (1), 192-197. doi: 10.1006/bbrc.1998.8240
Pennington, H.L., Wilce, P.A. and Worrall, S. (1998). A comparison of lipopolysaccharide-induced hepatitis in ethanol-fed Wistar and Lewis rats. Alcoholism: Clinical and Experimental Research, 22 (7), 1525-1530. doi: 10.1097/00000374-199810000-00023
Worrall, S, de Jersey, J, Wilce, PA, Seppa, K, Hurme, L and Sillanaukee, P (1998). Comparison of carbohydrate-deficient transferrin, immunoglobulin A antibodies reactive with acetaldehyde-modified protein and acetaldehyde-modified albumin with conventional markers of alcohol consumption. Alcoholism-clinical And Experimental Research, 22 (9), 1921-1926. doi: 10.1111/j.1530-0277.1998.tb05899.x
Shahin, M., Moore, M. R., Worrall, S., Smith, B. L., Seawright, A. A. and Prakash, A. S. (1998). H-ras activation is an early event in the ptaquiloside-induced carcinogenesis: Comparison of acute and chronic toxicity in rats. Biochemical And Biophysical Research Communications, 250 (2), 491-497. doi: 10.1006/bbrc.1998.9341
Pennington, H.L., Wilce, P.A. and Worrall, S. (1998). Chemokine and cell adhesion molecule mRNA expression and neutrophil infiltration in lipopolysaccharide-induced hepatitis in ethanol-fed rats. Alcoholism-clinical And Experimental Research, 22 (8), 1713-1718. doi: 10.1097/00000374-199811000-00014
Pennington, H.L., Hall, P.D., Wilce, P.A. and Worrall, S. (1997). Ethanol feeding enhances inflammatory cytokine expression in lipopolysaccharide-induced hepatitis. Journal of Gastroenterology And Hepatology, 12 (4), 305-313. doi: 10.1111/j.1440-1746.1997.tb00426.x
Worrall, S, deJersey, J, Wilce, PA, Seppa, K, Hurme, L and Sillanaukee, P (1996). Relationship between alcohol intake and immunoglobulin A immunoreactivity with acetaldehyde-modified bovine serum albumin. Alcoholism-Clinical and Experimental Research, 20 (5), 836-840. doi: 10.1111/j.1530-0277.1996.tb05260.x
Fowles, LF, Beck, E, Worrall, S, Shanley, BC and deJersey, J (1996). The formation and stability of imidazolidinone adducts from acetaldehyde and model peptides - A kinetic study with implications for protein modification in alcohol abuse. Biochemical Pharmacology, 51 (10), 1259-1267. doi: 10.1016/0006-2952(95)02408-5
Worrall, S and Dickinson, RG (1995). Rat Serum-Albumin Modified by Diflunisal Acyl Glucuronide Is Immunogenic in Rats. Life Sciences, 56 (22), 1921-1930. doi: 10.1016/0024-3205(95)00167-5
Williams, AM, Worrall, S, Dejersey, J and Dickinson, RG (1995). Studies On the Reactivity of Acyl Glucuronides .8. Generation of An Antiserum for the Detection of Diflunisal-Modified Proteins in Diflunisal-Dosed Rats. Biochemical Pharmacology, 49 (2), 209-217. doi: 10.1016/S0006-2952(94)00408-0
Nicholls, RM, Fowles, LF, Worrall, S, Dejersey, J and Wilce, PA (1994). Distribution and Turnover of Acetaldehyde-Modified Proteins in Liver and Blood of Ethanol-Fed Rats. Alcohol and Alcoholism, 29 (2), 149-157. doi: 10.1093/oxfordjournals.alcalc.a045501
Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1994). Anti-Acetaldehyde Adduct Antibodies Generated by Ethanol-Fed Rats React with Reduced and Unreduced Acetaldehyde-Modified Proteins. Alcohol and Alcoholism, 29 (1), 43-50. doi: 10.1093/oxfordjournals.alcalc.a045483
Worrall S., Jersey J.D., Wilce P.A., Seppa K. and Sillanaukee P. (1994). Studies on the usefulness of acetaldehyde-modified proteins and associated antibodies as markers of alcohol abuse.. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement., 2, 503-507.
Worrall S. and Wilce P.A. (1994). The effect of chronic ethanol feeding on cytokines in a rat model of alcoholic liver disease.. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement., 2, 447-451.
Worrall, S, Dejersey, J and Wilce, PA (1993). Antibodies From Alcoholics, Ethanol-Fed Rats and a Rabbit Immunized with Proteins Modified by Acetaldehyde In-Vitro React with Liver Cytosolic Proteins From Ethanol-Fed Rats. Alcohol and Alcoholism, 28 (5), 513-519.
Worrall, S, Dejersey, J, Nicholls, R and Wilce, P (1993). Acetaldehyde-Protein Interactions - Are They Involved in the Pathogenesis of Alcoholic Liver-Disease. Digestive Diseases, 11 (4-5), 265-277. doi: 10.1159/000171418
Nicholls, R, Dejersey, J, Worrall, S and Wilce, P (1992). Modification of Proteins and Other Biological Molecules by Acetaldehyde - Adduct Structure and Functional-Significance. International Journal of Biochemistry, 24 (12), 1899-1906. doi: 10.1016/0020-711X(92)90285-9
Williams, AM, Worrall, S, Dejersey, J and Dickinson, RG (1992). Studies On the Reactivity of Acyl Glucuronides .3. Glucuronide-Derived Adducts of Valproic Acid and Plasma-Protein and Anti-Adduct Antibodies in Humans. Biochemical Pharmacology, 43 (4), 745-755. doi: 10.1016/0006-2952(92)90239-F
Worrall, S., De Jersey, J., Shanley, B. C. and Wilce, P. A. (1991). Acetaldehyde-modified proteins and associated antibodies in ethanol-fed rats. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement, 1, 255-260.
Worrall, S., De Jersey, J., Shanley, B. C. and Wilce, P. A. (1991). Alcohol abusers exhibit a higher IgA response to acetaldehyde-modified proteins. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement, 1, 261-264.
Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1991). Antibodies Against Acetaldehyde-Modified Epitopes - An Elevated Iga Response in Alcoholics. European Journal of Clinical Investigation, 21 (1), 90-95. doi: 10.1111/j.1365-2362.1991.tb01364.x
Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1991). Detection of Stable Acetaldehyde-Modified Proteins in the Livers of Ethanol-Fed Rats. Alcohol and Alcoholism, 26 (4), 437-444. doi: 10.1093/oxfordjournals.alcalc.a045136
Worrall, S., De Jersey, J., Shanley, B. C. and Wilce, P. A. (1990). Antibodies against acetaldehyde-modified epitopes: Presence in alcoholic, non-alcoholic liver disease and control subjects. Alcohol and Alcoholism, 25 (5), 509-517. doi: 10.1093/oxfordjournals.alcalc.a045044
Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1990). Antibodies Against Acetaldehyde-Modified Epitopes - Presence in Alcoholic, Nonalcoholic Liver-Disease and Control Subjects. Alcohol and Alcoholism, 25 (5), 509-517.
Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1989). Ethanol Induces the Production of Antibodies to Acetaldehyde-Modified Epitopes in Rats. Alcohol and Alcoholism, 24 (3), 217-223. doi: 10.1093/oxfordjournals.alcalc.a044898
Williamson, RA, Worrall, S, Chazot, PL and Strange, PG (1988). Purification of Brain D2 Dopamine Receptor. Embo Journal, 7 (13), 4129-4133. doi: 10.1002/j.1460-2075.1988.tb03307.x
Williamson, RA, Worrall, S, Chazot, PL and Strange, PG (1988). Partial-Purification of the D-2 Dopamine Receptor From Bovine Caudate-Nucleus. Biochemical Society Transactions, 16 (4), 450-452. doi: 10.1042/bst0160450
Strange, PG, Abbott, WM, Juszczak, R and Worrall, S (1985). Isolation and Characterization of D2-Dopamine Receptors. Biochemical Society Transactions, 13 (6), 1099-1100. doi: 10.1042/bst0131099

Conference Papers

Worrall, S., Simmons, G., Mills, P., Rainger, J., Keates, H., Plan, M. and Nixon, P. F. (2018). Alcohol, in vivo, changes CSF chemistry to increase neuroactive amino acids. 19th World Congress of International-Society-for-Biomedical-Research-on-Alcoholism (ISBRA), Kyoto Japan, 9-13 September 2018. Hoboken, NJ United States: Wiley-Blackwell.
Toselli, Francesca, Worrall, Simon, Wilce, Peter A., Dodd, Peter R. and Gillam, Elizabeth M. J. (2014). Cyp2E1 and Cyp2U1 Protein Expression in Human Amygdala and Prefrontal Cortex: Influence of Alcoholism and Smoking. 10th International Meeting of the International Society for the Study of Xenobiotics (ISSX), Toronto, Canada, 29 September - 03 October 2013. New York, NY United States: Informa Healthcare.
Heim, M., Worrall, S. and Wurst, F. (2014). Urinary ethyl glucuronide and blood phosphatidylethanol values in patients undergoing liver biopsy: (i) relationship with alcohol consumption. 37th Annual Scientific Meeting of the Research Society on Alcoholism (RSA) and 17th Congress of the International Society for Biomedical Research on Alcoholism (ISBRA), Bellevue, WA, USA, 21-25 June, 2014. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1111/acer.12451
Heim, M., Worrall, S. and Wurst, F. (2014). Urinary ethyl glucuronide and blood phosphatidylethanol values in patients undergoing liver biopsy: (ii) effect on liver disease. 37th Annual Scientific Meeting of the Research Society on Alcoholism (RSA) and 17th Congress of the International Society for Biomedical Research on Alcoholism (ISBRA), Bellevue, WA, USA, 21-25 June, 2014. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1111/acer.12451
Richards, S., Perry, A., Dodd, P. R. and Worrall, S. (2012). Increased protein carbonyl content and elevated adduct formation in alcoholic cerebellar degeneration. 16th World Congress of the International-Society for Biomedical Research on Alcoholism (ISBRA), Sapporo, Japan, 9-12 September 2012. Hoboken, NJ, United States: Wiley-Blackwell. doi: 10.1111/j.1530-0277.2012.01917.x
Thornalley, Paul J., Worrall, Simon, Niemelä, Onni, Rao, Radhakrishna K., Preedy, Victor R., Apte, Minoti V., Albano, Emanuele and Seitz, Helmut K. (2007). Discussion.
Crabb, David W., Seitz, Helmut K., Emery, Peter, Worrall, Simon, Thornalley, Paul J., Rao, Radhakrishna K., Shukla, Shivendra D., Apte, Minoti V., Deitrich, Richard A., Salaspuro, Mikko, Yin, Shih-Jiun, Ren, Jun, Okamura, Tomonori, Eriksson, C. J. Peter, Preedy, Victor R. and Albano, Emanuele (2007). Discussion.
Deitrich, Richard A., Crabb, David W., Salaspuro, Mikko, Peter Eriksson, C. J., Apte, Minoti V., Emery, Peter, Niemelä, Onni, Worrall, Simon, Thornalley, Paul J., Albano, Emanuele, Seitz, Helmut K. and Shukla, Shivendra D. (2007). Discussion.
Quertemont, Etienne, Jamal, Mostofa, Peter Eriksson, C. J., Preedy, Victor R., Worrall, Simon, Deitrich, Richard A., Yin, Shih-Jiun and Apte, Minoti V. (2007). Discussion.
Seitz, Helmut K., Deitrich, Richard A., Peter Eriksson, C. J., Apte, Minoti V., Preedy, Victor R., Morris, John B., Albano, Emanuele, Worrall, Simon, Emery, Peter, Ren, Jun, Crabb, David W., Salaspuro, Mikko, Quertemont, Etienne, Thornalley, Paul J., Rao, Radhakrishna K., Aranda, Agustin, Okamura, Tomonori, Shukla, Shivendra D., Niemelä, Onni and Jamal, Mostofa (2007). Discussion.
Worrall, Simon, Eriksson, C. J. Peter, Preedy, Victor R., Seitz, Helmut K., Salaspuro, Ville, Salaspuro, Mikko, Apte, Minoti V., Rao, Radhakrishna K., Morris, John B., Thornalley, Paul J. and Ren, Jun (2007). Discussion.
Preedy, Victor R., Peter Eriksson, C. J., Morris, John B., Salaspuro, Mikko, Emery, Peter, Thornalley, Paul J., Seitz, Helmut K., Rao, Radhakrishna K., Worrall, Simon, Apte, Minoti V., Okamura, Tomonori and Yin, Shih-Jiun (2007). Discussion.
Eriksson, C. J. Peter, Preedy, Victor R., Albano, Emanuele, Salaspuro, Mikko, Seitz, Helmut K., Emery, Peter, Apte, Minoti V., Shukla, Shivendra D., Worrall, Simon, Thornalley, Paul J., Rao, Radhakrishna K., Niemelä, Onni, Crabb, David W. and Ren, Jun (2007). Discussion.
Worrall, Simon (2007). General discussion. Symposium on Acetaldehyde-related pathology: Bridging the Trans-disciplinary Divide, London, UK, 5-7 September 2006. Chichester, UK: John Wiley.
Preedy, Victor R., Hashimoto, Kijiro, Hirano, Makoto, Hunter, Ross, Nakahara, Tatsuo, Niemela, Onni, Parkkila, Seppo and Worrall, Simon (2006). Cellular and molecular changes in rat models of alcoholic cardiomyopathy. World Congress on Alcohol Research, Sydney, Australia, 10-13 Septmeber 2006. Hoboken, NJ, United States: Wiley-Blackwell Publishing, Inc.. doi: 10.1111/j.1530-0277.2006.00197.x
Worrall, Simon (2006). Hepatic adduct levels do not predict the levels of extrahepatic modification. World Congress on Alcohol Research (ISBRA 2006), Sydney, Australia, 10 - 13 September 2006. Oxford: Blackwell Publishing. doi: 10.1111/j.1530-0277.2006.00197.x
Perry, Anthony, Dodd, Peter R. and Worrall, Simon (2006). Detection of elevated protein modification in human cerebellum in alcoholic cerebellar degeneration. 29th Annual Meeting of the Research Society on Alcoholism ( RSA 2006), Baltimore, MD, USA, 23rd- 29th June, 2006. Maryland: John Wiley & Sons, Inc. doi: 10.1111/j.1530-0277.2006.00150.x
Perry, Anthony, Dodd, Peter and Worrall, Simon (2006). Detection of elevated protein modification in alcoholic cerebellar degeneration. 29th Annual Meeting of Research Society on Alcoholism, Sydney, Australia, 10-13 September, 2006. Maryland, USA: Blackwell. doi: 10.1111/j.1530-0277.2006.00197.x
Freeman, Thomas L., Tuma, Dean J., Thiele, Geoffrey M., Klassen, Lynell W., Worrall, Simon, Niemela, Onni, Parkkila, Seppo, Emery, Peter W. and Preedy, Victor R. (2005). Recent advances in alcohol-induced adduct formation. 12th International Congress of the International Society for Biomedical Research on Alcoholism, Heidelberg, Germany, 29 September-2 October 2004. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1097/01.ALC.0000171484.52201.52
Worrall, S (2004). Liver adduct formation does not predict adduct levels in extrahepatic tissues.. 12th International Congress of the International-Society-for-Biomedical-Research-on-Alcoholism, Heidelberg Germany, Sep 29-Oct 02, 2004. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. doi: 10.1097/00000374-200408002-00010
Freeman, TL, Klassen, LW, Worrall, S, Sorrell, MF, Tuma, DJ and Thiele, GM (2004). Adduct chemistry and mechanisms of adduct formation.. 12th International Congress of the International-Society-for-Biomedical-Research-on-Alcoholism, Heidelberg Germany, Sep 29-Oct 02, 2004. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. doi: 10.1097/00000374-200408002-00363
Preedy, VR, Emery, P, Niemela, O, Parkkila, S, Peters, TJ and Worrall, S (2004). Alcoholic skeletal muscle myopathy: A role for protein adducts?. 12th International Congress of the International-Society-for-Biomedical-Research-on-Alcoholism, Heidelberg Germany, Sep 29-Oct 02, 2004. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. doi: 10.1097/00000374-200408002-00367
Worrall, S (2004). Adduct formation in the liver.. 12th International Congress of the International-Society-for-Biomedical-Research-on-Alcoholism, Heidelberg Germany, Sep 29-Oct 02, 2004. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. doi: 10.1097/00000374-200408002-00365
Preedy, VR, Peters, TJ, Adachi, J, Ahmed, S, Mantle, D, Niemela, O, Parkkila, S and Worrall, S (2001). Pathogenic mechanisms in alcoholic myopathy. International Titisee Symposium on Health Effects of Alcohol Intake, Titisee Germany, Dec 09-12, 1999. NEW YORK: MARCEL DEKKER.
Worrall, S (2001). Proteins modified by direct and indirect ethanol metabolites, and their associated antibodies, as markers of alcohol intake. 11th World Congress of Psychiatry, Hamburg Germany, Aug 06-11, 1999. BERLIN 33: STEINKOPFF DARMSTADT.
Worrall, S. (2000). Studies on protein modification by ethanol metabolites in alcohol abuse. Joint Meeting of ASCEPT and the British Pharmacological Society, Monash University, Melbourne, 3-6 December 2000. Melbourne, Vic: Australasian Society of Clinical and Experimental Pharmacologists & Toxicologists.
Swagell, C. D., Rothnagel, J. A. and Worrall, S. (2000). The effect of keratin mutants on hepatocytes metabolising ethanol in culture. 10th Congress of the International Society for Biomedical Research on Alcoholism: ISBRA 2000, Yokohama, Japan, 2-8 July 2000.
Worrall, Simon (2000). The formation and clearance of MAA adducts in ethanol-fed rats. 10th Congress of the International Society for Biomedical Reseach on Alcoholism, Yokohama, Japan, 2-8 July, 2000. doi: 10.1111/(ISSN)1530-0277
Niemlea, O., Parkkila, S. and Worrall, S. (2000). Protein adducts in type I and type II fibre-predominant muscles of the ethanol-fed rat. 10th Congress of the International Society for Biomedical Research on Alcoholism, Yokohama, Japan, 2-8 July, 2000.
Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1991). Alcohol Abusers Exhibit a Higher Iga Response to Acetaldehyde-Modified Proteins. 5th Congress of the International Soc for Biomedical Research On Alcoholism / 1990 Annual Meeting of the Research On Alcoholism, Toronto Canada, Jun 17-22, 1990. OXFORD: OXFORD UNIV PRESS UNITED KINGDOM.
Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1991). Acetaldehyde-Modified Proteins and Associated Antibodies in Ethanol-Fed Rats. 5th Congress of the International Soc for Biomedical Research On Alcoholism / 1990 Annual Meeting of the Research On Alcoholism, Toronto Canada, Jun 17-22, 1990. OXFORD: OXFORD UNIV PRESS UNITED KINGDOM.
Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1990). Detection of Acetaldehyde-Modified Proteins in the Livers of Ethanol-Fed Rats. LONDON: PORTLAND PRESS. doi: 10.1042/bst0180678
Williamson, RA, Worrall, S and Strange, PG (1987). Partial-Purification of D2 Dopamine-Receptors From Bovine Brain. LONDON: WALTER DE GRUYTER & CO. doi: 10.1042/bst0151155
Worrall, S, Williamson, RA and Strange, PG (1986). Purification of D2-Dopamine Receptors From Bovine Brain. LONDON: PORTLAND PRESS. doi: 10.1042/bst0141138
Worrall, S, Williamson, R and Strange, PG (1986). Partial-Purification of D2-Dopamine Receptors From Bovine Brain. BERLIN: PORTLAND PRESS.

Areas of research

Biochemistry and molecular biology discipline
Structural biology and biochemistry theme