School of Chemistry and Molecular Biosciences

Dr David Harrich

Honorary Associate Professor
School of Chemistry and Molecular Biosciences

Publications

Journal Articles (25)
Preprint (1)

Journal Articles

Pang, Huiwen, Qu, Zhi, Kumar, Vinod, Wang, Yinuo, Wu, Youzhi, Lin, Min‐Hsuan, Harrich, David and Han, Felicity Y. (2024). Novel Delivery Systems for Oral Administration of Enfuvirtide: New Treatment Options for HIV/AIDS. Advanced Therapeutics, 7 (8) 2300439, 1-9. doi: 10.1002/adtp.202300439
Rawle, Daniel J., Li, Dongsheng, Swedberg, Joakim E., Wang, Lu, Soares, Dinesh C and Harrich, David (2018). HIV-1 Uncoating and Reverse Transcription Require eEF1A Binding to Surface-Exposed Acidic Residues of the Reverse Transcriptase Thumb Domain. mBio, 9 (2) e00316-18, e00316-18. doi: 10.1128/mBio.00316-18
Rustanti, Lina, Jin, Hongping, Li, Dongsheng, Lor, Mary, Sivakumaran, Haran and Harrich, David (2018). Differential effects of strategies to improve the transduction efficiency of lentiviral vector that conveys an anti-HIV protein, nullbasic, in human T cells. Virologica Sinica, 33 (2), 1-11. doi: 10.1007/s12250-018-0004-7
Rustanti, Lina, Jin, Hongping, Lor, Mary, Lin, Min Hsuan, Rawle, Daniel J. and Harrich, David (2017). A mutant Tat protein inhibits infection of human cells by strains from diverse HIV-1 subtypes. Virology Journal, 14 (1) 52, 52. doi: 10.1186/s12985-017-0705-9
Fulcher, Alex J., Sivakumaran, Haran, Jin, Hongpin, Rawle, Daniel J., Harrich, David and Jans, David A. (2016). The protein arginine methyltransferase PRMT6 inhibits HIV-1 Tat nucleolar retention. Biochimica et Biophysica Acta - Molecular Cell Research, 1863 (2), 254-262. doi: 10.1016/j.bbamcr.2015.11.019
Li, Dongsheng, Wei, Ting, Rawle, Daniel J., Qin, Fangyun, Wang, Rui, Soares, Dinesh C., Jin, Hongping, Sivakumaran, Haran, Lin, Min-Hsuan, Spann, Kirsten, Abbott, Catherine M. and Harrich, David (2015). Specific interaction between eEF1A and HIV RT is critical for HIV-1 reverse transcription and a potential anti-HIV target. PLoS Pathogens, 11 (12) e1005289, e1005289.1-e1005289.12. doi: 10.1371/journal.ppat.1005289
Lin, Min-Hsuan, Apolloni, Ann, Cutillas, Vincent, Sivakumaran, Haran, Martin, Sally, Li, Dongsheng, Wei, Ting, Wang, Rui, Jin, Hongping, Spann, Kirsten and Harrich, David (2015). A mutant tat protein inhibits HIV-1 reverse transcription by targeting the reverse transcription complex. Journal of Virology, 89 (9), 4827-4836. doi: 10.1128/JVI.03440-14
Wei, Ting, Li, Dongsheng, Marcial, Daneth, Khan, Moshin, Lin, Min-Hsuan, Snape, Natale, Ghildyal, Reena, Harrich, David and Spann, Kirsten (2014). The eukaryotic elongation factor 1A is critical for genome replication of the paramyxovirus respiratory syncytial virus. PLoS ONE, 9 (12) e114447, 1-14. doi: 10.1371/journal.pone.0114447
Lin, Min-Hsuan, Sivakumaran, Haran, Jones, Alun, Li, Dongsheng, Harper, Callista, Wei, Ting, Jin, Hongping, Rustanti, Lina, Meunier, Frederic A., Spann, Kirsten and Harrich, David (2014). A HIV-1 Tat mutant protein disrupts HIV-1 Rev function by targeting the DEAD-box RNA helicase DDX1. Retrovirology, 11 (1) 9, 121.1-121.16. doi: 10.1186/s12977-014-0121-9
Dang, Nhung T. T., Sivakumaran, Haran, Harrich, David and Coombes, Allan G. A. (2013). An evaluation of polycaprolactone matrices for vaginal delivery of the antiviral, tenofovir, in preventing heterosexual transmission of HIV. Journal of Pharmaceutical Sciences, 102 (10), 3725-3735. doi: 10.1002/jps.23684
Apolloni, Ann, Lin, Min-Husan, Sivakumaran, Haran, Li, Dongsheng, Kershaw, Michael H. R. and Harrich, David (2013). A mutant tat protein provides strong protection from HIV-1 infection in human CD4+ T cells. Human Gene Therapy, 24 (3), 270-282. doi: 10.1089/hum.2012.176
Lin, Min-Hsuan, Sivakumaran, Haran, Apolloni, Ann, Wei, Ting, Jans, David A. and Harrich, David (2012). Nullbasic, a potent Anti-HIV Tat mutant, induces CRM1-dependent disruption of HIV Rev trafficking. PloS One, 7 (12) e51466, e51466-1-e51466-12. doi: 10.1371/journal.pone.0051466
Warren, Kylie, Wei, Ting, Li, Dongsheng, Qin, Fangyun, Warrilow, David, Lin, Min-Hsuan, Sivakumaran, Haran, Apolloni, Ann, Abbott, Catherine M., Jones, Alun, Anderson, Jenny L. and Harrich, David (2012). Eukaryotic elongation factor 1 complex subunits are critical HIV-1 reverse transcription cofactors. Proceedings of the National Academy of Sciences of USA, 109 (24), 9587-9592. doi: 10.1073/pnas.1204673109
Meredith, Luke W., Sivakumaran, Haran, Major, Lee, Suhrbier, Andreas and Harrich, David (2009). Potent inhibition of HIV-1 replication by a tat mutant. PloS One, 4 (11) e7769, e7769.1-e7769.10. doi: 10.1371/journal.pone.0007769
Sivakumaran, Haran, van der Horst, Armando, Fulcher, Alex J., Apolloni, Ann, Lin, Min-Hsuan, Jans, David A. and Harrich, David (2009). Arginine methylation increases the stability of HIV-1 Tat. Journal of Virology, 83 (22), 11694-11703. doi: 10.1128/JVI.00499-09
Sivakumaran, Haran and Harrich, David (2008). SOCS1: a host factor required for HIV-1 Gag trafficking. Future HIV Therapy, 2 (3), 247-251. doi: 10.2217/17469600.2.3.247
Sivakumaran, H., Wang, B., Gill, M.J., Beckholdt, B., Saksena, N.K. and Harrich, D. (2007). Functional relevance of nonsynonymous mutations in the HIV-1 tat gene within an epidemiologically-linked transmission cohort. Virology Journal, 4 (1) 107, 107-107. doi: 10.1186/1743-422X-4-107
Harrich, D., McMillan, N., Munoz, L., Apolloni, A. and Meredith, L. (2006). Will diverse Tat interactions lead to novel antiretroviral drug targets?. Current Drug Targets, 7 (12), 1595-1606. doi: 10.2174/138945006779025338
Hooker, C. W. and Harrich, D. (2003). The first strand transfer reaction of HIV-1 reverse transcription is more efficient in infected cells than in cell-free natural endogenous reverse transcription reactions. Journal of Clinical Virology, 26 (2), 229-238. doi: 10.1016/S1386-6532(02)00121-X
Anraku, Itaru, Harvey, Tracey J., Linedale, Richard, Gardner, Joy, Harrich, David, Suhrbier, Andreas and Khromykh, Alexander A. (2002). Kunjin virus replicon vaccine vectors induce protective CD8(+) T-cell immunity. Journal of Virology, 76 (8), 3791-3799. doi: 10.1128/JVI.76.8.3791-3799.2002
Hooker, C. William, Scott, Julie, Apolloni, Ann, Parry, Emma and Harrich, David (2002). Human immunodeficiency virus type 1 reverse transcription is stimulated by Tat from other lentiviruses. Virology, 300 (2), 226-235. doi: 10.1006/viro.2002.1554
Hill, M. K., Hooker, C. W., Harrich, D., Crowe, S. M. and Mak, J. (2001). Gag-Pol supplied in trans is efficiently packaged and supports viral function in human immunodeficiency virus type 1. Journal of Virology, 75 (15), 6835-6840. doi: 10.1128/JVI.75.15.6835-6840.2001
Hooker, C. William, Lott, William B. and Harrich, David (2001). Inhibitors of human immunodeficiency virus type 1 reverse transcriptase target distinct phases of early reverse transcription. Journal of Virology, 75 (7), 3095-3104. doi: 10.1128/JVI.75.7.3095-3104.2001
Hooker, C. W. and Harrich, D. (2001). Characterization of reverse transcription inhibitors using natural endogenous reverse transcription. International Antiviral News, 9 (6), 97-99.
Harrich, David, Hooker, C. William and Parry, Emma (2000). The human immunodeficiency virus type 1 TAR RNA upper stem-loop plays distinct roles in reverse transcription and RNA pagaging. Journal of Virology, 74 (12), 5639-5646. doi: 10.1128/JVI.74.12.5639-5646.2000

Preprint

Sivakumaran, Dhivakaren and Harrich, David (2008). SOCS1: a host factor required for HIV-1 Gag trafficking.