Dr Alain Wuethrich
NHMRC Emerging Leadership Fellow
School of Chemistry and Molecular Biosciences
Researcher biography
Dr Wuethrich is an NHMRC Emerging Leader fellow and ARC DECRA awardee at the Centre for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland (UQ). Dr Wuethrich obtained his PhD from the University of Tasmania in 2016 after completing a Master's degree in Switzerland. His research expertise lies in liquid biopsy, electrohydrodynamics, surface-enhanced Raman spectroscopy, nanotechnology and diagnostics. He held positions in international pharmaceutical companies and became lead inventor on a European patent. He has actively engaged with national and international companies to translate diagnostic nanotechnologies. Since 2017 he has provided continuous research mentoring to the group and has supervised >30 postgraduate and graduate students in nanotechnological strategies to detect cancer and other diseases.
Book Chapters
Wang, Jing, Trau, Matt and Wuethrich, Alain (2023). A microfluidic SERS assay to characterize the phenotypic heterogeneity in cancer-derived small extracellular vesicles. Microfluidic systems for cancer diagnosis. (pp. 241-253) edited by Jose L. Garcia-Cordero and Alexander Revzin. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-3271-0_17
Wuethrich, Alain, Dey, Shuvashis, Koo, Kevin M, Sina, Abu A. I. and Trau, Matt (2021). Simultaneous BRAFV600E protein and DNA aberration detection in circulating melanoma cells using an integrated multimolecular sensor. Melanoma. (pp. 265-276) New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-1205-7_20
Yu, Raymond B., Dalman, Neil A. V., Wuethrich, Alain and Quirino, Joselito P. (2021). Derivatization of carbohydrates for analysis by liquid chromatography and capillary electrophoresis. Carbohydrate Analysis by Modern Liquid Phase Separation Techniques. (pp. 1-33) edited by Ziad El Rassi. Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-12-821447-3.00019-6
Quirino, Joselito P. and Wuethrich, Alain (2018). Capillary electrophoresis: overview. Reference module in chemistry, molecular sciences and chemical engineering. (pp. 1-32) edited by Jan Reedijk. Oxford, United Kingdom: Elsevier. doi: 10.1016/b978-0-12-409547-2.14461-0
Wuethrich, Alain and Quirino, Joselito P. (2018). Stacking or On-line Sample Concentration in CE-MS for Metabolomics. Capillary electrophoresis–mass spectrometry for metabolomics. (pp. 83-112) Cambridge, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781788012737-00083
Wuethrich, Alain and Quirino, Joselito P. (2017). Capillary Electrophoresis as a Green Alternative Separation Technique. The Application of Green Solvents in Separation Processes. (pp. 517-532) Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-12-805297-6.00017-6
Journal Articles
Zhang, Zhen, Wang, Jing, Wuethrich, Alain and Trau, Matt (2025). Conventional techniques and emerging nanotechnologies for early detection of cancer metastasis via epithelial-mesenchymal transition monitoring. National Science Review, 12 (3) nwae452, 1-17. doi: 10.1093/nsr/nwae452
Sinclair, Jane E., Vedelago, Courtney, Ryan, Feargal J., Carney, Meagan, Redd, Meredith A., Lynn, Miriam A., Grubor-Bauk, Branka, Cao, Yuanzhao, Henders, Anjali K., Chew, Keng Yih, Gilroy, Deborah, Greaves, Kim, Labzin, Larisa, Ziser, Laura, Ronacher, Katharina, Wallace, Leanne M., Zhang, Yiwen, Macauslane, Kyle, Ellis, Daniel J., Rao, Sudha, Burr, Lucy, Bain, Amanda, Karawita, Anjana, Schulz, Benjamin L., Li, Junrong, Lynn, David J., Palpant, Nathan, Wuethrich, Alain, Trau, Matt and Short, Kirsty R. (2024). Post-acute sequelae of SARS-CoV-2 cardiovascular symptoms are associated with trace-level cytokines that affect cardiomyocyte function. Nature Microbiology, 9 (12), 1-13. doi: 10.1038/s41564-024-01838-z
Zhou, Quan, Niu, Xueming, Zhang, Zhen, O'Byrne, Kenneth, Kulasinghe, Arutha, Fielding, David, Möller, Andreas, Wuethrich, Alain, Lobb, Richard J. and Trau, Matt (2024). Glycan profiling in small extracellular vesicles with a SERS microfluidic biosensor identifies early malignant development in lung cancer. Advanced Science, 11 (33) 2401818, 1-12. doi: 10.1002/advs.202401818
Shanmugasundaram, Karthik B., Ahmed, Emtiaz, Miao, Xinzhe, Kulasinghe, Arutha, Fletcher, James A., Monkman, James, Mainwaring, Paul, Masud, Mostafa Kamal, Park, Hyeongyu, Hossain, Md Shahriar A., Yamauchi, Yusuke, Sina, Abu A. I., O’Byrne, Kenneth, Wuethrich, Alain and Trau, Matt (2024). A mesoporous gold sensor unveils phospho PD-L1 in extracellular vesicles as a proxy for PD-L1 expression in lung cancer tissue. ACS Sensors, 9 (6), 3009-3016. doi: 10.1021/acssensors.4c00192
Niu, Xueming, Zhang, Zhen, Zhou, Quan, Wuethrich, Alain, Lobb, Richard and Trau, Matt (2024). Analysis of secreted small extracellular vesicles from activated human microglial cell lines reveals distinct pro‐ and anti‐inflammatory proteomic profiles. Proteomics, 24 (11) 2300094, 1-13. doi: 10.1002/pmic.202300094
Li, Junrong, Li, Meiqin, Wuethrich, Alain, Guan, Rui, Zhao, Lihui, Hu, Cong, Trau, Matt and Sun, Yao (2024). Molecular stratification and treatment monitoring of lung cancer using a small extracellular vesicle-activated nanocavity architecture. Analytical Chemistry, 96 (19), 7651-7660. doi: 10.1021/acs.analchem.4c00558
Li, Junrong, Guan, Rui, Wuethrich, Alain, Yan, Mingzhe, Cheng, Jing, Liu, Guorong, Zhan, Jianbo, Trau, Matt and Sun, Yao (2024). High accuracy of clinical verification of electrohydrodynamic-driven nanobox-on-mirror platform for molecular identification of respiratory viruses. Analytical Chemistry, 96 (11), 4495-4504. doi: 10.1021/acs.analchem.3c05120
Li, Li and Wuethrich, Alain (2024). Special issue Methods: Nano-/bio-interface and biomedical applications. Methods, 223, 146-147. doi: 10.1016/j.ymeth.2024.02.001
Li, Junrong, Zhang, Zhen, Trau, Matt and Wuethrich, Alain (2024). Digital platforms enabling single-molecule analysis for cancer detection. TrAC Trends in Analytical Chemistry, 171 117502, 1-12. doi: 10.1016/j.trac.2023.117502
Zhou, Quan, Wang, Jing, Zhang, Zhen, Wuethrich, Alain, Lobb, Richard J. and Trau, Matt (2024). Tracking the EMT-like phenotype switching during targeted therapy in melanoma by analyzing extracellular vesicle phenotypes. Biosensors and Bioelectronics, 244 115819, 1-10. doi: 10.1016/j.bios.2023.115819
Wuethrich, Alain, Crouse, Jacob J., Vedelago, Courtney, Zhang, Yiwen, Farokhinejad, Fahimeh, Hickie, Ian B. and Trau, Matt (2024). A perspective about the potential use of nanotechnology to monitor immune correlates of the clinical course of major mood disorders. Research Directions: Depression, 1 e20, 1-4. doi: 10.1017/dep.2024.3
Khamis, Ramlah, Shanmugasundaram, Karthik B., Zhou, Quan, Lu, Jennifer, Zhang, Zhen, Hill, Michelle M., Sina, Abu Ali Ibn, Trau, Matt and Wuethrich, Alain (2023). Multiplex SERS-lectin-immunoassay for esophageal adenocarcinoma screening. ACS Applied Nano Materials, 6 (21), 20190-20197. doi: 10.1021/acsanm.3c03987
Yuan, Liwen, Chen, Yanpin, Ke, Longfeng, Zhou, Quan, Chen, Jiayou, Fan, Min, Wuethrich, Alain, Trau, Matt and Wang, Jing (2023). Erratum: Correction: Plasma extracellular vesicle phenotyping for the differentiation of early-stage lung cancer and benign lung diseases (Nanoscale horizons (2023) 8 6 (746-758)). Nanoscale horizons, 8 (9) d3nh90028b, 1288-1289. doi: 10.1039/d3nh90028b
Ahmed, Emtiaz, Shanmugasundaram, Karthik Balaji, Li, Junrong, Behren, Andreas, Lobb, Richard, Möller, Andreas, Wuethrich, Alain, Dey, Shuvashis, Sina, Abu Ali Ibn and Trau, Matt (2023). A microfluidic liquid biopsy platform to monitor protein biomarker heterogeneity in single circulating therapy‐resistance cancer cell. Advanced Sensor Research, 2 (12) 2300059. doi: 10.1002/adsr.202300059
Li, Junrong, Howard, Christopher B., Dey, Shuvashis, Lowry, Kym, Whiley, David M., Puttick, Simon, Rose, Stephen, Lobb, Richard J., Wuethrich, Alain, Edwardraja, Selvakumar and Trau, Matt (2023). A universal reagent for detection of emerging diseases using bioengineered multifunctional yeast nanofragments. Nature Nanotechnology, 18 (10), 1222-1229. doi: 10.1038/s41565-023-01415-1
Yuan, Liwen, Chen, Yanping, Ke, Longfeng, Zhou, Quan, Chen, Jiayou, Fan, Min, Wuethrich, Alain, Trau, Matt and Wang, Jing (2023). Plasma extracellular vesicle phenotyping for the differentiation of early-stage lung cancer and benign lung disease. Nanoscale Horizons, 8 (6), 746-758. doi: 10.1039/d2nh00570k
Ahmed, Mostak, Wuethrich, Alain, Constantin, Nicolas, Shanmugasundaram, Karthik Balaji, Mainwaring, Paul, Kulasinghe, Arutha, O’Leary, Connor, O’Byrne, Ken, Sina, Abu Ali Ibn, Carrascosa, Laura G. and Trau, Matt (2023). Liquid biopsy snapshots of key phosphoproteomic pathways in lung cancer patients for diagnosis and therapy monitoring. Analytical Chemistry, 95 (22), 8522-8532. doi: 10.1021/acs.analchem.3c00519
Vedelago, Courtney, Li, Junrong, Lowry, Kym, Howard, Christopher, Wuethrich, Alain and Trau, Matt (2023). A multiplexed SERS microassay for accurate detection of SARS-CoV-2 and variants of concern. ACS Sensors, 8 (4), 1648-1657. doi: 10.1021/acssensors.2c02782
Liao, Caizhi, Wu, Zhihao, Lin, Chan, Chen, Xiaofeng, Zou, Yaqun, Zhao, Wan, Li, Xin, Huang, Guangqi, Xu, Baisheng, Briganti, Giovanni E., Qi, Yan, Wang, Xianshu, Zeng, Tao, Wuethrich, Alain and Zou, Hongzhi (2023). Nurturing the marriages of urinary liquid biopsies and nano‐diagnostics for precision urinalysis of prostate cancer. Smart Medicine, 2 (1), 1-30. doi: 10.1002/smmd.20220020
Li, Junrong, Sina, Abu A. I., Antaw, Fiach, Fielding, David, Möller, Andreas, Lobb, Richard, Wuethrich, Alain and Trau, Matt (2023). Digital decoding of single extracellular vesicle phenotype differentiates early malignant and benign lung lesions. Advanced Science, 10 (1) 2204207, e2204207. doi: 10.1002/advs.202204207
Visan, Kekoolani S., Wu, Li-Ying, Voss, Sarah, Wuethrich, Alain and Möller, Andreas (2023). Status quo of extracellular vesicle isolation and detection methods for clinical utility. Seminars in Cancer Biology, 88, 157-171. doi: 10.1016/j.semcancer.2022.12.008
Li, Junrong, Wuethrich, Alain, Zhang, Zhen, Wang, Jing, Lin, Lynlee L., Behren, Andreas, Wang, Yuling and Trau, Matt (2022). SERS multiplex profiling of melanoma circulating tumor cells for predicting the response to immune checkpoint blockade therapy. Analytical Chemistry, 94 (42), 14573-14582. doi: 10.1021/acs.analchem.2c02398
Farokhinejad, Fahimeh, Li, Junrong, Hugo, Leon E., Howard, Christopher B., Wuethrich, Alain and Trau, Matt (2022). Detection of Dengue Virus 2 with single infected mosquito resolution using yeast affinity bionanofragments and plasmonic SERS nanoboxes. Analytical Chemistry, 94 (41), 14177-14184. doi: 10.1021/acs.analchem.2c02012
Liao, Caizhi, Antaw, Fiach, Wuethrich, Alain and Trau, Matt (2022). A T‐junction dual nanopore for single nanoparticle analysis. Advanced Engineering Materials, 24 (4) 2101015, 2101015. doi: 10.1002/adem.202101015
Kolka, Cathryn M., Webster, Julie, Lepletier, Ailin, Winterford, Clay, Brown, Ian, Richards, Renee S., Zelek, Wioleta M., Cao, Yilang, Khamis, Ramlah, Shanmugasundaram, Karthik B., Wuethrich, Alain, Trau, Matt, Brosda, Sandra, Barbour, Andrew, Shah, Alok K., Eslick, Guy D., Clemons, Nicholas J., Morgan, B. Paul and Hill, Michelle M. (2022). C5b-9 membrane attack complex formation and extracellular vesicle shedding in Barrett’s esophagus and esophageal adenocarcinoma. Frontiers in Immunology, 13 842023. doi: 10.3389/fimmu.2022.842023
Dey, Shuvashis, Ahmed, Emtiaz, Somvanshi, Pranjal Satishchandra, Sina, Abu Ali Ibn, Wuethrich, Alain and Trau, Matt (2022). An electrochemical and raman scattering dual detection biosensor for rapid screening and biomolecular profiling of cancer biomarkers. Chemosensors, 10 (3) 93, 93. doi: 10.3390/chemosensors10030093
Shanmugasundaram, Karthik Balaji, Li, Junrong, Sina, Abu Ibn, Wuethrich, Alain and Trau, Matt (2022). Toward precision oncology: SERS microfluidic systems for multiplex biomarker analysis in liquid biopsy. Materials Advances, 3 (3), 1459-1471. doi: 10.1039/d1ma00848j
Zhang, Zhen, Wuethrich, Alain, Wang, Jing, Korbie, Darren, Lin, Lynlee L. and Trau, Matt (2021). Dynamic monitoring of EMT in CTCs as an indicator of cancer metastasis. Analytical Chemistry, 93 (50) acs.analchem.1c03167, 16787-16795. doi: 10.1021/acs.analchem.1c03167
Farokhinejad, Fahimeh, Lane, Rebecca E., Lobb, Richard J., Edwardraja, Selvakumar, Wuethrich, Alain, Howard, Christopher B. and Trau, Matt (2021). Generation of nanoyeast single-chain variable fragments as high-avidity biomaterials for dengue virus detection. ACS Biomaterials Science and Engineering, 7 (12) acsbiomaterials.1c01001, 5850-5860. doi: 10.1021/acsbiomaterials.1c01001
Ahmed, Mohamed Adel, Felisilda, Bren Mark, Wuethrich, Alain and Quirino, Joselito P. (2021). A stationary pseudophase semi-permanent coating for open-tubular capillary liquid chromatography and electrochromatography. Journal of Chromatography A, 1657 462553, 462553. doi: 10.1016/j.chroma.2021.462553
Wang, Jing, Kao, Yung‐Ching, Zhou, Quan, Wuethrich, Alain, Stark, Mitchell S., Schaider, Helmut, Soyer, H. Peter, Lin, Lynlee L. and Trau, Matt (2021). An integrated microfluidic‐SERS platform enables sensitive phenotyping of serum extracellular vesicles in early stage melanomas. Advanced Functional Materials, 32 (3) 2010296, 1-9. doi: 10.1002/adfm.202010296
Wang, Jing, Wuethrich, Alain, Lobb, Richard J., Antaw, Fiach, Sina, Abu Ali Ibn, Lane, Rebecca E., Zhou, Quan, Zieschank, Chloe, Bell, Caroline, Bonazzi, Vanessa F., Aoude, Lauren G., Everitt, Sarah, Yeo, Belinda, Barbour, Andrew P., Möller, Andreas and Trau, Matt (2021). Characterizing the heterogeneity of small extracellular vesicle populations in multiple cancer types via an ultrasensitive chip. ACS Sensors, 6 (9) acssensors.1c00358, 3182-3194. doi: 10.1021/acssensors.1c00358
Li, Junrong, Wuethrich, Alain, Edwardraja, Selvakumar, Lobb, Richard J., Puttick, Simon, Rose, Stephen, Howard, Christopher B. and Trau, Matt (2021). Amplification-free SARS-CoV-2 detection using nanoyeast-scFv and ultrasensitive plasmonic nanobox-integrated nanomixing microassay. Analytical Chemistry, 93 (29) acs.analchem.1c01657, 10251-10260. doi: 10.1021/acs.analchem.1c01657
Reza, K. Kamil, Dey, Shuvashis, Wuethrich, Alain, Wang, Jing, Behren, Andreas, Antaw, Fiach, Wang, Yuling, Sina, Abu Ali Ibn and Trau, Matt (2021). In situ single cell proteomics reveals circulating tumor cell heterogeneity during treatment. ACS Nano, 15 (7) acsnano.0c10008, 11231-11243. doi: 10.1021/acsnano.0c10008
Webster, Julie A., Wuethrich, Alain, Shanmugasundaram, Karthik B., Richards, Renee S., Zelek, Wioleta M., Shah, Alok K., Gordon, Louisa G., Kendall, Bradley J., Hartel, Gunter, Morgan, B. Paul, Trau, Matt and Hill, Michelle M. (2021). Development of EndoScreen chip, a microfluidic pre-endoscopy triage test for esophageal adenocarcinoma. Cancers, 13 (12) 2865, 2865. doi: 10.3390/cancers13122865
Antaw, Fiach, Anderson, Will, Wuethrich, Alain and Trau, Matt (2021). On the behavior of nanoparticles beyond the nanopore interface. Langmuir, 37 (16), 4772-4782. doi: 10.1021/acs.langmuir.0c03083
Li, Junrong, Wuethrich, Alain, Sina, Abu A. I., Cheng, Han-Hao, Wang, Yuling, Behren, Andreas, Mainwaring, Paul N. and Trau, Matt (2021). A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy. Nature Communications, 12 (1) 1087, 1-12. doi: 10.1038/s41467-021-21431-w
Liao, Caizhi, Antaw, Fiach, Wuethrich, Alain and Trau, Matt (2020). Stacked dual‐pore architecture for deciphering and manipulating dynamics of individual nanoparticles. Advanced Materials Technologies, 5 (11) 2000701, 2000701. doi: 10.1002/admt.202000701
Liao, Caizhi, Antaw, Fiach, Wuethrich, Alain, Anderson, Will and Trau, Matt (2020). Configurable miniaturized 3D pores for robust single‐nanoparticle analysis. Small Structures, 1 (2) 2000011. doi: 10.1002/sstr.202000011
Li, Junrong, Wuethrich, Alain, Dey, Shuvashi, Lane, Rebecca E., Sina, Abu A. I., Wang, Jing, Wang, Yuling, Puttick, Simon, Koo, Kevin M. and Trau, Matt (2020). Multiomics: The Growing Impact of Micro/Nanomaterial‐Based Systems in Precision Oncology: Translating “Multiomics” Technologies (Adv. Funct. Mater. 37/2020). Advanced Functional Materials, 30 (37) 2070248. doi: 10.1002/adfm.202070248
Sina, Abu Ali Ibn, Lin, Ting-Yun, Vaidyanathan, Ramanathan, Wang, Zhaoran, Dey, Shuvashis, Wang, Jing, Behren, Andreas, Wuethrich, Alain, Carrascosa, Laura G. and Trau, Matt (2020). Methylation dependent gold adsorption behaviour identifies cancer derived extracellular vesicular DNA. Nanoscale Horizons, 5 (9), 1317-1323. doi: 10.1039/d0nh00258e
Liao, Caizhi, Wuethrich, Alain and Trau, Matt (2020). A material odyssey for 3D nano/microstructures: two photon polymerization based nanolithography in bioapplications. Applied Materials Today, 19 100635, 100635. doi: 10.1016/j.apmt.2020.100635
Zhang, Zhen, Wang, Jing, Shanmugasundaram, Karthik Balaji, Yeo, Belinda, Möller, Andreas, Wuethrich, Alain, Lin, Lynlee L. and Trau, Matt (2020). Tracking drug-induced epithelial–mesenchymal transition in breast cancer by a microfluidic surface-enhanced raman spectroscopy immunoassay. Small, 16 (13) 1905614, e1905614. doi: 10.1002/smll.201905614
Wang, Jing, Wuethrich, Alain, Sina, Abu Ali Ibn, Lane, Rebecca E., Lin, Lynlee L., Wang, Yuling, Cebon, Jonathan, Behren, Andreas and Trau, Matt (2020). Tracking extracellular vesicle phenotypic changes enables treatment monitoring in melanoma. Science Advances, 6 (9) eaax3223, eaax3223. doi: 10.1126/sciadv.aax3223
Li, Junrong, Wuethrich, Alain, Dey, Shuvashi, Lane, Rebecca E., Sina, Abu A. I., Wang, Jing, Wang, Yuling, Puttick, Simon, Koo, Kevin M. and Trau, Matt (2020). The growing impact of micro/nanomaterial-based systems in precision oncology: translating “multiomics” technologies. Advanced Functional Materials, 30 (37) 1909306, 1909306. doi: 10.1002/adfm.201909306
Kumar, Aswin Raj, Shanmugasundaram, Karthik Balaji, Li, Junrong, Zhang, Zhen, Ibn Sina, Abu Ali, Wuethrich, Alain and Trau, Matt (2020). Ultrasensitive melanoma biomarker detection using a microchip SERS immunoassay with anisotropic Au–Ag alloy nanoboxes. RSC Advances, 10 (48), 28778-28785. doi: 10.1039/d0ra05032f
Wuethrich, Alain, Rajkumar, Aswin Raj, Shanmugasundaram, Karthik Balaji, Reza, Kamil K., Dey, Shuvashis, Howard, Christopher B., Sina, Abu Ali Ibn and Trau, Matt (2019). Single droplet detection of immune checkpoints on a multiplexed electrohydrodynamic biosensor. The Analyst, 144 (23), 6914-6921. doi: 10.1039/c9an01450k
Khondakar, Kamil Reza, Dey, Shuvashis, Wuethrich, Alain, Sina, Abu Ali Ibn and Trau, Matt (2019). Toward personalized cancer treatment: from diagnostics to therapy monitoring in miniaturized electrohydrodynamic systems. Accounts of Chemical Research, 52 (8) acs.accounts.9b00192, 2113-2123. doi: 10.1021/acs.accounts.9b00192
Dey, Shuvashis, Kamil Reza, K., Wuethrich, Alain, Korbie, Darren, Ibn Sina, Abu Ali and Trau, Matt (2019). Tracking antigen specific T-cells: technological advancement and limitations. Biotechnology Advances, 37 (1), 145-153. doi: 10.1016/j.biotechadv.2018.11.010
Sina, A.A.I., Vaidyanathan, R., Wuethrich, A., Carrascosa, L. G. and Trau, M. (2019). Label-free detection of exosomes using surface plasmon resonance biosensor. Analytical and Bioanalytical Chemistry, 411 (7), 1311-1318. doi: 10.1007/s00216-019-01608-5
Breadmore, Michael C., Grochocki, Wojciech, Kalsoom, Umme, Alves, Mónica N., Phung, Sui Ching, Rokh, Masoomeh Tehrani, Cabot, Joan M., Ghiasvand, Alireza, Li, Feng, Shallan, Aliaa I., Keyon, Aemi S. Abdul, Alhusban, Ala A., See, Hong Heng, Wuethrich, Alain, Dawod, Mohamed and Quirino, Joselito P. (2019). Recent advances in enhancing the sensitivity of electrophoresis and electrochromatography in capillaries and microchips (2016–2018). Electrophoresis, 40 (1), 17-39. doi: 10.1002/elps.201800384
Dey, Shuvashis, Koo, Kevin, Wang, Zhaoran, Sina, Abu Ali Ibn, Wuethrich, Alain and Trau, Matt (2018). An integrated multi-molecular sensor for simultaneous BRAFV600E protein and DNA single point mutation detection in circulating tumour cells. Lab on a Chip, 19 (5), 738-748. doi: 10.1039/c8lc00991k
Reza, K. Kamil, Sina, Abu Ali Ibn, Wuethrich, Alain, Grewal, Yadveer S., Howard, Christopher B., Korbie, Darren and Trau, Matt (2018). A SERS microfluidic platform for targeting multiple soluble immune checkpoints. Biosensors and Bioelectronics, 126, 178-186. doi: 10.1016/j.bios.2018.10.044
Reza, K. Kamil, Dey, Shuvashis, Wuethrich, Alain, Sina, Abu Ali Ibn, Korbie, Darren, Wang, Yuling and Trau, Matt (2018). Parallel profiling of cancer cells and proteins using a graphene oxide functionalized ac-EHD SERS immunoassay. Nanoscale, 10 (39), 18482-18491. doi: 10.1039/c8nr02886a
Wuethrich, Alain and Quirino, Joselito P. (2018). A decade of microchip electrophoresis for clinical diagnostics – a review of 2008-2017. Analytica Chimica Acta, 1045, 42-66. doi: 10.1016/j.aca.2018.08.009
Ahmed, Mostak, Carrascosa, Laura G, Wuethrich, Alain, Mainwaring, Paul and Trau, Matt (2018). An exosomal- and interfacial-biosensing based strategy for remote monitoring of aberrantly phosphorylated proteins in lung cancer cells. Biomaterials Science, 6 (9), 2336-2341. doi: 10.1039/c8bm00629f
Wuethrich, Alain, Sina, Abu Ali Ibn, Ahmed, Mostak, Lin, Ting-Yun, Carrascosa, Laura G. and Trau, Matt (2018). Interfacial nano-mixing in a miniaturised platform enables signal enhancement and in situ detection of cancer biomarkers. Nanoscale, 10 (23), 10884-10890. doi: 10.1039/C7NR09496E
Wuethrich, Alain and Quirino, Joselito P. (2018). Derivatisation for separation and detection in capillary electrophoresis (2015–2017). Electrophoresis, 39 (1), 82-96. doi: 10.1002/elps.201700252
Wuethrich, Alain, Howard, Christopher B. and Trau, Matt (2017). Geometric optimisation of electrohydrodynamic fluid flows for enhanced biosensing. Microchemical Journal, 137, 231-237. doi: 10.1016/j.microc.2017.10.012
Wuethrich, Alain, Haddad, Paul R. and Quirino, Joselito P. (2017). Electrophoretic concentration - a simple and green approach for sample preparation. LCGC North America: solution for separation scientists, 35 (3), 197-201.
Wuethrich, Alain and Quirino, Joselito P. (2017). Sensitivity enhancing injection from a sample reservoir and channel interface in microchip electrophoresis. Journal of Separation Science, 40 (4), 927-932. doi: 10.1002/jssc.201601064
Wuethrich, Alain, Haddad, Paul R. and Quirino, Joselito P. (2017). Electrophoretic concentration — a simple and green approach for sample preparation. LC-GC Europe, 30 (2), 60-67.
Breadmore, Michael C., Grochocki, Wojciech, Kalsoom, Umme, Alves, Mónica N., Phung, Sui Ching, Rokh, Masoomeh Tehrani, Cabot, Joan M., Ghiasvand, Alireza, Li, Feng, Shallan, Aliaa I., Keyon, Aemi S. Abdul, Alhusban, Ala A., See, Hong Heng, Wuethrich, Alain, Dawod, Mohamed and Quirino, Joselito P. (2017). Recent advances in enhancing the sensitivity of electrophoresis and electrochromatography in capillaries and microchips (2014–2016). Electrophoresis, 38 (1), 33-59. doi: 10.1002/elps.201600331
Wuethrich, Alain and Quirino, Joselito P. (2016). Unusual stacking with electrokinetic injection of cationic analytes from micellar solutions in capillary zone electrophoresis. Analytical and Bioanalytical Chemistry, 408 (30), 8663-8668. doi: 10.1007/s00216-016-9735-1
Wuethrich, Alain, Haddad, Paul R. and Quirino, Joselito P. (2016). The electric field - an emerging driver in sample preparation. TrAC - Trends in Analytical Chemistry, 80, 604-611. doi: 10.1016/j.trac.2016.04.016
Wuethrich, Alain, Haddad, Paul R. and Quirino, Joselito P. (2016). Simultaneous electrophoretic concentration and separation of herbicides in beer prior to stacking capillary electrophoresis UV and liquid chromatography-mass spectrometry. Electrophoresis, 37 (9), 1122-1128. doi: 10.1002/elps.201600050
Wuethrich, Alain, Haddad, Paul R. and Quirino, Joselito P. (2016). Field-enhanced sample injection micelle-to-solvent stacking capillary zone electrophoresis-electrospray ionization mass spectrometry of antibiotics in seawater after solid-phase extraction: CE and CEC. Electrophoresis, 37 (9), 1139-1142. doi: 10.1002/elps.201500448
Greene, George W., Duffy, Emer, Shallan, Aliaa, Wuethrich, Alain and Paull, Brett (2016). Electrokinetic properties of lubricin antiadhesive coatings in microfluidic systems. Langmuir, 32 (7), 1899-1908. doi: 10.1021/acs.langmuir.5b03535
Wuethrich, Alain and Quirino, Joselito P. (2016). Derivatisation for separation and detection in capillary electrophoresis (2012-2015). Electrophoresis, 37 (1), 45-55. doi: 10.1002/elps.201500290
Wuethrich, Alain, Haddad, Paul R. and Quirino, Joselito P. (2015). Electrophoretic concentration and sweeping-micellar electrokinetic chromatography analysis of cationic drugs in water samples. Journal of Chromatography A, 1401, 84-88. doi: 10.1016/j.chroma.2015.05.018
Wuethrich, Alain, Haddad, Paul R. and Quirino, Joselito P. (2015). Green sample preparation for liquid chromatography and capillary electrophoresis of anionic and cationic analytes. Analytical Chemistry, 87 (8), 4117-4123. doi: 10.1021/ac504765h
Wuethrich, Alain, Haddad, Paul R. and Quirino, Joselito P. (2014). Off-line sample preparation by electrophoretic concentration using a micropipette and hydrogel. Journal of Chromatography A, 1369, 186-190. doi: 10.1016/j.chroma.2014.10.006
Wuethrich, Alain, Haddad, Paul R. and Quirino, Joselito P. (2014). Online sample concentration in partial-filling chiral electrokinetic chromatography - mass spectrometry. Chirality, 26 (11), 734-738. doi: 10.1002/chir.22257
Wuethrich, Alain, Haddad, Paul R. and Quirino, Joselito P. (2014). Zero net-flow in capillary electrophoresis using acrylamide based hydrogel. Analyst, 139 (15), 3722-3726. doi: 10.1039/c4an00557k
Wuethrich, Alain, Haddad, Paul R. and Quirino, Joselito P. (2014). Chiral capillary electromigration techniques-mass spectrometry-hope and promise. Electrophoresis, 35 (1), 2-11. doi: 10.1002/elps.201300377
Conference Papers
O'Byrne, K., Shanmugasundaram, K.B., Ahmed, E., Kulasinghe, A., Monkman, J., Fletcher, J.A., Mainwaring, P.N., Masud, M.K., Park, H., Hossain, M.S.A., Yamauchi, Y., Sina, A.A.I., Wuethrich, A. and Trau, M. (2023). Extracellular Small Vesicle Phosphorylated PD-L1 Liquid Biopsy Levels Correlate with Tumour Proportion Score (TPS) in NSCLC. 2023 World Conference on Lung Cancer, Singapore, 9-12 September 2023. New York, NY United States: Elsevier. doi: 10.1016/j.jtho.2023.09.432
Chavanne, Philippe, Stevanovic, Sabrina, Wüthrich, Alain, Braissant, Olivier, Pieles, Uwe, Gruner, Philipp and Schumacher, Ralf (2013). 3D printed chitosan / hydroxyapatite scaffolds for potential use in regenerative medicine. BMT (Biomedizinische Technik) 2013, Graz, Austria, 2013. Berlin, Germany: Walter de Gruyter. doi: 10.1515/bmt-2013-4069