Professor Nicholas West
Primary research interest
Tuberculosis microbiology
About me
After completing my PhD, I began postdoctoral research at the University of Oxford, UK, working as a part of a European collaboration towards the development of a vaccine for the causative pathogen of serious bacterial dysentery. This work was later continued and completed at the Imperial College London. During this time, I spent significant time collaborating and working at the Institute Pasteur in Paris. In 2004 I returned to Australia as a postdoctoral scientist at the Centenary Institute in Sydney where I began researching TB. I moved to The University of Queensland as an NHMRC Research Fellow in mid-2012. I now hold a continuing academic position as Assoc. Professor in the School of Chemistry and Molecular Biosciences.
Research focus and collaborations
Lab: Tuberculosis Research
My laboratory is committed to understanding the mechanisms by which Mycobacterium tuberculosis causes Tuberculosis (TB). One in four people in the world are infected with this bacterium, resulting in approximately 4,000 deaths every day. My lab utilises modern molecular genomic technologies to identify the genetic requirements for M. tuberculosis to cause TB. This information is being translated into the development of new therapies and control measures for TB. Research within the group will fall largely into one of the following four themes: Essential Gene Identification in M. tuberculosis, Understanding TB Latency, Targeted TB Drug Development and Improving TB Vaccination.
National research collaborations
- University of Sydney, School of Chemistry and Sydney Medical School
- Walter and Eliza Hall Institute of Medical Research
- Centenary Institute, Mycobacterial Research Laboratory
- Australian National University
International collaborations
- Francis Crick Institute, London, UK
- Southwest University, China
- Stellenbosch Universtiy, South Africa
- Colarado State University, USA
Funded projects (recent and current only)
- 2021-2024: ARC Discovery Project - Mycobacterial Cholesterol Degradation: A Unique Metabolic Weakness? ($498,000)
- 2019–2022 NHMRC Project Grant - Blocking TB Latency: The Key to Reducing Therapy Duration ($606,732)
- 2018–2021 NHMRC Project Grant - Ketol-acid reductoisomerase: An important antituberculosis drug target ($680,585)
- 2018–2021 NHMRC Project Grant - Killing infected cells as a mechanism to eradicate tuberculosis (led by Walter & Eliza Hall Institute of Medical Research) ($1,070,780)
- 2018–2020 NHMRC Project Grant - Novel TB Drug Candidates via the Inhibition of Lipid I Biosynthesis (led by University of Sydney) ($780,743)
- 2018–2020 NHMRC Project Grant - Preventing the evolution of transmissible nitroimidazole resistance in Mycobacterium tuberculosis (led by ANU) ($664,463)
Teaching interests
Undergraduate
- MICR3003, Molecular Microbiology (Course Co-ordinator)
- MICR3001, Microbes and Human Health
- BIOL2202/BIOL2902, Genetics/Advanced Genetics
Postgraduate coursework
- MICR7002, Immunology and Infectious Diseases
Student supervision
For many years now there has been a constant presence of undergraduate and postgraduate research students in the group. Currently, I supervise students at all levels, ie. undergraduate research, Hons, MSc. and PhD.
Enquiries from students regarding available positions are always welcome.
Achievements and awards
- Dean’s Commendation for Excellent Teaching, Executive Dean, FoS (2021)
- COVID19 – Above and Beyond Honour Roll, Office of the VC(A), UQ (2020)
- Faculty of Science, Teaching Excellence Award. Finalist. FoS, UQ (2020)
- Chair, Scientific Program; Australian Society of Microbiology National Conference, Brisbane (2018)
- Research Excellence Award, Australian Infectious Disease Research Centre (2015)
- NHMRC CDA2 Research Fellow (2011)
- Australian Society of Microbiology NSW/ACT branch Executive (2010-2012)
- Centenary Institute “Innovation Award” (2010)
Featured publications
- Stutz, Michael Dominic, Allison, Cody Charles, Ojaimi, Samar, Preston, Simon Peter, Doerflinger, Marcel, Arandjelovic, Philip, Whitehead, Lachlan, Bader, Stefanie M., Batey, Daniel, Asselin-Labat, Marie-Liesse, Herold, Marco J., Strasser, Andreas, West, Nicholas P. and Pellegrini, Marc (2021).Macrophage and neutrophil death programs differentially confer resistance to tuberculosis. Immunity, 54 (8), 1758-1771.e7. doi: 10.1016/j.immuni.2021.06.009
- Blaskovich, Mark A. T., Kavanagh, Angela M., Elliott, Alysha G., Zhang, Bing, Ramu, Soumya, Amado, Maite, Lowe, Gabrielle J., Hinton, Alexandra O., Pham, Do Minh Thu, Zuegg, Johannes, Beare, Neil, Quach, Diana, Sharp, Marc D., Pogliano, Joe, Rogers, Ashleigh P., Lyras, Dena, Tan, Lendl, West, Nicholas P., Crawford, David W., Peterson, Marnie L., Callahan, Matthew and Thurn, Michael (2021).The antimicrobial potential of cannabidiol. Communications Biology, 4 (1) 7, 1-18. doi: 10.1038/s42003-020-01530-y
- Bartlett, Stacey, Gemiarto, Adrian Tandhyka, Ngo, Minh Dao, Sajiir, Haressh, Hailu, Semira, Sinha, Roma, Foo, Cheng Xiang, Kleynhans, Léanie, Tshivhula, Happy, Webber, Tariq, Bielefeldt-Ohmann, Helle, West, Nicholas P., Hiemstra, Andriette M., MacDonald, Candice E., Christensen, Liv von Voss, Schlesinger, Larry S., Walzl, Gerhard, Rosenkilde, Mette Marie, Mandrup-Poulsen, Thomas and Ronacher, Katharina (2020).GPR183 regulates interferons, autophagy, and bacterial growth during Mycobacterium tuberculosis infection and is associated with TB disease severity. Frontiers in Immunology, 11 601534, 601534. doi: 10.3389/fimmu.2020.601534
- Awad, Milena M., Hutton, Melanie L., Quek, Adam J., Klare, William P., Mileto, Steven J., Mackin, Kate, Ly, Diane, Oorschot, Viola, Bosnjak, Marijana, Jenkin, Grant, Conroy, Paul J., West, Nick, Fulcher, Alex, Costin, Adam, Day, Christopher J., Jennings, Michael P., Medcalf, Robert L., Sanderson-Smith, Martina, Cordwell, Stuart J., Law, Ruby H.P., Whisstock, James C. and Lyras, Dena (2020).Human plasminogen exacerbates Clostridioides difficile enteric disease and alters the spore surface. Gastroenterology, 159 (4), 1431-1443.e6. doi: 10.1053/j.gastro.2020.06.032
- Lonhienne, Thierry, Low, Yu Shang, Garcia, Mario D., Croll, Tristan, Gao, Yan, Wang, Quan, Brillault, Lou, Williams, Craig M., Fraser, James A., McGeary, Ross P., West, Nicholas P., Landsberg, Michael J., Rao, Zihe, Schenk, Gerhard and Guddat, Luke W. (2020).Structures of fungal and plant acetohydroxyacid synthases. Nature, 586 (7828), 317-321+. doi: 10.1038/s41586-020-2514-3
- Lee, Brendon M., Harold, Liam K., Almeida, Deepak V., Afriat-Jurnou, Livnat, Aung, Htin Lin, Forde, Brian M., Hards, Kiel, Pidot, Sacha J., Ahmed, F. Hafna, Mohamed, A. Elaaf, Taylor, Matthew C., West, Nicholas P., Stinear, Timothy P., Greening, Chris, Beatson, Scott A., Nuermberger, Eric L., Cook, Gregory M. and Jackson, Colin J. (2020).Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering. PLoS Pathogens, 16 (2) e1008287, e1008287. doi: 10.1371/journal.ppat.1008287
- Serafini, Agnese, Tan, Lendl, Horswell, Stuart, Howell, Steven, Greenwood, Daniel J., Hunt, Deborah M., Phan, Minh-Duy, Schembri, Mark, Monteleone, Mercedes, Montague, Christine R., Britton, Warwick, Garza-Garcia, Acely, Snijders, Ambrosius P., VanderVen, Brian, Gutierrez, Maximiliano G., West, Nicholas P. and de Carvalho, Luiz Pedro S. (2019).Mycobacterium tuberculosis requires glyoxylate shunt and reverse methylcitrate cycle for lactate and pyruvate metabolism. Molecular Microbiology, 112 (4) mmi.14362, 1284-1307. doi: 10.1111/mmi.14362
- Jarrad, Angie M., Ang, Chee Wei, Debnath, Anjan, Hahn, Hye Jee, Woods, Kyra, Tan, Lendl, Sykes, Melissa L., Jones, Amy J., Pelingon, Ruby, Butler, Mark S., Avery, Vicky M., West, Nicholas P., Karoli, Tomislav, Blaskovich, Mark A. T. and Cooper, Matthew A. (2018).Design, synthesis and biological evaluation of 2-nitroimidazopyrazin-one/-es with antitubercular and antiparasitic activity. Journal of Medicinal Chemistry, 61 (24) acs.jmedchem.8b01578, 11349-11371. doi: 10.1021/acs.jmedchem.8b01578
- Tan, Lendl, Strong, Emily J., Woods, Kyra and West, Nicholas P. (2018).Homologous alignment cloning: a rapid, flexible and highly efficient general molecular cloning method. PeerJ, 6 (6) e5146, e5146. doi: 10.7717/peerj.5146
- Strong, Emily J. and West, Nicholas P. (2018).Use of soluble extracellular regions of MmpL (SERoM) as vaccines for tuberculosis. Scientific Reports, 8 (1) 5604, 5604. doi: 10.1038/s41598-018-23893-3
- Tran, Anh T., Watson, Emma E., Pujari, Venugopal, Conroy, Trent, Dowman, Luke J., Giltrap, Andrew M., Pang, Angel, Wong, Weng Ruh, Linington, Roger G., Mahapatra, Sebabrata , Saunders, Jessica, Charman, Susan A., West, Nicholas P., Bugg, Timothy D. H., Tod, Julie, Dowson, Christopher G., Roper, David I., Crick, Dean C., Britton, Warwick J. and Payne, Richard J. (2017).Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis. Nature Communications, 8 (1) 14414, 14414. doi: 10.1038/ncomms14414
Researcher biography
Associate Professor West is a molecular microbiologist, expert in bacterial pathogenesis. He is Head of "Tuberculosis Research" in the School of Chemistry and Molecular Biosciences, University of Queensland. Nick has a particular interest in drug development for TB. His research utilises modern molecular technologies to identify the genetic requirements for Mycobacterium tuberculosis to cause Tuberculosis (TB) with these genetic discoveries translated into novel antibiotic therapies. Research within his group falls largely into one of the following four themes: Essential Gene Identification in M. tuberculosis, Understanding TB Latency, Targeted TB Drug Development and Improving TB Vaccination.
Nick conducted postdoctoral research at the University of Oxford and Imperial College London. Returning to Australia in 2004, he spent several years at Sydney's Centenary Institute as an Associate Faculty member before relocating to University of Queensland in 2012. In addition to drug development, Nick's research portfolio includes programmes of vaccine and diagnostic development and testing.