Dr Andrii Slonchak

Dr Slonchak obtained PhD in molecular biology in 2010. During PhD he was investigating cell-specific mechanisms responsible for transcriptional regulation of the human gene encoding for phase II detoxification enzyme glutathione S-transferase P1 in normal and cancer cells. When working on this project he acquired an interest in the role of noncoding RNAs in regulation of gene expression, which he further developed by joining the RNA virology lab at University of Queensland to study the role of noncoding RNAs in flavivirus-host interactions under supervision of Prof. Alexander Khromykh.

His current research into the role of noncoding RNAs in flavivirus infection involves a combination of molecular, biochemical and computational techniques. His research includes studying the role of host miRNAs in response to flavivirus infection, identifying the functions of virus-derived long noncoding RNA (subgenomic flaviviral RNA, sfRNA) in viral replication and inhibition of the host immune pathways and determining the mechanisms of sfRNA biogenesis in insect-specific flaviviruses. In his research Dr Slonchak make an extensive use of high-throughput technologies such as RNA-seq followed by reconstruction of gene interaction networks and computational modeling of signaling pathways.