Emeritus Professor Robert Tindle
Emeritus Professor
School of Chemistry and Molecular Biosciences
Book Chapters
Frazer, I. H. and Tindle, R. (1999). Cell mediated immunity to papillomaviruses. In Charles Lacey (Ed.), Current research on papillomaviruses (pp. 151-164) Leeds, England: Leeds University Press.
Frazer, I. H., Tindle, R. W., Fernando, G. J., Malcolm, K. M., Herd, K. A., McFadyen, S. M., Cooper, P. D. and Ward, B. G. (1999). Safety and Immunogenicity of HPV16 E7/Algammulin. In R. W. Tindle (Ed.), Vaccines for Human Papillomavirus Infection and Anogenital Disease (pp. 91-104) Austin, USA: R.G. Landes Company.
Tindle, R. W. (1999). Immunomodulation of HPV infection and disease. In Robert W. Tindle (Ed.), Vaccines for Human Papillomavirus Infection and Anogenital Disease 1st ed. (pp. 1-12) Texas, USA: R. G. Landes Company.
Journal Articles
Frias-Soler, Roberto, Tindle, Elizabeth, Lopez, Georgina Espinosa, Blomberg, Simon, Studer-Thiersch, Adelheid, Wink, Michael and Tindle, Robert (2014) Genetic and phenotypic evidence supports evolutionary divergence of the American flamingo (Phoenicopterus ruber) population in the Galápagos Islands. Waterbirds, 37 4: 349-361. doi:10.1675/063.037.0402
Tindle, Robert W., Tindle, Elizabeth, Vagenas, Dimitrios and Harris, Michael P. (2013) Population dynamics of the Galapagos Flightless Cormorant Phalacrocorax harrisi in relation to sea temperature. Marine Ornithology, 41 2: 121-133.
Haigh, O., Kattenbelt, J., Cochrane, M., Thomson, S., Gould, A. and Tindle, R. (2010) Hepatitis B surface antigen fusions delivered by DNA vaccination elicit CTL responses to human papillomavirus oncoproteins associated with tumor protection. Cancer Gene Therapy, 17 10: 708-720. doi:10.1038/cgt.2010.27
Chen, Dekun, Edgtton, Kristy, Gould, Allan, Guo, Huayang, Mather, Michael, Haigh, Oscar, Cochrane, Melanie, Kattenbelt, Jacqueline, Thomson, Scott and Tindle, Robert (2010) HBsAg-vectored vaccines simultaneously deliver CTL responses to protective epitopes from multiple viral pathogens. Virology, 398 1: 68-78. doi:10.1016/j.virol.2009.11.042
Herd, K. A., Nelson, M., Mahalingam, S. and Tindle, R. W. (2010) Pulmonary infection of mice with human metapneumovirus induces local cytotoxic T-cell and immunoregulatory cytokine responses similar to those seen with human respiratory syncytial virus.. Journal of General Virology, 91 5: 1302-1310. doi:10.1099/vir.0.015396-0
Gu, Wenyi, Cochrane, Melanie, Leggatt, Graham, Payne, Elizabeth, Choyce, Allison, Zhou, Fang, Tindle, Robert and McMillan, Nigel (2009) Both treated and untreated tumors are eliminated by short hairpin RNA-based induction of target-specific immune responses. Proceedings of the National Academy of Sciences of the United States of America, 106 20: 8314-8319. doi:10.1073/pnas.0812085106
Thomson, S., Haigh, O., Gould, A. R. and Tindle, R. W. (2008) Genetically modified hepatitis B surface antigen: A Powerful vaccine technology for the delivery of disease-associated foreign antigens.. Current Drug Therapy, 3 3: 226-234. doi:10.2174/157488508785747844
Herd, K. A., Nissen, M. D., Hopkins, P. M., Sloots, T. P. and Tindle, R. W. (2008) Major histocompatibility complex class I cytotoxic T lymphocyte immunity to human metapneumovirus (hMPV) in individuals with previous hMPV infection and respiratory disease. The Journal of Infectious Diseases, 197 4: 584-592. doi:10.1086/526536
Tindle, Robert W., Oscar Haigh, Gould, Allan R. and Scott Thomson (2008) Recombinant Hepatitis B surface antigen vaccines for the delivery of disease-related antigens.. Current Trends in Immunology, 9 51-60.
Haigh, Oscar, Guo, Huayang, Edgtton, Kristy, Mather, Michael, Herd, Karen A. and Tindle, Robert W. (2007) Multiple copies of a tumor epitope in a recombinant hepatitis B surface antigen (HBsAg)vaccine enhance CTL responses, but not tumor protection. Virology, 368 2: 363-375. doi:10.1016/j.virol.2007.06.041
Herd, Karen A., Wiethe, Carsten and Tindle, Robert W. (2007) Co-immunisation with DNA encoding RANK/RANKL or 4-1BBL costimulatory molecules does not enhance effector or memory CTL responses afforded by immunisation with a tumour antigen-encoding DNA vaccine. Vaccine, 25 28: 5209-5219. doi:10.1016/j.vaccine.2007.04.083
Woo, Wai-Ping, Doan, Tracy, Herd, Karen A., Netter, Hans-Jurgen and Tindle, Robert W. (2006) Hepatitis B surface antigen vector delivers protective cytotoxic T-lymphocyte responses to disease-relevant foreign epitopes. Journal Of Virology, 80 8: 3975-3984. doi:10.1128/JVI.80.8.3975-3984.2006
Herd, Karen A., Mahalingam, Suresh, Mackay, Ian M., Nissen, Michael, Sloots, Theo P. and Tindle, Robert W. (2006) Cytotoxic T-lymphocyte epitope vaccination protects against human metapneumovirus infection and disease in mice. Journal of Virology, 80 4: 2034-2044. doi:10.1128/JVI.80.4.2034-2044.2006
Doan, T., Herd, K., Ramshaw, I., Thomson, S. and Tindle, R. W. (2005) A polytope DNA vaccine elicits multiple effector and memory CTL responses and protects against human papillomavirus 16 E7-expressing tumour. Cancer Immunology Immunotherapy, 54 2: 157-171. doi:10.1007/s00262-004-0544-6
Herd, Karen A., Harvey, Tracey, Khromykh, Alexander A. and Tindle, Robert W. (2004) Recombinant Kunjin virus replicon vaccines induce protective T-cell immunity against human papillomavirus 16 E7-expressing tumour. Virology, 319 2: 237-248. doi:10.1016/j.virol.2003.10.032
Wiethe, C., Dittmar, K., Doan, T., Lindenmaier, W. and Tindle, R. (2003) Enhanced effector and memory CTL responses generated by incorporation of receptor activator of NF-kappa B(RANK)/RANK ligand costimulatory molecules into dendritic cell immunogens expressing a human tumor-specific antigen. Journal of Immunology, 171 8: 4121-4130.
Ward, Scott M., Tindle, Robert W., Khromykh, Alexander A. and Gowans, Eric J. (2003) Generation of CTL responses using Kunjin replicon RNA. Immunology And Cell Biology, 81 1: 73-78. doi:10.1046/j.0818-9641.2002.01137.x
Khammanivong, Vithagna, Liu, Xiao Song, Liu, Wen Jun, Rodda, Stuart J., Leggatt, Graham R., Tindle, Robert W., Frazer, Ian H. and Fernando, Germain J. P. (2003) Paucity of functional CTL epitopes in the E7 oncoprotein of cervical cancer associated human papillomavirus type 16. Immunology and Cell Biology, 81 1: 1-7. doi:10.1046/j.1440-1711.2003.01130.x
Wiethe, C, Dittmar, K, Doan, T, Lindenmaier, W and Tindle, R (2003) Provision of 4-1BB ligand enhances effector and memory CTL responses generated by immunization with dendritic cells expressing a human tumor-associated antigen. Journal of Immunology, 170 6: 2912-2922. doi:10.4049/jimmunol.170.6.2912
Netter, HJ, Woo, WP, Tindle, R, Macfarlan, RI and Gowans, EJ (2003) Immunogenicity of recombinant HBsAg/HCV particles in mice pre-immunised with hepatitis B virus-specific vaccine. Vaccine, 21 21-22: 2692-2697. doi:10.1016/S0264-410X(03)00182-8
Tindle, R. W. (2002) Immune evasion in human papillomavirus-associated cervical cancer. Nature Reviews Cancer, 2 1: 59-65. doi:10.1038/nrc700
Street, MD, Doan, T, Herd, KA and Tindle, RW (2002) Limitations of HLA-transgenic mice in presentation of HLA-restricted cytotoxic T-cell epitopes from endogenously processed human papillomavirus type 16 E7 protein. Immunology, 106 4: 526-536. doi:10.1046/j.1365-2567.2002.01442.x
Tindle, Robert W., Herd, Karen A., Doan, Tracy, Bryson, Greg, Leggatt, Graham R., Lambert, Paul, Ian H. Frazer, and Street, Michael D. (2001) Nonspecific down-regulation of CD8+ T-Cell responses in mice expressing human Papillomavirus Type 16 E7 oncoprotein from the keratin-14 promoter. Journal of Virology, 75 13: 5985-5997. doi:10.1128/JVI.75.13.5985-5997.2001
Netter, Hans J., MacNaughton, Thomas B., Woo, Wai-Ping, Tindle, Robert and Gowans, Eric J. (2001) Antigenicity and immunogenicity of novel chimeric hepatitis B surface antigen particles with exposed hepatitis C virus epitopes. Journal of Virology, 75 5: 2130-2141. doi:10.1128/JVI.75.5.2130-2141.2001
Azoury-Ziadeh, R, Herd, K, Fernando, GJP, Lambert, P, Frazer, IH and Tindle, RW (2001) Low level expression of human papillomavirus type 16 (HPV16) E6 in squamous epithelium does not elicit E6 specific B- or T-helper immunological responses, or influence the outcome of immunisation with E6 protein. Virus Research, 73 2: 189-199. doi:10.1016/S0168-1702(00)00241-0
Tindle, RW (2001) Peripheral T-Cell tolerance defined through transgenic mouse studies. Autoimmunity, 33 2: 135-149. doi:10.3109/08916930108995998
Doan, Tracy, Herd, Karen A., Lambert, Paul F., Fernando, Germain J. P., Street, Michael D. and Tindle, Robert W. (2000) Peripheral tolerance to human papillomavirus E7 oncoprotein occurs by cross-tolerization, is largely Th-2-independent, and is broken by dendritic cell immunization. Cancer Research, 60 11: 2810-2815.
Peng, Shiwen, Qi, Yingmei, Christensen, Neil, Hengst, Kylie, Kennedy, Lynn, Frazer, Ian H. and Tindle, Robert W. (1999) Capture ELISA and in vitro cell binding assay for the detection of antibodies to human papillomavirus type 6b virus-like particles in patients with anogenital warts. Pathology, 31 4: 418-422. doi:10.1080/003130299104846
Doan, Tracy, Herd, Karen, Street, Michael, Bryson, Gregory, Fernando, Germain, Lambert, Paul and Tindle, Robert (1999) Human papillomavirus type 16 E7 oncoprotein expressed in peripheral epithelium tolerizes E7-directed cytotoxic T-lymphocyte precursors restricted through human (and mouse) major histocompatibility complex class I alleles. Journal of Virology, 73 7: 6166-6170.
Street, M., Herd, K., Londono, P., Doan, T., Dougan, G., Kast, W. M. and Tindle, R. W. (1999) Differences in the effectiveness of delivery of B- and CTL-epitopes incorporated into the Hepatitis B core antigen (HBcAg) c/e1-region. Archives of Virology, 144 7: 1323-1343. doi:10.1007/s007050050590
Frazer, Ian H., Thomas, Ranjeny, Zhou, Jian A., Leggatt, Graham R., Dunn, Linda, Mcmillan, Nigel A. J., Tindle, Robert W., Filgueira, Luis, Manders, Peter, Barnard, Paula and Sharkey, Michael (1999) Potential strategies utilised by papillomavirus to evade host immunity. Immunological Reviews, 168 1: 131-142. doi:10.1111/j.1600-065X.1999.tb01288.x
Street, M. D. and Tindle, R. W. (1999) Vaccines for human papillomavirus-associated anogenital disease and cervical cancer: Practical and theoretical approaches. Expert Opinion in Investigational Drugs, 8 6: 1-16.
Azoury-Ziadeh, Rania, Herd, Karen, Fernando, Germain J. P., Frazer, Ian H. and Tindle, Robert W. (1999) T-Helper epitopes identified within the E6 transforming protein of cervical cancer-associated human papillomavirus type 16. Viral Immunology, 12 4: 297-312. doi:10.1089/vim.1999.12.297
Frazer, Ian H., Fernando, Germain J. P., Fowler, Nina, Leggatt, Graham R., Lambert, Paul F., Liem, Amy, Malcolm, Karen and Tindle, Robert W. (1998) Split tolerance to a viral antigen expressed in thymic epithelium and keratinocytes. European Journal of Immunology, 28 9: 2791-2800. doi:10.1002/(SICI)1521-4141(199809)28:09<2791::AID-IMMU2791>3.0.CO;2-B
Fernando, Germain J. P., Stewart, Trina J., Tindle, Robert W. and Frazer, Ian H. (1998) Th2-type CD4(+) cells neither enhance nor suppress antitumor CTL activity in a mouse tumor model. Journal of Immunology, 161 5: 2421-2427.
Doan, Tracy, Chambers, Melita, Street, Michael, Fernando, Germain J. P., Herd, Karen, Lambert, Paul and Tindle, Robert (1998) Mice expressing the E7 oncogene of HPV16 in epithelium show central tolerance, and evidence of peripheral anergising tolerance, to E7-encoded cytotoxic T-lymphocyte epitopes. Virology, 244 2: 352-364. doi:10.1006/viro.1998.9128
Fernando, G. J. P., Stewart, T. J., Tindle, R. W. and Frazer, I. H. (1998) Vaccine-induced Th1-type responses are dominant over Th2-type responses in the short term whereas pre-existing Th2 responses are dominant in the longer term. Scandinavian Journal of Immunology, 47 5: 459-465. doi:10.1046/j.1365-3083.1998.00327.x
Tindle, Robert W. (1997) Immunomanipulative strategies for the control of human papillomavirus associated cervical disease. Immunologic Research, 16 4: 387-400. doi:10.1007/BF02786401
Dunn, Linda A., Evander, Magnus, Tindle, Robert W., Bulloch, Anne Louise, de Kluyver, Rachel L., Fernando, Germain J. P., Lambert, Paul F. and Frazer, Ian H. (1997) Presentation of the HPV16E7 protein by skin grafts is insufficient to allow graft rejection in an E7-primed animal. Virology, 235 1: 94-103. doi:10.1006/viro.1997.8650
Herd, K., Fernando, G. J. P., Dunn, L. A., Frazer, I. H., Lambert, P. and Tindle, R. W. (1997) E7 oncoprotein of human papillomavirus type 16 expressed constitutively in the epidermis has no effect on E7-specific B- or Th-repertoires or on the immune response induced or sustained after immunization with E7 protein. Virology, 231 1: 155-165. doi:10.1006/viro.1997.8491
Londono, L. Patricia, Chatfield, Steven, Tindle, Robert W., Herd, Karen, Gao, Xiao-Ming, Frazer, Ian and Dougan, Gordon (1996) Immunisation of mice using Salmonella typhimurium expressing human papillomavirus type 16 E7 epitopes inserted into hepatitis B virus core antigen. Vaccine, 14 6: 545-552. doi:10.1016/0264-410X(95)00216-N
Tindle, Robert W (1996) Human papillomavirus vaccines for cervical cancer. Current Opinion in Immunology, 8 5: 643-650. doi:10.1016/S0952-7915(96)80080-X
Frazer, I. H., Leippe, D. M., Dunn, L. A., Liem, A., Tindle, R. W., Fernando, G. J. P., Phelps, W. C. and Lambert, P. F. (1995) Immunological responses in human papillomavirus 16 E6/E7-transgenic mice to E7 protein correlate with the presence of skin disease. Cancer Research, 55 12: 2635-2639.
Fernando, G.J.P., Tindle, R.W and Frazer, I.H. (1995) T-helper epitopes of the E7 transforming protein of cervical-cancer associated human papillomavirus type-18 (hpv18). Virus Research, 36 1: 1-13. doi:10.1016/0168-1702(94)00101-H
Tindle, R. W., Croft, S., Herd, K., Malcolm, K., Geczy, A. F., Stewart, T. and Fernando, G. J. (1995) A vaccine conjugate of 'ISCAR' immunocarrier and peptide epitopes of the E7 cervical cancer-associated protein of human papillomavirus type 16 elicits specific Th1- and Th2-type responses in immunized mice in the absence of oil-based adjuvants. Clinical and Experimental Immunology, 101 2: 265-271. doi:10.1111/j.1365-2249.1995.tb08349.x
Kadish, Anna S., Romney, Seymour L., Ledwidge, Richard, Tindle, Robert, Fernando, Germain J. P., Zee, Sui Y., Van Ranst, Marc A. and Burk, Robert D. (1994) Cell-mediated immune responses to E7 peptides of human papillomavirus (HPV) type 16 are dependent on the HPV type infecting the cervix whereas serological reactivity is not type-specific. Journal of General Virology, 75 9: 2277-2284. doi:10.1099/0022-1317-75-9-2277
Tindle, Robert W., Herd, Karen, Londoño, Patricia, Fernando, Germain J. P., Chatfield, Steven N., Malcolm, Karen and Dougan, Gordon (1994) Chimeric hepatitis B core antigen particles containing B- and Th-epitopes of human papillomavirus type 16 E7 protein induce specific antibody and T-helper responses in immunised mice. Virology, 200 2: 547-557. doi:10.1006/viro.1994.1217
Tindle, Robert W., Fernando, Germain J. P., Sterling, Jane C. and Frazer, Ian H. (1991) A 'public' T-helper epitope of the E7 transforming protein of human papillomavirus 16 provides cognate help for several E7 B-cell epitopes from cervical cancer-associated human papillomavirus genotypes. Proceedings of the National Academy of Sciences of the United States of America, 88 13: 5887-5891. doi:10.1073/pnas.88.13.5887