School of Chemistry and Molecular Biosciences

Professor James De Voss

BSc(Hons) PhD Cantab
Head of School & Head of School
School of Chemistry and Molecular Biosciences
+61 7 336 53825
+61 7 336 54622
Chemistry Building (68), Room 1003
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Primary research interest

Biological and synthetic chemistry

About me

After graduating from The University of Queensland with First Class Honours in Organic Chemistry I received a Royal Commission for the Exhibition of 1851 Overseas Scholarship to carry out my PhD on the biosynthesis of Vitamin B12 at the University of Cambridge. Upon completion of my studies, I moved to the Johns Hopkins University as a Royal Commission for the Exhibition of 1851 Postdoctoral Fellow and investigated the mechanism of action of the enediyne antitumour antibiotic calicheamicin. I then moved to the University of California San Francisco where I became interested in molecular biology and the enzmyes of the Cytochrome P450 family. I returned to The University of Queensland in 1995 as a Senior Lecturer and was appointed Professor in 2008.

    Research focus and collaborations

    My group is interested in problems at the interface of chemistry and biology.  We apply chemical principles and techniques to understanding biologically important reactions.  We are broadly interested in the way in which nature makes various compounds, the structure and bioactivity of these compounds and in the enzymes that are involved in these pathways. As the work carried out in my group is at the interface of chemistry and biology we use techniques that are drawn from both disciplines including recombinant DNA technology, protein purification and structure determination, organic synthesis, and small molecule structure determination by MS, NMR etc. 

    Cytochrome P450s

    One group of enzymes that we work with are the cytochrome P450s.  These are oxidative proteins that contain a prosthetic haem group and catalyse a fascinating array of transformations which range from simple epoxidations all the way through to oxygen insertion into unactivated C-H bonds and C-C bond cleavage.  P450s are essentially ubiquitous in nature and we have projects involved with: bacterial P450s, including ones from Mycobacterium tuberculosis in collaboration with Prof. Paul Ortiz de Montellano at the University of California San Francisco; P450s from the human pathogen Leishmania sp.; fruit-fly P450s (in collaboration with Prof. W. Kitching); in vitro evolution of some human P450s (in collaboration with Dr. E. Gillam).

    Natural products from herbal medicines

    Herbal medicines have a long history of traditional use and are still widely used today with up to 70% of Australians in a recent survey reporting that they used Complementary and Alternative Medicines. The herbal medicine industry is a rapidly expanding and estimated to have annual revenues of up to $60 billion per annum world wide. Unfortunately, despite their widespread use, the chemical constituents of many of these herbal medicines are often poorly characterised. In collaboration with a local company we have embarked upon a program of phytochemical characterisation of a number of therapeutically prescribed herbs. The results have been surprising with a number of previously unknown compounds isolated from supposedly well-characterised species. We identify these compounds mainly via a range of 1D and 2D NMR techniques and in some cases we undertake the total synthesis of these new compounds.

    Funded projects

    • ARC Linkage Project (2014-2017): Bioproduction and bioavailability of steroidal saponins, bioactives in herbal medicines
    • ARC Discovery Project (2014-2016): Understanding the mechanism of two important cytochrome P450 catalysed reactions: dehydrogenation and C-C cleavage

    Teaching interests

    • Organic Chemistry in first, second, third and fourth year
    • Organic Reactions and Mechanisms
    • Introduction to Structure Elucidation
    • Enantioselective Organic Synthesis
    • Stereoelectronic Effects in Organic Chemistry

    Featured publications

    Researcher biography

    James De Voss received a B. Sc (Hons) in Chemistry and a University Medal from the University of Queensland in 1984. He was a Royal Commission for the Exhibition of 1851 scholar at Cambridge University, where he worked on the biosynthesis of Vitamin B12 with Prof. Sir Alan Battersby. A postdoctoral fellowship, again from the Royal Commission for the Exhibition of 1851, allowed him to work with Prof. Craig Townsend at Johns Hopkins University on the mechanism of DNA cleavage caused by the enediyne antibiotic calicheamicin. He was then introduced to the cytochromes P450 by Prof. Paul Ortiz de Montellano with whom he worked while at the University of California, San Francisco. Since returning to the University of Queensland to take up an academic appointment, initially as a Senior lecturer and subsequently as a Reader and then a Professor, he has continued his interest in problems at the interface of chemistry and biology and currently works with a range of bacterial, insect and mammalian P450s, as well as on the biogenesis of insect pheromones and phytochemistry of herbal medicines.

    Publications

    Book Chapters (5)
    Journal Articles (191)
    Conference Papers (50)

    Book Chapters

    Harbort, Joshua S., De Voss, James J., Stok, Jeanette E., Bell, Stephen G. and Harmer, Jeffrey R. (2017). CW and pulse EPR of cytochrome P450 to determine structure and function. Future directions in metalloprotein and metalloenzyme research. (pp. 103-142) edited by Graeme Hanson and Lawrence Berliner. New York, United States: Springer. doi: 10.1007/978-3-319-59100-1_5
    Stok, Jeanette E., Slessor, Kate E., Farlow, Anthony J., Hawkes, David B. and De Voss, James J. (2015). Cytochrome P450cin (CYP176A1). Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450. (pp. 319-339) edited by Eugene G. Hrycay and Stelvio M. Bandiera. New York, NY United States: Springer New York LLC. doi: 10.1007/978-3-319-16009-2_12
    Challinor, Victoria L. and de Voss, James J. (2013). Plant steroidal saponins: A focus on open-chain glycosides. Natural Products: Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes. (pp. 3225-3250) edited by Kishan Gopal Ramawat and Jean-Michel Mérillon. Berlin, Germany: Springer. doi: 10.1007/978-3-642-22144-6_139
    De Voss, J. and Cryle, M. (2007). Carbon-Carbon Bond Cleavage by P450 Systems. The Ubiquitous Roles of Cytochrome P450 Proteins: Metal Ions in Life Sciences, Volume 3. (pp. 397-435) edited by A. Sigel, H. Sigel and R. Sigel. United Kingdom: Wiley & Sons. doi: 10.1002/9780470028155.ch13
    Ortiz de Montellano, P.R. and De Voss, J. J. (2005). Substrate oxidation by cytochrome P450 enzymes. Cytochrome P450: Structure, Mechanism and Biochemistry. (pp. 183-245) edited by P. Ortiz de Montellano. New York: Kluwer/Plenum. doi: 10.1007/0-387-27447-2_6

    Journal Articles

    Chhabra, Mohit, Shanthamurthy, Chethan D., Kumar, Nanjudaswamy Vijendra, Mardhekar, Sandhya, Vishweshwara, Sharath S., Wimmer, Norbert, Modhiran, Naphak, Watterson, Daniel, Amarilla, Alberto A., Cha, Jonathan S., Beckett, James R., De Voss, James J., Kayal, Yasmin, Vlodavsky, Israel, Dorsett, Lauren R., Smith, Raymond A. A., Gandhi, Neha S., Kikkeri, Raghavendra and Ferro, Vito (2024). Amphiphilic heparinoids as potent antiviral agents against SARS-CoV-2. Journal of Medicinal Chemistry, 67 (14), 11885-11916. doi: 10.1021/acs.jmedchem.4c00487
    Forster, Louise C., Pierens, Gregory K., De Voss, James J. and Garson, Mary J. (2024). Structural diversity in nudibranch chemistry: elucidation of norditerpenes with a dendrillane scaffold from the Australian nudibranch Goniobranchus coi. Australian Journal of Chemistry, 77 (7) CH24073. doi: 10.1071/ch24073
    Coe, Laura J., Zhao, Yongwei, Padva, Leo, Keto, Angus, Schittenhelm, Ralf, Tailhades, Julien, Pierens, Greg, Krenske, Elizabeth H., Crüsemann, Max, De Voss, James and Cryle, Max J. (2024). Reassignment of the structure of a tryptophan‐containing cyclic tripeptide produced by the biarylitide crosslinking cytochrome P450blt. Chemistry: A European Journal, 30 (38) e202400988. doi: 10.1002/chem.202400988
    Lee, Joel H. Z., Coleman, Tom, Mclean, Mark A., Podgorski, Matthew N., Hayball, Eva F., Stone, Isobella S. J., Bruning, John B., Whelan, Fiona, De Voss, James J., Sligar, Stephen G. and Bell, Stephen G. (2024). Selective α-hydroxyketone formation and subsequent C–C bond cleavage by cytochrome P450 monooxygenase enzymes. ACS Catalysis, 14 (11), 8958-8971. doi: 10.1021/acscatal.4c01766
    Churchman, Luke R., Beckett, James R., Tan, Lendl, Woods, Kyra, Doherty, Daniel Z., Ghith, Amna, Bernhardt, Paul V., Bell, Stephen G., West, Nicholas P. and De Voss, James J. (2024). Synthesis of steroidal inhibitors for Mycobacterium tuberculosis. The Journal of Steroid Biochemistry and Molecular Biology, 239 106479, 1-16. doi: 10.1016/j.jsbmb.2024.106479
    Podgorski, Matthew N., Akter, Jinia, Churchman, Luke R., Bruning, John B., De Voss, James J. and Bell, Stephen G. (2024). Engineering peroxygenase activity into cytochrome P450 monooxygenases through modification of the oxygen binding region. ACS Catalysis, 14 (10), 7426-7443. doi: 10.1021/acscatal.4c01326
    Treisman, Maxine, Coe, Laura, Zhao, Yongwei, Sasi, Vishnu Mini, Gullick, Jemma, Hansen, Mathias H., Ly, Aviva, Leichthammer, Victor, Hess, Caroline, Machell, Daniel L., Schittenhelm, Ralf B., Hooper, Joel, Jackson, Colin J., Tailhades, Julien, De Voss, James J. and Cryle, Max J. (2024). An Engineered Biarylitide Cross-Linking P450 from RiPP Biosynthesis Generates Alternative Cyclic Peptides. Organic Letters, 26 (9), 1828-1833. doi: 10.1021/acs.orglett.3c04366
    Giang, Peter D., Churchman, Luke R., Buczynski, Julia B., Bell, Stephen G., Stok, Jeanette E. and De Voss, James J. (2024). CYP108N14: a monoterpene monooxygenase from Rhodococcus globerulus. Archives of Biochemistry and Biophysics, 752 109852, 1-8. doi: 10.1016/j.abb.2023.109852
    Hansen, Mathias H., Keto, Angus, Treisman, Maxine, Sasi, Vishnu Mini, Coe, Laura, Zhao, Yongwei, Padva, Leo, Hess, Caroline, Leichthammer, Victor, Machell, Daniel L., Schittenhelm, Ralf B., Jackson, Colin J., Tailhades, Julien, Crüsemann, Max, De Voss, James J., Krenske, Elizabeth H. and Cryle, Max J. (2024). Structural insights into a side chain cross-linking Biarylitide P450 from RiPP biosynthesis. ACS Catalysis, 14 (2), 812-826. doi: 10.1021/acscatal.3c05417
    Zhao, Yongwei, Gullick, Jemma, Hansen, Mathias H., Coe, Laura, Treisman, Maxine, Schittenhelm, Ralf B., McKay, Alasdair, Murray, Lauren A. M., Tailhades, Julien, De Voss, James J., Krenske, Elizabeth H. and Cryle, Max J. (2024). Loss of fluorine during crosslinking by the biarylitide P450Blt proceeds due to restricted peptide orientation. Chemical Communications. doi: 10.1039/d4cc04092a
    Churchman, Luke R., Giang, Peter D., Buczynski, Julia B., Stok, Jeanette E., Bell, Stephen G. and De Voss, James J. (2023). Synthesis of substituted norcaranes for use as probes of enzyme mechanisms. Organic and Biomolecular Chemistry, 21 (48), 9647-9658. doi: 10.1039/d3ob01571h
    Carpinelli de Jesus, Matheus, Church, Taylah, Wapling, Johanna A., Collins, Raelene, Leach, Gregory J., Leach, David, De Voss, James J. and Blanchfield, Joanne T. (2023). Differentiating dyes: A Spectroscopic investigation into the composition of scarlet bloodroot (Haemodorum coccineum R.Br.) rhizome. Molecules, 28 (21) 7422, 1-14. doi: 10.3390/molecules28217422
    Gee, Alecia R., Stone, Isobella S. J., Stockdale, Tegan P., Pukala, Tara L., De Voss, James J. and Bell, Stephen G. (2023). Efficient biocatalytic C–H bond oxidation: an engineered heme-thiolate peroxygenase from a thermostable cytochrome P450. Chemical Communications, 59 (90), 13486-13489. doi: 10.1039/d3cc04626e
    Podgorski, Matthew N, Keto, Angus B, Coleman, Tom, Bruning, John B, De Voss, James J, Krenske, Elizabeth H and Bell, Stephen Graham (2023). The oxidation of oxygen and sulfur‐containing heterocycles by cytochrome P450 enzymes. Chemistry – A European Journal, 29 (50) e202301371, e202301371. doi: 10.1002/chem.202301371
    Akter, Jinia, Stockdale, Tegan P., Child, Stella A., Lee, Joel H. Z., De Voss, James J. and Bell, Stephen G. (2023). Selective carbon-hydrogen bond hydroxylation using an engineered cytochrome P450 peroxygenase. Journal of Inorganic Biochemistry, 244 112209, 1-9. doi: 10.1016/j.jinorgbio.2023.112209
    Coleman, Tom, Podgorski, Matthew N., Doyle, Maya L., Scaffidi-Muta, Jarred M., Campbell, Eleanor C., Bruning, John B., De Voss, James J. and Bell, Stephen G. (2023). Cytochrome P450-catalyzed oxidation of halogen-containing substrates. Journal of Inorganic Biochemistry, 244 112234, 1-12. doi: 10.1016/j.jinorgbio.2023.112234
    Doherty, Daniel Z., Ghith, Amna, Ho, Ava, De Voss, James J. and Bell, Stephen G. (2023). The bacterial cytochrome P450 (CYP) CYP125 enzymes can competitively oxidise sitosterol in the presence of cholesterol. Chemical Communications, 59 (61), 9392-9395. doi: 10.1039/d3cc02312e
    Salisbury, Lauren J., Fletcher, Stephen J., Stok, Jeanette E., Churchman, Luke R., Blanchfield, Joanne T. and De Voss, James J. (2023). Characterization of the cholesterol biosynthetic pathway in Dioscorea transversa. Journal of Biological Chemistry, 299 (6) 104768, 1-16. doi: 10.1016/j.jbc.2023.104768
    Miller, Justin C., Lee, Joel H. Z., Mclean, Mark A., Chao, Rebecca R., Stone, Isobella S. J., Pukala, Tara L., Bruning, John B., De Voss, James J., Schuler, Mary A., Sligar, Stephen G. and Bell, Stephen G. (2023). Engineering C–C bond cleavage activity into a P450 monooxygenase enzyme. Journal of the American Chemical Society, 145 (16), 9207-9222. doi: 10.1021/jacs.3c01456
    Mu, Andre, Klare, William P., Baines, Sarah L., Ignatius Pang, C. N., Guérillot, Romain, Harbison-Price, Nichaela, Keller, Nadia, Wilksch, Jonathan, Nhu, Nguyen Thi Khanh, Phan, Minh-Duy, Keller, Bernhard, Nijagal, Brunda, Tull, Dedreia, Dayalan, Saravanan, Chua, Hwa Huat Charlie, Skoneczny, Dominik, Koval, Jason, Hachani, Abderrahman, Shah, Anup D., Neha, Nitika, Jadhav, Snehal, Partridge, Sally R., Cork, Amanda J., Peters, Kate, Bertolla, Olivia, Brouwer, Stephan, Hancock, Steven J., Álvarez-Fraga, Laura, De Oliveira, David M. P. ... Walker, Mark J. (2023). Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria. Nature Communications, 14 (1) 1530, 1-21. doi: 10.1038/s41467-023-37200-w
    Giang, Peter D., Churchman, Luke R., Stok, Jeanette E., Bell, Stephen G. and De Voss, James J. (2023). Cymredoxin, a [2Fe–2S] ferredoxin, supports catalytic activity of the p-cymene oxidising P450 enzyme CYP108N12. Archives of Biochemistry and Biophysics, 737 109549, 109549. doi: 10.1016/j.abb.2023.109549
    Podgorski, Matthew N., Coleman, Tom, Churchman, Luke R., Bruning, John B., De Voss, James J. and Bell, Stephen G. (2022). Investigating the active oxidants involved in cytochrome P450 catalyzed sulfoxidation reactions. Chemistry: A European Journal, 28 (72) e202202428, 1-12. doi: 10.1002/chem.202202428
    Coleman, Tom, Doherty, Daniel Z., Zhang, Ting, Podgorski, Matthew N., Qiao, Ruihong, Lee, Joel H. Z., Bruning, John B., De Voss, James J., Zhou, Weihong and Bell, Stephen G. (2022). Exploring the factors which result in cytochrome P450 catalyzed desaturation versus hydroxylation. Chemistry - An Asian Journal, 17 (24) e202200986, 1-14. doi: 10.1002/asia.202200986
    Coleman, Tom, Lee, Joel, Kirk, Alicia M, Doherty, Daniel Z, Podgorski, Matthew N, Pinidiya, Dilshi K, Bruning, John B, De Voss, James J, Krenske, Elizabeth H and Bell, Stephen Graham (2022). Enabling aromatic hydroxylation in a cytochrome P450 monooxygenase rnzyme through protein engineering. Chemistry: A European Journal, 28 (67) e202201895, 1-14. doi: 10.1002/chem.202201895
    Giang, Peter D., Churchman, Luke R., Stok, Jeanette E., Soo, Rochelle M. and De Voss, James J. (2022). CYP108N12 initiates p-cymene biodegradation in Rhodococcus globerulus. Archives of Biochemistry and Biophysics, 730 109410, 109410. doi: 10.1016/j.abb.2022.109410
    Jesus, Matheus Carpinelli De, Wapling, Johanna, Kiem, Eunice, Stockdale, Tegan, Whittaker, Jacob J., Clegg, Jack K., Leach, David, Church, Taylah, Collins, Raelene, Leach, Greg, Hewitt, David, De Voss, James J. and Blanchfield, Joanne T. (2022). Phytochemical composition of Denhamia obscura (A. Rich.) Meisn. Ex Walp. root bark, seeds and leaves. Arkivoc, 2022 (4), 123-142. doi: 10.24820/ark.5550190.p011.828
    Churchman, Luke R., Salisbury, Lauren J. and De Voss, James J. (2022). Synthesis of obtusifoliol and analogues as CYP51 substrates. Organic and Biomolecular Chemistry, 20 (36), 7316-7324. doi: 10.1039/d2ob01307j
    Ghith, Amna, Doherty, Daniel Z., Bruning, John B., Russell, Robert A., De Voss, James J. and Bell, Stephen G. (2022). The structures of the steroid binding CYP142 cytochrome P450 enzymes from Mycobacterium ulcerans and Mycobacterium marinum. ACS Infectious Diseases, 8 (8), 1606-1617. doi: 10.1021/acsinfecdis.2c00215
    Greule, Anja, Izoré, Thierry, Machell, Daniel, Hansen, Mathias H., Schoppet, Melanie, De Voss, James J., Charkoudian, Louise K., Schittenhelm, Ralf B., Harmer, Jeffrey R. and Cryle, Max J. (2022). The cytochrome P450 OxyA from the kistamicin biosynthesis cyclization cascade is highly sensitive to oxidative damage. Frontiers in Chemistry, 10 868240, 868240. doi: 10.3389/fchem.2022.868240
    Coleman, Tom, Kirk, Alicia M., Lee, Joel H. Z., Doherty, Daniel Z., Bruning, John B., Krenske, Elizabeth H., De Voss, James J. and Bell, Stephen G. (2022). Different geometric requirements for cytochrome P450-catalyzed aliphatic versus aromatic hydroxylation results in chemoselective oxidation. ACS Catalysis, 12 (2), 1258-1267. doi: 10.1021/acscatal.1c05483
    Podgorski, Matthew N., Coleman, Tom, Giang, Peter D., Wang, C. Ruth, Bruning, John B., Bernhardt, Paul V., De Voss, James J. and Bell, Stephen G. (2022). To be, or not to be, an inhibitor: a comparison of Azole interactions with and oxidation by a cytochrome P450 enzyme. Inorganic Chemistry, 61 (1) acs.inorgchem.1c02786, 236-245. doi: 10.1021/acs.inorgchem.1c02786
    Chao, Rebecca R., Lau, Ian C.-K., Coleman, Tom, Churchman, Luke R., Child, Stella A., Lee, Joel H. Z., Bruning, John B., De Voss, James J. and Bell, Stephen G. (2021). The stereoselective oxidation of para-substituted benzenes by a cytochrome P450 biocatalyst. Chemistry - A European Journal, 27 (59), 14765-14777. doi: 10.1002/chem.202102757
    Huang, Li, Yong, Ken W. L., Fernando, W. Chrishanthi, Carpinelli de Jesus, Matheus, De Voss, James J., Sultanbawa, Yasmina and Fletcher, Mary T. (2021). The inactivation by curcumin-mediated photosensitization of Botrytis cinerea apores isolated from strawberry fruits. Toxins, 13 (3) 196, 196. doi: 10.3390/toxins13030196
    Coleman, Tom, Kirk, Alicia M., Chao, Rebecca R., Podgorski, Matthew N., Harbort, Joshua S., Churchman, Luke R., Bruning, John B., Bernhardt, Paul V., Harmer, Jeffrey R., Krenske, Elizabeth H., De Voss, James J. and Bell, Stephen G. (2021). Understanding the mechanistic requirements for efficient and stereoselective alkene epoxidation by a cytochrome P450 enzyme. ACS Catalysis, 11 (4), 1995-2010. doi: 10.1021/acscatal.0c04872
    Ahmed, Iftekhar, Leach, David N., Wohlmuth, Hans, De Voss, James J. and Blanchfield, Joanne T. (2020). Caco-2 cell permeability of flavonoids and saponins from Gynostemma pentaphyllum: the immortal herb. ACS Omega, 5 (34) acsomega.0c02180, 21561-21569. doi: 10.1021/acsomega.0c02180
    Tailhades, Julien, Zhao, Yongwei, Ho, Y. T. Candace, Greule, Anja, Ahmed, Iftekhar, Schoppet, Melanie, Kulkarni, Ketav, Goode, Rob J. A., Schittenhelm, Ralf B., De Voss, James J. and Cryle, Max J. (2020). A chemoenzymatic approach to the synthesis of glycopeptide antibiotic analogues. Angewandte Chemie, 132 (27), 10991-10995. doi: 10.1002/ange.202003726
    Strohmaier, Silja J., De Voss, James J., Jurva, Ulrik, Andersson, Shalini and Gillam, Elizabeth M. J. (2020). Oxygen surrogate systems for supporting human drug-metabolizing cytochrome P450 enzymes. Drug Metabolism and Disposition , 48 (6), 432-437. doi: 10.1124/dmd.120.090555
    Tailhades, Julien, Zhao, Yongwei, Ho, Y. T. Candace, Greule, Anja, Ahmed, Iftekhar, Schoppet, Melanie, Kulkarni, Ketav, Goode, Rob J. A., Schittenhelm, Ralf B., De Voss, James J. and Cryle, Max J. (2020). A chemoenzymatic approach to the synthesis of glycopeptide antibiotic analogues. Angewandte Chemie International Edition, 59 (27) anie.202003726, 10899-10903. doi: 10.1002/anie.202003726
    Coleman, Tom, Stok, Jeanette E., Podgorski, Matthew N., Bruning, John B., De Voss, James J. and Bell, Stephen G. (2020). Structural insights into the role of the acid-alcohol pair of residues required for dioxygen activation in cytochrome P450 enzymes. JBIC Journal of Biological Inorganic Chemistry, 25 (4), 583-596. doi: 10.1007/s00775-020-01781-4
    Podgorski, Matthew N., Harbort, Joshua S., Coleman, Tom, Stok, Jeanette E., Yorke, Jake A., Wong, Luet-Lok, Bruning, John B., Bernhardt, Paul V., De Voss, James J., Harmer, Jeffrey R. and Bell, Stephen G. (2020). Biophysical techniques for distinguishing ligand binding modes in cytochrome P450 monooxygenases. Biochemistry, 59 (9) acs.biochem.0c00027, 1038-1050. doi: 10.1021/acs.biochem.0c00027
    Strohmaier, Silja J., Baek, Jong Min, De Voss, James J., Jurva, Ulrik, Andersson, Shalini and Gillam, Elizabeth M. J. (2020). An inexpensive, efficient alternative to NADPH to support catalysis by thermostable cytochrome P450 enzymes. ChemCatChem, 12 (6) cctc.201902235, 1750-1761. doi: 10.1002/cctc.201902235
    Podgorski, Matthew N., Coleman, Tom, Chao, Rebecca R., De Voss, James J., Bruning, John B. and Bell, Stephen G. (2020). Investigation of the requirements for efficient and selective cytochrome P450 monooxygenase catalysis across different reactions. Journal of Inorganic Biochemistry, 203 110913, 1-13. doi: 10.1016/j.jinorgbio.2019.110913
    Sarkar, Md. Raihan, Houston, Sevan D., Savage, G. Paul, Williams, Craig M., Krenske, Elizabeth H., Bell, Stephen G. and De Voss, James J. (2019). Rearrangement-free hydroxylation of methylcubanes by a cytochrome P450: the case for dynamical coupling of C–H abstraction and rebound. Journal of the American Chemical Society, 141 (50) jacs.9b08064, 19688-19699. doi: 10.1021/jacs.9b08064
    Stok, Jeanette E., Giang, Peter D., Wong, Siew Hoon and De Voss, James J. (2019). Exploring the substrate specificity of cytochrome P450cin. Archives of Biochemistry and Biophysics, 672 108060, 108060. doi: 10.1016/j.abb.2019.07.025
    Houston, Sevan D., Fahrenhorst-Jones, Tyler, Xing, Hui, Chalmers, Benjamin A., Sykes, Melissa L., Stok, Jeanette E., Farfan Soto, Clementina, Burns, Jed M., Bernhardt, Paul V., De Voss, James J., Boyle, Glen M., Smith, Maree T., Tsanaktsidis, John, Savage, G. Paul, Avery, Vicky M. and Williams, Craig M. (2019). The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement. Organic and Biomolecular Chemistry, 17 (28), 6790-6798. doi: 10.1039/c9ob01238a
    Greule, Anja, Izoré, Thierry, Iftime, Dumitrita, Tailhades, Julien, Schoppet, Melanie, Zhao, Yongwei, Peschke, Madeleine, Ahmed, Iftekhar, Kulik, Andreas, Adamek, Martina, Goode, Robert J. A., Schittenhelm, Ralf B., Kaczmarski, Joe A., Jackson, Colin J., Ziemert, Nadine, Krenske, Elizabeth H., De Voss, James J., Stegmann, Evi and Cryle, Max J. (2019). Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics. Nature Communications, 10 (1) 2613, 2613. doi: 10.1038/s41467-019-10384-w
    Carpinelli de Jesus, Matheus, Hungerford, Natasha L., Carter, Steve J., Anuj, Shalona R., Blanchfield, Joanne T., De Voss, James Joseph and Fletcher, Mary T. (2019). Pyrrolizidine alkaloids of Blue Heliotrope (Heliotropium amplexicaule) and their presence in Australian honey. Journal of Agricultural and Food Chemistry, 67 (28) acs.jafc.9b02136, 7995-8006. doi: 10.1021/acs.jafc.9b02136
    Stockdale, Tegan P., Challinor, Victoria L., Lehmann, Reginald P., De Voss, James J. and Blanchfield, Joanne T. (2019). Caco-2 monolayer permeability and stability of Chamaelirium luteum (false unicorn) open-chain steroidal saponins. ACS Omega, 4 (4), 7658-7666. doi: 10.1021/acsomega.9b00496
    Lee, Joel H.Z., Wong, Siew Hoon, Stok, Jeanette E., Bagster, Sarah A., Beckett, James, Clegg, Jack K., Brock, Aidan, De Voss, James J. and Bell, Stephen G. (2019). Selective hydroxylation of 1,8- and 1,4-cineole using bacterial P450 variants. Archives of Biochemistry and Biophysics, 663, 54-63. doi: 10.1016/j.abb.2018.12.025
    Slessor, Kate E., Stok, Jeanette E., Chow, Sharon and De Voss, James J. (2019). Significance of protein-substrate hydrogen bonding for the selectivity of P450-catalysed oxidations. Chemistry: A European Journal, 25 (16), 4149-4155. doi: 10.1002/chem.201805705
    Xing, Hui, Houston, Sevan D., Chen, Xuejie, Ghassabian, Sussan, Fahrenhorst-Jones, Tyler, Kuo, Andy, Murray, Cody-Ellen P., Conn, Kyna-Anne, Jaeschke, Kara N., Jin, Da-Yun, Pasay, Cielo, Bernhardt, Paul V., Burns, Jed M., Tsanaktsidis, John, Savage, G. Paul, Boyle, Glen M., De Voss, James J., McCarthy, James, Walter, Gimme H., Burne, Thomas H. J., Smith, Maree T., Tie, Jian-Ke and Williams, Craig M. (2019). Cyclooctatetraene: a bioactive cubane paradigm complement. Chemistry: A European Journal, 25 (11), 2729-2734. doi: 10.1002/chem.201806277
    Gumulya, Yosephine, Huang, Weiliang, D'Cunha, Stephlina A., Richards, Katelyn E., Thomson, Raine E.S., Hunter, Dominic J.B., Baek, Jong-Min, Harris, Kurt L., Boden, Mikael, De Voss, James J., Hayes, Martin A., Isin, Emre M., Andersson, Shalini, Jurva, Ulrik and Gillam, Elizabeth (2019). Engineering thermostable CYP2D enzymes for biocatalysis using combinatorial libraries of ancestors for directed evolution (CLADE). ChemCatChem, 11 (2) cctc.201801644, 841-850. doi: 10.1002/cctc.201801644
    Tailhades, Julien, Zhao, Yongwei, Schoppet, Melanie, Greule, Anja, Goode, Robert J. A., Schittenhelm, Ralf B., De Voss, James J. and Cryle, Max J. (2019). Enzymatic cascade to evaluate the tricyclization of glycopeptide antibiotic precursor peptides as a prequel to biosynthetic redesign. Organic Letters, 21 (21) acs.orglett.9b03245, 8635-8640. doi: 10.1021/acs.orglett.9b03245
    Gumulya, Yosephin, Baek, Jong-Min, Wun, Shun-Jie, Thomson, Raine E. S., Harris, Kurt L., Hunter, Dominic J. B., Behrendorff, James B. Y. H., Kulig, Justyna, Zheng, Shan, Wu, Xueming, Wu, Bin, Stok, Jeanette E., De Voss, James J., Schenk, Gerhard, Jurva, Ulrik, Andersson, Shalini, Isin, Emre M., Bodén, Mikael, Guddat, Luke and Gillam, Elizabeth M. J. (2018). Engineering highly functional thermostable proteins using ancestral sequence reconstruction. Nature Catalysis, 1 (11), 878-888. doi: 10.1038/s41929-018-0159-5
    Chalmers, Benjamin A., Xing, Hui, Houston, Sevan, Clark, Charlotte, Ghassabian, Sussan, Kuo, Andy, Cao, Benjamin, Reitsma, Andrea, Murray, Cody-Ellen P., Stok, Jeanette E., Boyle, Glen M., Pierce, Carly J., Littler, Stuart W., Winkler, David A., Bernhardt, Paul V., Pasay, Cielo, De Voss, James J., McCarthy, James, Parsons, Peter G., Walter, Gimme H., Smith, Maree T., Cooper, Helen M., Nilsson, Susan K., Tsanaktsidis, John, Savage, G. Paul and Williams, Craig M. (2018). Corrigendum to: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere (Angewandte Chemie International Edition, (2016), 55, 11, (3580-3585), 10.1002/anie.201510675). Angewandte Chemie - International Edition, 57 (28), 8359-8359. doi: 10.1002/anie.201711161
    Coleman, Tom, Wong, Siew Hoon, Podgorski, Matthew N., Bruning, John B., De Voss, James J. and Bell, Stephen G. (2018). Cytochrome P450 CYP199A4 from Rhodopseudomonas palustris catalyzes heteroatom dealkylations, sulfoxidation, and amide and cyclic hemiacetal formation. ACS Catalysis, 8 (7), 5915-5927. doi: 10.1021/acscatal.8b00909
    Greule, Anja, Stok, Jeanette E., De Voss, James J. and Cryle, Max J. (2018). Unrivalled diversity: the many roles and reactions of bacterial cytochromes P450 in secondary metabolism. Natural Product Reports, 35 (8), 757-791. doi: 10.1039/c7np00063d
    Daygon, Venea Dara, Calingacion, Mariafe, Forster, Louise C., De Voss, James J., Schwartz, Brett D., Ovenden, Ben, Alonso, David E., McCouch, Susan R., Garson, Mary J. and Fitzgerald, Melissa A. (2017). Metabolomics and genomics combine to unravel the pathway for the presence of fragrance in rice. Scientific Reports, 7 (1) 8767, 8767. doi: 10.1038/s41598-017-07693-9
    San, Anh T., Joyce, Daryl C., Hofman, Peter J., Macnish, Andrew J., Webb, Richard I., Matovic, Nicolas J., Williams, Craig M., De Voss, James J., Wong, Siew H. and Smyth, Heather E. (2017). Stable isotope dilution assay (SIDA) and HS-SPME-GCMS quantification of key aroma volatiles for fruit and sap of Australian mango cultivars. Food Chemistry, 221, 613-619. doi: 10.1016/j.foodchem.2016.11.130
    Chao, Rebecca R., Lau, Ian C. -K., De Voss, James J. and Bell, Stephen G. (2016). Modification of an enzyme biocatalyst for the efficient and selective oxidative demethylation of para-substituted benzene derivatives. ChemCatChem, 8 (23), 3626-3635. doi: 10.1002/cctc.201600951
    Tan, Eddie T. T., Yong, Ken W. L., Wong, Siew-Hoon, D'Arcy, Bruce R., Al Jassim, Rafat, De Voss, James J. and Fletcher, Mary T. (2016). Thermo-alkaline treatment as a practical degradation strategy to reduce indospicine contamination in camel meat. Journal of Agricultural And Food Chemistry, 64 (44), 8447-8453. doi: 10.1021/acs.jafc.6b03499
    Chao, Rebecca R., De Voss, James J. and Bell, Stephen G. (2016). The efficient and selective catalytic oxidation of para-substituted cinnamic acid derivatives by the cytochrome P450 monooxygenase, CYP199A4. Rsc Advances, 6 (60), 55286-55297. doi: 10.1039/c6ra11025h
    Stok, Jeanette E., Hall, Emma A., Stone, Isobella S. J, Noble, Margaret C., Wong, Siew Hoon, Bell, Stephen G. and De Voss, James J. (2016). In vivo and in vitro hydroxylation of cineole and camphor by cytochromes P450CYP101A1, CYP101B1 and N242A CYP176A1. Journal of Molecular Catalysis B: Enzymatic, 128, 52-64. doi: 10.1016/j.molcatb.2016.03.004
    Coleman, Tom, Chao, Rebecca R., de Voss, James J. and Bell, Stephen G. (2016). The importance of the benzoic acid carboxylate moiety for substrate recognition by CYP199A4 from Rhodopseudomonas palustris HaA2. Biochimica et Biophysica Acta, 1864 (6), 667-675. doi: 10.1016/j.bbapap.2016.03.006
    Frank, Daniel J., Zhao, Yan, Wong, Siew Hoon, Basudhar, Debashree, De Voss, James J. and De Montellano, Paul R. Ortiz (2016). Cholesterol analogs with degradation-resistant alkyl side chains are effective Mycobacterium tuberculosis growth inhibitors. Journal of Biological Chemistry, 291 (14), 7325-7333. doi: 10.1074/jbc.M115.708172
    Chalmers, Benjamin A., Xing, Hui, Houston, Sevan, Clark, Charlotte, Ghassabian, Sussan, Kuo, Andy, Cao, Benjamin, Reitsma, Andrea, Murray, Cody-Ellen P., Stok, Jeanette E., Boyle, Glen M., Pierce, Carly J., Littler, Stuart W., Winkler, David A., Bernhardt, Paul V., Pasay, Cielo, De Voss, James J., McCarthy, James, Parsons, Peter G., Walter, Gimme H., Smith, Maree T., Cooper, Helen M., Nilsson, Susan K., Tsanaktsidis, John, Savage, G. Paul and Williams, Craig M. (2016). Frontispiece: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere. Angewandte Chemie International Edition, 55 (11), 8359-8359. doi: 10.1002/anie.201681161
    Stok, Jeanette E., Chow, Sharon, Krenske, Elizabeth H., Farfan Soto, Clementina, Matyas, Csongor, Poirier, Raymond A., Williams, Craig M. and De Voss, James J. (2016). Direct observation of an oxepin from a bacterial cytochrome P450-catalyzed oxidation. Chemistry: A European Journal, 22 (13), 4408-4412. doi: 10.1002/chem.201600246
    Chalmers, Benjamin A., Xing, Hui, Houston, Sevan, Clark, Charlotte, Ghassabian, Sussan, Kuo, Andy, Cao, Benjamin, Reitsma, Andrea, Murray, Cody-Ellen P., Stok, Jeanette E., Boyle, Glen M., Pierce, Carly J., Littler, Stuart W., Winkler, David A., Bernhardt, Paul V., Pasay, Cielo, De Voss, James J., McCarthy, James, Parsons, Peter G., Walter, Gimme H., Smith, Maree T., Cooper, Helen M., Nilsson, Susan K., Tsanaktsidis, John, Savage, G. Paul and Williams, Craig M. (2016). Validating Eaton's hypothesis: cubane as a benzene bioisostere. Angewandte Chemie (International Edition), 55 (11), 3580-3585. doi: 10.1002/anie.201510675
    Lang, Cheng-Shan, Wong, Siew-Hoon, Chow, Sharon, Challinor, Victoria L., Yong, Ken W. L., Fletcher, Mary T., Arthur, Dionne M., Ng, Jack C. and De Voss, James J. (2016). Synthesis of L-Indospicine, [5,5,6-2H3 ]- L-Indospicine and L-Norindospicine. Organic and Biomolecular Chemistry, 14 (28), 6826-6832. doi: 10.1039/C6OB01187J
    Challinor, Victoria L., Johnston, Ryne C., Bernhardt, Paul V., Lehmann, Reginald P., Krenske, Elizabeth H. and De Voss, James J. (2015). Biosynthetic insights provided by unusual sesterterpenes from the medicinal herb Aletris farinosa. Chemical Science, 6 (10), 5740-5745. doi: 10.1039/c5sc02056e
    Coleman, Tom, Chao, Rebecca R., Bruning, John B., De Voss, James J. and Bell, Stephen G. (2015). CYP199A4 catalyses the efficient demethylation and demethenylation of para-substituted benzoic acid derivatives. RSC Advances, 5 (64), 52007-52018. doi: 10.1039/c5ra08730a
    Chen, Kuan I., Challinor, Victoria L., Kielmann, Linda, Sharpe, Philip C., De Voss, James J., Kappler, Ulrike, McEwan, Alastair G. and Bernhardt, Paul V. (2014). Electrochemically mediated enantioselective reduction of chiral sulfoxides. Journal of Biological Inorganic Chemistry, 20 (2), 395-402. doi: 10.1007/s00775-014-1215-5
    Singh, Arti A., Rowley, Jessica A., Schwartz, Brett D., Kitching, William and De Voss, James J. (2014). Oxidative carbon-carbon bond cleavage is a key step in spiroacetal biosynthesis in the fruit fly Bactrocera cacuminata. Journal of Organic Chemistry, 79 (17), 7799-7821. doi: 10.1021/jo500791y
    Alonso, Hernan, Kleifeld, Oded, Yeheskel, Adva, Ong, Poh C., Liu, Yu C., Stok, Jeanette E., De Voss, James J. and Roujeinikova, Anna (2014). Structural and mechanistic insight into alkane hydroxylation by Pseudomonas putida AlkB. Biochemical Journal, 460 (2), 283-293. doi: 10.1042/BJ20131648
    Varfaj, Fatbardha, Zulkifli, Siti N. A., Park, Hyoung-Goo, Challinor, Victoria L., De Voss, James J. and De Montellano, Paul R. Ortiz (2014). Carbon-Carbon bond cleavage in activation of the prodrug nabumetone. Drug Metabolism and Disposition, 42 (5), 828-838. doi: 10.1124/dmd.114.056903
    Mudianta, I. Wayan, Challinor, Victoria L., Winters, Anne E., Cheney, Karen L., De Voss, James J. and Garson, Mary J. (2013). Synthesis and determination of the absolute configuration of (-)-(5R,6Z)-dendrolasin-5-acetate from the nudibranch Hypselodoris jacksoni. Beilstein Journal of Organic Chemistry, 9 (1), 2925-2933. doi: 10.3762/bjoc.9.329
    Challinor, Victoria L., Chap, Sonet, Lehmann, Reginald P., Bernhardt, Paul V. and De Voss, James J. (2013). Structure and absolute configuration of methyl (3R)-malonyl-(13S)-hydroxycheilanth-17-en-19-oate, a sesterterpene derivative from the roots of Aletris farinosa. Journal of Natural Products, 76 (4), 485-488. doi: 10.1021/np400035n
    Farlow, Anthony J., Bernhardt, Paul V. and De Voss, James J. (2013). Synthesis of oxygenated cineole derivatives from cineole: utility of cytochrome P450(cin) as an enantioselective catalyst. Tetrahedron: Asymmetry, 24 (5-6), 324-333. doi: 10.1016/j.tetasy.2013.02.004
    Stok, Jeanette E., Yamada, Sean, Farlow, Anthony J., Slessor, Kate E. and De Voss, James J. (2013). Cytochrome P450(cin) (CYP176A1) D241N: investigating the role of the conserved acid in the active site of cytochrome P450s. Biochimica et Biophysica Acta: Proteins and Proteomics, 1834 (3), 688-696. doi: 10.1016/j.bbapap.2012.12.022
    Challinor, Victoria L. and De Voss, James J. (2013). Open-chain steroidal glycosides, a diverse class of plant saponins. Natural Product Reports, 30 (3), 429-454. doi: 10.1039/c3np20105h
    Cryle, Max J., Hayes, Patricia Y. and De Voss, James J. (2012). Enzyme-substrate complementarity governs access to a cationic reaction manifold in the P450(BM3) -catalysed oxidation of cyclopropyl fatty acids. Chemistry : A European Journal, 18 (50), 15994-15999. doi: 10.1002/chem.201203035
    Yong, Ken W. L., Barnych, Bogdan, De Voss, James J., Vatele, Jean-Michael and Garson, Mary J. (2012). Plakortolide stereochemistry revisited: the checkered history of plakortolides e and i. Journal of Natural Products, 75 (10), 1792-1797. doi: 10.1021/np3005634
    Challinor, Victoria L., Stuthe, Julia M. U., Parsons, Peter G., Lambert, Lynette K., Lehmann, Reginald P., Kitching, William and De Voss, James J. (2012). Structure and bioactivity of steroidal saponins isolated from the roots of Chamaelirium luteum (False Unicorn). Journal of Natural Products, 75 (8), 1469-1479. doi: 10.1021/np300393y
    Johnston, Jonathan B., Singh, Arti A., Clary, Anaelle A., Chen, Chiung-Kuan, Hayes, Patricia Y., Chow, Sharon, De Voss, James J. and de Montellano, Paul R. O. (2012). Substrate analog studies of the ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes CYP124A1, CYP125A1 and CYP142A1. Bioorganic and Medicinal Chemistry, 20 (13), 4064-4081. doi: 10.1016/j.bmc.2012.05.003
    Slessor, Kate E., Hawkes, David B., Farlow, Anthony, Pearson, Andrew G., Stok, Jeanette E. and De Voss, James J. (2012). An in vivo cytochrome P450(cin) (CYP176A1) catalytic system for metabolite production. Journal of Molecular Catalysis B: Enzymatic, 79, 15-20. doi: 10.1016/j.molcatb.2012.03.007
    Challinor, Victoria L., Piacente, Sonia and De Voss, James J. (2012). NMR assignment of the absolute configuration of C-25 in furostanol steroidal saponins. Steroids, 77 (6), 602-608. doi: 10.1016/j.steroids.2012.02.002
    Challinor, Victoria L., Parsons, Peter G., Chap, Sonet, White, Eve F., Blanchfield, Joanne T., Lehmann, Reginald P. and De Voss, James J. (2012). Steroidal saponins from the roots of Smilax sp.: Structure and bioactivity. Steroids, 77 (5), 504-511. doi: 10.1016/j.steroids.2012.01.009
    Yong, Ken W. L., Lambert, Lynette K., Hayes, Patricia Y., De Voss, James J. and Garson, Mary J. (2012). Oxidative processes in the Australian marine sponge Plakinastrella clathrata: Isolation of plakortolides with oxidatively modified side chains. Journal of Natural Products, 75 (3), 351-360. doi: 10.1021/np200619q
    Challinor, Victoria L. and De Voss, James J. (2012). Assignment of stereochemistry in open-chain steroidal saponins. Pure and Applied Chemistry, 84 (6), 1469-1478. doi: 10.1351/PAC-CON-11-09-12
    Watts, Rebecca E., Totsika, Makrina, Challinor, Victoria L., Mabbett, Amanda N., Ulett, Glen C., De Voss, James J. and Schembri, Mark A. (2012). Contribution of siderophore systems to growth and urinary tract colonization of asymptomatic bacteriuria Escherichia coli. Infection and Immunity, 80 (1-2), 333-344. doi: 10.1128/IAI.05594-11
    Johnston, Wayne A., Hunter, Dominic J. B., Noble, Christopher J., Hanson, Graeme R., Stok, Jeanette E., Hayes, Martin A., De Voss, James J. and Gillam, Elizabeth M.J. (2011). Cytochrome P450 is present in both ferrous and ferric forms in the resting state within intact Escherichia coli and hepatocytes. Journal of Biological Chemistry, 286 (47), 40750-40759. doi: 10.1074/jbc.M111.300871
    Fletcher, Mary T., Hayes, Patricia Y., Somerville, Michael J. and De Voss, James J. (2011). Crotalaria medicaginea associated with horse deaths in Northern Australia: New pyrrolizidine alkaloids. Journal of Agricultural and Food Chemistry, 59 (21), 11888-11892. doi: 10.1021/jf203147x
    Hunter, D.J.B., Behrendorff, J.B.Y.H., Johnston, W.A., Hayes, P.Y., Huang, W., Bonn, B., Hayes, M.A., De Voss, J.J. and Gillam, E.M.J (2011). Facile production of minor metabolites for drug development using a CYP3A shuffled library. Metabolic Engineering, 13 (6), 682-693. doi: 10.1016/j.ymben.2011.09.001
    McCallum, Emily J., Cunningham, John Paul, Lücker, Joost, Zalucki, Myron P., De Voss, James J . and Botella, José R. (2011). Increased plant volatile production affects oviposition, but not larval development, in the moth Helicoverpa armigera. Journal of Experimental Biology, 214 (21), 3672-3677. doi: 10.1242/jeb.059923
    Singh, Arti A., Zulkifli, Siti N. A., Meyns, Michaela, Hayes, Patricia Y. and De Voss, James J. (2011). Synthesis of highly enantioenriched hydroxy- and dihydroxy-fatty esters: substrate precursors for cytochrome P450(BioI). Tetrahedron-Asymmetry, 22 (18-19), 1709-1719. doi: 10.1016/j.tetasy.2011.08.027
    Challinor, Victoria L., Hayes, Patricia Y., Bernhardt, Paul V., Kitching, William, Lehmann, Reginald P. and De Voss, James J. (2011). Revision of the absolute configurations of bethosides B and C and their aglycone. Journal of Organic Chemistry, 76 (17), 7275-7280. doi: 10.1021/jo2012797
    Challinor, Victoria L., Stuthe, Julia M. U., Bernhardt, Paul V., Lehmann, Reginald P., Kitching, William and De Voss, James J. (2011). Structure and absolute configuration of helosides A and B, new saponins from Chamaelirium luteum. Journal of Natural Products, 74 (7), 1557-1560. doi: 10.1021/np200100a
    Matovic, Nicholas J., Stuthe, Julia M. U., Challinor, Victoria L., Bernhardt, Paul V., Lehmann, Reginald P., Kitching, William and De Voss, James J. (2011). The truth about false unicorn (Chamaelirium luteum): Total synthesis of 23R,24S-Chiograsterol B defines the structure and stereochemistry of the major saponins from this medicinal herb. Chemistry-A European Journal, 17 (27), 7578-7591. doi: 10.1002/chem.201100503
    Matovic, Nicholas J., Hayes, Patricia Y., Penman, Kerry, Lehmann, Reginald P. and De Voss, James J. (2011). Polyunsaturated alkyl amides from Echinacea: Synthesis of diynes, enynes, and dienes. Journal of Organic Chemistry, 76 (11), 4467-4481. doi: 10.1021/jo200289f
    De Voss, James J. (2011). The First International Collaborative and Cooperative Chemistry Symposium. Australian Journal of Chemistry, 64 (5), 517-518. doi: 10.1071/CH11187
    Slessor, KE, Farlow, AJ, Cavaignac, SM, Stok, JE and De Voss, JJ (2011). Oxygen activation by P450(cin): Protein and substrate mutagenesis. Archives of Biochemistry And Biophysics, 507 (1), 154-162. doi: 10.1016/j.abb.2010.09.009
    Yong, Ken W. L., De Voss, James J., Hooper, John N. A. and Garson, Mary J. (2011). Configurational assignment of cyclic peroxy metabolites provides an insight into their biosynthesis: Isolation of plakortolides, seco-plakortolides, and plakortones from the Australian marine sponge Plakinastrella clathrata. Journal of Natural Products, 74 (2), 194-207. doi: 10.1021/np100620x
    Challinor, Victoria L., Smith, David M. and De Voss, James J. (2011). Corrigendum: Steroidal Saponins Isolated from an Australian Yam (Dioscorea sp.). Australian Journal of Chemistry, 64 (11), 1540-1540. doi: 10.1071/CH11056_CO
    Booth, Yvonne K., Kitching, William and De Voss, James J. (2011). Biosynthesis of the spiroacetal suite in bactrocera tryoni. ChemBioChem, 12 (1), 155-172. doi: 10.1002/cbic.201000481
    Challinor, Victoria L., Smith, David M. and De Voss, James J. (2011). Erratum: Steroidal saponins isolated from an Australian Yam (Dioscorea sp.) (Australian Journal of Chemistry (2011) 64:5 (545-549)). Australian Journal of Chemistry, 64 (11). doi: 10.1071/CH11056-CO
    Hayes, PY, Chow, S, Somerville, MJ, Fletcher, MT and De Voss, JJ (2010). Daphnane- and tigliane-type diterpenoid esters and orthoesters from Pimelea elongata. Journal of Natural Products, 73 (11), 1907-1913. doi: 10.1021/np1005746
    Hayes, PY, Chow, S, Rahm, F, Bernhardt, PV, De Voss, JJ and Kitching, W (2010). Synthesis of the sponge-derived plakortone series of bioactive compounds. Journal of Organic Chemistry, 75 (19), 6489-6501. doi: 10.1021/jo101224w
    Hawkes, David B., Slessor, Kate E., Bernhardt, Paul V. and De Voss, James J. (2010). Cloning, expression and purification of cindoxin, an unusual FMN-containing cytochrome P450 redox partner. ChemBioChem, 11 (8), 1107-1114. doi: 10.1002/cbic.201000119
    Fletcher, Mary T., Hayes, Patricia Y., Somerville, Michael, J. and De Voss, James J. (2010). Ptesculentoside, a novel norsesquiterpene glucoside from the Australian bracken fern Pteridium esculentum. Tetrahedron Letters, 51 (15), 1997-1999. doi: 10.1016/j.tetlet.2010.02.032
    Slessor, Kate E., Stok, Jeanette E., Cavaignac, Sonia M., Hawkes, David B., Ghasemi, Younes and De Voss, James J. (2010). Cineole biodegradation: Molecular cloning, expression and characterisation of (1R)-6beta - hydroxycineole dehydrogenase from Citrobacter braakii. Bioorganic Chemistry, 38 (2), 81-86. doi: 10.1016/j.bioorg.2009.12.003
    Schwartz, Brett D., Booth, Yvonne K., Fletcher, Mary T., Kitching, William and De Voss, James J. (2010). Spiroacetal biosynthesis in fruit flies is complex: distinguishable origins of the same major spiroacetal released by different Bactrocera spp.. Chemical Communications, 46 (9), 1526-1528. doi: 10.1039/b917977a
    Hayes, Patricia Y., Chow, Sharon, Somerville, Michael J., De Voss, James J. and Fletcher, Mary T. (2009). Pimelotides A and B, diterpenoid ketal-lactone orthoesters with an unprecedented skeleton from Pimelea elongata. Journal of Natural Products, 72 (12), 2081-2083. doi: 10.1021/np900573k
    Booth, Yvonne K., Kitching, William and De Voss, James J. (2009). Biosynthesis of insect spiroacetals. Natural Product Reports, 26 (4), 490-525. doi: 10.1039/b717392j
    Hayes, Patricia Y., Lehmann, Reg, Penman, Kerry, Kitching, William and De Voss, James J. (2009). Steroidal saponins from the roots of Trillium erectum (Beth root). Phytochemistry, 70 (1), 105-113. doi: 10.1016/j.phytochem.2008.10.019
    Schwartz, Brett D., Moore, Christopher J., Rahm, Frederik, Hayes, Patricia Y., Kitching, William and De Voss, James J. (2008). Spiroacetal biosynthesis in insects from Diptera to Hymenoptera: The Giant Ichneumon wasp Megarhyssa nortoni nortoni Cresson. Journal of the American Chemical Society, 130 (44), 14853-14860. doi: 10.1021/ja8036433
    Tai, Guoying, Dickmann, Leslie J., Matovic, Nicholas, DeVoss, James J., Gillam, Elizabeth M. J. and Rettie, Allan E. (2008). Re-engineering of CYP2C9 to probe acid-base substrate selectivity. Drug Metabolism and Disposition, 36 (10), 1992-1997. doi: 10.1124/dmd.108.022186
    Meharenna, YT, Slessor, KE, Cavaignac, SM, Poulos, TL and De Voss, JJ (2008). The critical role of substrate-protein hydrogen bonding in the control of regioselective hydroxylation in P450cin. Journal of Biological Chemistry, 283 (16), 10804-10812. doi: 10.1074/jbc.M709722200
    Johnston, Wayne A., Huang, Weiliang, De Voss, James J., Hayes, Martin A. and Gillam, Elizabeth M.J. (2008). Quantitative whole-cell cytochrome P450 measurement suitable for high-throughput application. Journal of Biomolecular Screening, 13 (2), 135-141. doi: 10.1177/1087057107312780
    Hayes, P., Jahidin, A., Lehmann, R., Penman, K., Kitching, W. and De Voss, J. (2008). Steroidal saponins from the roots of Asparagus racemosus. Phytochemistry, 69 (3), 796-804. doi: 10.1016/j.phytochem.2007.09.001
    Cryle, Max J. and De Voss, James J. (2008). The role of the conserved threonine in P450BM3 oxygen activation: Substrate-determined hydroxylation activity of the Thr268Ala mutant. ChemBioChem, 9 (2), 261-266. doi: 10.1002/cbic.200700537
    Hayes, Patricia Y., Lambert, Lynette K., Lehmann, Reg, Penman, Kerry, Kitching, William and De Voss, James J. (2007). Complete 1H and 13C assignments of the four major saponins from Dioscorea villosa (wild yam). Magnetic Resonance in Chemistry, 45 (11), 1001-1005. doi: 10.1002/mrc.2071
    Johnston, Wayne A., Huang, Weiliang, De Voss, James J., Hayes, Martin A. and Gillam, Elizabeth M.J. (2007). A shuffled CYP1A library shows both structural integrity and functional diversity. Drug Metabolism And Disposition, 35 (12), 2177-2185. doi: 10.1124/dmd.107.017939
    Huang, Weiliang, Johnston, Wayne A., Hayes, Martin A., De Voss, James J. and Gillam, Elizabeth M.J. (2007). A shuffled CYP2C library with a high degree of structural integrity and functional versatility. Archives of Biochemistry And Biophysics, 467 (2), 193-205. doi: 10.1016/j.abb.2007.08.023
    Kim, Donghak, Cryle, Max J., De Voss, James J. and de Montellano, Paul R. Ortiz (2007). Functional expression and characterization of cytochrome P450 52A21 from Candida albicans. Archives of Biochemistry And Biophysics, 464 (2), 213-220. doi: 10.1016/j.abb.2007.02.032
    Booth, Yvonne K., Hayes, Patricia Y., Moore, Christopher J., Lambert, Lynette K., Kitching, William and De Voss, James J. (2007). Synthesis and absolute configuration of a constitutionally-new [5.6] spiroacetal from B. tryoni (Queensland fruit fly). Organic & Biomolecular Chemistry, 5 (7), 1111-1117. doi: 10.1039/b701833a
    Cryle, Max J. and De Voss, James J. (2007). Facile determination of the absolute stereochemistry of hydroxy fatty acids by GC: application to the analysis of fatty acid oxidation by a P450(BM3) mutant. Tetrahedron: Asymmetry, 18 (4), 547-551. doi: 10.1016/j.tetasy.2007.01.034
    Rosic, Nedeljka N., Huang, Weiliang, Johnston, Wayne A., DeVoss, James J. and Gillam, Elizabeth M.J. (2007). Extending the diversity of cytochrome P450 enzymes by DNA family shuffling. Gene, 395 (1-2), 40-48. doi: 10.1016/j.gene.2007.01.031
    Matovic, N., Matthias, A., Gertsch, J., Raduner, S., Bone, K. M., Lehmann, R. P. and DeVoss, J. J. (2007). Stereoselective synthesis, natural occurrence and CB2 receptor binding affinities of alkylamides from herbal medicines such as Echinacea sp.. Organic & Biomolecular Chemistry, 5 (1), 169-174. doi: 10.1039/b615487e
    Cryle, Max J., Matovic, Nick J. and De Voss, James J. (2007). The stereochemistry of fatty acid hydroxylation by cytochrome P450(BM3). Tetrahedron Letters, 48 (1), 133-136. doi: 10.1016/j.tetlet.2006.10.136
    Cryle, Max J. and De Voss, James J. (2006). Is the ferric hydroperoxy species responsible for sulfur oxidation in cytochrome P450s?. Angewandte Chemie International Edition, 45 (48), 8221-8223. doi: 10.1002/anie.200603411
    Cryle, Max J., Espinoza, Rocio D., Smith, Sarah J., Matovic, Nicholas J. and De Voss, James J. (2006). Are branched chain fatty acids the natural substrates for P450(BM3)?. Chemical Communications (22), 2353-2355. doi: 10.1039/b601202g
    Booth, Yvonne K., Schwartz, Brett D., Fletcher, Mary T., Lambert, Lynette K., Kitching, William and De Voss, James J. (2006). A diverse suite of spiroacetals, including a novel branched representative, is released by female Bactrocera tryoni (Queensland fruit fly). Chemical Communications (38), 3975-3977. doi: 10.1039/b611953k
    Hayes, P. Y., Jahidin, A. H., Lehmann, R., Penman, K., Kitching, W. and De Voss, J. J. (2006). Asparinins, asparosides, curillins, curillosides and shavatarins: structural clarification with the isolation of shatavarin V, a new steroidal saponin from the root of Asparagus racemosus. Tetrahedron Letters, 47 (-), 8683-8687. doi: 10.1016/j.tetlet.2006.10.030
    Hayes, P. Y., Jahidin, A. H., Lehmann, R., Penman, K., Kitching, W. and De Voss, J. J. (2006). Structural revision of shatavarins I and IV, the major components from the roots of Asparagus racemosus. Tetrahedron Letters, 47 (39), 6965-6969. doi: 10.1016/j.tetlet.2006.07.121
    Hayes, P. Y., Lehmann, R., Penman, K., Bone, K. M., Kitching, W. and De Voss, J. J. (2006). RP-HPLC detection of a sulphiting-induced artefact from paeoniflorin in dried roots of Paeonia lactiflora. Phytochemical Analysis, 17 (4), 251-254. doi: 10.1002/pca.911
    Penman, K. G., Halstead, C. W., Matthias, A., De Voss, J. J., Stuthe, J. M. U., Bone, K. M. and Lehmann, R. P. (2006). Bilberry adulteration using the food dye amaranth. Journal of Agricultural and Food Chemistry, 54 (19), 7378-7382. doi: 10.1021/jf061387d
    Avent, Kathryn M., DeVoss, J. J. and Gillam, Elizabeth M. J. (2006). Cytochrome P450-mediated metabolism of haloperidol and reduced haloperidol to pyridinium metabolites. Chemical Research In Toxicology, 19 (7), 914-920. doi: 10.1021/tx0600090
    Matthias, A., Gillam, E. M. J., Penman, K. G., Matovic, N. J., Bone, K. M., De Voss, J. J. and Lehmann, R. P. (2005). Cytochrome P450 enzyme-mediated degradation of Echinacea alkylamides in human liver microsomes. Chemico-biological Interactions, 155 (1-2), 62-70. doi: 10.1016/j.cbi.2005.04.003
    Schwartz, B. D., McErlean, C. S. P., Fletcher, M. T., Mazomenos, B. E., Konstantopoulou, M. A., Kitching, W. and De Voss, J. J. (2005). Spiroacetal biosynthesis: ()-1,7-dioxaspiro[5.5]undecane in Bactrocera cacuminata and Bactrocera oleae (olive fruit fly). Organic Letters, 7 (6), 1173-1176. doi: 10.1021/ol050143w
    Hayes, P. Y. N., Lehmann, R. P., Penman, K. G., Kitching, W. and De Voss, J. J. (2005). Sodium paeoniflorin sulfonate, a process derived artefact from paeoniflorin. Tetrahedron Letters, 46 (15), 2615-2618. doi: 10.1016/j.tetlet.2005.02.082
    Schwartz, B. D., Hayes, P. Y. N., Kitching, W. and De Voss, J. J. (2005). Flexible synthesis of enantiomerically pure 2,8-dialkyl-1,7-dioxaspiro[5.5]undecanes and 2,7-dialkyl-1,6-dioxaspiro[4.5]decanes from propargylic and homopropargylic alcohols. Journal Of Organic Chemistry, 70 (8), 3054-3065. doi: 10.1021/jo0477547
    Cryle, Max J., Ortiz de Montellano, Paul R. and De Voss, James J. (2005). Cyclopropyl containing fatty acids as mechanistic probes for cytochromes P450. Journal of Organic Chemistry, 70 (7), 2455-2469. doi: 10.1021/jo047985d
    He, X., Cryle, M. J., De Voss, J. J. and de Montellano, P. R. O. (2005). Calibration of the channel that determines the omega-hydroxylation regiospecificity of cytochrome P4504A1 - Catalytic oxidation of 12-halododecanoic acids. Journal of Biological Chemistry, 280 (24), 22697-22705. doi: 10.1074/jbc.M502632200
    Fletcher, Mary T., Wood, Barry J., Schwartz, Brett D., Rahm, Fredrik, Lambert, Lynette K., Brereton, Ian M., Moore, Christopher J., De Voss, James J. and Kitching, William (2004). A precision apparatus, with solid phase micro-extraction monitoring capability, for incorporation studies of gaseous precursors into insect-derived metabolites. Arkivoc, 2004 (x), 109-117. doi: 10.3998/ark.5550190.0005.a12
    Cryle, Max J., Stuthe, Julia M. U., Ortiz de Montellano, Paul R. and De Voss, James J. (2004). Cyclopropyl fatty acids implicate a radical but not a cation as an intermediate in P450(BM3)-catalysed hydroxylations. Chemical Communications, 10 (5), 512-513. doi: 10.1039/b315911f
    Matthias, A., Blanchfield, J. T., Penman, K. G., Toth, I., Lang, C. S., De Voss, J. J. and Lehmann, R. P. (2004). Permeability studies of alkylamides and caffeic acid conjugates from echinacea using a Caco-2 cell monolayer model. Journal of Clinical Pharmacy And Therapeutics, 29 (1), 7-13. doi: 10.1046/j.1365-2710.2003.00530.x
    Davies, C., Witham, K., Scott, J. R., Pearson, A., De Voss, J. J., Graham, S. E. and Gillam, E. M. J. (2004). Assessment of arginine 97 and lysine 72 as determinants of substrate specificity in cytochrome P450 2C9 (CYP2C9). Drug Metabolism and Disposition, 32 (4), 431-436. doi: 10.1124/dmd.32.4.431
    Meharenna, Y. T., Li, H. Y., Hawkes, D. B., Pearson, A. G., De Voss, J. and Poulos, T. L. (2004). Crystal structure of P450cin in a complex with its substrate, 1,8-cineole, a close structural homologue to D-camphor, the substrate for P450cam. Biochemistry, 43 (29), 9487-9494. doi: 10.1021/bi049293p
    Cryle, Max J. and De Voss, James J. (2004). Carbon-carbon bond cleavage by cytochrome P450Biol (CYP107H1). Chemical Communications, 2004 (1), 86-87. doi: 10.1039/b311652b
    Cryle, M. J., Stok, J. E. and De Voss, J. J. (2003). Reactions catalyzed by bacterial cytochromes P450. Australian Journal of Chemistry, 56 (8), 749-762. doi: 10.1071/CH03040
    Cryle, M. J., Matovic, N. J. and De Voss, J. J. (2003). Products of Cytochrome P450BioI (CYP107H1)-Catalyzed Oxidation of Fatty Acids. Organic Letters, 5 (18), 3341-3344. doi: 10.1021/ol035254e
    Aguey-Zinsou, Kondo-François, Bernhardt, Paul V., De Voss, James J. and Slessor, Kate E. (2003). Electrochemistry of P450cin: new insights into P450 electron transfer. Chemical Communications, 3 (3), 418-419. doi: 10.1039/b211567k
    Hayes, Patricia Y., Fletcher, Mary T., Chow, Sharon, McGrath, Matthew J., Tu, Yong Q., Zhang, Hesheng, Hungerford, Natasha L., McErlean, Christopher S. P., Stok, Jeannette E., Moore, Christopher J., De Voss, James J. and Kitching, William (2003). Insect chemistry and chirality. Chirality, 15 (S1), S116-S127. doi: 10.1002/chir.10273
    Fletcher, Mary T., Wood, Barry J., Brereton, Ian M., Stok, Jeanette E., De Voss, James J. and Kitching, William (2002). [18O]-Oxygen incorporation reveals novel pathways in spiroacetal biosynthesis by Bactrocera cacuminata and B. cucumis. Journal of the American Chemical Society, 124 (26), 7666-7667. doi: 10.1021/ja026215l
    Coster, M. J. and De Voss, J. J. (2002). Medium ring ethers by ring expansion-ring contraction: Synthesis of lauthisan. Organic Letters, 4 (18), 3047-3050. doi: 10.1021/ol0262946
    McErlean, Christopher S. P., Fletcher, Mary T., Wood, Barry J., De Voss, James J. and Kitching, William (2002). Monooxygenase stereoselectivity in the biosynthesis of stereoisomeric spiroacetals in the cucumber fly, Bactrocera cucumis. Organic Letters, 4 (16), 2775-2778. doi: 10.1021/ol0263090
    de Montellano, P. R. O. and De Voss, J. J. (2002). Oxidizing species in the mechanism of cytochrome P450. Natural Product Reports, 19 (4), 477-493. doi: 10.1039/b101297p
    Fletcher, Mary T., Mazomenos, Basilis E., Georgakopoulos, John H., Konstantopoulou, Maria A., Wood, Barry J., De Voss, James J. and Kitching, William (2002). Sex pheromone biosynthesis in the female olive fruit-fly. Double labelling from [O-18(2)]-dioxygen into 1,7-dioxaspiro[5.5]undecane. Chemical Communications, 12 (12), 1302-1303. doi: 10.1039/b202697j
    Hawkes, David B., Adams, Gregory W., Burlingame, Alma L., de Montellano, Paul R. Ortiz and De Voss, James J. (2002). Cytochrome P450(cin) (CYP176A), isolation, expression, and characterization. Journal of Biological Chemistry, 277 (31), 27725-27732. doi: 10.1074/jbc.M203382200
    Stok, J. E., Lang, C. S., Schwartz, B. D., Fletcher, M. T., Kitching, W. and De Voss, J. J. (2001). Carbon hydroxylation of alkyltetrahydropyranols: A paradigm for spiroacetal biosynthesis in Bactrocera sp.. Organic Letters, 3 (3), 397-400. doi: 10.1021/ol0069047
    Schwartz, B. D. and De Voss, J. J. (2001). Structure and absolute configuration of mycobactin J. Tetrahedron Letters, 42 (21), 3653-3655. doi: 10.1016/S0040-4039(01)00531-7
    Carballeira, N. M., Cruz, H., Hill, C. A., De Voss, J. J. and Garson, M. (2001). Identification and total synthesis of novel fatty acids from the siphonarid limpet Siphonaria denticulata. Journal of Natural Products, 64 (11), 1426-1429. doi: 10.1021/np010307r
    Stok, J. and De Voss, J. J. (2000). Expression, purification, and characterization of biol: A carbon-carbon bond cleaving cytochrome P450 involved in biotin biosynthesis in Bacillus subtilis. Archives of Biochemistry And Biophysics, 384 (2), 351-360. doi: 10.1006/abbi.2000.2067
    De Voss, J. J., Rutter, K., Schroeder, B. G., Su, H., Zhu, Y. Q. and Barry, C. E. (2000). The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages. Proceedings of The National Academy of Sciences of The United States of America, 97 (3), 1252-1257. doi: 10.1073/pnas.97.3.1252
    Gillam, E. M. J., Notley, L. M., Cai, H. L., De Voss, J. J. and Guengerich, F. P. (2000). Oxidation of Indole by Cytochrome P450 Enzymes. Biochemistry, 39 (45), 13817-13824. doi: 10.1021/bi001229u
    De Voss, James J., Rutter, Kerry, Schroeder, Benjamin G. and Barry, Clifton E. (1999). Iron acquisition and metabolism by mycobacteria. Journal of Bacteriology, 181 (15), 4443-4451. doi: 10.1128/jb.181.15.4443-4451.1999
    Gillam, E. M. J., Aguinaldo, A. M. A., Notley, L. M., Kim, D., Mundkowski, R. G., Volkov, A. A., Arnold, F. H., Soucek, P., DeVoss, J. J. and Guengerich, F. P. (1999). Formation of indigo by recombinant mammalian cytochrome P450. Biochemical and Biophysical Research Communications, 265 (2), 469-472. doi: 10.1006/bbrc.1999.1702
    Hungerford, Natasha L., Mazomenos, Basilis E., Konstantopoulou, Maria A., Krokos, Fragoulis D., Haniotakis, George E., Hubener, Achim, Fletcher, Mary T., Moore, Christopher J., DeVoss, James J. and Kitching, William (1998). Biogenesis of sex pheromones in the female olive fruit-fly. Chemical Communications, 29 (8), 863-864. doi: 10.1039/a800691a
    Munns, Andrew J., De Voss, James J., Hooper, Wayne D., Dickinson, Ronald G. and Gillam, Elizabeth M. J. (1997). Bioactivation of Phenytoin by Human Cytochrome P450: Characterization of the Mechanism and Targets of Covalent Adduct Formation. Chemical Research In Toxicology, 10 (9), 1049-1058. doi: 10.1021/tx9700836
    Rutenber, Earl E., De Voss, James J., Hoffman, Lucas, Stroud, Robert M., Lee, Kwan H., Alvarez, Juan, McPhee, Fiona, Craik, Charles and Ortiz De Montellano, Paul R. (1997). The discovery, characterization and crystallographically determined binding mode of an FMOC-containing inhibitor of HIV-1 protease. Bioorganic and Medicinal Chemistry, 5 (7), 1311-1320. doi: 10.1016/S0968-0896(97)00078-3
    De Voss, James J., Sibbesen, Ole, Zhang, Zhoupeng and Ortiz De Montellano, Paul R. (1997). Substrate docking algorithms and prediction of the substrate specificity of cytochrome P450(cam) and its L244A mutant. Journal of the American Chemical Society, 119 (24), 5489-5498. doi: 10.1021/ja970349v
    De Voss, James J., Leeper, Finian J. and Battersby, Alan R. (1997). Synthetic studies relevant to biosynthetic research on vitamin B12. Part 12. Modification of the periphery of chlorins and isobacteriochlorins. Journal of the Chemical Society - Perkin Transactions 1 (8), 1105-1116. doi: 10.1039/a607852d
    De Voss J.J. and Stok J.E. (1997). Purification and characterisation of P450Biol. FASEB Journal, 11 (9)
    Sibbesen, Ole, De Voss, James J. and Ortiz de Montellano, Paul R. (1996). Putidaredoxin reductase-putidaredoxin-cytochrome P450(cam) triple fusion protein. Construction of a self-sufficient Escherichia coli catalytic system. Journal of Biological Chemistry, 271 (37), 22462-22469. doi: 10.1074/jbc.271.37.22462
    Yu, Z., Caldera, P., McPhee, F., De Voss, J. J., Jones, P. R., Burlingame, A. L., Kuntz, I. D., Craik, C. S. and Ortiz De Montellano, P. R. (1996). Irreversible inhibition of the HIV-1 protease: Targeting alkylating agents to the catalytic aspartate groups. Journal of the American Chemical Society, 118 (25), 5846-5856. doi: 10.1021/ja954069w
    De Voss, James J. and Ortiz De Montellano, Paul R. (1996). Substrate docking algorithms and the predicition of substrate specificity. Methods in Enzymology, 272, 336-347.
    Brown Jr., R. S., Lomri, N., De Voss, J., Rahmaoui, C. M., Xie, M. H., Hua, T., Lidofsky, S. D. and Scharschmidt, B. F. (1995). Enhanced secretion of glycocholic acid in a specially adapted cell line is associated with overexpression of apparently novel ATP-binding cassette proteins. Proceedings of the National Academy of Sciences of the United States of America, 92 (12), 5421-5425. doi: 10.1073/pnas.92.12.5421
    De Voss, James J. and Ortiz de Montellano, Paul R. (1995). Computer-Assisted, Structure-Based Prediction of Substrates for Cytochrome P450cam. Journal of the American Chemical Society, 117 (14), 4185-4186. doi: 10.1021/ja00119a041
    Lee, Kwan Hee, McPhee, Fiona, DeVoss, James J., Craik, Charles S. and de Montellano, Paul R. Ortiz (1994). Nonpeptide HIV Protease Inhibitors. Differential Introduction of Alkylamino Groups into the Two Aryl Rings of Haloperidol. Journal of Organic Chemistry, 59 (21), 6194-6199. doi: 10.1021/jo00100a021
    De Voss, James J., Hangeland, Jon J. and Townsend, Craig A. (1994). General Approach to the Synthesis of Specifically Deuterium-Labeled Nucleosides. Journal of Organic Chemistry, 59 (10), 2715-2723. doi: 10.1021/jo00089a013
    Salto, Rafael, Babé, Lilia M., Li, Jia, Rosé, Jason R., Yu, Zhonghua, Burlingame, Aima, De Voss, James J., Sui, Zhihua, Ortiz De Montellano, Paul and Craik, Charles S. (1994). In vitro characterization of nonpeptide irreversible inhibitors of HIV proteases. Journal of Biological Chemistry, 269 (14), 10691-10698.
    De Voss, James J., Sui, Zhihua, DeCamp, Dianne L., Salto, Rafael, Babé, Lilia M., Craik, Charles S. and de Montellano, Paul R. Ortiz (1994). Haloperidol-Based Irreversible Inhibitors of the HIV-1 and HIV-2 Proteases. Journal of Medicinal Chemistry, 37 (5), 665-673. doi: 10.1021/jm00031a017
    De Voss, James J. and Sui, Zhihua (1994). Synthesis of medium size rings containing oxygen and sulfur by ring expansion of halodioxolanes, dioxanes and oxathiolanes. Tetrahedron Letters, 35 (1), 49-52. doi: 10.1016/0040-4039(94)88159-6
    Sui, Z., De Voss, J. J., DeCamp, D. L., Li, J., Craik, C. S. and Ortiz De Montellano, P. R. (1993). Synthesis of haloperidol ethanedithioketal HIV-1 protease inhibitors: Magnesium chloride facilitated addition of Grignard reagents. Synthesis (8), 803-808.
    Sui, Zhihua, Furth, Paul S. and De Voss, James J. (1992). Ring Expansion of Halo Dithiolanes and Dithianes: A Facile Synthesis of Medium-Ring Dithiacycloalkenes. Journal of Organic Chemistry, 57 (24), 6658-6662. doi: 10.1021/jo00050a058
    Devoss, JJ, Jamie, JF, Blanchfield, JT, Fletcher, MT, Oshea, MG and Kitching, W (1991). Mercury(II)-mediated routes to some side-chain functionalised 1,7-dioxaspiro[5.5]undecanes. Applications of Luche-Barbier chemoselective addition to ketoaldehydes. Tetrahedron, 47 (10-11), 1985-1996. doi: 10.1016/S0040-4020(01)96110-1
    De Voss, James J., Hangeland, Jon J. and Townsend, Craig A. (1990). Characterization of the in vitro cyclization chemistry of calicheamicin and its relation to dna cleavage. Journal of the American Chemical Society, 112 (11), 4554-4556. doi: 10.1021/ja00167a069
    De Voss, James J., Townsend, Craig A., Ding, Wei Dong, Morton, George O., Ellestad, George A., Zein, Nada, Tabor, Alethea B. and Schreiber, Stuart L. (1990). Site-Specific Atom Transfer from DNA to a Bound Ligand Defines the Geometry of a DNA-Calicheamicin ϒ11 Complex. Journal of the American Chemical Society, 112 (26), 9669-9670. doi: 10.1021/ja00182a053
    Allen, F. H., Battersby, A. R., De Voss, J. J., Doyle, M. J. and Raithby, P. R. (1989). 1‐Mesyl‐4‐[2‐(methoxycarbonyl)ethyl]‐3‐(methoxycarbonyl)methyl‐N,N‐dimethylpyrrole‐2‐carboxamide. Acta Crystallographica Section C, 45 (4), 692-694. doi: 10.1107/S0108270188012740
    Kitching, William, Lewis, Judith A., Fletcher, Mary T., De Voss, James J., Drew, Richard A.I. and Moore, Christopher J. (1986). Spiroacetals from dienones and hydroxyenones by mercury(II) cyclisation. Journal of the Chemical Society. Chemical Communications, 1986 (11), 855-856. doi: 10.1039/c39860000855
    Carman R.M., De Voss J.J. and Greenfield K.L. (1985). The Diastereomeric 8, 9-Epoxides of Limonene (The 8, 9-Epoxy-p-menth-1-enes). Australian Journal of Chemistry, 39 (3), 441-446. doi: 10.1071/CH9860441

    Conference Papers

    Carpinelli de Jesus, M., Hungerford, N. L., Carter, S. J., Anuj, S. R., De Voss, J. J., Blanchfield, J. T. and Fletcher, M. T. (2018). Pyrrolizidine alkaloids in Blue Heliotrope (Heliotropium amplexicaule) in Australia. 10th International Symposium of Poisonous Plants (ISOPP10), St George, Utah, United States, 16-20 September 2018.
    Matheus Carpinelli de Jesus, Natasha Hungerford, Steve Carter, Shalona Anuj, Joanne Blanchfield, James De Voss and Mary Fletcher (2018). Identifying the pyrrolizidine alkaloid LC-MS/MS profile of Blue heliotrope (Heliotropium amplexicaule). QMSS 2018 – 3rd Queensland Mass Spectrometry Symposium, QUT, Brisbane, 6-7 December 2018.
    Wong, Siew Hoon, Bell, Stephen G. and De Voss, James J. (2017). P450 catalysed dehydrogenation. Berlin, Germany: Walter de Gruyter GmbH. doi: 10.1515/pac-2016-1216
    Wohlmuth, H., Leach, D., McGrath, K., Gordon, L., Mouatt, P. and De Voss, J. (2016). An assessment of the utility of DNA barcoding in the quality control of herbal raw materials, extracts and finished products. 9th Joint Meeting of AFERP, ASP, GA, JSP, PSE and SIF, Copenhagen, Denmark, 24 - 27 July 2016. Stuttgart, Germany: Georg Thieme Verlag. doi: 10.1055/s-0036-1597032
    Leach, D., Ahmed, I., De Voss, J. and Wohlmuth, H. (2016). Establishing compositional guidelines for flavonoids and saponins in Gynostemma pentaphyllum. 9th Joint Meeting of AFERP, ASP, GA, JSP, PSE and SIF, Copenhagen Denmark, 24 - 27 July 2016. Stuttgart, Germany: Georg Thieme Verlag. doi: 10.1055/s-0036-1597033
    Yong, Ken W.L., De Voss, James J., Hooper, John N.A. and Garson, Mary J. (2011). Spectroscopic insights into Cyclic Polyketide Peroxides: New Plakortolides from Plakinastrella clathrata Kirkpatrick, 1900. 27th International Symposium on the Chemistry of Natural Products and the 7th International Conference on Biodiversity, Brisbane, Australia, 10 - 15 July 2011. Research Triangle Park, United States: International Union of Pure and Applied Chemistry.
    Yong, Ken W., Lambert, Lynette K., De Voss, James J. and Garson, Mary J. (2011). Using NMR-based methods to assign the stereochemistry of bioactive cyclic peroxide metabolites. NZ Institute of Chemistry Conference (NZIC, 2011), Hamilton, N.Z., 27 November-1 December 2011. Harewood, Christchurch, N.Z.: NZ Institute of Chemistry.
    Yong, Ken W.L., De Voss, James J. and Garson, Mary J. (2011). Using NMR-based methods to assign the stereochemistry of natural products. International Congress for Innovation in Chemistry (VII, PERCH-CIC, 2011), Pattaya, Thailand, 4-7 May 2011. Bangkok, Thailand: Centre of Excellence for Innovation in Chemistry.
    Challinor, Victoria L., Smith, David M. and De Voss, James J. (2011). Steroidal saponins isolated from an Australian Yam Dioscorea sp.. Collingwood, VIC, Australia: C S I R O Publishing. doi: 10.1071/CH11056
    Yong, K. W. L., De Voss, J. J., Hooper, J. N. A. and Garson, M. J. (2010). Spectroscopic insight into cyclic polyketide peroxides: Plakortolide F and 6-epiplakortolide F. 5th Annual Symposium on Marine Natural Products and Drug Discovery, Pohan, South Korea, September 2010.
    Yong, K. W. L., De Voss, J. J., Hooper, J. N. A. and Garson, M. J. (2010). Spectroscopic insight into cyclic polyketide peroxides: plakortolide F and 6-epiplakortolide F. 6th Annual SCMB Research Students Symposium, Brisbane, QLD, Austalia, 25 November 2010.
    Singh, Arti, Cryle, M., Hunter, D,, Stok, J. and De Voss, J. (2009). Cytochrome P450-mediated fatty acid oxidation: Mechanistic investigations. ICCC2009: 16th International Conference on Cytochrome P450. Biochemistry, Biophysics, Biotechnology, Nago, Okinawa, Japan, 21-25 June 2009. Bologna, Italy: Medimond S.r.l..
    Penman, K., Bone, K.M., Hayes, P.C., De Voss, J., Agarwal, A., Murali, B, Mundkinajeddu, D., Mayachari, A., Shenoy, R. and Lehmann, R. P. (2007). NMR studies found that a commercially supplied standard reference purported to be Withanolide D was instead Withanolide. 55th International Congress & Annual Meeting of the Society for Medicinal Plant Research, Karl Franzens University, Graz, Austria, 2-6 September, 2007. Stuttgart, Germany: Thieme.
    De Voss, J. (2006). Biodiversity and Natural Products - IUPAC International Conference (ICOB-5 & ISCNP-25) - 23-28 July 2006, Kyoto, Japan. London: Current Drugs.
    Penman, K. G., Halstead, C. W., Matthias, A., De Voss, J J, Stuthe, J. M., Bone, K. M. and Lehmann, R P (2006). Bilberry adulteration using the food dye amaranth. RACI Natural Products Group Symposium, Wollongong, 29 Sept, 2006.
    Stuthe, J. M., Lambert, L. K., Lehmann, R P, Kitching, W and De Voss, J J (2006). Chemical constituents of Chamaelirium luteum. ANZMAG, Murramarang, NSW, 13-16 Feb, 2006.
    De Voss, J J (2006). Insect spiroacetal biosynthesis. Biodiversity- IUPAC International Conference, Kyoto, 23-28 July, 2006.
    Gillam, Elizabeth M. J., Johnston, W. A., DeVoss, J. J., Soucek, Pavel and Hunter, D. J. B. (2006). Dna family shuffling of mammalian P450s from CYP2A and CYP3A subfamilies. 14th North American Meeting of the International-Society-for-the-Study-of-Xenobiotics, Rio Grande, Puerto Rico, 22-26 October 2006. Philadelphia, PA USA: Taylor & Francis.
    Matthias, Anita, Penman, Kerry G., Matovic, Nick J., Bone, Kerry M., De Voss, James J. and Lehmann, Reg P. (2005). Bioavailability of Echinacea Constituents: Caco-2 Monolayers and Pharmacokinetics of the Alkylamides and Caffeic Acid Conjugates. Basel, Switzerland: Molecules/Molecular Diversity Preservation International. doi: 10.3390/10101242
    Booth, Y. K., Schwartz, B. D., Fletcher, M. T., Hayes, P. Y. N., Kitching, W. and De Voss, J. J. (2005). Spiroacetal biosynthesis in Bactrocera tryoni (Queensland fruit fly). 14th European Symposium in Organic Chemistry, Helsinki, 4-8 July, 2005.
    De Voss, J. J., Cryle, M. J. and Hayes, P. Y. N. (2005). Modified fatty acids as cytochrome P450 substrates. 14th International Conference on Cytochromes P450, Dallas, 31 May - 5 June, 2005.
    Matovic, N. J. and De Voss, J. J. (2005). Synthesis of polyunsaturated alkyl amide constituents from Echinacea. 14th European Symposium in Organic Chemistry, Helsinki, 4-8 July, 2005.
    Slessor, K., Schloendorn, J. and De Voss, J. J. (2005). Alternative reactions catalysed by cytochrome P450cin. Connect 2005, Sydney, 3-7 July, 2005.
    De Voss, J. J. (2005). Cyclopropyl containing fatty acids as probes of cytochrome P450. Prof Michael Paddon-Rowe Symposium, Sydney, 25 Feb, 2005.
    Farlow, A. J. and De Voss, J. J. (2005). Cytochrome P450cin - alternative reactions with alternative substrates. Brisbane Biological & Organic Chemistry Symposium, Brisbane, 25 Nov, 2005.
    Slessor, K. and De Voss, J. J. (2005). C-C bond cleavaged reactions catalysed by cytochrome P450. Brisbane Biological & Organic Chemistry Symposium, Brisbane, 25 Nov, 2005.
    De Voss, J. J., Cryle, M. J. and Ortiz de Montellano, P.R. (2004). Small molecule probes of cytochrome P450 mechanism. 20th RACI Organic Chemistry Meeting, Cairns, 4-8 July, 2004.
    He, X., Deng, D., Cryle, M. J., De Voss, J. J., Groves, J. and Ortiz de Montellano, P.R. (2004). Reaffirmation of the radical recombination mechanism of cytochrome P450-catalyzed hydroxylations. 3rd Int Congress of Porphyrins and Pthalocyanines, New Orleans, 11-16 July, 2004.
    Slessor, K. E., Cavaignac, S. M., Hawkes, D. B. and De Voss, J. J. (2004). Is Asn242 important in P450cin catalysis?. 7th International Symposium on Cytochrome P450 Biodiversity &y, Hyogo, Japan, 1-5 Aug, 2004.
    Booth, Y. K. and De Voss, J. J. (2004). Delineating the biosynthetic pathway to spiroacetal pheromones in Bactrocera tryoni (Queensland fruit fly). BBOCS, Brisbane, 26 Nov, 2004.
    Cryle, M. J., Stuthe, J. M. U., Lambert, L. K. and De Voss, J. J. (2004). NMR elucidation of the products from cationic rearrangement of cyclopropane rings. ANZMAG 2004, Tanunda, South Australia, 15-19 Feb, 2004.
    Stuthe, J. M. U., Lambert, L. K., Lehmann, R.P., Kitching, W. and De Voss, J. J. (2004). Chemical constituents of Chamaelirum luteum by NMR. ANZMAG 2004, Barossa Valley, 15-19 Feb, 2004.
    Ortiz de Montellano, P. R., He, X., Cryle, M. J. and De Voss, J. J. (2004). The radical recombination mechanism of cytochrome P450-catalyzed hydroxylations. ISSX 2004: 7th International Society for Study of Xenobiotics Meeting, Vancouver, 29 August - 2 September, 2004. UK: Informa Healthcare. doi: 10.1081/DMR-200027024
    Slessor, K., Cavaignac, S. M., Hawkes, D. and De Voss, J. J. (2003). Dioxygen bond activation in P450cin. The Brisbane Biological & Organic Chemistry Symposium, Brisbane, 28 Nov, 2003.
    Bernhardt, Paul V., Aguey-Zinsou, Kondo-Francois, De Voss, James J. and Slessor, Kate E. (2003). Direct electrochemistry of cytochrome P450cin : new insights into P450 mechanism. 11th International Conference on Biological Inorganic Chemistry, Cairns, Qld, 19-23 July, 2003. New York: Elsevier. doi: 10.1016/S0162-0134(03)80462-2
    Rosic, Nedeljka, Lonhienne, Thierry G.A., DeVoss, James J. and Gillam, Elizabeth M.J. (2003). Directed evolution of mammalian cytochrome P450 enzymes involved in xenobiotic metabolism. 8th European Meeting of the International-Society-for-the-Study-of-Xenobiotics (ISSX), Dijon, France, 27 April - 1 May, 2003. New York: Marcel Dekker. doi: 10.1081/DMR-120020120
    Stuthe, J. M. U., Fletcher, M. T., Lambert, L. K., Penman, K. G., Lehmann, R.P., Kitching, W. and De Voss, J. J. (2002). Chemical constitutents of chamaelirium luteum. 50th Ann Congress of the Society for Medicinal Plant Research, Barcelona, 8-12 September, 2002.
    Schwartz, B. D., McErlean, C. S. P., Fletcher, M. T., Kitching, W. and De Voss, J. J. (2002). Elucidation of biosynthetic pathways to the spiroacetals in Australian fruit fly species (Bactrocera sp.). Brisbane Biological & Organic Chemistry Symposium, Brisbane, 29 November, 2002.
    Schwartz, B. D. and De Voss, J. J. (2002). Synthesis and characterisation of [2,4']-bisthaizolines, [2,4]-bisoxazolines, [4,2'] and [2,4']-thiazolinyloxazolines. IUPAC 14th International Conference on Organic Synthesis, Christchurch, 14-18 July, 2002.
    De Voss, J. J. (2002). Mechanism of a C-C bond cleaving enzyme: P450 BioI. Cornforth Foundation for Chemistry Symposium, Sydney, 30 September - 1 October, 2002.
    De Voss, J. J. (2002). P450cin: A new P450 with a novel redox partner. 6th Int Symposium on Cytochrome P450, Los Angeles, 20-25 August, 2002.
    Pearson, A. G., Hawkes, D. B., De Voss, J. J. and Martin, J. L. (2001). Expression, purification and preliminary X-ray crystallographic trials of P450cin, an oxidative hemoprotein of Citrobacter braakii. Crystal 22, Society of Crystallographers in Aust and NZ, Couran Cove, Qld, 7-10 July, 2001.
    Lang, C. S. and De Voss, J. J. (2001). Enantioselective synthesis of labelled serine and cysteine. IUPAC World Chemistry Congress 2001, Brisbane, July, 2001.
    Cryle, M.J., Stok, J. and De Voss, J. J. (2001). Elucidation of the mechanism of carbon carbon bond cleavage. IUPAC World Chemistry Congress 2001, Brisbane, July, 2001.
    Stok, J., Cryle, M. J. and De Voss, J. J. (2000). A carbon-carbon bond cleaving enzyme involved in biotin biosynthesis. BICS III, Brisbane, 30 November, 2000. Australia: Royal Australian Chemical Institute.
    Cryle, M. J., Stok, J. and De Voss, J. J. (2000). Elucidation of the mechanism of action of the cytochrome P450 enzyme BioI. Brisbane Biological and Organic Chemistry Symposium 2000, Griffith University, 27 November, 2000.
    Guengerich, F. P., Cai, H., Notley, L., De Voss, J. J. and Gillam, E. M. J. (2000). Oxidation of indole by human cytochrome P450 enzymes. Joint meeting ASBMB/ASPET 2000, Boston, MA, USA, 4 - 8 June, 2000. BETHESDA: The Federation of American Societies for Experimental Biology.
    Kim, D., Gillam, E. M. J., Aguinaldo, A. M., Notley, L., Mundkowski, R. G., Volkov, A. A., Arnold, F. H., Soucek, P., De Voss, J. J. and Guengerich, F. P. (2000). Formation of indigo by recombinant mammalian cytochrome P450. Joint meeting ASBMB/ASPET 2000, Boston, MA, USA, 4 - 8 June, 2000. USA: The Federation of American Societies for Experimental Biology.
    Stok, J., De Voss, J. J. and Kitching, W. (1999). Investigation into the biosynthesis of the major sex pheromone from B.cacuminata and B. cucumis. 1st Asia-Pacific Conference on Chemical Ecology, Shanghai, China, 1 -4 November 1999. Shanghai, China: Chinese Academy of Science.
    De Voss, J. J. and Stok, J. E. (1997). Purification and characterisation of P450. 1997 Faseb Summer Research Conference On Amyloid, Copper Mountain, Colorado, 13-18 July, 1997. Bethesda, MD: Federation of American Societies for Experimental Biology.

    Areas of research

    Biochemistry and molecular biology discipline
    Biomolecular chemistry theme
    Organic chemistry discipline