Dr Peter Nixon
Honorary Associate Professor
School of Chemistry and Molecular Biosciences
+61 7 336 53925
Journal Articles
Nixon, P.F. (2008) Glutamate export at the choroid plexus in health, thiamin deficiency, and ethanol intoxication: Review and hypothesis. Alcoholism Clinical and Experimental Research, 32 8: 1339-1349. doi:10.1111/j.1530-0277.2008.00727.x
Nixon, Peter F., Jordan, L.R., Zimitat, C., Rose, S.E. and Zelaya, F. (2008) Choroid plexus dysfunction: The initial event in the pathogenesis of Wernicke's encephalopathy and ethanol intoxication. Alcoholism: Clinical and Experimental Research, 32 8: 1513-1523. doi:10.1111/j.1530-0277.2008.00723.x
McCourt, J. A., Nixon, P. F. and Duggleby, R. G. (2006) Thiamin nutrition and catalysis-induced instability of thiamin diphosphate. British Journal of Nutrition, 96 4: 636-638. doi:10.1079/BJN20061842
Nixon, P. F., Jones, M. and Winzor, D. J. (2004) Quantitative description of the interaction between folate and the folate-binding protein from cow's milk. Biochemical Journal, 382 1: 215-221. doi:10.1042/BJ20040411
Jones, ML, Treloar, T and Nixon, PF (2003) Dietary interactions influence the effects of bovine folate-binding protein on the bioavailability of tetrahydrofolates in rats. Journal of Nutrition, 133 2: 489-495.
Jones, M. L. and Nixon, P. F. (2002) Tetrahydrofolates are greatly stabilized by binding to bovine milk folate-binding protein. Journal of Nutrition, 132 9: 2690-2694.
Hutchinson-Jones, M. L., Treloar, T. and Nixon, P. F. (2001) Availability of folate bound to folate-binding protein: Environmental effects. Australian Journal of Dairy Technology, 56 2: .
Zimitat, C. and Nixon, P. F. (2001) Glucose induced IEG expression in the thiamin-deficient rat brain. Brain Research, 892 1: 218-227. doi:10.1016/S0006-8993(00)03297-2
Huang, C., Chang, A. K., Nixon, P. F. and Duggleby, R. G. (2001) Site-directed mutagenesis of the ionisable groups in the active site of Zymomonas mobilis pyruvate decarboxylase. European Journal of Biochemistry, 268 12: 3558-3565. doi:10.1046/j.1432-1327.2001.02260.x
Wu, Y. G., Widjaja, S. L., Huang, C. Y., Li, W., Nixon, P. F. and Duggleby, R. G. (2001) Congenital lactic acidosis: Evaluation of the properties of the A199T natural variant of human pyruvate dehydrogenase E1 alpha by in vitro mutation. Molecular Genetics And Metabolism, 72 3: 269-272. doi:10.1006/mgme.2000.3137
Hutchinson, M. L., Jones, M. D. and Nixon, P. F. (2000) Stability of labile folates is enhanced by binding to milk folate-binding protein. Australian Journal of Dairy Technology, 55 2: .
Jones, M. D., Hutchinson, M. L. and Nixon, P. F. (2000) Milk folate-binding protein; ligand-binding and polymerisation properties. Australian Journal of Dairy Technology, 55 2: .
Treloar, W., Grieve, P. and Nixon, P. F. (2000) One-step affinity purification of folate-binding protein, a minor whey protein. Australian Journal of Dairy Technology, 55 2: 96-96.
Chang, AK, Nixon, PF and Duggleby, RG (2000) Effects of deletions at the carboxyl terminus of Zymomonas mobilis pyruvate decarboxylase on the kinetic properties and substrate specificity. Biochemistry, 39 31: 9430-9437. doi:10.1021/bi0002683
Wu, Y-G., Chang, A. K., Nixon, P. F., Li, W. and Duggleby, R. G. (2000) Mutagenesis at Asp-27 of pyruvate decarboxylase from Zymomonas mobilis: Effect on its ability to form acetoin and acetolactate. European Journal of Biochemistry, 267 21: 6493-6500. doi:10.1046/j.1432-1327.2000.01744.x
Chang, A. K., Nixon, P. F. and Duggleby, R. G. (1999) Asparate-27 and glutamate-473 are involved in catalysis by Zymomonas mobilis pyruvate decarboxylase. Biochemical Journal, 339 2: 255-260. doi:10.1042/0264-6021:3390255
Huang, C-Y., Nixon, P. F. and Duggleby, R.G. (1999) Effect of Mutagenesis of V111 and L112 on the Substrate Specificity of Zymomonas mobilis Pyruvate Decarboxylase. Journal of Biochemistry and Molecular Biology, 32 1: 39-44.
Zimitat, C. and Nixon, P. F. (1999) Glucose loading precipitates acute encephalopathy in thiamin-deficient rats.. Metabolic Brain Disease, 14 1: 1-20. doi:10.1023/A:1020653312697
Fang, R, Nixon, PF and Duggleby, RG (1998) Identification of the catalytic glutamate in the E1 component of human pyruvate dehydrogenase. FEBS Letters, 437 3: 273-277. doi:10.1016/S0014-5793(98)01249-6
Jordan, LR, Zelaya, FO, Rose, SE, Bower, AJ, Galloway, G, Wholohan, T and Nixon, PF (1998) Changes in the hippocampus induced by glucose in thiamin deficient rats detected by MRI. Brain Research, 791 1-2: 347-351. doi:10.1016/S0006-8993(98)00203-0
Schenk, G, Duggleby, RG and Nixon, PF (1998) Heterologous expression of human transketolase. International Journal of Biochemistry and Cell Biology, 30 3: 369-378. doi:10.1016/S1357-2725(97)00154-4
Schenk, G, Duggleby, RG and Nixon, PF (1998) Properties and functions of the thiamin diphosphate dependent enzyme transketolase. International Journal of Biochemistry and Cell Biology, 30 12: 1297-1318. doi:10.1016/S1357-2725(98)00095-8
Schenk, G, Leeper, FJ, England, R, Nixon, PF and Duggleby, RG (1997) The role of His113 and His114 in pyruvate decarboxylase from Zymomonas mobilis. European Journal of Biochemistry, 248 1: 63-71. doi:10.1111/j.1432-1033.1997.t01-1-00063.x
Schenk, G, Layfield, R, Candy, JM, Duggleby, RG and Nixon, PF (1997) Molecular evolutionary analysis of the thiamine-diphosphate-dependent enzyme, transketolase. Journal of Molecular Evolution, 44 5: 552-572. doi:10.1007/PL00006179
Candy, JM, Koga, J, Nixon, PF and Duggleby, RG (1996) The role of residues glutamate-50 and phenylalanine-496 in Zymomonas mobilis pyruvate decarboxylase. Biochemical Journal, 315 3: 745-751. doi:10.1042/bj3150745
Hidiroglou, N, Camilo, ME, Beckenhauer, HC, Tuma, DJ, Barak, AJ, Nixon, PF and Selhub, J (1994) Effect of chronic alcohol ingestion on hepatic folate distribution in the rat. Biochemical Pharmacology, 47 9: 1561-1566. doi:10.1016/0006-2952(94)90532-0
Booth, CK and Nixon, PF (1993) Reconstitution of holotransketolase is by a thiamin-disphosphate-magnesium complex. European Journal of Biochemistry, 218 1: 261-265. doi:10.1111/j.1432-1033.1993.tb18373.x
Berthon, HA, Kuchel, PW and Nixon, PF (1992) High Control Coefficient of Transketolase in the Nonoxidative Pentose-Phosphate Pathway of Human Erythrocytes - Nmr, Antibody, and Computer-Simulation Studies. Biochemistry, 31 51: 12792-12798. doi:10.1021/bi00166a012
Booth, CK, Nixon, PF and Winzor, DJ (1992) Gel chromatographic evaluation of the binding constant for the interaction of thiamin diphosphate with magnesium ion. Journal of Chromatography A, 609 1-2: 83-87. doi:10.1016/0021-9673(92)80151-J
Nixon, PF, Diefenbach, RJ and Duggleby, RG (1992) Inhibition of transketolase and pyruvate decarboxylase by omeprazole. Biochemical Pharmacology, 44 1: 177-179. doi:10.1016/0006-2952(92)90053-L
Abedinia, M, Layfield, R, Jones, SM, Nixon, PF and Mattick, JS (1992) Nucleotide and predicted amino acid sequence of a cDNA clone encoding part of human transketolase. Biochemical and Biophysical Research Communications, 183 3: 1159-1166. doi:10.1016/S0006-291X(05)80312-2
Nixon P.F. and Waltham M.C. (1991) Interactions of Methotrexate, Trimetrexate and Piritrexim with Human and L. casei Dihydrofolate Reductases — Steady State Inhibition Constants and Dissociation Rates. Pteridines, 3 1-2: 123-124. doi:10.1515/pteridines.1991.3.12.123
Nixon P., Price J., Jago J. and Davis R. (1991) The stability of thiamine and thiamine tetrahydrofurfuryl disulfide added to table wines. Journal of Nutritional Science and Vitaminology, 37 2: 201-206. doi:10.3177/jnsv.37.201
Grimes, DJ, Bowles, MR, Buttsworth, JA, Thomson, DB, Ravenscroft, PJ, Nixon, PF, Whiting, RF and Pond, SM (1990) Survival After Unexpected High Serum Methotrexate Concentrations in a Patient with Osteogenic-Sarcoma. Drug Safety, 5 6: 447-454. doi:10.2165/00002018-199005060-00005
Nixon, Peter F., Price, John, Norman-Hicks, Maureen, Wiliams, Gail M. and Kerr, Ray A (1990) The relationship between erythrocyte transketolase activity and the 'TPP effect' in Wernicke's encephalopathy and other thiamine deficiency states. Clinica Chimica Acta, 192 2: 89-98. doi:10.1016/0009-8981(90)90072-Z
Zimitat, C, Kril, J, Harper, CG and Nixon, PF (1990) Progression of neurological disease in thiamin-deficient rats is enhanced by ethanol. Alcohol, 7 6: 493-501. doi:10.1016/0741-8329(90)90038-E
Atukorala, Tms, Duggleby, RG and Nixon, PF (1988) Effects of acetaldehyde upon catalysis by human erythrocyte transketolase. Biochemical Pharmacology, 37 10: 2100-2101. doi:10.1016/0006-2952(88)90563-1
Waltham, MC, Holland, JW, Nixon, PF and Winzor, DJ (1988) Thermodynamic Characterization of the Interactions of Methotrexate with Dihydrofolate-Reductase by Quantitative Affinity-Chromatography. Biochemical Pharmacology, 37 3: 541-545. doi:10.1016/0006-2952(88)90226-2
Waltham, MC, Holland, JW, Robinson, SC, Winzor, DJ and Nixon, PF (1988) Direct Experimental-Evidence for Competitive-Inhibition of Dihydrofolate-Reductase by Methotrexate. Biochemical Pharmacology, 37 3: 535-539. doi:10.1016/0006-2952(88)90225-0
Nixon, Peter F. (1988) Biochemical Aspects of the Pathogenesis of the Wernicke‐Korsakoff Syndrome. Australian Drug and Alcohol Review, 7 1: 75-77. doi:10.1080/09595238880000171
Price, J, Kerr, R, Hicks, M and Nixon, PF (1987) The Wernicke-Korsakoff-Syndrome - a Reappraisal in Queensland with Special Reference to Prevention. Medical Journal of Australia, 147 11-12: 561-565.
Tate, JR and Nixon, PF (1987) Measurement of Michaelis constant for human erythrocyte transketolase and thiamin diphosphate. Analytical Biochemistry, 160 1: 78-87. doi:10.1016/0003-2697(87)90616-6
NIXON, PETER F. (1986) REPLY. Australian and New Zealand Journal of Medicine, 16 1: 109-109. doi:10.1111/j.1445-5994.1986.tb01144.x
Tate, Jill, Kaczmarek, M.Jan and Nixon, Peter F. (1984) Stimulation of erythrocyte transketolase by added thiamin diphosphate is pH dependent. Clinica Chimica Acta, 137 1: 81-86. doi:10.1016/0009-8981(84)90315-2
Nixon, PF, Kaczmarek, MJ, Tate, J, Kerr, RA and Price, J (1984) An Erythrocyte Transketolase Isoenzyme Pattern Associated with the Wernicke-Korsakoff Syndrome. European Journal of Clinical Investigation, 14 4: 278-281. doi:10.1111/j.1365-2362.1984.tb01181.x
Kaczmarek, M.Jan and Nixon, Peter F. (1983) Variants of transketolase from human erythrocytes. Clinica Chimica Acta, 130 3: 349-356. doi:10.1016/0009-8981(83)90309-1
Nixon, P., Knudsen, H. A. and Sharon, S. M. (1981) Os interphalangeale II: A case report. Journal of Foot Surgery, 20 2: 79-80.
Cassady, IA, Budge, MM, Healy, MJ and Nixon, PF (1980) An inverse relationship of rat liver folate polyglutamate chain length to nutritional folate sufficiency. BBA - General Subjects, 633 2: 258-268. doi:10.1016/0304-4165(80)90411-0
Nixon, P. F. and Bertino, J. R. (1980) [74] Enzymic Preparations of Radiolabeled +-L-5-Methyltetrahydrofolate and +-L-Formyltetrahydrofolate. Methods in Enzymology, 66 C: 547-553. doi:10.1016/0076-6879(80)66504-5
Richardson, RE, Healy, MJ and Nixon, PF (1979) Folates of rat tissue. Bioassay of tissue folypolyglutamates and a relationship of liver folypolyglutamates to nutritional folate sufficiency. BBA - General Subjects, 585 1: 128-133. doi:10.1016/0304-4165(79)90332-5
Nixon, PF (1979) Folinic Acid - Pharmacokinetics and Pharmacodynamics. Clinical and Experimental Pharmacology and Physiology, 5 35-41.
Nixon, P. F. (1979) Folinic acid: Pharmacokinetics and pharmacodynamics. Clinical and Experimental Pharmacology and Physiology, 6 5 Supp.: 35-41.
Nixon P.F. (1978) The urinary melanogen cysteinyldopa in melanoma and in suntanning: Australian experience. Australian and New Zealand Journal of Surgery, 48 1: 17-21. doi:10.1111/j.1445-2197.1978.tb05797.x
Nixon, PF (1976) Melanin Biosynthesis in Skin - Red-Skinned New Guinean. Papua New Guinea Medical Journal, 19 4: 243-253.
Nixon, PF (1974) Clinical Pharmacology in Australia. Clinical Pharmacology & Therapeutics, 16 3: 545-553.
Nixon, Peter F., Slutsky, Gerald, Nahas, Aly and Bertino, Joseph R. (1973) The turnover of folate coenzymes in murine lymphoma cells. Journal of Biological Chemistry, 248 17: 5932-5936.
Nixon, P. F. and Bertino, J. R. (1972) Impaired utilization of serum folate in pernicious anemia. A study with radiolabeled 5-methyltetrahydrofolate. The Journal of clinical investigation, 51 6: 1431-1439. doi:10.1172/JCI106939
Nixon, Peter F. and Bertino, Joseph R. (1972) Effective absorption and utilization of oral formyltetrahydrofolate in man. New England Journal of Medicine, 286 4: 175-179. doi:10.1056/NEJM197201272860402
McCullough, Jerry L., Nixon, Peter F. and Bertino, Joseph R. (1971) DISCUSSION PAPER: KINETIC INVESTIGATION OF THE REACTION MECHANISM OF DIHYDROFOLATE REDUCTASE FROM L1210 CELLS. Annals of the New York Academy of Sciences, 186 1: 131-142. doi:10.1111/j.1749-6632.1971.tb46964.x
Levitt, M., Nixon, P. F., Pincus, J. H. and Bertino, J. R. (1971) Transport characteristics of folates in cerebrospinal fluid; a study utilizing doubly labeled 5-methyltetrahydrofolate and 5-formyltetrahydrofolate. The Journal of clinical investigation, 50 6: 1301-1308. doi:10.1172/JCI106609
Blakley, R. L., Schrock, Mary, Sommer, Kathleen and Nixon, P. F. (1971) KINETIC STUDIES OF THE REACTION MECHANISM OF DIHYDROFOLATE REDUCTASE. Annals of the New York Academy of Sciences, 186 1: 119-130. doi:10.1111/j.1749-6632.1971.tb46963.x
Strum, W., Nixon, P. F., Bertino, J. B. and Binder, H. J. (1971) Intestinal folate absorption. I. 5-Methyltetrahydrofolic acid. The Journal of clinical investigation, 50 9: 1910-1916. doi:10.1172/JCI106683
Nixon, P. F. and Bertino, J. R. (1971) Separation and Identification of Folate Coenzymes on DEAE-Sephadex. Methods in Enzymology, 18 PB: 661-663. doi:10.1016/S0076-6879(71)18136-0
Nixon, PF and Bertino, JR (1971) Enzymic preparations of radiolabeled (+)-l-5-methyltetrahydrofolate and (+)-l-5-formyltetrahydrofolate. Analytical Biochemistry, 43 1: 162-172. doi:10.1016/0003-2697(71)90121-7
Nixon, PF and Bertino, JR (1970) Interrelationships of vitamin B12 and folate in man. The American Journal of Medicine, 48 5: 555-561. doi:10.1016/0002-9343(70)90004-5
Nixon, PF and Bertino, JR (1970) Inhibition of Peptide Chain Initiation in Escherichia-Coli by Hydroxylamine - Reaction of Hydroxylamine with Folate Coenzymes. Biochemistry, 9 25: 4833-&. doi:10.1021/bi00827a001
Bertino, J. R. and Nixon, P. F. (1969) Nutritional Factors in the Design of More Selective Antitumor Agents. Cancer Research, 29 12: 2417-2421.
Nixon, P. F. and Blakley, R. L. (1968) Dihydrofolate reductase of Streptococcus faecium II. Purification and some properties of two dihydrofolate reductases from the Amethopterin-resistant mutant, Streptococcus Faecium Var. Durans Strain A. Journal of Biological Chemistry, 243 18: 4722-4731.
Hillcoat, BL, Nixon, PF and Blakley, RL (1967) Effect of Substrate Decomposition On Spectrophotometric Assay of Dihydrofolate Reductase. Analytical Biochemistry, 21 2: 178-&. doi:10.1016/0003-2697(67)90179-0
Blakley, RL, Ghambeer, RK, Nixon, PF and Vitols, E (1965) Cobamide-Dependent Ribonucleoside Triphosphate Reductase of Lactobacilli. Biochemical and Biophysical Research Communications, 20 4: 439-&. doi:10.1016/0006-291X(65)90597-8
Bayrd, E, Nixon, PF, Jeremy, R and Hirst, E (1963) Conference At Sydney Hospital - Increased Platelets and Abdominal Mass. Medical Journal of Australia, 2 19: 796-&.
Conference Papers
Jones, M. L., Treloar, W. and Nixon, P. F. (2001). Availability of folate bound to folate-binding protein: Environmental effects. In: H. C. Deeth, Australian Journal of Dairy Technology: 2nd Dairy Industry Association of Australia World Series of Dairy Science Conference. 2nd Dairy Industry Association of Australia World Series of Dairy Science Conference, Australia, (95-95). 2001.
Hutchinson, M. L., Jones, M. and Nixon, P. F. (2000). Stability of labile folate is enhanced by binding milk folate-binding protein. In: Australian Journal of Dairy Technology: Dairy Ingredient Science 2000 Conference. Dairy Ingredient Science 2000 Conference, Melbourne, Australia, (98-98). 28-30 Jun, 2000.
Jones, MD, Hutchinson, ML and Nixon, PF (2000). Milk folate-binding protein; ligand-binding properties and polymerization properties. In: Dairy Ingredient Science 2000 Conference, Melbourne, Australia, (97-97). 2000.
Huang, C., Nixon, P. F. and Duggleby, R. G. (1999). Site-directed mutagenesis of four histidines (106, 110, 113 and 114) in Zymomonas mobilis pyruvate decarboxylase: activity and pH dependence. In: Enzyme Structure and Function: A Satellite Conference of the Australian Society for Biochemistry and Molecular Biology. A Satellite Conference of the Australian Society for Biochemistry and Molecular Biology, Fraser Island, Queensland, Australia, (9b-9b). 22-25 September, 1999.
Huang, C., Nixon, P. F. and Duggleby, R. G. (1999). Site-directed mutagenesis of four histidines (106, 110, 113 and 114) in Zymomonas mobilis pyruvate decarboxylase: Activity and pH dependence. In: Combined Conference Abstracts: 43rd Annual ASBMB, 18th Annual ANZSCDB and 39th Annual ASPP. ComBio 99, Conrad Jupiters, Gold Coast, (Pos-Wed-69). 27th - 30th September, 1999.
Chang, A. K., Duggleby, R. G. and Nixon, P. F. (1999). A study of the role of the C-terminal helix of Zymomonas mobilis pyruvate decarboxylase. In: Enzyme Structure and Function - A Satellite Conference of the Australian Society for Biochemistry and Molecular Biology. Enzyme Strucutre and Function, Fraser Island, (9a). 22-25 September, 1999.
Schenk, G, Leeper, FJ, England, R, Nixon, PF and Duggleby, RG (1997). Investigation of the mechanistic functions of residues HIS113 and HIS114 in pyruvate decarboxylase from Zymomonas mobilis: A proposed model in the binding of the substrate pyruvate. In: Faseb Journal. , , (A1135-A1135). .
Galea, C. A., Hanson, G. R., Reilly, P. and Nixon, P. F. (1994). A novel monooxygenase activity of methaemoglobin. In: Proceedings of the Australian Society for Biochemistry and Molecular Biology. 38th Annual Conference of the Australian Society for Biochemistry and Molecular Biology (ASBMB), Gold Coast, QLD, Australia, (). 26-29 September 1994.
Waltham, MC, Holland, JW, Robinson, SC, Nixon, PF and Winzor, DJ (1987). Methotrexate - a Tight-Binding But Classical Competitive Inhibitor of Dihydrofolate-Reductase From a Methotrexate Resistant Strain of Lactobacillus-Casei. In: Australian and New Zealand Journal of Medicine. , , (166-166). .
Kaczmarek, MJ, Tate, J and Nixon, PF (1983). Brain-Damage in Thiamine-Deficiency Correlates with a Particular Variant of Human-Erythrocyte Transketolase. In: Proceedings of the Australian Biochemical Society. , , (12-12). .
Kaczmarek, MJ and Nixon, PF (1982). Variants of Human Transketolase. In: Clinical and Experimental Pharmacology and Physiology. , , (548-548). .
Cassady, IC, Healy, MJ and Nixon, PF (1980). Folate Nutrition Affects the Distribution of Liver Folate Conjugates. In: Clinical and Experimental Pharmacology and Physiology. , , (91-91). .
Cassady, IC, Healy, MJ and Nixon, PF (1978). Liver Folate Conjugates Related to Nutritional Folate Sufficiency and a Fluorescence Assay for Pteroylpolyglutamates. In: Proceedings of the Australian Biochemical Society. , , (43-43). .
Healy, MJ, Nixon, PF and Halpern, B (1977). Role of Folates in Production of Tetrahydroisoquinolines in Rat-Brain. In: Proceedings of the Australian Biochemical Society. , , (48-48). .
Nixon, PF (1975). Studies On Mechanism of Inherited Red Skin Color Found Among New-Guineans. In: Proceedings of the Australian Biochemical Society. , , (66-66). .