School of Chemistry and Molecular Biosciences

Emeritus Professor Alastair McEwan

BSc (Hons) University of Leeds (1979), PhD University of Birmingham (1984), Postdoctoral research University of Illinois at Urbana-Champaign, University of Oxford
Professor & Emeritus Professor
School of Chemistry and Molecular Biosciences

Primary research interest

Redox biology and bacterial pathogenesis

Additional role

Investigator, Australian Infectious Diseases Research Centre

Research focus and collaborations

My research interests are in the role of transition metal ions and redox processes in biology. The main focus of our research is bacterial pathogens, principally Streptococcus pneumoniae, Neisseria gonorrhoeae, Haemophilus influenzae and enteric bacteria. This research also involves investigation of the interaction between bacterial pathogens and the host innate immune system.

Current research projects include:

  • the biochemical mechanism of action of the novel thiol-based sensor NmlR and its role in the regulation of the response to nitrosative and carbonyl stress in bacterial pathogens
  • interplay between manganese, iron and zinc in the control of the virulence of pneumococcus
  • trafficking of copper and iron in macrophages in response to bacterial pathogens
  • adaptation of the respiratory chains of bacterial pathogens in response to metal ion and carbon source availability.

 

Copper-containing vesicles in murine macrphages infected with Salmonella Typhimurium
Copper-containing vesicles in murine macrphages infected with SalmonellaTyphimurium. The image is a false colour overlay with copper pools in green and macrophage and Salmonella DNA (DAPI) in red.
Localisation of copper pools in murine macrophages infected with Salmonella Typhimurium. Left panel shows macrophage nucleus and Salmonella. Centre panel shows copper pools inside the infected macrophages. Right panel shows image analysis using InCell Developer (GE) - bacteria are circled in green, copper containing vesicles in purple and macrophage nucleus in red.

 

 

 

Funded projects

  • the biochemical mechanism of action of the novel thiol-based sensor NmlR and its role in the regulation of the response to nitrosative and carbonyl stress in bacterial pathogens
  • interplay between manganese, iron and zinc in the control of the virulence of pneumococcus
  • trafficking of copper and iron in macrophages in response to bacterial pathogens
  • adaptation of the respiratory chains of bacterial pathogens in response to metal ion and carbon source availability.
  • NHMRC Project Grant 2008-2010, Copper and its antibacterial action: an emerging aspect of host defence against bacterial pathogens, Total value of grant: $291,083
  • NHMRC Project Grant 2009-2011, The molecular physiology of Streptococcus pneumoniae during sepsis, Total value of grant: $1,097,500
  • ARC Discovery Project Grant 2010-2012, Disulfide Catalysis and Protein Folding in Bacterial Virulence, Total value of grant: $300,000 (2nd-named Chief Investigator)
  • ARC Discovery Project Grant 2009-2011, NmlR-dependent thiol-based redox systems and their role in global stress responses in bacteria, Total value of grant: $300,000
  • University of Adelaide 2010-2014, Pathogenesis, treatment and prevention of bacterial infectious diseases (Univ Adelaide lead institution), Total value of grant: $3,790,000 (2nd-named Chief Investigator)

Awards and achievements 

  • 1983 - University Research Fellowship
  • 1985 - NATO Postdoctoral Fellowship
  • 1988 - Royal Society

Featured publications

Publications

Book Chapters (2)
Journal Articles (202)
Conference Papers (43)

Book Chapters

Djoko, Karrera Y., Achard, Maud E. S. and McEwan, Alastair G. (2013). Copper in immune cells. Metals in Cells. (pp. 409-420) edited by Valeria Culotta and Robert A. Scott. Hoboken, New Jersey, USA: John Wiley & Sons. doi: 10.1002/9781119951438
McEwan, A. G., Kappler, U. and Mc Devitt, C. (2004). Microbial molybdenum-containing enzymes in respiration: Structural and functional aspects. Respiration in Archaea and Bacteria. (pp. 176-202) edited by D. Zannoni. Dordrecht, Netherlands: Kluwer.

Journal Articles

Hosmer, Jennifer, McEwan, Alastair G and Kappler, Ulrike (2024). Bacterial acetate metabolism and its influence on human epithelia. Emerging Topics in Life Sciences, 8 (1), 1-13. doi: 10.1042/ETLS20220092
McEwan, Alastair G. (2024). Metalloproteome plasticity - a factor in bacterial pathogen adaptive responses?. Emerging Topics in Life Sciences, 8 (1), 57-60. doi: 10.1042/ETLS20230116
Nasreen, Marufa, Ellis, Daniel, Hosmer, Jennifer, Essilfie, Ama-Tawiah, Fantino, Emmanuelle, Sly, Peter, McEwan, Alastair G. and Kappler, Ulrike (2024). The DmsABC S-oxide reductase is an essential component of a novel, hypochlorite-inducible system of extracellular stress defense in Haemophilus influenzae. Frontiers in Microbiology, 15 1359513. doi: 10.3389/fmicb.2024.1359513
Nasreen, Marufa, Nair, Remya Purushothaman, McEwan, Alastair G. and Kappler, Ulrike (2022). The peptide methionine sulfoxide reductase (MsrAB) of Haemophilus influenzae repairs oxidatively damaged outer membrane and periplasmic proteins involved in nutrient acquisition and virulence. Antioxidants, 11 (8) 1557, 1-18. doi: 10.3390/antiox11081557
De Oliveira, David M. P., Keller, Bernhard, Hayes, Andrew J., Ong, Cheryl-Lynn Y., Harbison-Price, Nichaela, El-Deeb, Ibrahim M., Li, Gen, Keller, Nadia, Bohlmann, Lisa, Brouwer, Stephan, Turner, Andrew G., Cork, Amanda J., Jones, Thomas R., Paterson, David L., McEwan, Alastair G., Davies, Mark R., McDevitt, Christopher A., Itzstein, Mark von and Walker, Mark J. (2022). Neurodegenerative disease treatment drug PBT2 breaks intrinsic polymyxin resistance in Gram-positive bacteria. Antibiotics, 11 (4) 449, 449. doi: 10.3390/antibiotics11040449
Hosmer, Jennifer, Nasreen, Marufa, Dhouib, Rabeb, Essilfie, Ama-Tawiah, Schirra, Horst Joachim, Henningham, Anna, Fantino, Emmanuelle, Sly, Peter, McEwan, Alastair G. and Kappler, Ulrike (2022). Access to highly specialized growth substrates and production of epithelial immunomodulatory metabolites determine survival of Haemophilus influenzae in human airway epithelial cells. PLoS Pathogens, 18 (1) e1010209, e1010209. doi: 10.1371/journal.ppat.1010209
De Oliveira, David M. P., Forde, Brian M., Phan, Minh-Duy, Steiner, Bernhard, Zhang, Bing, Zuegg, Johannes, El-deeb, Ibrahim M., Li, Gen, Keller, Nadia, Brouwer, Stephan, Harbison-Price, Nichaela, Cork, Amanda J., Bauer, Michelle J., Alquethamy, Saleh F., Beatson, Scott A., Roberts, Jason A., Paterson, David L., McEwan, Alastair G., Blaskovich, Mark A. T., Schembri, Mark A., McDevitt, Christopher A., von Itzstein, Mark and Walker, Mark J. (2022). Rescuing Tetracycline Class Antibiotics for the Treatment of Multidrug-Resistant Acinetobacter baumannii Pulmonary Infection. mBio, 13 (1) e03517, e0351721. doi: 10.1128/mbio.03517-21
Brazel, Erin B., Tan, Aimee, Neville, Stephanie L., Iverson, Amy R., Udagedara, Saumya R., Cunningham, Bliss A., Sikanyika, Mwilye, De Oliveira, David M.P., Keller, Bernhard, Bohlmann, Lisa, El-Deeb, Ibrahim M., Ganio, Katherine, Eijkelkamp, Bart A., McEwan, Alastair G., von Itzstein, Mark, Maher, Megan J., Walker, Mark J., Rosch, Jason W. and McDevitt, Christopher A. (2022). Dysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model. Cell Reports, 38 (2) 110202, 1-18. doi: 10.1016/j.celrep.2021.110202
Dhouib, Rabeb, Nasreen, Marufa, Othman, Dk Seti Maimonah Pg, Ellis, Daniel, Lee, Simon, Essilfie, Ama-Tawiah, Hansbro, Philip M., McEwan, Alastair G. and Kappler, Ulrike (2021). The DmsABC sulfoxide reductase supports virulence in non-typeable Haemophilus influenzae. Frontiers in Microbiology, 12 686833, 686833. doi: 10.3389/fmicb.2021.686833
Nasreen, Marufa, Fletcher, Aidan, Hosmer, Jennifer, Zhong, Qifeng, Essilfie, Ama-Tawiah, McEwan, Alastair G. and Kappler, Ulrike (2021). The alternative sigma factor RpoE2 Is involved in the stress response to hypochlorite and in vivo survival of Haemophilus influenzae. Frontiers in Microbiology, 12 637213, 637213. doi: 10.3389/fmicb.2021.637213
Struwe, Michel A., Kalimuthu, Palraj, Luo, Zhenyao, Zhong, Qifeng, Ellis, Daniel, Yang, Jing, Khadanand, K.C., Harmer, Jeffrey R., Kirk, Martin L., McEwan, Alastair G., Clement, Bernd, Bernhardt, Paul V., Kobe, Bostjan and Kappler, Ulrike (2021). Active site architecture reveals coordination sphere flexibility and specificity determinants in a group of closely related molybdoenzymes. Journal of Biological Chemistry, 296 100672, 1-16. doi: 10.1016/j.jbc.2021.100672
Stewart, Louisa J., Ong, Cheryl-Lynn Y., Zhang, May M., Brouwer, Stephan, McIntyre, Liam, Davies, Mark R., Walker, Mark J., McEwan, Alastair G., Waldron, Kevin J. and Djoko, Karrera Y. (2020). Role of glutathione in buffering excess intracellular copper in Streptococcus pyogenes. mBio, 11 (6) e02804-20, 1-19. doi: 10.1128/mBio.02804-20
De Oliveira, David M. P., Bohlmann, Lisa, Conroy, Trent, Jen, Freda E.-C., Everest-Dass, Arun, Hansford, Karl A., Bolisetti, Raghu, El-Deeb, Ibrahim M., Forde, Brian M., Phan, Minh-Duy, Lacey, Jake A., Tan, Aimee, Rivera-Hernandez, Tania, Brouwer, Stephan, Keller, Nadia, Kidd, Timothy J., Cork, Amanda J., Bauer, Michelle J., Cook, Gregory M., Davies, Mark R., Beatson, Scott A., Paterson, David L., McEwan, Alastair G., Li, Jian, Schembri, Mark A., Blaskovich, Mark A. T., Jennings, Michael P., McDevitt, Christopher A., von Itzstein, Mark and Walker, Mark J. (2020). Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis. Science Translational Medicine, 12 (570) abb3791, eabb3791. doi: 10.1126/scitranslmed.abb3791
Nasreen, Marufa, Dhouib, Rabeb, Hosmer, Jennifer, Wijesinghe, Hewa Godage Sithija, Fletcher, Aidan, Mahawar, Manish, Essilfie, Ama-Tawiah, Blackall, Patrick J., McEwan, Alastair G. and Kappler, Ulrike (2020). Peptide methionine sulfoxide reductase from Haemophilus influenzae is required for protection against HOCl and affects the host response to infection. ACS Infectious Diseases, 6 (7), 1928-1939. doi: 10.1021/acsinfecdis.0c00242
Chen, Nathan H., Ong, Cheryl-Lynn Y, O'Sullivan, Jonathan, Ibranovic, Ines, Davey, Krystelle, Edwards, Jennifer L. and McEwan, Alastair G. (2020). Two distinct L-lactate dehydrogenases play a role in the survival of Neisseria gonorrhoeae in cervical epithelial cells. The Journal of infectious diseases, 221 (3), 449-453. doi: 10.1093/infdis/jiz468
Eijkelkamp, Bart A., Morey, Jacqueline R., Neville, Stephanie L., Tan, Aimee, Pederick, Victoria G., Cole, Nerida, Singh, Prashina P., Ong, Cheryl-Lynn Y., Gonzalez de Vega, Raquel, Clases, David, Cunningham, Bliss A., Hughes, Catherine E., Comerford, Iain, Brazel, Erin B., Whittall, Jonathan J., Plumptre, Charles D., McColl, Shaun R., Paton, James C., McEwan, Alastair G., Doble, Philip A. and McDevitt, Christopher A. (2019). Dietary zinc and the control of Streptococcus pneumoniae infection. PLOS Pathogens, 15 (8) e1007957, e1007957. doi: 10.1371/journal.ppat.1007957
Kappler, Ulrike, Nasreen, Marufa and McEwan, Alastair (2019). New insights into the molecular physiology of sulfoxide reduction in bacteria. Advances in Microbial Physiology, 75, 1-51. doi: 10.1016/bs.ampbs.2019.05.001
Edgar, Rebecca J., van Hensbergen, Vincent P., Ruda, Alessandro, Turner, Andrew G., Deng, Pan, Le Breton, Yoann, El-Sayed, Najib M., Belew, Ashton T., McIver, Kevin S., McEwan, Alastair G., Morris, Andrew J., Lambeau, Gérard, Walker, Mark J., Rush, Jeffrey S., Korotkov, Konstantin V., Widmalm, Göran, van Sorge, Nina M. and Korotkova, Natalia (2019). Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides. Nature Chemical Biology, 15 (5), 463-471. doi: 10.1038/s41589-019-0251-4
Muda, Noor Marian, Nasreen, Marufa, Dhouib, Rabeb, Hosmer, Jennifer, Hill, Julian, Mahawar, Manish, Schirra, Horst Joachim, McEwan, Alastair G. and Kappler, Ulrike (2019). Metabolic analyses reveal common adaptations in two invasive Haemophilus influenzae strains. Pathogens and Disease, 77 (2) ftz015. doi: 10.1093/femspd/ftz015
Stocks, Claudia J., Phan, Minh-Duy, Achard, Maud E. S., Nhu, Nguyen Thi Khanh, Condon, Nicholas D., Gawthorne, Jayde A., Lo, Alvin W., Peters, Kate M., McEwan, Alastair G., Kapetanovic, Ronan, Schembri, Mark A. and Sweet, Matthew J. (2019). Uropathogenic Escherichia coli employs both evasion and resistance to subvert innate immune-mediated zinc toxicity for dissemination. Proceedings of the National Academy of Sciences, 116 (13), 6341-6350. doi: 10.1073/pnas.1820870116
Turner, Andrew G., Djoko, Karrera Y., Ong, Cheryl-Lynn Y., Barnett, Timothy C., Walker, Mark J. and McEwan, Alastair G. (2019). Group A Streptococcus co-ordinates manganese import and iron efflux in response to hydrogen peroxide stress. Biochemical Journal, 476 (3), 595-611. doi: 10.1042/BCJ20180902
Stewart, Louisa J., Thaqi, Denis, Kobe, Bostjan, McEwan, Alastair G., Waldron, Kevin J. and Djoko, Karrera Y. (2019). Handling of nutrient copper in the bacterial envelope. Metallomics, 11 (1), 50-63. doi: 10.1039/c8mt00218e
Bohlmann, Lisa, De Oliveira, David M. P., El-Deeb, Ibrahim M., Brazel, Erin B., Harbison-Price, Nichaela, Ong, Cheryl-lynn Y., Rivera-Hernandez, Tania, Ferguson, Scott A., Cork, Amanda J., Phan, Minh-Duy, Soderholm, Amelia T., Davies, Mark R., Nimmo, Graeme R., Dougan, Gordon, Schembri, Mark A., Cook, Gregory M., McEwan, Alastair G., von Itzstein, Mark, McDevitt, Christopher A. and Walker, Mark J. (2018). Chemical synergy between ionophore PBT2 and zinc reverses antibiotic resistance. mBio, 9 (6) e02391-18, 1-12. doi: 10.1128/mBio.02391-18
Bohlmann, Lisa, De Oliveira, David M. P., El-Deeb, Ibrahim M., Brazel, Erin B., Harbison-Price, Nichaela, Ong, Cheryl-lynn Y., Rivera-Hernandez, Tania, Ferguson, Scott A., Cork, Amanda J., Phan, Minh-Duy, Soderholm, Amelia T., Davies, Mark R., Nimmo, Graeme R., Dougan, Gordon, Schembri, Mark A., Cook, Gregory M., McEwan, Alastair G., von Itzstein, Mark, McDevitt, Christopher A. and Walker, Mark J. (2018). Chemical synergy between ionophore PBT2 and zinc reverses antibiotic resistance. mBio, 9 (6) e02391-18. doi: 10.1128/mbio.02391-18
Ong, Cheryl-Lynn Y., Berking, Olga, Walker, Mark J. and McEwan, Alastair G. (2018). The role of zinc acquisition and zinc tolerance in group A streptococcal infection. Infection and Immunity, 86 (6) e00048-18, e00048-18. doi: 10.1128/IAI.00048-18
Djoko, Karrera Y., Achard, Maud E. S., Phan, Minh-Duy, Lo, Alvin W., Miraula, Manfredi, Prombhul, Sasiprapa, Hancock, Steven J., Peters, Kate M., Sidjabat, Hanna E., Harris, Patrick N., Mitić, Nataša, Walsh, Timothy R., Anderson, Gregory J., Shafer, William M., Paterson, David L., Schenk, Gerhard, McEwan, Alastair G. and Schembri, Mark A. (2018). Copper ions and coordination complexes as novel carbapenem adjuvants. Antimicrobial Agents and Chemotherapy, 62 (2) e02280-17. doi: 10.1128/AAC.02280-17
Marsh, James W., Djoko, Karrera Y., McEwan, Alastair G. and Huston, Wilhelmina M. (2017). Copper(II)-bis(thiosemicarbazonato) complexes as anti-chlamydial agents. Pathogens and Disease, 75 (7) ftx084, 1-4. doi: 10.1093/femspd/ftx084
Djoko, Karrera Y., Phan, Minh-Duy, Peters, Kate M., Walker, Mark J. , Schembri, Mark A. and McEwan, Alastair G. (2017). Interplay between tolerance mechanisms to copper and acid stress in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America, 114 (26), 6818-6823. doi: 10.1073/pnas.1620232114
Turner, Andrew G., Ong, Cheryl-lynn Y., Djoko, Karrera Y., West, Nicholas P., Davies, Mark R., McEwan, Alastair G. and Walker, Mark J. (2017). The PerR-regulated P1B-4 type ATPase (PmtA) acts as a ferrous iron efflux pump in Streptococcus pyogenes. Infection and Immunity, 85 (6) e00140-17, e00140-17.1-e00140-17.13. doi: 10.1128/IAI.00140-17
Kappler, Ulrike, Dhouib, Rabeb, Nair, Remya Purushothaman and McEwan, Alastair G. (2017). Draft genome sequences of three nontypeable strains of Haemophilus influenzae, C188, R535, and 1200, isolated from different types of disease. Genome Announcements, 5 (12) e00035-17, e00035-17. doi: 10.1128/genomeA.00035-17
Turner, Andrew G., Ong, Cheryl-lynn Y., Walker, Mark J., Djoko, Karrera Y. and McEwan, Alastair G. (2017). Transition metal homeostasis in Streptococcus pyogenes and Streptococcus pneumoniae. Advances in Microbial Physiology, 70, 123-191. doi: 10.1016/bs.ampbs.2017.01.002
Dhouib, Rabeb, Othman, Dk. Seti Maimonah Pg, Lin, Victor, Lai, Xuanjie J., Wijesinghe, Hewa G. S., Essilfie, Ama-Tawiah, Davis, Amanda, Nasreen, Marufa, Bernhardt, Paul V., Hansbro, Philip M., McEwan, Alastair G. and Kappler, Ulrike (2016). A novel, molybdenum-containing methionine sulfoxide reductase supports survival of Haemophilus influenzae in an in vivo model of infection. Frontiers in Microbiology, 7 (NOV) 1743, 1743. doi: 10.3389/fmicb.2016.01743
Shepherd, Mark, Achard, Maud E. S., Idris, Adi, Totsika, Makrina, Phan, Minh-Duy, Peters, Kate M., Sarkar, Sohinee, Ribeiro, Cláudia A., Holyoake, Louise V., Ladakis, Dimitrios, Ulett, Glen C., Sweet, Matthew J., Poole, Robert K., McEwan, Alastair G. and Schembri, Mark A. (2016). The cytochrome bd-I respiratory oxidase augments survival of multidrug-resistant Escherichia coli during infection. Scientific Reports, 6 (1) 35285, 35285. doi: 10.1038/srep35285
Awad, Milena M., Cheung, Jackie K., Tan, Joanne E., McEwan, Alastair G., Lyras, Dena and Rood, Julian I. (2016). Functional analysis of an feoB mutant in Clostridium perfringens strain 13. Anaerobe, 41, 10-17. doi: 10.1016/j.anaerobe.2016.05.005
Couñago, Rafael M., Chen, Nathan H., Chang, Chiung-Wen, Djoko, Karrera Y., McEwan, Alastair G. and Kobe, Bostjan (2016). Structural basis of thiol-based regulation of formaldehyde detoxification in H. influenzae by a MerR regulator with no sensor region. Nucleic Acids Research, 44 (14), 6981-6993. doi: 10.1093/nar/gkw543
Chen, Nathan H., Djoko, Karrera Y., Veyrier, Frédéric J. and McEwan, Alastair G. (2016). Formaldehyde stress responses in bacterial pathogens. Frontiers in Microbiology, 7 (MAR) 257, 257.1-257.17. doi: 10.3389/fmicb.2016.00257
Kapetanovic, Ronan, Bokil, Nilesh J., Achard, Maud E. S., Ong, Cheryl-lynn Y, Peters, Kate M., Stocks, Claudia J., Phan, Minh-Duy, Monteleone, Mercedes, Schroder, Kate, Irvine, Katharine M., Saunders, Bernadette M., Walker, Mark J., Stacey, Katryn J., McEwan, Alastair G., Schembri, Mark A. and Sweet, Matthew J. (2016). Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages. The FASEB Journal, 30 (5), 1901-1912. doi: 10.1096/fj.201500061
Zhang, May M., Ong, Cheryl-lynn, Walker, Mark J. and McEwan, Alastair G. (2015). Defence against methylglyoxal in Group A Streptococcus: a role for Glyoxylase I in bacterial virulence and survival in neutrophils?. Pathogens and Disease, 74 (2), ftv122. doi: 10.1093/femspd/ftv122
Dhouib, Rabeb, Othman, Dk S. M. Pg, Essilfie, Ama-Tawiah, Hansbro, Phil M., Hanson, Jeffrey O., McEwan, Alastair G. and Kappler, Ulrike (2015). Maturation of molybdoenzymes and its influence on the pathogenesis of non-typeable Haemophilus influenzae. Frontiers in Microbiology, 6 (1219) 1219, 1-11. doi: 10.3389/fmicb.2015.01219
Djoko, Karrera Y., Schembri, Maira M., Donnelly, Paul S., Schembri, Mark A., Shafer, William M. and McEwan, Alastair G. (2015). Copper(II)-bis(thiosemicarbazonato) complexes as antibacterial agents: insights into their mode of action and potential as therapeutics. Antimicrobial Agents and Chemotherapy, 59 (10), 6444-6453. doi: 10.1128/aac.01289-15
Djoko, Karrera Y, Ong, Cheryl-lynn Y, Walker, Mark J and McEwan, Alastair G (2015). The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens.. Journal of Biological Chemistry, 290 (31), 18954-18961. doi: 10.1074/jbc.R115.647099
Atack, John M., Srikhanta, Yogitha N., Fox, Kate L., Jurcisek, Joseph A., Brockman, KL, Clark, Tyson A., Boitano, Matthew, Power, Peter M., Jen, Freda E.-C., McEwan, Alastair G., Grimmond, Sean M., Smith, Arnold L., Barenkamp, Stephen J., Korlach, Jonas, Bakaletz, Lauren O. and Jennings, Michael P. (2015). A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in non-typeable Haemophilus influenzae.. Nature Communications, 6 (Art No.: 7828) 7828, 7828. doi: 10.1038/ncomms8828
Ong, Cheryl-lynnY., Walker, Mark J. and McEwan, Alastair G. (2015). Zinc disrupts central carbon metabolism and capsule biosynthesis in Streptococcus pyogenes.. Scientific Reports, 5 (Art No.: 10799) 10799, 10799. doi: 10.1038/srep10799.
Jen, Freda E. C., Djoko, Karrera Y., Bent, Stephen J., Day, Christopher J., McEwan, Alastair G. and Jennings, Michael P. (2015). A genetic screen reveals a periplasmic copper chaperone required for nitrite reductase activity in pathogenic Neisseria.. The FASEB Journal, 29 (9), 3828-3838. doi: 10.1096/fj.15-270751
Turner, Andrew G., Ong, Cheryl-lynn, Gillen, Christine M., Davies, Mark R., West, Nicholas P., McEwan, Alastair G. and Walker, Mark J. (2015). Manganese homeostasis in group A Streptococcus is critical for resistance to oxidative stress and virulence. mBio, 6 (2) e00278-15, 1-10. doi: 10.1128/mBio.00278-15
Begg, Stephanie L., Eijkelkamp, Bart A., Luo, Zhenyao, Couñago, Rafael M., Morey, Jacqueline R., Maher, Megan J., Ong, Cheryl-lynn Y., McEwan, Alastair G., Kobe, Bostjan, O'Mara, Megan L., Paton, James C. and McDevitt, Christopher A. (2015). Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae. Nature Communications, 6 (6418) 6418, 1-11. doi: 10.1038/ncomms7418
Bajaj, Megha, Mamidyala, Sreeman K., Zuegg, Johannes, Begg, Stephanie L., Ween, Miranda P., Luo, Zhenyao, Huang, Johnny Xiao, McEwan, Alastair G., Kobe, Bostjan, Paton, James C., McDevitt, Christopher A. and Cooper, Matthew A. (2015). Discovery of novel pneumococcal surface antigen A (PsaA) inhibitors using a fragment-based drug design approach. ACS Chemical Biology, 10 (6), 1511-1520. doi: 10.1021/cb501032x
Chen, Kuan I., Challinor, Victoria L., Kielmann, Linda, Sharpe, Philip C., De Voss, James J., Kappler, Ulrike, McEwan, Alastair G. and Bernhardt, Paul V. (2014). Electrochemically mediated enantioselective reduction of chiral sulfoxides. Journal of Biological Inorganic Chemistry, 20 (2), 395-402. doi: 10.1007/s00775-014-1215-5
Djoko, Karrera Y., Donnelly, Paul S. and McEwan, Alastair G. (2014). Inhibition of respiratory Complex I by copper(ii)-bis(thiosemicarbazonato) complexes. Metallomics, 6 (12), 2250-2259. doi: 10.1039/C4MT00226A
Ong, Cheryl-lynn Y., Gillen, Christine M., Barnett, Timothy C., Walker, Mark J. and McEwan, Alastair G. (2014). An antimicrobial role for zinc in innate immune defence against group A streptococcus. Journal of Infectious Diseases, 209 (10), 1500-1508. doi: 10.1093/infdis/jiu053
Atack, John M., Ibranovic, Ines, Ong, Cheryl-lynn Y., Djoko, Karrera Y., Chen, Nathan H., vanden Hoven, Rachel, Jennings, Michael P., Edwards, Jennifer L. and McEwan, Alastair G. (2014). A role for lactate dehydrogenases in the survival of Neisseria gonorrhoeae in human polymorphonuclear leukocytes and cervical epithelial cells. Journal of Infectious Diseases, 210 (8), 1311-1318. doi: 10.1093/infdis/jiu230
Othman, Dk Seti Maimonah Pg, Schirra, Horst, McEwan, Alastair G. and Kappler, Ulrike (2014). Metabolic versatility in Haemophilus influenzae: a metabolomic and genomic analysis. Frontiers in Microbiology, 5 (MAR) 69, 69.1-69.10. doi: 10.3389/fmicb.2014.00069
Eijkelkamp, Bart A., Morey, Jacqueline R., Ween, Miranda P., Ong, Cheryl-lynn Y., McEwan, Alastair G., Paton, James C. and McDevitt, Christopher A. (2014). Extracellular zinc competitively inhibits manganese uptake and compromises oxidative stress management in streptococcus pneumoniae. PLoS One, 9 (2) e89427, e89427. doi: 10.1371/journal.pone.0089427
Djoko, Karrera Y., Paterson, Brett M., Donnelly, Paul S. and McEwan, Alastair G. (2014). Antimicrobial effects of copper(II) bis(thiosemicarbazonato) complexes provide new insight into their biochemical mode of action. Metallomics, Advance Article (4), 1-10. doi: 10.1039/C3MT00348E
Couñago, Rafael M., Ween, Miranda P., Begg, Stephanie L., Bajaj, Megha, Zuegg, Johannes, O'Mara, Megan L., Cooper, Matthew A., McEwan, Alastair G., Paton, James C., Kobe, Bostjan and McDevitt, Christopher A. (2014). Imperfect coordination chemistry facilitates metal ion release in the Psa permease. Nature Chemical Biology, 10 (1), 35-41. doi: 10.1038/nCHeMBIO.1382
Shepherd, Mark, Heras, Begona, Achard, Maud E. S., King, Gordon J., Argente, M. Pilar, Kurth, Fabian, Taylor, Samantha L., Howard, Mark J., King, Nathan P., Schembri, Mark A. and McEwan, Alastair G. (2013). Structural and functional characterization of ScsC, a periplasmic thioredoxin-like protein from Salmonella enterica Serovar typhimurium. Antioxidants and Redox Signaling, 19 (13), 1494-1506. doi: 10.1089/ars.2012.4939
Djoko, Karrera Y. and McEwan, Alastair G. (2013). Antimicrobial action of copper is amplified via inhibition of heme biosynthesis. ACS Chemical Biology, 8 (10), 2217-2223. doi: 10.1021/cb4002443
Achard, Maud E. S, Chen, Kaiwen W., Sweet, Matthew J., Watts, Rebecca E., Schroder, Kate, Schembri, Mark A. and McEwan, Alastair G. (2013). An antioxidant role for catecholate siderophores in Salmonella. Biochemical Journal, 454 (3), 543-549. doi: 10.1042/BJ20121771
Stafford, Sian L., Bokil, Nilesh J., Achard, Maud E. S., Kapetanovic, Ronan, Schembri, Mark A., McEwan, Alastair G. and Sweet, Matthew J. (2013). Metal ions in macrophage antimicrobial pathways: emerging roles for zinc and copper. Bioscience Reports, 33 (4) ARTN e00049, 541-554. doi: 10.1042/BSR20130014
Atack, John M., Srikhanta, Yogitha N., Djoko, Karrera Y., Welch, Jessica P., Hasri, Norain H. M., Steichen, Christopher T., Vanden Hoven, Rachel N., Grimmond, Sean M., Othman, Dk Seti Maimonah Pg, Kappler, Ulrike, Apicella, Michael A., Jennings, Michael P., Edwards, Jennifer L. and McEwan, Alastair G. (2013). Characterisation of an ntrX mutant of Neisseria gonorrhoeae reveals a response regulator that controls expression of respiratory enzymes in oxidase-positive proteobacteria. Journal of Bacteriology, 195 (11), 2632-2641. doi: 10.1128/JB.02062-12
Chen, Nathan H., Couñago, Rafael M., Djoko, Karrera Y., Jennings, Michael P., Apicella, Michael A., Kobe, Bostjan and McEwan, Alastair G. (2013). A glutathione-dependent detoxification system is required for formaldehyde resistance and optimal survival of Neisseria meningitidis in biofilms. Antioxidants and Redox Signaling, 18 (7), 743-755. doi: 10.1089/ars.2012.4749
Ong, Cheryl-lynn Y., Potter, Adam J., Trappetti, Claudia, Walker, Mark J., Jennings, Michael P., Paton, James C. and McEwan, Alastair G. (2013). Interplay between manganese and iron in pneumococcal pathogenesis: role of the orphan response regulator RitR. Infection and Immunity, 81 (2), 421-429. doi: 10.1128/IAI.00805-12
Kidd, Stephen P., Jiang, Donald, Tikhomirova, Alexandra, Jennings, Michael P. and McEwan, Alastair G. (2012). A glutathione-based system for defense against carbonyl stress in Haemophilus influenzae. BMC Microbiology, 12 (1) 159, 159-1-159-6. doi: 10.1186/1471-2180-12-159
Achard, Maud E. S., Stafford, Sian L., Bokil, Nilesh J., Chartres, Jy, Bernhardt, Paul V., Schembri, Mark A., Sweet, Matthew J. and McEwan, Alastair G. (2012). Copper redistribution in murine macrophages in response to Salmonella infection. Biochemical Journal, 444 (1), 51-57. doi: 10.1042/BJ20112180
Djoko, Karrera Y., Franiek, Jessica A., Edwards, Jennifer L., Falsetta, Megan L., Kidd, Stephen P., Potter, Adam J., Chen, Nathan H., Apicella, Michael A., Jennings, Michael P. and McEwan, Alastair G. (2012). Phenotypic characterization of a copA mutant of Neisseria gonorrhoeae identifies a link between copper and nitrosative stress. Infection and Immunity, 80 (3), 1065-1071. doi: 10.1128/IAI.06163-11
McDevitt, Christopher A., Ogunniyi, Abiodun D., Valkov, Eugene, Lawrence, Michael C., Kobe, Bostjan, McEwan, Alastair G. and Paton, James C. (2011). A molecular mechanism for bacterial susceptibility to zinc. PLoS Pathogens, 7 (11) e1002357, e1002357.1-e1002357.9. doi: 10.1371/journal.ppat.1002357
Kidd, Stephen P., Djoko, Karrera Y., Ng, JiaQi, Argente, M. Pilar, Jennings, Michael P. and McEwan, Alastair G. (2011). A novel nickel responsive MerR-like regulator, NimR, from Haemophilus influenzae. Metallomics, 3 (10), 1009-1018. doi: 10.1039/c1mt00127b
McEwan, Alistair G., Djoko, Karrera Y., Chen, Nathan H., Counago, Rafael L. M., Kidd, Stephen P., Potter, Adam J. and Jennings, Michael P. (2011). Novel bacterial MerR-like regulators: Their role in the response to carbonyl and nitrosative stress. Advances in Microbial Physiology, 58, 1-22. doi: 10.1016/B978-0-12-381043-4.00001-5
Falsetta, Megan L., Steichen, Christopher T., McEwan, Alastair G., Cho, Christine, Ketterer, Margaret, Shao, Jianqiang, Hunt, Jason, Jennings, Michael P. and Apicella, Michael A. (2011). The composition and metabolic phenotype of Neisseria gonorrhoeae biofilms. Frontiers in Microbiology, 2 (APR). doi: 10.3389/fmicb.2011.00075
Chen, Kuan-I., McEwan, Alastair G. and Bernhardt, Paul V. (2011). Cobalt hexaamine mediated electrocatalytic voltammetry of dimethyl sulfoxide reductase: Driving force effects on catalysis. Journal of Biological Inorganic Chemistry, 16 (2), 227-234. doi: 10.1007/s00775-010-0719-x
Ogunniyi, A. D., Mahdi, L. K., Jennings, M. P., McEwan, A. G., McDevitt, C. A., Van der Hoek, M. B., Bagley, C. J., Hoffmann, P., Gould, K. A. and Paton, J. C. (2010). Central role of manganese in regulation of stress responses, physiology, and metabolism in Streptococcus pneumoniae. Journal of Bacteriology, 192 (17), 4489-4497. doi: 10.1128/JB.00064-10
Potter, A. J., Kidd, S. P., McEwan, A. G. and Paton, J. C. (2010). The MerR/NmlR family transcription factor of Streptococcus pneumoniae responds to carbonyl stress and modulates hydrogen peroxide production. Journal of Bacteriology, 192 (15), 4063-4066. doi: 10.1128/JB.00383-10
Ong, Cheryl-lynn Y., Beatson, Scott A., Totsika, Makrina, Forestier, Christiane, McEwan, Alastair G. and Schembri, Mark A. (2010). Molecular analysis of type 3 fimbrial genes from Escherichia coli, Klebsiella and Citrobacter species. BMC Microbiology, 10 (183) 183, 1-12. doi: 10.1186/1471-2180-10-183
Heras, B, Totsika, M, Jarrott, R, Shouldice, SR, Guncar, G, Achard, MES, Wells, TJ, Argente, MP, McEwan, AG and Schembri, MA (2010). Structural and functional characterization of three DsbA paralogues from Salmonella enterica serovar typhimurium. Journal of Biological Chemistry, 285 (24), 18423-18432. doi: 10.1074/jbc.M110.101360
Falsetta, Megan L., McEwan, Alastair G., Jennings, Michael P. and Apicella, Michael A. (2010). Anaerobic metabolism occurs in the substratum of gonococcal biofilms and may be sustained in part by nitric oxide. Infection and Immunity, 78 (5), 2320-2328. doi: 10.1128/IAI.01312-09
Achard, Maud E. S., Tree, Jai J., Holden, James A., Simpfendorfer, Kim R., Wijburg, Odilia L. C., Strugnell, Richard A., Schembri, Mark A., Sweet, Matthew J., Jennings, Michael P. and McEwan, Alastair G. (2010). The multi-copper-ion oxidase CueO of Salmonella enterica serovar Typhimurium is required for systemic virulence. Infection and Immunity, 78 (5), 2312-2319. doi: 10.1128/IAI.01208-09
Wu, Hsing-Ju, Seib, Kate L., Srikhanta, Yogitha N., Edwards, Jennifer, Kidd, Stephen P., Maguire,Tina L., Hamilton, Amanda, Pan, Kuan-Tin, Hsiao, He-Hsuan, Yao, Chen-Wen, Grimmond, Sean M., Apicella, Michael A., McEwan, Alastair G., Wang, Andrew H-J. and Jennings, Michael P. (2010). Manganese regulation of virulence factors and oxidative stress resistance in Neisseria gonorrhoeae. Journal of Proteomics, 73 (5), 899-916. doi: 10.1016/j.jprot.2009.12.001
Achard, Maud E. S., Hamilton, Amanda J., Dankowski, Tarek, Heras, Begona, Schembri, Mark A., Edwards, Jennifer L., Jennings, Michael P. and McEwan, Alastair G. (2009). A periplasmic thioredoxin-like protein plays a role in defense against oxidative stress in Neisseria gonorrhoeae. Infection And Immunity, 77 (11), 4934-4939. doi: 10.1128/IAI.00714-09
Mikkelsen, Deirdre, Kappler, Ulrike, McEwan, Alastair G. and Sly, Lindsay I. (2009). Probing the archaeal diversity of a mixed thermophilic bioleaching culture by TGGE and FISH. Systematic and Applied Microbiology, 32 (7), 501-513. doi: 10.1016/j.syapm.2009.06.001
Falsetta, Megan L., Bair, Thomas B., Ku, Shan Chi, Vanden Hoven, Rachel N., Steichen, Christopher T., McEwan, Alastair G., Jennings, Michael P. and Apicella, Michael A. (2009). Transcriptional profiling identifies the metabolic phenotype of gonococcal biofilms. Infection and Immunity, 77 (9), 3522-3532. doi: 10.1128/IAI.00036-09
Ong, Cheryl-Lynn Y., Beatson, Scott A., McEwan, Alastair G. and Schembri, Mark A. (2009). Conjugative plasmid transfer and adhesion dynamics in an Escherichia coli Biofilm. Applied and Environmental Microbiology, 75 (21), 6783-6791. doi: 10.1128/AEM.00974-09
Potter, AJ, Kidd, SP, Edwards, JL, Falsetta, ML, Apicella, MA, Jennings, MP and McEwan, AG (2009). Esterase D is essential for protection of Neisseria gonorrhoeae against nitrosative stress and for bacterial growth during interaction with cervical epithelial cells. Journal of Infectious Diseases, 200 (2), 273-278. doi: 10.1086/599987
McEwan, Alastair G. (2009). New insights into the protective effect of manganese against oxidative stress. Molecular Microbiology, 72 (4), 812-814. doi: 10.1111/j.1365-2958.2009.06700.x
Goh, S. H. M., Mabbett, A. N., Welch, J. P., Hall, S. J. and McEwan, A. G. (2009). Molecular ecology of a facultative swine waste lagoon.. Letters in Applied Microbiology, 48 (4), 486-492. doi: 10.1111/j.1472-765X.2009.02560.x
Kuan-I Chen, McEwan, Alastair G. and Bernhardt, Paul V. (2009). Mediated electrochemistry of dimethyl sulfoxide reductase from Rhodobacter capsulatus. Journal of Biological Inorganic Chemistry, 14 (3), 409-419. doi: 10.1007/s00775-008-0458-4
Potter, AJ, Kidd, SP, Edwards, JL, Falsetta, ML, Apicella, MA, Jennings, MP and McEwan, AG (2009). Thioredoxin reductase is essential for protection of Neisseria gonorrhoeae against killing by nitric oxide and for bacterial growth during interaction with cervical epithelial cells. Journal of Infectious Diseases, 199 (2), 227-235. doi: 10.1086/595737
Creevey, Nicole L., McEwan, Alastair G. and Bernhardt, Paul V. (2008). A mechanistic and electrochemical study of the interaction between dimethyl sulfide dehydrogenase and its electron transfer partner cytochrome c(2). Journal of Biological Inorganic Chemistry, 13 (8), 1231-1238. doi: 10.1007/s00775-008-0406-3
Tree, Jai J., Ulett, Glen C., Ong, Cheryl-Lynn Y., Trott, Darren J., McEwan, Alastair G. and Schembri, Mark A. (2008). Trade-off between iron uptake and protection against oxidative stress: Deletion of cueO promotes uropathogenic Escherichia coli virulence in a mouse model of urinary tract infection. Journal of Bacteriology, 190 (20), 6909-6912. doi: 10.1128/JB.00451-08
Lim, Karen H. L., Jones, Christopher E., vanden Hoven, Rachel N., Edwards, Jennifer L., Falsetta, Megan L., Apicella, Michael A., Jennings, Michael P. and McEwan, Alastair G. (2008). Metal binding specificity of the MntABC permease of Neisseria gonorrhoeae and its influence on bacterial growth and interaction with cervical epithelial cells. Infection and Immunity, 76 (8), 3569-3576. doi: 10.1128/IAI.01725-07
Huston, Wilhelmina M., Naylor, Jennifer, Cianciotto, Nicholas P., Jennings, Michael P. and McEwan, Alastair G. (2008). Functional analysis of the multi-copper oxidase from Legionella pneumophila. Microbes And Infection, 10 (5), 497-503. doi: 10.1016/j.micinf.2008.01.011
Creevey, N.L., McEwan, A.G., Hanson, G.R. and Bernhardt, P.V. (2008). Thermodynamic characterization of the redox centers within dimethylsulfide dehydrogenase. Biochemistry, 47 (12), 3770-3776. doi: 10.1021/bi702444r
Burow, Luke C., Mabbett, Amanda N., McEwan, Alastair G., Bond, Philip L. and Blackall, Linda L. (2008). Bioenergetic Models for Acetate and Phosphate Transport in Bacteria Important in Enhanced Biological Phosphorus Removal. Environmental Microbiology, 10 (1), 87-98. doi: 10.1111/j.1462-2920.2007.01432.x
Ong, C., Ulett, G., Mabbett, A., Beatson, S., Webb, R., Monaghan, W., Nimmo, G., Looke, D., McEwan, A. and Schembri, M. (2008). Identification of Type 3 Fimbriae in Uropathogenic Escherichia coli Reveals a Role in Biofilm Formation. Journal of Bacteriology, 190 (3), 1054-1063. doi: 10.1128/JB.01523-07
Stroeher, Uwe H., Kidd, Stephen P., Stafford, Sian L., Jennings, Michael P., Paton, James C. and McEwan, Alastair G. (2007). A pneumococcal MerR-like regulator and S-nitrosoglutathione reductase are required for systemic virulence. The Journal of Infectious Diseases, 196 (12), 1820-1826. doi: 10.1086/523107
Cobb, N, Hemann, C, Polsinelli, GA, Ridge, JP, McEwan, AG and Hille, R (2007). Spectroscopic and kinetic studies of Y114F and W116F mutants of Me2SO reductase from Rhodobacter capsulatus. Journal of Biological Chemistry, 282 (49), 35519-35529. doi: 10.1074/jbc.M704458200
Badrick, Alison C., Hamilton, Amanda J., Bernhardt, Paul V., Jones, Christopher E., Kappler, Ulrike, Jennings, Michael P. and McEwan, Alastair G. (2007). PrrC, a Sco homologue from Rhodobacter sphaeroides, possesses thiol-disulfide oxidoreductase activity. FEBS Letters, 581 (24), 4663-4667. doi: 10.1016/j.febslet.2007.08.058
Kidd, Stephen P., Jiang, Donald, Jennings, Michael P. and McEwan, Alastair G. (2007). Glutathione-dependent alcohol dehydrogenase AdhC is required for Defense against nitrosative stress in Haemophilus influenzae. Infection And Immunity, 75 (9), 4506-4513. doi: 10.1128/IAI.00487-07
Saunders, AM, Mabbett, AN, McEwan, AG and Blackall, LL (2007). Proton motive force generation from stored polymers for the uptake of acetate under anaerobic conditions. Fems Microbiology Letters, 274 (2), 245-251. doi: 10.1111/j.1574-6968.2007.00839.x
Mikkelsen, D., Kappler, U., Webb, R. I., Rasch, R., McEwan, A. G. and Sly, L. I. (2007). Visualisation of pyrite leaching by selected thermophilic archaea: nature of microorganism-ore interactions during bioleaching. Hydrometallurgy, 88 (1-4), 143-153. doi: 10.1016/j.hydromet.2007.02.013
Ridge, Justin P., Lin, Marianne, Larsen, Eloise I., Fegan, Mark, McEwan, Alastair G. and Sly, Lindsay I. (2007). A multicopper oxidase is essential for manganese oxidation and laccase-like activity in Pedomicrobium sp ACM 3067. Environmental Microbiology, 9 (4), 944-953. doi: 10.1111/j.1462-2920.2006.01216.x
Tree, JJ, Ulett, GC, Hobman, JL, Constantinidou, C, Brown, NL, Kershaw, C, Schembri, MA, Jennings, MP and McEwan, AG (2007). The multicopper oxidase (CueO) and cell aggregation in Escherichia coli. Environmental Microbiology, 9 (8), 2110-2116. doi: 10.1111/j.1462-2920.2007.01320.x
Potter, Adam J., Kidd, Stephen P., Jennings, Michael P. and McEwan, Alastair G. (2007). Evidence for distinctive mechanisms of S-nitrosoglutathione metabolism by AdhC in two closely related species, Neisseria gonorrhoeae and Neisseria meningitidis. Infection And Immunity, 75 (3), 1534-1536. doi: 10.1128/IAI.01634-06
Seib, KL, Wu, HJ, Srikhanta, YN, Edwards, JL, Falsetta, ML, Hamilton, AJ, Maguire, TL, Grimmond, SM, Apicella, MA, McEwan, AG and Jennings, MP (2007). Characterization of the OxyR regulon of Neisseria gonorrhoeae. Molecular Microbiology, 63 (1), 54-68. doi: 10.1111/j.1365-2958.2006.05478.x
Mikkelsen, Deirdre, Kappler, Ulrike, McEwan, Alastair G. and Sly, Lindsay I. (2006). Archaeal diversity in two thermophilic chalcopyrite bioleaching reactors. Environmental Microbiology, 8 (11), 2050-2055. doi: 10.1111/j.1462-2920.2005.01115.x
Bernhardt, P. V., Honeychurch, M. J. and McEwan, A. G. (2006). Direct electrochemically driven catalysis of bovine milk xanthine oxidase. Electrochemistry Communications, 8 (2), 257-261. doi: 10.1016/j.elecom.2005.08.009
Wu, H. J., Seib, K. L., Srikhanta, Y. N., Kidd, S. P., Edwards, J. L., Maguire, T. L., Grimmond, S. M., Apicella, M. A., McEwan, A. G. and Jennings, M. P. (2006). PerR controls Mn-dependent resistance to oxidative stress in Neisseria gonorrhoeae. Molecular Microbiology, 60 (2), 401-416. doi: 10.1111/j.1365-2958.2006.05079.x
Jones, C. E., Taylor, P. J., McEwan, A. G. and Hanson, G. R. (2006). Spectroscopic characterization of copper(II) binding to the immunosuppressive drug mycophenolic acid. Journal of The American Chemical Society, 128 (29), 9378-9386. doi: 10.1021/ja057651l
Seib, K. L., Wu, H. J., Kidd, S. P., Apicella, M. A., Jennings, M. P. and McEwan, A. G. (2006). Defenses against oxidative stress in Neisseria gonorrhoeae: A system tailored for a challenging environment. Microbiology And Molecular Biology Reviews, 70 (2), 344-361. doi: 10.1128/MMBR.00044-05
Drepper, T., Wiethaus, J., Giaourakis, D., Gross, S., Schubert, B., Vogt, M., Wiencek, Y., McEwan, A. G. and Masepohl, B. (2006). Cross-talk towards the response regulator NtrC controlling nitrogen metabolism in Rhodobacter capsulatus. Fems Microbiology Letters, 258 (2), 250-256. doi: 10.1111/j.1574-6968.2006.00228.x
Wu, Hsing-Ju, Seib, Kate L., Edwards, Jennifer L., Apicella, Michael A., McEwan, Alastair G. and Jennings, Michael P. (2005). Azurin of pathogenic Neisseria spp. is involved in defense against hydrogen peroxide and survival within cervical epithelial cells. Infection And Immunity, 73 (12), 8444-8448. doi: 10.1128/IAI.73.12.8444-8448.2005
Kidd, SP, Potter, AJ, Apicella, MA, Jennings, MP and McEwan, AG (2005). NmlR of Neisseria gonorrhoeae: a novel redox responsive transcription factor from the MerR family. Molecular Microbiology, 57 (6), 1676-1689. doi: 10.1111/j.1365-2958.2005.04773.x
Seib, Kate L., Simons, Mark P., Wu, Hsing-Ju, McEwan, Alastair G., Nauseef, William M., Apicella, Michael A. and Jennings, Michael P. (2005). Investigation of oxidative stress defenses of Neisseria gonorrhoeae by using a human polymorphonuclear leukocyte survival assay. Infection and Immunity, 73 (8), 5269-5272. doi: 10.1128/IAI.73.8.5269-5272.2005
Kappler, Ulrike, Hanson, Graeme R., Jones, Alun and McEwan, Alastair G. (2005). A recombinant diheme SoxAX cytochrome - Implications for the relationship between EPR signals and modified heme-ligands. Febs Letters, 579 (11), 2491-2498. doi: 10.1016/j.febslet.2005.03.060
Kappler, U., Sly, L. I. and McEwan, A. G. (2005). Respiratory gene clusters of Metallosphaera sedula - differential expression and transcriptional organization. Microbiology-sgm, 151 (Part 1), 35-43. doi: 10.1099/mic.0.27515-0
Tree, J. J., Kidd, S. P., Jennings, M. P. and McEwan, A. G. (2005). Copper sensitivity of cueO mutants of Escherichia coli K-12 and the biochemical suppression of this phenotype. Biochemical And Biophysical Research Communications, 328 (4), 1205-1210. doi: 10.1016/j.bbrc.2005.01.084
McCrindle, S. L., Kappler, U. and McEwan, A. G. (2005). Microbial dimethylsulfoxide and trimethylamine-N-oxide respiration. Advances In Microbial Physiology, Vol 50, 50, 147-198. doi: 10.1016/S0065-2911(05)50004-3
Seib, Kate L., Tseng, Hsing‐Ju, McEwan, Alastair G., Apicella, Michael A. and Jennings, Michael P. (2004). Defenses against oxidative stress in Neisseria gonorrhoeae and Neisseria meningitidis: Distinctive systems for different lifestyles. Journal of Infectious Diseases, 190 (1), 136-147. doi: 10.1086/421299
McAllister, Lauren J., Tseng, Hsing-Ju, Ogunniyi, A. David, Jennings, Michael P., McEwan, Alastair G. and Paton, James C. (2004). Molecular analysis of the psa permease complex of Streptococcus pneumoniae. Molecular Microbiology, 53 (3), 889-901. doi: 10.1111/j.1365-2958.2004.04164.x
Huston, W. M., Potter, A. J., Jennings, M. P., Rello, J., Hauser, A. R. and McEwan, A. G. (2004). Survey of ferroxidase expression and siderophore production in clinical isolates of Pseudomonas aeruginosa. Journal of Clinical Microbiology, 42 (6), 2806-2809. doi: 10.1128/JCM.42.6.2806-2809.2004
Kappler, U., Aguey-Zinsou, K. F., Hanson, G. R., Bernhardt, P. V. and McEwan, A. G. (2004). Cytochrome c(551) from Starkeya novella - Characterization, spectroscopic properties, and phylogeny of a diheme protein of the SoxAX family. The Journal of Biological Chemistry, 279 (8), 6252-6260. doi: 10.1074/jbc.M310644200
Ridge, J. P., Aguey-Zinsou, K. F., Bernhardt, P. V., Hanson, G. R. and McEwan, A. G. (2004). The critical role of tryptophan-116 in the catalytic cycle of dimethylsulfoxide reductase from Rhodobacter capsulatus. FEBS Letters, 563 (1-3), 197-202. doi: 10.1016/S0014-5793(04)00301-1
Gomelsky, L., Sram, J., Moskvin, O. V., Horne, I. M., Dodd, H. N., Pemberton, J. M., McEwan, A. G., Kaplan, S. and Gomelsky, M. (2003). Identification and in vivo characterization of PpaA, a regulator of photosystem formation in Rhodobacter sphaeroides. Microbiology-sgm, 149 (2), 377-388. doi: 10.1099/mic.0.25972-0
Seib, K. L., Jennings, M. P. and McEwan, A. G. (2003). A Sco homologue plays a role in defence against oxidative stress in pathogenic Neisseria. Febs Letters, 546 (2-3), 411-415. doi: 10.1016/S0014-5793(03)00632-X
Tseng, Hsing-Ju, McEwan, Alastair G., Apicella, Michael A. and Jennings, Michael P. (2003). OxyR acts as a repressor of catalase expression in Neisseria gonorrhoeae. Infection and Immunity, 71 (1), 550-556. doi: 10.1128/IAI.71.1.550-556.2003
Aguey-Zinsou, Kondo-Francois, Bernhardt, Paul. V., Kappler, Ulrike and McEwan, Alastair G. (2003). Direct electrochemistry of a bacterial sulfite dehydrogenase. Journal of The American Chemical Society, 125 (2), 530-535. doi: 10.1021/ja028293e
Aguey, F. K., Bernhardt, P. V., McEwan, A. G. and Ridge, J. P. (2002). The first non-turnover voltammetric response from a molybdenum enzyme: direct electroscopy of dimethylsulfoxide reductase from Rhodobacter capsulatus. Journal of Biological Inorganic Chemistry, 7 (7-8), 879-883. doi: 10.1007/s00775-002-0374-y
Huston, Wilhelmina M., Jennings, Michael P. and McEwan, Alastair G. (2002). The multicopper oxidase of Pseudomonas aeruginosa is a ferroxidase with a central role in iron acquisition. Molecular Microbiology, 45 (6), 1741-1750. doi: 10.1046/j.1365-2958.2002.03132.x
McDevitt, Christopher A., Hugenholtz, Philip, Hanson, Graeme R. and McEwan, Alastair G. (2002). Molecular analysis of dimethyl sulphide dehydrogenase from Rhodovulum sulfidophilum: its place in the dimethyl sulphoxide reductase family of microbial molybdopterin-containing enzymes. Molecular Microbiology, 44 (6), 1575-1587. doi: 10.1046/j.1365-2958.2002.02978.x
McEwan, Alastair G., Lewin, Allison, Davy, Sharon L., Boetzel, Ruth, Leech, Andrew, Walker, Daniel, Wood, Tania and Moore, Geoffrey R. (2002). PrrC from Rhodobacter sphaeroides, a homologue of eukaryotic Sco proteins, is a copper-binding protein and may have a thiol-disulfide oxidoreductase activity. Febs Letters, 518 (1-3), 10-16. doi: 10.1016/S0014-5793(02)02532-2
Tseng, Hsing-Ju, McEwan, Alastair G., Paton, James C. and Jennings, Michael P. (2002). Virulence of Streptococcus pneumoniae: PsaA mutants are hypersensitive to oxidative stress. Infection And Immunity, 70 (3), 1635-1639. doi: 10.1128/IAI.70.3.1635-1639.2002
Ridge, Justin P., Aguey, Kondo-Francois, Bernhardt, Paul V., Brereton, Ian M., Hanson, Graeme R. and McEwan, Alastair G. (2002). Site-Directed Mutagenesis of Dimethyl Sulfoxide Reductase from Rhodobacter capsulatus: Characterization of a Y114 → F Mutant. Biochemistry, 41 (52), 15762-15769. doi: 10.1021/bi0266582
McEwan, A. G., Ridge, J. P., McDevitt, C. A. and Hugenholtz, P. (2002). The DMSO reductase family of microbial molybdenum enzymes; Molecular properties and role in the dissimilatory reduction of toxic elements. Geomicrobiology Journal, 19 (1), 3-21. doi: 10.1080/014904502317246138
Kappler, U., Huston, W. M. and McEwan, A. G. (2002). Control of dimethylsulfoxide reductase expression in Rhodobacter capsulatus: the role of carbon metabolites and the response regulators DorR and RegA. Microbiology-sgm, 148 (2), 605-614. doi: 10.1099/00221287-148-2-605
McDevitt, C. A., Hanson, G. R., Noble, C. J., Cheesman, M. R. and McEwan, A. G. (2002). Characterization of redox centers in dimethyl sulfide dehydrogenase from Rhodovulum sulfidophilum. Biochemistry, 41 (51), 15234-15244. doi: 10.1021/bi026221u
Kappler, U. and McEwan, A. G. (2002). A system for the heterologous expression of complex redox proteins in Rhodobacter capsulatus: characterisation of recombinant sulphite : cytochrome c oxidoreductase from Starkeya novella. Febs Letters, 529 (2-3), 208-214. doi: 10.1016/S0014-5793(02)03344-6
Tseng, Hsing-Ju, Srikhanta, Yogitha, McEwan, Alastair G. and Jennings, Michael P. (2001). Accumulation of manganese in Neisseria gonorrhoeae correlates with resistance to oxidative killing by superoxide anion and is independent of superoxide dismutase activity. Molecular Microbiology, 40 (5), 1175-1186. doi: 10.1046/j.1365-2958.2001.02460.x
Bell, A. F., He, X., Ridge, J. P., Hanson, G. R., McEwan, A. G. and Tonge, P. J. (2001). Active site heterogeneity in dimethyl sulfoxide reductase from Rhodobacter capsulatus revealed by raman spectroscopy. Biochemistry, 40 (2), 440-448. doi: 10.1021/bi002065k
Solomon, Peter S., Shaw, Anthony L., Young, Michael D., Leimkuhler, Silke, Hanson, Graeme R., Klipp, Werner and McEwan, Alastair G. (2000). Molybdate-dependent expression of dimethylsulfoxide reductase in Rhodobacter capsulatus. FEMS Microbiology Letters, 190 (2), 203-208. doi: 10.1016/S0378-1097(00)00336-0
Gomelsky, Mark, Horne, Irene M., Lee, Hye-Joo, Pemberton, John M., McEwan, Alastair G. and Kaplan, Samuel (2000). Domain structure, oligomeric state, and mutational analysis of PpSR, the Rhodobacter sphaeroides repressor of photosystem gene expression. Journal of Bacteriology, 182 (8), 2253-2261. doi: 10.1128/JB.182.8.2253-2261.2000
Kappler, U, Bennett, B, Rethmeier, J, Schwarz, G, Deutzmann, R, McEwan, AG and Dahl, C (2000). Sulfite : Cytochrome c oxidoreductase from Thiobacillus novellus - Purification, characterization, and molecular biology of a heterodimeric member of the sulfite oxidase family. Journal of Biological Chemistry, 275 (18), 13202-13212. doi: 10.1074/jbc.275.18.13202
McDevitt, C., Burrell, P., Blackall, L. L. and McEwan, A. G. (2000). Aerobic nitrate respiration in a nitrite-oxidising bioreactor. FEMS Microbiology Letters, 184 (1), 113-118. doi: 10.1111/j.1574-6968.2000.tb09000.x
Shaw, Anthony L., Hochkoeppler, Alejandro, Bonora, Patrizia, Zannoni, Davide, Hanson, Graeme R. and Mcewan, Alastair G. (1999). Characterization of DorC from Rhodobacter capsulatus, a c-type Cytochrome Involved in Electron Transfer to Dimethylsulfoxide Reductase. Communication, 274 (15), 9911-9914. doi: 10.1074/jbc.274.15.9911
Solomon, P. S., Shaw, A. L., Lane, I., Hanson, G. R., Palmer, T. and McEwan, A. G. (1999). Characterization of a molybdenum cofactor biosynthetic gene cluster in Rhodobacter capsulatus which is specific for the biogenesis of dimethylsulfoxide reductase. Microbiology, 145 (6), 1421-1429. doi: 10.1099/13500872-145-6-1421
Larsen, E. I., Sly, L. I. and McEwan, A. G. (1999). Manganese(II) adsorption and oxidation by whole cells and a membrane fraction of Pedomicrobium sp. ACM 3067. Archives of Microbiology, 171 (4), 257-264. doi: 10.1007/s002030050708
Shaw, A., Leimkuhler, S., Klipp, W., Hanson, G. R. and Mcewan, A. G. (1999). Mutational analysis of the dimethysulfoxide respiratory (dor) operon of Rhodobacter capsulatus. Microbiology, 145 (6), 1409-1420. doi: 10.1099/13500872-145-6-1409
Adams, B., Smith, A. T., Bailey, S., McEwan, A. G. and Bray, R. C. (1999). Reactions of dimethylsulfoxide reductase from Rhodobacter capsulatus with dimethyl sulfide and dimethyl sulfoxide: Complexities revealed by conventional and stopped-flow spectrophotometry. Biochemistry, 38 (26), 8501-8511. doi: 10.1021/bi9902034
Horne I. and McEwan A.G. (1998). Dimethylsulfoxide enhances phototrophic growth of Rhodobacter sphaeroides in blue light. FEMS Microbiology Letters, 168 (2), 283-288. doi: 10.1016/S0378-1097(98)00453-4
Leimkühler, Silke, Kern, Monika, Solomon, Peter S., McEwan, Alastair G., Schwarz, Günter, Mendel, Ralf R. and Klipp, Werner (1998). Xanthine dehydrogenase from the phototrophic purple bacterium Rhodobacter capsulatus is more similar to its eukaryotic counterparts than to prokaryotic molybdenum enzymes. Molecular Microbiology, 27 (4), 853-869. doi: 10.1046/j.1365-2958.1998.00733.x
Palmer, Tracy, Goodfellow, Ian P.G., Sockett, R. Elizabeth, McEwan, Alastair G. and Boxer, David H. (1998). Characterisation of the mob locus from Rhodobacter sphaeroides required for molybdenum cofactor biosynthesis. Biochimica et Biophysica Acta - Gene Structure and Expression, 1395 (2), 135-140. doi: 10.1016/S0167-4781(97)00145-0
Pemberton J.M., Horne I.M. and McEwan A.G. (1998). Regulation of photosynthetic gene expression in purple bacteria. Microbiology, 144 (2), 267-278. doi: 10.1099/00221287-144-2-267
McAlpine A.S., McEwan A.G. and Bailey S. (1998). The high resolution crystal structure of DMSO reductase in complex with DMSO. Journal of Molecular Biology, 275 (4), 613-623. doi: 10.1006/jmbi.1997.1513
Smith, Andrew T., Bray, Robert C., McEwan, Alastair G., McAlpine, Alan S. and Bailey, Sue (1998). Stopped-flow studies on dimethylsulphoxide reductase from Rhodobacter capsulatus: Kinetic competence of the dimethylsulphide-reduced intermediate. Biochemical Society Transactions, 26 (3), S211-S211. doi: 10.1042/bst026s211
Horne I.M., Pemberton J.M. and McEwan A.G. (1998). Manganous ions suppress photosynthesis gene expression in Rhodobacter sphaeroides. Microbiology, 144 (8), 2255-2261. doi: 10.1099/00221287-144-8-2255
Hanlon, Steven P., Graham, Daniel L., Hogan, Philip J., Holt, Robert A., Reeve, Christopher D., Shaw, Anthony L. and McEwan, Alastair G. (1998). Asymmetric reduction of racemic sulfoxides by dimethyl sulfoxide reductases from Rhodobacter capsulatus, Escherichia coli and Proteus species. Microbiology, 144 (8), 2247-2253. doi: 10.1099/00221287-144-8-2247
McAlpine, A. S., McEwan, A. G., Shaw, A. L. and Bailey, S. (1997). Molybdenum active centre of DMSO reductase from Rhodobacter capsulatus: Crystal structure of the oxidised enzyme at 1.82-Å resolution and the dithionite-reduced enzyme at 2.8-Å resolution. Journal of Biological Inorganic Chemistry, 2 (6), 690-701. doi: 10.1007/s007750050185
Baugh, Philippa E., Garner, C.D., Charnock, John M., Collison, David, Davies, E. Stephen, McAlpine, Alan S., Bailey, S., Lane, Ian, Hanson, Graeme R. and McEwan, Alastair G. (1997). X-ray absorption spectroscopy of dimethylsulfoxide reductase from Rhodobacter capsulatus. Journal of Biological Inorganic Chemistry, 2 (5), 634-643. doi: 10.1007/s007750050178
Solomon, Peter S., Lane, Ian, Hanson, Graeme R. and McEwan, Alastair G. (1997). Characterisation of the Pterin Molybdenum Cofactor in Dimethylsulfoxide Reductase of Rhodobacter capsulatus and the periplasmic Nitrate Reductase of Paracoccus denitrificans. European Journal of Biochemistry, 246 (1), 200-203. doi: 10.1111/j.1432-1033.1997.t01-2-00200.x
Shaw, A. L., Hanson, G. R. and McEwan, A. G. (1996). Cloning and sequence analysis of the dimethylsulfoxide reductase structural gene from Rhodobacter capsulatus. Biochimica Et Biophysica Acta-bioenergetics, 1276 (3), 176-180. doi: 10.1016/0005-2728(96)00092-8
Dobbin, Paul S., Requena Burmeister, Laura M., Heath, Sarah L., Powell, Anne K., McEwan, Alastair G. and Richardson, David J. (1996). The influence of chelating agents upon the dissimilatory reduction of Fe(III) by Shewanella putrefaciens. Part 2. Oxo- and hydroxo-bridged polynuclear Fe(III) complexes. BioMetals, 9 (3), 291-301. doi: 10.1007/BF00817930
Penfold, Christopher N., Ringeling, Patricia L., Davy, Sharon L., Moore, Geoffrey R., McEwan, Alastair G. and Spiro, Stephen (1996). Isolation, characterisation and expression of the bacterioferritin gene of Rhodobacter capsulatus. FEMS Microbiology Letters, 139 (2-3), 143-148. doi: 10.1016/0378-1097(96)00133-4
Horne, Irene M., Pemberton, John M. and McEwan, Alastair G. (1996). Photosynthesis gene expression in Rhodobacter sphaeroides is regulated by redox changes which are linked to electron transport. Microbiology, 142 (10), 2831-2838. doi: 10.1099/13500872-142-10-2831
Dobbin, Paul S., Warren, Louise H., Cook, Nicola J., McEwan, Alastair G., Powell, Anne K. and Richardson, David J. (1996). Dissimilatory iron(III) reduction by Rhodobacter capsulatus. Microbiology, 142 (4), 765-774. doi: 10.1099/00221287-142-4-765
Hanlon, Steven P., Toh, Tze-Hsien, Solomon, Peter S., Holt, Robert A. and McEwan, Alastair G. (1996). Dimethylsulfide: Acceptor oxidoreductase from Rhodobacter sulfidophilus - The purified enzyme contains b-type haem and a pterin molybdenum cofactor. European Journal of Biochemistry, 239 (2), 391-396. doi: 10.1111/j.1432-1033.1996.0391u.x
Bailey, S., Mcalpine, A. S., Duke, E. M.H., Benson, N. and Mcewan, A. G. (1996). Preliminary crystallographic studies of dimethylsulfoxide reductase from Rhodobacter capsulatus. Acta Crystallographica Section D: Biological Crystallography, 52 (1), 194-196. doi: 10.1107/S0907444995007712
Bonnett, Tracey C., Cobine, Paul, Sockett, R.Elizabeth and McEwan, Alastair G. (1995). Phenotypic characterisation and genetic complementation of dimethylsulfoxide respiratory mutants of Rhodobacter sphaeroides and Rhodobacter capsulatus. FEMS Microbiology Letters, 133 (1-2), 163-168. doi: 10.1016/0378-1097(95)00358-C
Dobbin, Paul S., Powell, Anne K., McEwan, Alastair G. and Richardson, David J. (1995). The influence of chelating agents upon the dissimilatory reduction of Fe(III) by Shewanella putrefaciens. Biometals, 8 (2), 163-173. doi: 10.1007/BF00142016
Hatton, A. D., Malin, G., McEwan, A. G., Liss, P. S. and McEwan, A. G. (1994). Determination of Dimethyl Sulfoxide in Aqueous Solution by an Enzyme-Linked Method. Analytical Chemistry, 66 (22), 4093-4096. doi: 10.1021/ac00094a036
Hatton, Angela D., Malin, Gill and McEwan, Alastair G. (1994). Identification of a periplasmic dimethylsulphoxide reductase in Hyphomicrobium EG grown under chemolithoheterotrophic conditions with dimethylsulphoxide as carbon source. Archives of Microbiology, 162 (1-2), 148-150. doi: 10.1007/bf00264389
Hanlon S.P., Holt R.A., Moore G.R. and McEwan A.G. (1994). Isolation and characterization of a strain of Rhodobacter sulfidophilus: A bacterium which grows autotrophically with dimethylsulphide as electron donor. Microbiology, 140 (8), 1953-1958. doi: 10.1099/13500872-140-8-1953
Bennett, Brian, Benson, Neil, McEwan, Alastair G. and Bray, Robert C. (1994). Multiple States of the Molybdenum Centre of Dimethylsulphoxide Reductase from Rhodobacter Capsulatus Revealed by EPR Spectroscopy. European Journal of Biochemistry, 225 (1), 321-331. doi: 10.1111/j.1432-1033.1994.00321.x
Jackson, J. Baz and McEwan, Alastair G. (1994). Proton-Translocating NAD(P)-H Transhydrogenase and NADH Dehydrogenase in Photosynthetic Membranes. Advances in Molecular and Cell Biology, 10 (C), 253-286. doi: 10.1016/S1569-2558(08)60399-9
McEwan A.G. (1994). Photosynthetic electron transport and anaerobic metabolism in purple non-sulfur phototrophic bacteria. Antonie van Leeuwenhoek, 66 (1-3), 151-164. doi: 10.1007/BF00871637
RINGELING, Patricia L., DAVY, Sharon L., MONKARA, Fayez A., HUNT, Colette, DICKSON, Dominic P. E., McEWAN, Alastair G. and MOORE, Geoffrey R. (1994). Iron metabolism in Rhodobacter capsulatus Characterisation of bacterioferritin and formation of non‐haem iron particles in intact cells. European Journal of Biochemistry, 223 (3), 847-855. doi: 10.1111/j.1432-1033.1994.tb19061.x
Vargas, C., McEwan, A. G. and Downie, J. A. (1993). Detection of c-type cytochromes using enhanced chemiluminescence. Analytical Biochemistry, 209 (2), 323-326. doi: 10.1006/abio.1993.1127
Berks, B. C., McEwan, A. G. and Ferguson, S. J. (1993). Membrane-associated NADH dehydrogenase activities in Rhodobacter capsulatus: Purification of a dihydrolipoyl dehydrogenase. Journal of General Microbiology, 139 (8), 1841-1851. doi: 10.1099/00221287-139-8-1841
Hanlon, Steven P., Holt, Robert A. and McEwan, Alastair G. (1992). The 44-kDa c-type cytochrome induced in Rhodobacter capsulatus during growth with dimethylsulphoxide as an electron acceptor is a cytochrome c peroxidase. FEMS Microbiology Letters, 97 (3), 283-287. doi: 10.1016/0378-1097(92)90349-S
Benson, Neil, Farrar, Jaqui A., McEwan, Alastair G. and Thomson, Andrew J. (1992). Detection of the optical bands of molybdenum(V) in DMSO reductase (Rhodobacter capsulatus ) by low-temperature MCD spectroscopy. FEBS Letters, 307 (2), 169-172. doi: 10.1016/0014-5793(92)80760-e
Monkara, Fayez, Bingham, Stephen J., Kadir, Fahmi H.A., McEwan, Alastair G., Thomson, Andrew J., Thurgood, Andrew G.P. and Moore, Geoffrey R. (1992). Spectroscopic studies of Rhodobacter capsulatus cytochrome c′ in the isolated state and in intact cells. BBA - Bioenergetics, 1100 (2), 184-188. doi: 10.1016/0005-2728(92)90080-L
McEwan, A. G., Ferguson, S. J. and Jackson, J. B. (1991). Purification and properties of dimethyl sulphoxide reductase from Rhodobacter capsulatus. A periplasmic molybdoenzyme. Biochemical Journal, 274 (1), 305-307. doi: 10.1042/bj2740305
RICHARDSON, David J., BELL, Louise C., McEWAN, Alastair G., JACKSON, J. Baz and FERGUSON, Stuart J. (1991). Cytochrome c2 is essential for electron transfer to nitrous oxide reductase from physiological substrates in Rhodobacter capsulatus and can act as an electron donor to the reductase in vitro Correlation with photoinhibition studies. European Journal of Biochemistry, 199 (3), 677-683. doi: 10.1111/j.1432-1033.1991.tb16170.x
Jones, M. R., McEwan, A. G. and Jackson, J. B. (1990). The role of c-type cytochromes in the photosynthetic electron transport pathway of Rhodobacter capsulatus. BBA - Bioenergetics, 1019 (1), 59-66. doi: 10.1016/0005-2728(90)90124-M
Ballard, Anna L., McEwan, Alastair G., Richardson, David J., Jackson, J.Baz and Ferguson, Stuart J. (1990). Rhodobacter capsulatus strain BK5 possesses a membrane bound respiratory nitrate reductase rather than the periplasmic enzyme found in other strains. Archives of Microbiology, 154 (3), 301-303. doi: 10.1007/BF00248971
Jones, M. R., Richardson, D. J., McEwan, A. G., Ferguson, S. J. and Jackson, J. B. (1990). In vivo redox poising of the cyclic electron transport system of Rhodobacter capsulatus and the effects of the auxiliary oxidants, nitrate, nitrous oxide and trimethylamine N-oxide, as revealed by multiple short flash excitation. BBA - Bioenergetics, 1017 (3), 209-216. doi: 10.1016/0005-2728(90)90186-8
RICHARDSON, David J., McEWAN, Alastair G., PAGE, M. Dudley, JACKSON, J. Baz and FERGUSON, Stuart J. (1990). The identification of cytochromes involved in the transfer of electrons to the periplasmic NO−3 reductase of Rhodobacter capsulatus and resolution of a soluble NO−3 ‐reductase − cytochrome‐c552 redox complex. European Journal of Biochemistry, 194 (1), 263-270. doi: 10.1111/j.1432-1033.1990.tb19452.x
McEwan, Alastair G., Kaplan, Samuel and Donohue, Timothy J. (1989). Synthesis of Rhodobacter sphaeroides cytochrome c2 in Escherichia coli. FEMS Microbiology Letters, 59 (3), 253-258. doi: 10.1016/0378-1097(89)90427-8
McEwan, Alastair G., Richardson, David J., Hudig, Hendrik, Ferguson, Stuart J. and Jackson, J. Barry (1989). Identification of cytochromes involved in electron transport to trimethylamine N-oxide/dimethylsulphoxide reductase in Rhodobacter capsulatus. BBA - Bioenergetics, 973 (2), 308-314. doi: 10.1016/S0005-2728(89)80437-2
RICHARDSON, David J., McEWAN, Alastair G., JACKSON, J. Baz and FERGUSON, Stuart J. (1989). Electron transport pathways to nitrous oxide in Rhodobacter species. European Journal of Biochemistry, 185 (3), 659-669. doi: 10.1111/j.1432-1033.1989.tb15163.x
Brandner, J. P., McEwan, A. G., Kaplan, S. and Donohue, T. J. (1989). Expression of the Rhodobacter sphaeroides cytochrome c2 structural gene. Journal of bacteriology, 171 (1), 360-368. doi: 10.1128/jb.171.1.360-368.1989
McEwan, Alastair G., Kaplan, Samuel and Donohue, Timothy J. (1989). Synthesis of Rhodobacter sphaeroides cytochrome c2 in Escherichia coli. FEMS Microbiology Letters, 59 (3), 253-258. doi: 10.1111/j.1574-6968.1989.tb03120.x
Richardson, DJ, King, GF, Kelly, DJ, McEwan, AG, Ferguson, SJ and Jackson, JB (1988). The Role of Auxiliary Oxidants in Maintaining Redox Balance During Phototrophic Growth of Rhodobacter-Capsulatus On Propionate or Butyrate. Archives of Microbiology, 150 (2), 131-137. doi: 10.1007/BF00425152
Donohue, Timothy J., McEwan, Alastair G., Doren, Steven Van, Crofts, Antony R. and Kaplan, Samuel (1988). Phenotypic and Genetic Characterization of Cytochrome c2Deficient Mutants of Rhodobacter sphaeroides. Biochemistry, 27 (6), 1918-1925. doi: 10.1021/bi00406a018
McEwan, A. G., Richardson, D. J., Jackson, J. B. and Ferguson, S. J. (1988). The periplasmic nitrate reductase and trimethylamine-N-oxide reductase of the photosynthetic bacterium Rhodobacter capsulatus. Biochemical Society Transactions, 16 (2), 182-183. doi: 10.1042/bst0160182
McEwan, A. G., Wetzstein, H. G., Meyer, O., Jackson, J. B. and Ferguson, S. J. (1987). The periplasmic nitrate reductase of Rhodobacter capsulatus; purification, characterisation and distinction from a single reductase for trimethylamine-N-oxide, dimethylsulphoxide and chlorate. Archives of Microbiology, 147 (4), 340-345. doi: 10.1007/BF00406130
Ferguson, Stuart J., Jackson, J.Barry and McEwan, Alastair G. (1987). Anaerobic respiration in the Rhodospirillaceae: characterisation of pathways and evaluation of roles in redox balancing during photosynthesis. FEMS Microbiology Letters, 46 (2), 117-143. doi: 10.1016/0378-1097(87)90060-7
Donohue, T. J., McEwan, A. G. and Kaplan, S. (1986). Cloning, DNA sequence, and expression of the Rhodobacter sphaeroides cytochrome c2 gene. Journal of Bacteriology, 168 (2), 962-972. doi: 10.1128/jb.168.2.962-972.1986
McEwan, A. G., Greenfield, A. J., Wetzstein, H. G., Jackson, J. B. and Ferguson, S. J. (1985). Nitrous oxide reduction by members of the family Rhodospirillaceae and the nitrous oxide reductase of Rhodopseudomonas capsulata. Journal of Bacteriology, 164 (2), 823-830.
McEwan, A. G., Cotton, N. P.J., Ferguson, S. J. and Jackson, J. B. (1985). The role of auxiliary oxidants in the maintenance of a balanced redox poise for photosynthesis in bacteria. BBA - Bioenergetics, 810 (2), 140-147. doi: 10.1016/0005-2728(85)90129-X
Alef, Kassem, Jackson, J. Barry, McEwan, Alastair G. and Ferguson, Stuart J. (1985). The activities of two pathways of nitrate reduction in Rhodopseudomonas capsulata. Archives of Microbiology, 142 (4), 403-408. doi: 10.1007/bf00491912
McEwan, A. G., Wetzstein, H. G., Ferguson, S. J. and Jackson, J. B. (1985). Periplasmic location of the terminal reductase in trimethylamine N-oxide and dimethylsulphoxide respiration in the photosynthetic bacterium Rhodopseudomonas capsulata. BBA - Bioenergetics, 806 (3), 410-417. doi: 10.1016/0005-2728(85)90248-8
McEwan, Alastair G., Jackson, J. Barry and Ferguson, Stuart J. (1984). Rationalization of properties of nitrate reductases in Rhodopseudomonas capsulata. Archives of Microbiology, 137 (4), 344-349. doi: 10.1007/bf00410732
McEwan, Alastair G., Ferguson, Stuart J. and Jackson, J. Barry (1983). Electron flow to dimethylsulphoxide or trimethylamine-N-oxide generates a membrane potential in Rhodopseudomonas capsulata. Archives of Microbiology, 136 (4), 300-305. doi: 10.1007/bf00425221
McEwan, Alastair G., George, Christina L., Ferguson, Stuart J. and Jackson, J.Barry (1982). A nitrate reductase activity in Rhodopseudomonas capsulata linked to electron transfer and generation of a membrane potential. FEBS Letters, 150 (2), 277-280. doi: 10.1016/0014-5793(82)80751-5

Conference Papers

Chan, B. A., Sim, H-W., Ravikumar, A., Bailey, D., Chan, D., Lawrence, B., McEwan, A., Pavlakis, N., Segelov, E., Singh, S., Roach, P. and Wyld, D. (2016). Availability and Utility of Functional Imaging (FI) and Peptide Receptor Radionuclide Therapy (PRRT) in the CommNETS Collaboration (Australia, Canada and New Zealand). Oxford, United Kingdom: Oxford University Press.
Othman, Dk Seti Maimonah Pg, McEwan, Alastair G. and Kappler, Ulrike (2011). Is anaerobic respiration central to the ability of Haemophilus influenzae to colonize the human host?. BacPath 11: Molecular Analysis of Bacterial Pathogens, Wyong, New South Wales, 25 - 28 September 2011.
Noble, C. J., Drew, S. C., Lane, I., Benson, S., McEwan, A. G., Young, C. G. and Hanson, G. R. (2007). Application of CW and pulsed EPR, MoSophe, and DFT calculations in unravelling the electronic structure of the molybdenum(V) centre in dimethylsulfoxide reductase. IC07 - Conference of the Inorganic Chemistry Division - Royal Australian Chemical Institute, Hobart, Australia, 4-8 February 2007.
Lane, I., Drew, S. C., Noble, C. J., McEwan, A. G., Pilbrow, J. R. and Hanson, G. R. (2006). EPR Studies of Sulfur Centered Radicals and the Low-g Type-I Mo(V) Species in Dimtheylsulfoxide reductase Implications for Catalysis and Electron Transfer. Australian and New Zealand Magnetic Resonance Society, ANZMAG-2006, Murramarang National Park, 13-16 February 2006. ANZMAG.
Ridge, J. P., Lin, M., Larsen, E., Fegan, M., McEwan, A. G. and Sly, L. I. (2006). A multi-copper oxidase is essential for manganese oxidation and Laccase-like activity in Pedomicrobium sp. ACM 3067. ASM 2006, Gold Coast, 2-6 July, 2006.
Noble, C. J., Drew, S., Lane, I., Benson, S., McEwan, A. G. and Hanson, G. R. (2006). Application of CW and pulsed EPR, MoSophe and DFT calculations in unravelling the electron structure of the molybdenum(V) centre in dimethylsulfoxide reductase. Sendai-Berlin-Novosibirsk Seminar on Advanced EPR, Novosibirsk, Russia, 28-31 August, 2006.
Lane, I., Noble, C. J., McEwan, A. G. and Hanson, G. R. (2006). EPR Studies of Dimethylsulfoxide Reductase: Mo(V) Species and Sulfur Centered Radicals - their Role in Catalysis. 48th Rocky Mountain Conference on Analytical Chemistry, Beaver Run Resort & Conference Center, Breckenridge, Colorado, USA, 23-27 July 2006. not found: not found.
Mabbett, A. N., Pioch, K. A., Webb, R. I. and McEwan, A. G. (2006). Heavy metal ions and nanobiotechnology. ASM 2006, Gold Coast, 2-6 July, 2006.
Kappler, U., Sly, L. I. and McEwan, A. G. (2004). Respiratory gene clusters of Metallosphaera sedula. VAAM (German Microbiology Society) Meeting, Braunschweig, 28-31 March, 2004.
Kappler, U., Aguey, F.K., Hanson, G. R., Bernhardt, P. V. and McEwan, A. G. (2004). Cytochrome c551 from Starkeya novella - characterization, spectroscopic properties and phylogeny of a diheme protein of the SoxAX family. VAAM (Germany Microbiology Society) Meeting, Braunschweig, 28-31 March, 2004.
Hanson, G. R., Noble, C. J., Mitchell, A., Benson, S., Lane, I., McEwan, A. G. and Gates, K. E. (2004). Molecular Sophe: An integrated approach to the analysis of CW and pulsed EPR spectra of biomolecules. 4th Asia Pacific EPR/ESR Symposium, Bangalore, India, 22-25 November, 2004.
Mikkelsen, D., Kappler, U., McEwan, A. and Sly, L. (2004). Development of molecular methods for monitoring thermophilic chalcopyrite bioleaching cultures. Australian Society for Microbiology (ASM) Annual Scientific Meeting & Exhibition, Sydney, Australia, 26th Sep – 1st Oct 2004.
Hanson, GR, Noble, CJ, McDevitt, CA and McEwan, AG (2003). CW and pulsed EPR spectroscopy reveal a new structural motif for the active site Mo centre and an unusual [4Fe-4S](+) cluster in dimethylsulfide dehydrogenase.. 11th International Conference on Biological Inorganic Chemistry, Caims Australia, Jul 19-23, 2003. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/S0162-0134(03)80633-5
McEwan, Alastair G., Ridge, Justin P., Aguey-Zinsou, Kondo-Francois, Bernhardt, Paul V. and Hanson, Graeme R. (2003). Site-directed mutagenesis of dimethylsulfoxide reductase from Rhodobacter capsulatus: The critical roles of tyrosine-114 and tryptophan-116. 11th International Conference on Biological Inorganic Chemistry, Cairns, Australia, 19 - 23 July, 2003. New York: Elsevier. doi: 10.1016/S0162-0134(03)80496-8
Aguey, F.K., Bernhardt, P. V., Kappler, U. and McEwan, A. G. (2003). Probing molecular properties: Direct electrochemistry of sulfite dehydrogenase from Starkeya novella. Biospektrum, Berlin, 23-26 March, 2003.
Kappler, U. and McEwan, A. G. (2003). The Rhodobacter capsulatus dor promoter: A useful tool for the heterologous expression of redox proteins. Biospektrum, Berlin, 23-26 March, 2003.
Hanson, G. R., Noble, C. J., McDevitt, C. and McEwan, A. G. (2003). CW and Pulsed EPR Spectroscopy Reveal a New Structural Motif for the Active Site Mo Centre and an Unusual [4Fe-4S]+ Cluster in Dimethylsulfide Dehydrogenase. 45th Rocky Mountain Conference on Analytical Chemistry, Denver, Colorado, 27-31 July 2003. Milestone Presentations.
Hanson, G. R., Lane, I., Noble, C. J., McEwan, A. G. and Benson, N. (2003). Structural characterisation of the Mo(V) High-g unsplit species from Rhodobacter capsulatus dimethylsulfoxide reductase. 45th Rocky Mountain Conference on Analytical Chemistry, Denver, USA, 27-31 July, 2003.
Hanson, Graeme R., Noble, Christopher J., McDevitt, Christopher A. and McEwan, Alastair G. (2003). CW and pulsed EPR spectroscopy revealnext term a new structural motif for the active site Mo centre and an unusual [4Fe-4S]+ cluster in dimethylsulfide dehydrogenase. 11th International Conference on Biological Inorganic Chemistry, Cairns, Australia, 19 - 23 July 2003. New York, USA: Elsevier. doi: 10.1016/S0162-0134(03)80633-5
Hanson, Graeme R., Lane, Ian, Noble, Christopher J., McEwan , Alastair G. and Benson, Neil (2003). Structural characterisation of the Mo(V) High-g unsplit species from Rhodobacter capsulatus dimethylsulfoxide reductase. 11th International Conference on Biological Inorganic Chemistry, Cairns, Australia, 19-23 July, 2003. New York, USA: Elsevier. doi: 10.1016/S0162-0134(03)80633-5
Aguey-Zinsou, K. F., Bernhardt, P. V. and McEwan, A. G. (2003). Direct electrochemistry of bacterial molybdoenzymes. 11th International Conference on Biological Inorganic Chemistry, Cairns, Australia, 19-23 Jul 2003. New York, NY, USA: Elsevier Science Inc. doi: 10.1016/S0162-0134(03)80545-7
Tseng, H. J., Srikhanta, Y., McEwan, A. G., Apicella, M. A. and Jennings, M. P. (2002). Virulence factor expression in Neisseria gonorrhoeae: Regulation by manganese and the Mn(II) binding protein MntC. 13th International Pathogenic Neisseria Conference 2002, Oslo, Norway, 1st - 6th September, 2002. Norway: Norwegian Institute of Public Health.
Seib, K. L., Tseng, Hsing-Ju, McEwan, A. G. and Jennings, M. P. (2002). A comparative study of oxidative stress defence mechanisms in Neisseria meningitidis and Neisseria gonorrhoeae. 13th International Pathogenic Neisseria Conference 2002, Oslo, Norway, 1st - 6th September, 2002. Norwegian Institute of Public Health.
Tseng, Hsing-Ju, McEwan, Alastair G., Apicella, Michael and Jennings, Michael P. (2002). OxyR acts as a repressor of catalase expression in Neisseria gonorrhoeae. 13th International Pathogenic Neisseria Conference 2002, Oslo, 1st - 6th September, 2002.
Noble, C. J., McDevitt, C. A., Lane, I., Griffin, M. P., Mcewan, A. G., Gates, K. E. and Hanson, G. R. (2001). Xsophe and its application to the analysis of EPR spectra from the molybdoenzymes dimethylsulfoxide reductase and dimethylsulfide dehydrogenase. 14th Conference of ISMRM, Rhodes, Greece, 19-23 August 2001. Italy: Dan Knassim Ltd.
McDevitt, C. A., Hanson, G. R. and Mcewan, A. G. (2001). An EPR spectroscopic characterisation of dimethylsulfide dehydrogenase from rhodovulum sulfidophilum. 43rd Rocky Mountain Conference on Analytical Chemistry, Denver, Colorado, USA, 29 July to 2 August 2001. Denver: Milestone Presentations.
McEwan, A. G., Tseng, H. J., Srikhanta, Y. N. and Jennings, M. P. (2001). A role for manganese and the MntABC primary transporter in the superoxide dismutase-independent protection of Neisseria gonorrhoeae. SEB Annual Meeting, Canterbury, UK, March, 2001.
Hanson, G. R., McDevitt, C. A. and Mcewan, A. G. (2001). Dimethylsulfide dehydrogenase from rhodovulum sulfidophilum: EPR spectroscopy and biochemical analysis reveal its place in the DMSO reductase family of molybdenum enzymes. 10th International Conference on Bioinoragnic Chemistry, Florence, Italy, 26th - 31st August, 2001.
Lane, I., Hanson, G. R., McEwan, A. G., Noble, C. J. and Pilbrow, J. (2000). EPR studies of sulfur centered radicals in dimethylsulfoxide reductase. ANZMAG 2000, Mt Buller, Vic, 13-17 February 2000. Australia: ANZMAG.
McEwan, A. G., Ridge, J. P., Mc Devitt, C., Pfluger, C. M., Hanson, G. R., Bell, A. and Tonge, P. (2000). The DMSO reductase family of molybdenum enzymes in purple phototrophic bacteria. International Symposium on Phototrophic Prokaryotes (10th, 2000, ISPP), Barcelona, Spain, 26-31 August 2000.
Dodd, H. N., Horne, I., Gomelsky, M., Kaplan, S., Pemberton, J. M. and McEwan, A. G. (2000). Characterization of PpsR the central regulator of photosynthesis gene expression in Rhodobacter sphaeroides in response to oxygen. International Symposium on Phototrophic Prokaryotes (10th, 2000, ISPP), Barcelona, 26-31 August 2000.
Hanson, G. R., McDevitt, C. A., Ridge, J. P. and McEwan, A. G. (2000). Spectroscopic characterisation of two complimentary molybdoenzymes. Brisbane Inorganic Chemistry Symposium (BICS III), Dept of Chemistry, UQ, 30 November 2000. Upper Mt Gravatt, Qld.: Queensland Branch (Inorganic Chemistry Group) of the Royal Australian Chemical Institute.
Lane, I., Shaw, A., Ridge, J. P., Hanson, G. R. and Mcewan, A. G. (1999). Characterisation of Dimethylsulfoxide reductase and DorC from Rhodobacter capsulatus: implications for electron transfer. The Fourth Brisbane Biological Chemistry Symposium, Brisbane, 9 July 1999. Brisbane: Univ. of Qld.
Lane, I., Hanson, G. R., Mcewan, A. G., McAlpine, A. S. and Bailey, S. (1999). Spectroscopic and crystallographic characterisation of dimethylsulfoxide reductase from Rhodobacter capsulatus: structure and implications for electron transfer. Joint meeting of the Inorganic Division of the RACI, Wellington, NZ, 31 Jan - 4 Feb 1999. Wellington, NZ: NZ Institute of Chemistry.
Ridge, J. P., Hanson, G. R. and Mcewan, A. G. (1999). Molybdenum-Containing Enzymes: Dimethyl Sulfoxide Reductase as a model. RACI 1999 Brisbane Inorganic Chemistry Symposium, Brisbane, 6 December 1999. Australia: Royal Australian Chemical Institute (Qld. Branch).
Hanson, G.R., Lane, I. and McEwan, A.G. (1998). EPR Spectroscopy of Dimethylsulfoxide Reductase from Rhodobacter capsulatus. A joint 29th AMPERE — 13th ISMAR International Conference on Magnetic Resonance and Related Phenomena Revisited, Berlin, Germany, 2-7 August, 1998. Berlin, Germany: Springer Wien. doi: 10.1007/BF03162015
McEwan, A.G., Hanson, G.R. and Bailey, S. (1998). Dimethylsulphoxide Reductase From Purple Phototrophic Bacteria: Structures and Mechanism(s). 665th Meeting University of Southampton: Royal Irish Academy Lecture, Southampton, United Kingdom, 1998. Colchester, England: Portland Press. doi: 10.1042/bst0260390
Lane, Ian, Solomon, Peter S., Shaw, Anthony L., McAlpine, Alan S., Hanson, Graeme R., Bailey, Susan and McEwan, Alastair G. (1997). EPR and X-ray crystallographic studies of dimethylsulfoxide reductase from Rhodobacter capsulatus: Implications for electron transfer and catalysis. ICBIC 8: 8th International Conference on Bioinorganic Chemistry, Yokohama, Japan, 27 July-1 August 1997. New York, NY, U.S.A.: Elsevier. doi: 10.1016/S0162-0134(97)89892-3
Lane, I., Solomon, P.S., Shaw, A.L., McAlpine, A.S., Hanson, G.R., Bailey, S. and McEwan, A.G. (1997). EPR and X-ray Crystallographic Studies of Dimethylsulfoxide Reductase from Rhodobacter capsulatus: Implications for Electron Transfer and Catalysis. 39th Rocky Mountain Conference, Denver, Colorado, U.S.A., 3-7 August, 1997.
Shaw, A. L., Solomon, P. S., McAlpine A. S., Bailey S., Hanson, G. R. and McEwan, A. G. (1996). Molecular properties of DMSO reductase: A model molybdenum oxotransferase. 21st Annual Lorne Conference on Protein Structure and Function, Lorne, VIC, Australia, 4-8 February 1996.
Shaw, A. L., Hanson, G. R., Lane, I., Solomon, P. S., Cobine, P., McEwan, A. G. and Benson, N. (1995). Molecular studies of dimethylsulfoxide (DMSO) reductase from Rhodobacter capsulatus. ICBIC-7: Seventh International Conference on Bioinorganic Chemistry, Lübeck, Germany, 3-8 September 1995. New York, NY, U.S.A.: Elsevier.
Bennett, B., Benson, N., McEwan, A. G. and Bray, R. C. (1994). E.p.r. characterisation of the molybdenum centre of Rhodobacter capsulatus dimethylsulphoxide reductase: New signals on reduction with Na2S2O4.
McEwan, A. G., Benson, N., Bonnett, T. C., Hanlon, S. P., Ferguson, S. J., Richardson, D. J. and Jackson, J. B. (1991). Bacterial dimethyl sulphoxide reductases and nitrate reductases. doi: 10.1042/bst0190605

Areas of research

Biochemistry and molecular biology discipline
Infection and immunity theme
Microbiology discipline