Honorary Professor Volker Sieber
Honorary Professor
School of Chemistry and Molecular Biosciences
Publications
Journal Articles
Jain, Ankit, Teshima, Mariko, Buryska, Tomas, Romeis, Dennis, Haslbeck, Magdalena, Döring, Manuel, Sieber, Volker, Stavrakis, Stavros and de Mello, Andrew (2024). High-throughput absorbance-activated droplet sorting for engineering aldehyde dehydrogenases. Angewandte Chemie, 63 (49) e202409610. doi: 10.1002/anie.202409610
Paschalidis, Leandros, Fröschl, Daniela, Ibañez, Manuel, Sutiono, Samuel, Sieber, Volker and Burger, Jakob (2024). Boosting of enzymatic cascades by intermediates: theoretical analysis and model-based optimization. Biochemical Engineering Journal, 210 109440, 109440. doi: 10.1016/j.bej.2024.109440
Al-Shameri, Ammar, Schmermund, Luca and Sieber, Volker (2024). Current advances in the enzyme engineering of o2-dependent enzymes – boosting the versatility and applicability of oxygenases and oxidases. ChemCatChem, 16 (12) e202301109. doi: 10.1002/cctc.202301109
Fuchs, Alexander, Hupfeld, Enrico and Sieber, Volker (2024). To gel or not to gel – Tuning the sulfation pattern of carrageenans to expand their field of application. Carbohydrate Polymers, 333 121930. doi: 10.1016/j.carbpol.2024.121930
Fuchs, Alexander, Romeis, Dennis, Hupfeld, Enrico and Sieber, Volker (2024). Biocatalytic conversion of carrageenans for the production of 3,6-anhydro-D-galactose. Journal of Agricultural and Food Chemistry, 72 (11), 5816-5827. doi: 10.1021/acs.jafc.3c08613
Sinzinger, Korbinian, Obst, Ulrike, Güner, Samed, Döring, Manuel, Haslbeck, Magdalena, Schieder, Doris and Sieber, Volker (2024). The Pichia pastoris enzyme production platform: From combinatorial library screening to bench-top fermentation on residual cyanobacterial biomass. Journal of Bioresources and Bioproducts, 9 (1), 43-57. doi: 10.1016/j.jobab.2023.12.005
Sutiono, Samuel, Melse, Okke, Doering, Manuel, Lommes, Petra and Sieber, Volker (2024). Integrating chemocatalysis and enzyme engineering for coproduction of bioplastic precursors butanediol and succinic acid from xylose. Advanced Synthesis and Catalysis, 366 (2), 299-308. doi: 10.1002/adsc.202300819
Jeshua Friedrichs, Jan-Simon, Schmermund, Luca, Urmann, Corinna and Sieber, Volker (2024). Synthesis of N-Substituted Pyrrole-2,5-dicarboxylic Acids from Pyrroles. Helvetica Chimica Acta, 107 (6) e202400036. doi: 10.1002/hlca.202400036
Paschalidis, Leandros, Arana-Peña, Sara, Sieber, Volker and Burger, Jakob (2024). Modeling enzymatic cascade reactions immobilized in plug-flow reactors for flow biocatalysis. Chemie-Ingenieur-Technik, 96 (6), 741-748. doi: 10.1002/cite.202300159
Laudage, Tatjana, Hüsing, Torben, Rühmann, Broder, Beer, Barbara, Schmermund, Luca and Sieber, Volker (2024). N-substituted pyrrole carboxylic acid derivatives from 3,4-dihydroxyketons. ChemSusChem, 17 (9) e202301169. doi: 10.1002/cssc.202301169
Al-Shameri, Ammar, Siebert, Dominik L., Sutiono, Samuel, Lauterbach, Lars and Sieber, Volker (2023). Hydrogenase-based oxidative biocatalysis without oxygen. Nature Communications, 14 (1) 2693, 1-8. doi: 10.1038/s41467-023-38227-9
Schilling, Christoph, Gansbiller, Moritz, Rühmann, Broder, Sieber, Volker and Schmid, Jochen (2023). Rheological characterization of artificial paenan compositions produced by Paenibacillus polymyxa DSM 365. Carbohydrate Polymers, 320 121243, 121243. doi: 10.1016/j.carbpol.2023.121243
Sinzinger, Korbinian, Bieringer, Sebastian, Schieder, Doris, Riepl, Herbert and Sieber, Volker (2023). Biorefinery concept for Cylindrospermum alatosporum CCALA 988 extracting multiple high-value compounds and residue utilization by P. pastoris fermentation producing phytase. Algal Research, 76 103302, 1-11. doi: 10.1016/j.algal.2023.103302
Paschalidis, Leandros, Arana-Peña, Sara, Sieber, Volker and Burger, Jakob (2023). Mechanistic modeling, parametric study, and optimization of immobilization of enzymatic cascades in porous particles. Reaction Chemistry and Engineering, 8 (9), 2234-2244. doi: 10.1039/d3re00072a
Sutiono, Samuel, Zachos, Ioannis, Paschalidis, Leandros, Pick, André, Burger, Jakob and Sieber, Volker (2023). Biocatalytic Production of 1,2,4-Butanetriol beyond a Titer of 100 g/L: Boosting by Intermediates. ACS Sustainable Chemistry and Engineering, 11 (17), 6592-6599. doi: 10.1021/acssuschemeng.2c07418
Al-Shameri, Ammar, Schmermund, Luca and Sieber, Volker (2023). Engineering approaches for O2-dependent enzymes. Current Opinion in Green and Sustainable Chemistry, 40 100733. doi: 10.1016/j.cogsc.2022.100733
Willers, Vivian Pascal, Beer, Barbara and Sieber, Volker (2023). Integrating Carbohydrate and C1 Utilization for Chemicals Production. ChemSusChem, 16 (6) e202202122, 1-12. doi: 10.1002/cssc.202202122
Willers, Vivian Pascal, Döring, Manuel, Beer, Barbara and Sieber, Volker (2023). Cell-free enzymatic L-alanine synthesis from green methanol. Chem Catalysis, 3 (3) 100502, 1-13. doi: 10.1016/j.checat.2022.100502
Teshima, Mariko, Willers, Vivian Pascal and Sieber, Volker (2023). Cell-free enzyme cascades — application and transition from development to industrial implementation. Current Opinion in Biotechnology, 79 102868, 1-8. doi: 10.1016/j.copbio.2022.102868
Bayaraa, Tenuun, Lonhienne, Thierry, Sutiono, Samuel, Melse, Okke, Brück, Thomas B., Marcellin, Esteban, Bernhardt, Paul V., Boden, Mikael, Harmer, Jeffrey R., Sieber, Volker, Guddat, Luke W. and Schenk, Gerhard (2023). Structural and functional insight into the mechanism of the Fe‐S cluster‐dependent dehydratase from Paralcaligenes ureilyticus. Chemistry: A European Journal, 29 (9) e202203140, 1-13. doi: 10.1002/chem.202203140
Schieder, Andreas, Diener, Julia, Diekmann, Martin, Bartsch, Christian, Dietrich, Florian, Falcke, Claudia, Anic, Iva, Roth, Steffen, Sieber, Volker, Taden, Andreas and Richter, Michael (2023). A green process for the specific decomposition of chicken feather keratin into polythiol building blocks. RSC Sustainability, 2 (1), 197-210. doi: 10.1039/d3su00269a
Foley, Gabriel, Mora, Ariane, Ross, Connie M., Bottoms, Scott, Sützl, Leander, Lamprecht, Marnie L., Zaugg, Julian, Essebier, Alexandra, Balderson, Brad, Newell, Rhys, Thomson, Raine E. S., Kobe, Bostjan, Barnard, Ross T., Guddat, Luke, Schenk, Gerhard, Carsten, Jörg, Gumulya, Yosephine, Rost, Burkhard, Haltrich, Dietmar, Sieber, Volker, Gillam, Elizabeth M. J. and Bodén, Mikael (2022). Engineering indel and substitution variants of diverse and ancient enzymes using Graphical Representation of Ancestral Sequence Predictions (GRASP). PL o S Computational Biology, 18 (10) e1010633, e1010633. doi: 10.1371/journal.pcbi.1010633
Bayaraa, Tenuun, Gaete, Jose, Sutiono, Samuel, Kurz, Julia, Lonhienne, Thierry, Harmer, Jeffrey R., Bernhardt, Paul V., Sieber, Volker, Guddat, Luke and Schenk, Gerhard (2022). Dihydroxy‐acid dehydratases from pathogenic bacteria: emerging drug targets to combat antibiotic resistance. Chemistry: A European Journal, 28 (44) e202200927, 1-14. doi: 10.1002/chem.202200927
Sinzinger, Korbinian, Schieder, Doris, Rühmann, Broder and Sieber, Volker (2022). Towards a cyanobacterial biorefinery: Carbohydrate fingerprint, biocomposition and enzymatic hydrolysis of Nostoc biomass. Algal Research, 65 102744, 1-10. doi: 10.1016/j.algal.2022.102744
Paschalidis, Leandros, Beer, Barbara, Sutiono, Samuel, Sieber, Volker and Burger, Jakob (2022). Design of enzymatic cascade reactors through multi-objective dynamic optimization. Biochemical Engineering Journal, 181 108384, 108384. doi: 10.1016/j.bej.2022.108384
Melse, Okke, Sutiono, Samuel, Haslbeck, Magdalena, Schenk, Gerhard, Antes, Iris and Sieber, Volker (2022). Structure‐guided modulation of the catalytic properties of [2Fe‐2S]‐dependent dehydratases. ChemBioChem, 23 (10) e202200088, e202200088. doi: 10.1002/cbic.202200088
Schilling, Christoph, Klau, Leesa J., Aachmann, Finn L., Rühmann, Broder, Schmid, Jochen and Sieber, Volker (2022). Structural elucidation of the fucose containing polysaccharide of Paenibacillus polymyxa DSM 365. Carbohydrate Polymers, 278 118951, 118951. doi: 10.1016/j.carbpol.2021.118951
Zachos, Ioannis, Genth, Robert, Sutiono, Samuel, Marczynski, Matthias, Lieleg, Oliver and Sieber, Volker (2022). Hot flows: evolving an archaeal glucose dehydrogenase for ultrastable carba-NADP+using microfluidics at elevated temperatures. ACS Catalysis, 12 (3), 1841-1846. doi: 10.1021/acscatal.1c04320
Rath, Tristan, Rühmann, Broder, Schmid, Jochen and Sieber, Volker (2022). Systematic optimization of exopolysaccharide production by Gluconacetobacter sp. and use of (crude) glycerol as carbon source. Carbohydrate Polymers, 276 118769, 118769. doi: 10.1016/j.carbpol.2021.118769
Zachos, Ioannis, Güner, Samed, Essert, Arabella, Lommes, Peta and Sieber, Volker (2022). Boosting artificial nicotinamide cofactor systems. Chemical Communications, 58 (85), 11945-11948. doi: 10.1039/d2cc03423a
Güner, Samed, Wegat, Vanessa, Pick, André and Sieber, Volker (2021). Design of a synthetic enzyme cascade for the: In vitro fixation of a C1carbon source to a functional C4sugar. Green Chemistry, 23 (17), 6583-6590. doi: 10.1039/d1gc02226a
Zachos, Ioannis, Döring, Manuel, Tafertshofer, Georg, Simon, Robert C. and Sieber, Volker (2021). carba Nicotinamide Adenine Dinucleotide Phosphate: robust cofactor for redox biocatalysis. Angewandte Chemie - International Edition, 60 (26), 14701-14706. doi: 10.1002/anie.202017027
Sutiono, Samuel, Pick, André and Sieber, Volker (2021). Converging conversion - using promiscuous biocatalysts for the cell-free synthesis of chemicals from heterogeneous biomass. Green Chemistry, 23 (10), 3656-3663. doi: 10.1039/d0gc04288a
Medina-Cabrera, Edilberto Vicente, Gansbiller, Moritz, Rühmann, Broder, Schmid, Jochen and Sieber, Volker (2021). Rheological characterization of Porphyridium sordidum and Porphyridium purpureum exopolysaccharides. Carbohydrate Polymers, 253 117237, 117237. doi: 10.1016/j.carbpol.2020.117237
Begander, Benjamin, Huber, Anna, Sperl, Josef and Sieber, Volker (2020). Development of a cofactor balanced, multi enzymatic cascade reaction for the simultaneous production of l-alanine and l-serine from 2-keto-3-deoxy-gluconate. Catalysts, 11 (1) 31, 1-12. doi: 10.3390/catal11010031
Gansbiller, Moritz, Schmid, Jochen and Sieber, Volker (2020). Rheology of sphingans in EPS–surfactant systems. Carbohydrate Polymers, 248 116778, 1-11. doi: 10.1016/j.carbpol.2020.116778
Medina-Cabrera, Edilberto Vicente, Rühmann, Broder, Schmid, Jochen and Sieber, Volker (2020). Optimization of growth and EPS production in two Porphyridum strains. Bioresource Technology Reports, 11 100486, 1-10. doi: 10.1016/j.biteb.2020.100486
Schilling, Christoph, Ciccone, Rosario, Sieber, Volker and Schmid, Jochen (2020). Engineering of the 2,3-butanediol pathway of Paenibacillus polymyxa DSM 365. Metabolic Engineering, 61, 381-388. doi: 10.1016/j.ymben.2020.07.009
Medina-Cabrera, Edilberto Vicente, Rühmann, Broder, Schmid, Jochen and Sieber, Volker (2020). Characterization and comparison of Porphyridium sordidum and Porphyridium purpureum concerning growth characteristics and polysaccharide production. Algal Research, 49 101931, 101931. doi: 10.1016/j.algal.2020.101931
Sutiono, Samuel, Siebers, Bettina and Sieber, Volker (2020). Characterization of highly active 2-keto-3-deoxy-L-arabinonate and 2-keto-3-deoxy-D-xylonate dehydratases in terms of the biotransformation of hemicellulose sugars to chemicals. Applied Microbiology and Biotechnology, 104 (16), 7023-7035. doi: 10.1007/s00253-020-10742-5
Gmelch, Tobias J., Sperl, Josef M. and Sieber, Volker (2020). Molecular dynamics analysis of a rationally designed aldehyde dehydrogenase gives insights into improved activity for the non-native cofactor NAD+. ACS Synthetic Biology, 9 (4), 920-929. doi: 10.1021/acssynbio.9b00527
Begander, Benjamin, Huber, Anna, Döring, Manuel, Sperl, Josef and Sieber, Volker (2020). Development of an improved peroxidase-based high-throughput screening for the optimization of D-glycerate dehydratase activity. International Journal of Molecular Sciences, 21 (1) 335, 335. doi: 10.3390/ijms21010335
Bauer, Daniel, Zachos, Ioannis and Sieber, Volker (2020). Production of Propene from n-Butanol: A Three-Step Cascade Utilizing the Cytochrome P450 Fatty Acid Decarboxylase OleTJE. ChemBioChem, 21 (22) cbic.202000378, 3273-3281. doi: 10.1002/cbic.202000378
Schilling, Christoph, Koffas, Mattheos A. G., Sieber, Volker and Schmid, Jochen (2020). Novel prokaryotic CRISPR-Cas12a-based tool for programmable transcriptional activation and repression. ACS Synthetic Biology, 9 (12), 3353-3363. doi: 10.1021/acssynbio.0c00424
Sutiono, Samuel, Satzinger, Katharina, Pick, Andre, Carsten, Joerg and Sieber, Volker (2019). To beat the heat - engineering of the most thermostable pyruvate decarboxylase to date. RSC Advances, 9 (51), 29743-29746. doi: 10.1039/c9ra06251c
Gmelch, Tobias J., Sperl, Josef M. and Sieber, Volker (2019). Optimization of a reduced enzymatic reaction cascade for the production of L-alanine. Scientific Reports, 9 (1) 11754, 11754. doi: 10.1038/s41598-019-48151-y
Gansbiller, Moritz, Schmid, Jochen and Sieber, Volker (2019). In-depth rheological characterization of genetically modified xanthan-variants. Carbohydrate Polymers, 213, 236-246. doi: 10.1016/j.carbpol.2019.02.055
Zachos, Ioannis, Nowak, Claudia and Sieber, Volker (2019). Biomimetic cofactors and methods for their recycling. Current Opinion in Chemical Biology, 49, 59-66. doi: 10.1016/j.cbpa.2018.10.003
Sutiono, Samuel, Carsten, Jörg and Sieber, Volker (2018). Structure-guided engineering of α-keto acid decarboxylase for the production of higher alcohols at elevated temperature. ChemSusChem, 11 (18), 3335-3344. doi: 10.1002/cssc.201800944
Ranganathan, Sumanth and Sieber, Volker (2018). Recent advances in the direct synthesis of hydrogen peroxide using chemical catalysis—a review. Catalysts, 8 (9) 379, 379. doi: 10.3390/catal8090379
Beer, Barbara, Pick, André, Döring, Manuel, Lommes, Petra and Sieber, Volker (2018). Substrate scope of a dehydrogenase from Sphingomonas species A1 and its potential application in the synthesis of rare sugars and sugar derivatives. Microbial Biotechnology, 11 (4), 747-758. doi: 10.1111/1751-7915.13272
Ortiz-Tena, Jose G., Rühmann, Broder and Sieber, Volker (2018). Colorimetric determination of sulfate via an enzyme cascade for high-throughput detection of sulfatase activity. Analytical Chemistry, 90 (4), 2526-2533. doi: 10.1021/acs.analchem.7b03719
Rütering, Marius, Schmid, Jochen, Gansbiller, Moritz, Braun, Andre, Kleinen, Jochen, Schilling, Martin and Sieber, Volker (2017). Rheological characterization of the exopolysaccharide Paenan in surfactant systems. Carbohydrate Polymers, 181, 719-726. doi: 10.1016/j.carbpol.2017.11.086
Hohagen, Hendrik, Schwarz, Dominik, Schenk, Gerhard, Guddat, Luke W., Schieder, Doris, Carsten, Jörg and Sieber, Volker (2017). Deacidification of grass silage press juice by continuous production of acetoin from its lactate via an immobilized enzymatic reaction cascade. Bioresource Technology, 245 (Pt A), 1084-1092. doi: 10.1016/j.biortech.2017.08.203
Nowak, Claudia, Pick, André, Csepei, Lénárd-István and Sieber, Volker (2017). Characterization of Biomimetic Cofactors According to Stability, Redox Potentials, and Enzymatic Conversion by NADH Oxidase from Lactobacillus pentosus. ChemBioChem, 18 (19), 1944-1949. doi: 10.1002/cbic.201700258
You, Lv, Kandale, Ajit, Wun, Shun Jie, McGeary, Ross P., Williams, Simon J., Kobe, Bostjan, Sieber, Volker, Schembri, Mark A., Schenk, Gerhard and Guddat, Luke W. (2016). Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution: A potential target for anti-tuberculosis drug discovery. Febs Journal, 283 (7), 1184-1196. doi: 10.1111/febs.13672