Associate Professor Graham Leggatt
PhD
Senior Lecturer
School of Chemistry and Molecular Biosciences
Associate Professor in Immunology
Frazer Institute
Director (Research Training)
Faculty of Medicine
+61 7 344 36961
Primary research interest
Immunotherapy of non-melanoma skin cancers
Additional roles
Senior Lecturer and Senior Research fellow at SCMB and UQDI
About me
I completed a Bachelor of Science with honours at the University of Queensland in 1989 before undertaking Ph.D. studies on the immune response against parasitic worms (hydatid disease) at the Queensland Institute of Medical Research (QIMR). After receiving my doctorate from UQ in 1993, I headed to the NIH (USA) in Washington D.C. for a 4 year postdoctoral fellowship in T cell immunity to the HIV virus. Finally, I returned to Brisbane in 1997 to commence work on immune responses to cancer antigens expressed in the epithelium (including skin) with Prof. Ian Frazer. I am currently a senior lecturer with a joint appointment between SCMB and the UQ Diamantina Institute (Princess Alexandra Hospital).
Research focus and collaborations
The lab has a long term research focus on understanding the generation and regulation of cytotoxic T lymphocytes (CTL) in response to epithelial tumour. We particularly focus on the local T cell response to target antigens in the skin during the development of squamous cell carcinoma or cervical cancer. An understanding of the immune cells which regulate CTL function (e.g. Treg and NKT), the receptors which control CTL trafficking to the skin and the nature of the skin cells which present antigen to the T cell will aid in the development of immunotherapies for these debilitating diseases.
Funded projects
- 2014-2015: Cancer Council Queensland grant, Memory CD8 T cell subsets in non-melanoma skin cancer.
- 2017-2018: Cancer Council Queensland grant, Local targeting of immunomodulatory molecules on CD8 T cells in non-melanoma skin cancer.
Teaching interests
- BIOL3003: Course coordinator
- MICR7002: Course Cooordinator
- Contribute lectures to: BIOL1007, BIOM2011, Medicine
Featured publications
- Wong, Arthur, Lanyon, Janet M., McKee, Sara J., Linedale, Richard, Woolford, Lucy, Long, Trevor and Leggatt, Graham R. (2018) Development of a polyclonal anti-dugong immunoglobulin G (IgG) antibody with evaluation of total plasma IgG in a living dugong (Dugong dugon) population. Veterinary Immunology and Immunopathology, 200 16-25. doi:10.1016/j.vetimm.2018.04.003
- Kuo, Paula, Tuong, Zewen K, Teoh, Siok Min, Frazer, Ian H, Mattarollo, Stephen and Leggatt, Graham R(2018) HPV16E7 Induced Hyperplasia Promotes CXCL9/10 Expression and Induces CXCR3+ T cell Migration to Skin. The Journal of investigative dermatology, 138 6: 1348-1359. doi:10.1016/j.jid.2017.12.021
- Linedale, Richard, Schmidt, Campbell, King, Brigid T., Ganko, Annabelle G., Simpson, Fiona, Panizza, Benedict J. and Graham R. Leggatt (2017) Elevated frequencies of CD8 T cells expressing PD-1, CTLA-4 and Tim-3 within tumour from perineural squamous cell carcinoma patients. PLoS One, 12 4: e0175755.1-e0175755.13. doi:10.1371/journal.pone.0175755
- Bergot, Anne-Sophie, Ford, Neill, Leggatt, Graham R., Wells, James W., Frazer, Ian H. and Grimbaldeston, Michele A. (2014) HPV16-E7 expression in squamous epithelium creates a local immune suppressive environment via CCL2- and CCL5- mediated recruitment of mast cells. PLoS Pathogens, 10 10: 1-11. doi:10.1371/journal.ppat.1004466
- McKee, Sara J., Mattarollo, Stephen R. and Leggatt, Graham R. (2014) Immunosuppressive roles of natural killer T (NKT) cells in the skin. Journal of Leukocyte Biology, 96 1: 49-54. doi:10.1189/jlb.4RU0114-001R
Book
Book Chapter
Leggatt, G. R. and Frazer, I. H. (1999). Immunology of HPV infection. Vaccines for Human Papillomavirus Infection and Anogenital Disease. (pp. 13-31) edited by Robert W. Tindle. Austin, USA: R. G. Landes Company.
Journal Articles
Wright, Quentin G, Sinha, Debottam, Wells, James W, Frazer, Ian H, Gonzalez Cruz, Jazmina L and Leggatt, Graham Robert (2024). Peritumoral administration of immunomodulatory antibodies as a triple combination suppresses skin tumor growth without systemic toxicity. Journal for ImmunoTherapy of Cancer, 12 (1) e007960, e007960. doi: 10.1136/jitc-2023-007960
Berrell, Naomi, Sadeghirad, Habib, Blick, Tony, Bidgood, Charles, Leggatt, Graham R., O'Byrne, Ken and Kulasinghe, Arutha (2023). Metabolomics at the tumor microenvironment interface: Decoding cellular conversations. Medicinal Research Reviews, 44 (3), 1121-1146. doi: 10.1002/med.22010
Wright, Quentin, Gonzalez Cruz, Jazmina L., Wells, James W. and Leggatt, Graham R. (2021). PD-1 and beyond to activate T cells in cutaneous squamous cell cancers: the case for 4-1BB and VISTA antibodies in combination therapy. Cancers, 13 (13) 3310, 3310. doi: 10.3390/cancers13133310
Tay, Ban Qi, Wright, Quentin, Ladwa, Rahul, Perry, Christopher, Leggatt, Graham, Simpson, Fiona, Wells, James W., Panizza, Benedict J., Frazer, Ian H. and Cruz, Jazmina L. G. (2021). Evolution of cancer vaccines—challenges, achievements and future directions. Vaccines, 9 (5) 535, 535. doi: 10.3390/vaccines9050535
Zeng, Zhen, Chew, Hui Yi, Cruz, Jazmina G., Leggatt, Graham R. and Wells, James W. (2021). Investigating T cell immunity in cancer: achievements and prospects. International Journal of Molecular Sciences, 22 (6) 2907, 1-17. doi: 10.3390/ijms22062907
Kobayashi, Takumi, Lam, Pui Yeng, Jiang, Hui, Bednarska, Karolina, Gloury, Renee Elyse, Murigneux, Valentine, Tay, Joshua, Jacquelot, Nicolas, Li, Rui, Tuong, Zewen Kelvin, Leggatt, Graham, Gandhi, Maher K., Hill, Michelle M, Belz, Gabrielle T., Ngo, Shyuan, Kallies, Axel and Mattarollo, Stephen R. (2020). Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environment. Blood, 136 (26), 3004-3017. doi: 10.1182/blood.2020005602
Bashaw, Abate Assefa, Zhou, Chenhao, Yu, Meihua, Tolley, Lynn, Leggatt, Graham R., Frazer, Ian H. and Chandra, Janin (2020). Regulatory T-cells but not IL-10 impair cell-mediated immunity in HPV+ hyperplastic epithelium. The Journal of Investigative Dermatology, 141 (5), 1264-1273.e3. doi: 10.1016/j.jid.2020.10.011
Wright, Quentin, Minnie, Simone and Leggatt, Graham R (2020). Intradermal delivery of a combination of immunomodulatory antibodies can promote rejection of hyperplastic skin in a mouse model of actinic keratosis. The Journal of Immunology, 204 (1_Supplement), 241.23-241.23. doi: 10.4049/jimmunol.204.supp.241.23
Leggatt, Graham R, Salim, Nazhifah and Mattarollo, Stephen (2020). Upregulated 4-1BB (CD137) expression on skin T cells from a mouse model of precancerous skin. The Journal of Immunology, 204 (1_Supplement), 165.27-165.27. doi: 10.4049/jimmunol.204.supp.165.27
Wong, Arthur, Lanyon, Janet M., O'Handley, Ryan, Linedale, Richard, Woolford, Lucy, Long, Trevor and Leggatt, Graham R. (2020). Serum antibodies against Toxoplasma gondii and Neospora caninum in southeast Queensland dugongs. Marine Mammal Science, 36 (1) mms.12629, 180-194. doi: 10.1111/mms.12629
Tuong, Zewen, Lewandowski, Andrew, Bridge, Jennifer, Gonzalez-Cruz, Jazmina, Yamada, Miko, Lambie, Duncan, Lewandowski, Richard, Steptoe, Raymond, Leggatt, Graham, Simpson, Fiona, Frazer, Ian, Soyer, Peter and Wells, James W. (2019). Cytokine/chemokine profiles in squamous cell carcinoma correlate with precancerous and cancerous disease stage. Scientific Reports, 9 (1) 17754, 17754. doi: 10.1038/s41598-019-54435-0
Bashaw, Abate Assefa, Teoh, Siok M., Tuong, Zewen K., Leggatt, Graham R., Frazer, Ian H. and Chandra, Janin (2019). HPV16 E7-driven epithelial hyperplasia promotes impaired antigen presentation and regulatory T cell development. Journal of Investigative Dermatology, 139 (12), 2467-2476.e3. doi: 10.1016/j.jid.2019.03.1162
Lam, Pui Yeng, Kobayashi, Takumi, Soon, Megan, Zeng, Bijun, Dolcetti, Riccardo, Leggatt, Graham, Thomas, Ranjeny and Mattarollo, Stephen R. (2019). NKT cell-driven enhancement of antitumor immunity induced by Clec9a-targeted tailorable nanoemulsion. Cancer Immunology Research, 7 (6), 952-962. doi: 10.1158/2326-6066.cir-18-0650
Kuo, Paula, Teoh, Siok Min, Tuong, Zewen K., Leggatt, Graham R., Mattarollo, Stephen R. and Frazer, Ian H. (2018). Recruitment of antigen presenting cells to skin draining lymph node from HPV16E7-expressing skin requires E7-Rb interaction. Frontiers in Immunology, 9 2896, 2896. doi: 10.3389/fimmu.2018.02896
Kuo, Paula T., Zeng, Zhen, Salim, Nazhifah, Mattarollo, Stephen, Wells, James W. and Leggatt, Graham R. (2018). The role of CXCR3 and its chemokine ligands in skin disease and cancer. Frontiers in Medicine, 5 (SEP) 271, 271. doi: 10.3389/fmed.2018.00271
Joseph, Shannon R., Gaffney, Daniel, Barry, Rachael, Hu, Lingbo, Banushi, Blerida, Wells, James W., Lambie, Duncan, Strutton, Geoff, Porceddu, Sandro V., Burmeister, Bryan, Leggatt, Graham R., Schaider, Helmut, Dolcetti, Riccardo, Frazer, Ian H., Saunders, Nicholas A., Foote, Matthew, Soyer, H. Peter and Simpson, Fiona (2018). An ex vivo human tumour assay reveals distinct patterns of EGFR trafficking in squamous cell carcinoma correlating to therapeutic outcomes. Journal of Investigative Dermatology, 139 (1), 213-223. doi: 10.1016/j.jid.2018.06.190
Kerage, Daniel, Soon, Megan S. F., Doff, Brianna L., Kobayashi, Takumi, Nissen, Michael D., Lam, Pui Yeng, Leggatt, Graham R. and Mattarollo, Stephen R. (2018). Therapeutic vaccination with 4–1BB co-stimulation eradicates mouse acute myeloid leukemia. OncoImmunology, 7 (10) e1486952, 1-10. doi: 10.1080/2162402x.2018.1486952
Kuo, Paula, Tuong, Zewen K, Teoh, Siok Min, Frazer, Ian H, Mattarollo, Stephen and Leggatt, Graham R (2018). HPV16E7 Induced Hyperplasia Promotes CXCL9/10 Expression and Induces CXCR3+ T cell Migration to Skin. The Journal of investigative dermatology, 138 (6), 1348-1359. doi: 10.1016/j.jid.2017.12.021
Wong, Arthur, Lanyon, Janet M., McKee, Sara J., Linedale, Richard, Woolford, Lucy, Long, Trevor and Leggatt, Graham R. (2018). Development of a polyclonal anti-dugong immunoglobulin G (IgG) antibody with evaluation of total plasma IgG in a living dugong (Dugong dugon) population. Veterinary Immunology and Immunopathology, 200, 16-25. doi: 10.1016/j.vetimm.2018.04.003
Wong, Arthur W., Lanyon, Janet M., Sneath, Helen L., Leggatt, Graham R. and Woolford, Lucy (2018). Comparison of i-STAT® with traditional laboratory analysers in the measurement of blood analytes from field captured dugongs (Dugong dugon). Aquatic Mammals, 44 (1), 19-31. doi: 10.1578/AM.44.1.2018.19
McKee, Sara J., Tuong, Zewen K., Kobayashi, Takumi, Doff, Brianna L., Soon, Megan S. F ., Nissen, Michael, Lam, Pui Yeng, Keane, Colm, Vari, Frank, Moi, Davide, Mazzieri, Roberta, Leggatt, Graham, Gandhi, Maher K. and Mattarollo, Stephen R. (2018). B cell lymphoma progression promotes the accumulation of circulating Ly6Clo monocytes with immunosuppressive activity. OncoImmunology, 7 (2) e1393599, e1393599. doi: 10.1080/2162402X.2017.1393599
Bashaw, Abate Assefa, Leggatt, Graham R., Chandra, Janin, Tuong, Zewen K. and Frazer, Ian H. (2017). Modulation of antigen presenting cell functions during chronic HPV infection. Papillomavirus Research, 4, 58-65. doi: 10.1016/j.pvr.2017.08.002
Bhat, Purnima, Leggatt, Graham, Waterhouse, Nigel and Frazer, Ian H. (2017). Interferon-gamma derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity. Cell Death and Disease, 8 (6) e2836, e2836.1-e2836.11. doi: 10.1038/cddis.2017.67
Jazayeri, Seyed D., Kuo, Paula, Leggatt, Graham R. and Frazer, Ian (2017). HPV16-E7-specific activated CD8 T cells in E7 transgenic skin and skin grafts. Frontiers in Immunology, 8 (MAY) 524, 524. doi: 10.3389/fimmu.2017.00524
Linedale, Richard, Schmidt, Campbell, King, Brigid T., Ganko, Annabelle G., Simpson, Fiona, Panizza, Benedict J. and Graham R. Leggatt (2017). Elevated frequencies of CD8 T cells expressing PD-1, CTLA-4 and Tim-3 within tumour from perineural squamous cell carcinoma patients. PLoS One, 12 (4) e0175755, e0175755.1-e0175755.13. doi: 10.1371/journal.pone.0175755
Chandra, Janin, Dutton, Julie L., Li, Bo, Woo, Wai-Ping, Xu, Yan, Tolley, Lynn K., Yong, Michelle, Wells, James W., Leggatt, Graham R., Finlayson, Neil and Frazer, Ian H. (2017). DNA vaccine encoding HPV16 oncogenes E6 and E7 induces potent cell-mediated and humoral immunity which protects in tumor challenge and drives E7-expressing skin graft rejection. Journal of Immunotherapy, 40 (2), 62-70. doi: 10.1097/CJI.0000000000000156
Rearden, Rory, Sah, Amelia, Doff, Brianna, Kobayashi, Takumi, McKee, Sara J., Leggatt, Graham R. and Mattarollo, Stephen R. (2016). Control of B-cell lymphoma by therapeutic vaccination and acquisition of immune resistance is independent of direct tumour IFN-gamma signalling. Immunology and Cell Biology, 94 (6), 554-562. doi: 10.1038/icb.2016.9
Chawla, Sharad, Warren, Timothy A., Wockner, Leesa F., Lambie, Duncan L. J., Brown, Ian S., Martin, Thomas P. C., Khanna, Rajiv, Leggatt, Graham R. and Panizza, Benedict J. (2016). Galectin-1 is associated with poor prognosis in patients with cutaneous head and neck cancer with perineural spread. Cancer Immunology, Immunotherapy, 65 (2), 213-222. doi: 10.1007/s00262-015-1788-z
Gabrielli, Brian, Bokhari, Fawzi, Ranall, Max V., Oo, Zay Yar, Stevenson, Alexander J., Wang, Weili, Murrell, Melanie, Shaikh, Mushfiq, Fallaha, Sora, Clarke, Daniel, Kelly, Madison, Sedelies, Karin, Christensen, Melinda, McKee, Sara, Leggatt, Graham, Leo, Paul, Skalamera, Dubravka, Soyer, H. Peter, Gonda, Thomas J. and McMillan, Nigel A. J. (2015). Aurora A is critical for survival in HPV-transformed cervical cancer. Molecular Cancer Therapeutics, 14 (12), 2753-2761. doi: 10.1158/1535-7163.MCT-15-0506
Abd Warif, Nor Malia, Stoitzner, Patrizia, Leggatt, Graham R., Mattarollo, Stephen R., Frazer, Ian H. and Hibma, Merilyn H. (2015). Langerhans cell homeostasis and activation is altered in hyperplastic human papillomavirus type 16 E7 expressing epidermis. PLoS One, 10 (5) e0127155, e0127155-e0127155. doi: 10.1371/journal.pone.0127155
McKee, Sara J., Bergot, Anne-Sophie and Leggatt, Graham R. (2015). Recent progress in vaccination against human papillomavirus-mediated cervical cancer. Reviews in Medical Virology, 25 (S1), 54-71. doi: 10.1002/rmv.1824
Kobayashi, Takumi, Doff, Brianna L., Rearden, Rory C., Leggatt, Graham R. and Mattarollo, Stephen R. (2015). NKT cell-targeted vaccination plus anti-4-1BB antibody generates persistent CD8 T cell immunity against B cell lymphoma. Oncoimmunology, 4 (3), e990793-1-e990793-11. doi: 10.4161/2162402X.2014.990793
Bergot, Anne-Sophie, Ford, Neill, Leggatt, Graham R., Wells, James W., Frazer, Ian H. and Grimbaldeston, Michele A. (2014). HPV16-E7 expression in squamous epithelium creates a local immune suppressive environment via CCL2- and CCL5- mediated recruitment of mast cells. PLoS Pathogens, 10 (10), 1-11. doi: 10.1371/journal.ppat.1004466
Leggatt, Graham R. (2014). Peptide dose and/or structure in vaccines as a determinant of T cell responses. Vaccines, 2 (3), 537-548. doi: 10.3390/vaccines2030537
McKee, Sara J., Mattarollo, Stephen R. and Leggatt, Graham R. (2014). Immunosuppressive roles of natural killer T (NKT) cells in the skin. Journal of Leukocyte Biology, 96 (1), 49-54. doi: 10.1189/jlb.4RU0114-001R
Bhat, Purnima, Leggatt, Graham, Matthaei, Klaus I. and Frazer, Ian H. (2014). Correction: the kinematics of cytotoxic lymphocytes influence their ability to kill target cells. PLoS One, 9 (6) e101381, e101381. doi: 10.1371/journal.pone.0101381
Bhat, Purnima, Leggatt, Graham, Matthaei, Klaus I. and Frazer, Ian H. (2014). The kinematics of cytotoxic lymphocytes influence their ability to kill target cells. PLoS One, 9 (5) e95248, e95248.1-e95248.11. doi: 10.1371/journal.pone.0095248
Mittal, Deepak, Kassianos, Andrew. J, Tran, Lee S., Bergot, Anne-Sophie, Gosmann, Christina, Hofmann, Janin, Blumenthal, Antje, Leggatt, Graham R. and Frazer, Ian H. (2013). Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein E7. Journal of Investigative Dermatology, 133 (12), 2686-2694. doi: 10.1038/jid.2013.222
Choyce, Allison, Yong, Michelle, Narayan, Sharmal, Mattarollo, Stephen R., Liem, Amy, Lambert, Paul F., Frazer, Ian H. and Leggatt, Graham R. (2013). Expression of a single, viral oncoprotein in skin epithelium is sufficient to recruit lymphocytes. PLoS One, 8 (2) e57798, e57798.1-e57798.8. doi: 10.1371/journal.pone.0057798
Fiorenza, Salvatore, Kenna, Tony J., Comerford, Iain, McColl, Shaun, Steptoe, Raymond J., Leggatt, Graham R. and Frazer, Ian H. (2012). A Combination of Local Inflammation and Central Memory T Cells Potentiates Immunotherapy in the Skin. Journal of Immunology, 189 (12), 5622-5631. doi: 10.4049/jimmunol.1200709
Heng, Tracy S. P., Reiseger, Jessica J., Fletcher, Anne L., Leggatt, Graham R., White, Olivia J., Vlahos, Katerina, Frazer, Ian H., Turner, Stephen J. and Boyd, Richard L. (2012). Impact of sex steroid ablation on viral, tumour and vaccine responses in aged mice. PLoS One, 7 (8) e42677, e42677.1-e42677.11. doi: 10.1371/journal.pone.0042677
Rahimpour, Azad, Mattarollo, Stephen R., Yong, Michelle, Leggatt, Graham R., Steptoe, Raymond J. and Frazer, Ian H. (2012). gamma delta T cells augment rejection of skin grafts by enhancing cross-priming of CD8 T cells to skin-derived antigen. Journal of Investigative Dermatology, 132 (6), 1656-1664. doi: 10.1038/jid.2012.16
Saunders, Nicholas A., Simpson, Fiona, Thompson, Erik W., Hill, Michelle M., Endo-Munoz, Liliana, Leggatt, Graham, Minchin, Rodney F. and Guminski, Alexander (2012). Role of intratumoural heterogeneity in cancer drug resistance: Molecular and clinical perspectives. EMBO Molecular Medicine, 4 (8), 675-684. doi: 10.1002/emmm.201101131
Leggatt, Graham R. and Gabrielli, Brian (2012). Histone deacetylase inhibitors in the generation of the anti-tumour immune response. Immunology and Cell Biology, 90 (1), 33-38. doi: 10.1038/icb.2011.94
Mattarollo, Stephen R., Yong, Michelle, Gosmann, Christina, Choyce, Allison, Chan, Dora, Leggatt, Graham R. and Frazer, Ian H. (2011). NKT cells inhibit antigen-specific effector CD8 T cell induction to skin viral proteins. Journal of Immunology, 187 (4), 1601-1608. doi: 10.4049/jimmunol.1100756
Zhou, Fang, Leggatt, Graham R. and Frazer, Ian H. (2011). Human papillomavirus 16 E7 protein inhibits interferon-gamma-mediated enhancement of keratinocyte antigen processing and T-cell lysis. The Federation of European Biochemical Societies (FEBS) Journal, 278 (6), 955-963. doi: 10.1111/j.1742-4658.2011.08011.x
Frazer, Ian H., Leggatt, Graham R. and Mattarollo, Stephen R. (2011). Prevention and treatment of papillomavirus-related cancers through immunization. Annual Review of Immunology, 29, 111-138. doi: 10.1146/annurev-immunol-031210-101308
Bhat, Purnima, Mattarollo, Stephen R., Gosmann, Christina, Frazer, Ian H. and Leggatt, Graham R. (2011). Regulation of immune responses to HPVinfection and during HPV-directed immunotherapy. Immunological Reviews, 239 (1), 85-98. doi: 10.1111/j.1600-065X.2010.00966.x
Hadis, Usriansyah, Leggatt, Graham R., Thomas, Ranjeny, Frazer, Ian H. and Kovacs, Eva M. (2010). IL-1 signalling determines the fate of skin grafts expressing non-self protein in keratinocytes. Experimental Dermatology, 19 (8), 723-729. doi: 10.1111/j.1600-0625.2010.01092.x
Broom, Jennifer K., Lew, Andrew M., Azukizawa, Hiroaki, Kenna, Tony J., Leggatt, Graham R. and Frazer, Ian H. (2010). Antigen-specific CD4 cells assist CD8 T-effector cells in eliminating keratinocytes. Journal of Investigative Dermatology, 130 (6), 1581-1589. doi: 10.1038/jid.2010.17
Mattarollo, Stephen R., Yong, Michelle, Tan, Lieven, Frazer, Ian H. and Leggatt, Graham R. (2010). Secretion of IFN-gamma but not IL-17 by CD1d-restricted NKT cells enhances rejection of skin grafts expressing epithelial cell-derived antigen. Journal of Immunology, 184 (10), 5663-5669. doi: 10.4049/jimmunol.0903730
Mattarollo, Stephen R., Rahimpour, Azad, Choyce, Allison, Godfrey, Dale I., Leggatt, Graham R. and Frazer, Ian H. (2010). Invariant NKT Cells in Hyperplastic Skin Induce a Local Immune Suppressive Environment by IFN-gamma Production. Journal of Immunology, 184 (3), 1242-1250. doi: 10.4049/jimmunol.0902191
Zhou, F, Frazer, IH and Leggatt, GR (2009). Keratinocytes efficiently process endogenous antigens for cytotoxic T-cell mediated lysis. EXPERIMENTAL DERMATOLOGY, 18 (12), 1053-1059. doi: 10.1111/j.1600-0625.2009.00907.x
Dawson, P A, Choyce, A, Chuang, C, Whitelock, J, Markovich, D and Leggatt, GR (2009). Enhanced tumor growth in the NaS1 sulfate transporter null mouse. Cancer Science, 101 (2), 369-373. doi: 10.1111/j.1349-7006.2009.01399.x
Liu, Xiao Song, Leerberg, Joanne, MacDonald, Kelli, Leggatt, Graham and Frazer, Ian (2009). IFN-gamma promotes generation of IL-10 secreting CD4+ T cells that suppress generation of CD8 responses in an antigen-experienced host. The Jounral of Immunology, 183 (1), 51-58. doi: 10.4049/jimmunol.0802047
Gu, Wenyi, Cochrane, Melanie, Leggatt, Graham, Payne, Elizabeth, Choyce, Allison, Zhou, Fang, Tindle, Robert and McMillan, Nigel (2009). Both treated and untreated tumors are eliminated by short hairpin RNA-based induction of target-specific immune responses. Proceedings of the National Academy of Sciences of the United States of America, 106 (20), 8314-8319. doi: 10.1073/pnas.0812085106
Narayan, S., Choyce, A., Linedale, R., Saunders, N. A., Dahler, A., Chan, E., Fernando, G. J., Frazer, I. H. and Leggatt, G. R. (2009). Epithelial expression of human papillomavirus type 16 E7 protein results in peripheral CD8 T-cell suppression mediated by CD4(+)CD25(+) T cells. European Journal of Immunology, 39 (2), 481-490. doi: 10.1002/eji.200838527
Zhong, Jie, Usriansyah Usriansyah, Rachel De Kluyver, Leggatt, Graham R., Fernando, Germain J. and Frazer, Ian H. (2008). TLR7 stimulation augments T effector-mediated rejection, of skin expressing neo-self antigen in keratinocytes. European Journal of Immunology, 38 (1), 73-81. doi: 10.1002/eji.200737599
Leggatt, G. R. and Frazer, I. H. (2007). HPV vaccines: the beginning of the end for cervical cancer. Current Opinion In Immunology, 19 (2), 232-238. doi: 10.1016/j.coi.2007.01.004
Narayan, S., Choyce, A., Fernando, G. J. P. and Leggatt, G. R. (2007). Secondary immunisation with high-dose heterologous peptide leads to CD8 T cell populations with reduced functional avidity. European Journal of Immunology, 37 (2), 406-415. doi: 10.1002/eji.200535688
Gu, W., Putral, L., Hengst, K., Minto, K., Saunders, N. A., Leggatt, G. and McMillan, N. A. J. (2006). Inhibition of cervical cancer cell growth in vitro and in vivo with lentiviral-vector delivered short hairpin RNA targeting human papillomavirus E6 and E7 oncogenes. Cancer Gene Therapy, 13 (11), 1023-1032. doi: 10.1038/sj.cgt.7700971
Liu, Xiao Song, Dyer, Joanne, Leggatt, Graham R., Fernando, Germain J. P., Zhong, Jie, Thomas, Ranjeny and Frazer, Ian H. (2006). Overcoming original antigenic sin to generate new CD8 T cell IFN-gamma responses in an antigen-experienced host. Journal of Immunology, 177 (5), 2873-2879. doi: 10.4049/jimmunol.177.5.2873
Zhou, F., Leggatt, G., Zhong, J., Zhao, K., De Kluyver, R. and Frazer, I. H. (2005). Apoptosis mediated by CD8+T cells targeted to endogenous antigens in transgenic keratinocytes. Tissue Antigens, 66 (5), 600-600. doi: 10.1111/j.1399-0039.2005.00523.x
Zhong, J., De Kluyver, R., Leggatt, G. R., Fernando, G. J. and Frazer, I. H. (2005). Local inflammation is crucial for T cell mediated rejection of skin graft expressing foreign antigen. Tissue Antigens, 66 (5), 600-600.
De Kluyver, R. L., Morritz, L., Leggatt, G. R., Harris, C., Lambert, P. F. and Frazer, I. H. (2005). Interferon-gamma is required for killing keratinocytes in vitro and in vivo. Tissue Antigens, 66 (5), 394-394.
Khammanivong, V., Peters, T., Andrews, M., Leggatt, G. R., Frazer, I. H. and Fernando, G. J. (2005). The role of CD4 T help in multiple vaccinations when using minimal CD8 T cell epitope peptides. Tissue Antigens, 66 (5), 415-415.
Narayan, S., Fernando, G., Frazer, I. H. and Leggatt, G. (2005). A model of peripheral CD8(+) T cell tolerance against skin antigen. Tissue Antigens, 66 (5), 501-501. doi: 10.1111/j.1399-0039.2005.00523.x
Leggatt, G. R., Saunders, N., Dahler, A., Fernando, G. J., Matsumoto, K., Narayan, S., Linedale, R., Choyce, A. and Frazer, I. H. (2005). Transgenic expression of a viral oncoprotein exclusively in K14(+) epithelial cells results in peripheral but not central CD8 T cell tolerance. Tissue Antigens, 66 (5), 475-476.
Liu, X., Leggatt, G., Fernando, G. J. and Frazer, I. H. (2005). Overcoming original antigenic sin to generate effective immune responses in antigen primed host. Tissue Antigens, 66 (5), 481-481.
Putral, L. N., Bywater, M. J., Gu, W. Y., Saunders, N. A., Gabrielli, B. G., Leggatt, G. R. and McMillan, N. A. J. (2005). RNA interference against human papillomavirus oncogenes in cervical cancer cells results in increased sensitivity to cisplatin. Molecular Pharmacology, 68 (5), 1311-1319. doi: 10.1124/mol.105.014191
Andrews, Melanie R., Peters, Tania, Khammanivong, Vithagna, Leggatt, Graham R., Frazer, Ian H. and Fernando, Germain J. P. (2004). Functional memory CD8+ T cells can be generated in vivo without evident T help. Vaccine, 23 (6), 739-742. doi: 10.1016/j.vaccine.2004.07.027
Zhong, J., Matsumoto, K., De Kluyver, R., Fernando, G. J. P., Leggatt, G. R. and Frazer, I. H. (2004). Human growth hormone (hGH) presented by K14hGH-transgenic skin grafts induces a strong immune response but no graft rejection. Journal of Investigative Dermatology, 123 (6), A113-A113.
Leggatt, Graham R., Narayan, Sharmal, Fernando, Germain J. P. and Frazer, Ian H. (2004). Changes to peptide structure, not concentration, contribute to expansion of the lowest avidity cytotoxic T lymphocytes. Journal of Leukocyte Biology, 76 (4), 787-795. doi: 10.1189/jlb.0104026
Stewart, Trina J., Fernando, Germain J. P., Frazer, Ian H. and Leggatt, Graham R. (2004). Tumour susceptibility to innate and adaptive immunotherapy changes during tumour maturation. Immunology and Cell Biology, 82 (5), 455-461. doi: 10.1111/j.0818-9641.2004.01273.x
Matsumoto, K., Leggatt, G. R., Zhong, J., Liu, X. S., De Kluyver, R. L., Peters, T., Fernando, G. J. P., Liem, A., Lambert, P. F. and Frazer, I. H. (2004). Impaired Antigen Presentation and Effectiveness of Combined Active/Passive Immunotherapy for Epithelial Tumors. Journal of the National Cancer Institute, 96 (21), 1611-1619. doi: 10.1093/jnci/dhj301
Zhong, Jie, Matsumoto, Koji, De Kluyver, Rachel, Fernando, Germain J. P., Leggatt, Graham R. and Frazer, Ian H. (2004). Human growth hormone presented by K14hGH-transgenic skin grafts induces a strong immune response but no graft rejection. Immunology and Cell Biology, 82 (6), 577-586. doi: 10.1111/j.1440-1711.2004.01292.x
Liu, X. S., Xu, Y., Zhao, W. M., Fernando, G. J. P., Leggatt, G. R. and Frazer, I. H. (2004). Erratum: IL-10 Mediates Suppression of the CD8 T Cell IFN-γ Response to a Novel Viral Epitope in a Primed Host (Journal of Immunology (2003) 171 (4765-4772)). Journal of Immunology, 172 (2), 1311-1311. doi: 10.4049/jimmunol.172.2.1311-a
Liu, Xiao Song, Xu, Yan, Hardy, Lani, Khammanivong, Vithagna, Zhao, Weiming M., Fernando, Germain J. P., Leggatt, Graham R. and Frazer, Ian H. (2003). IL-10 Mediates Suppression of the CD8 T Cell IFN-γ Response to a Novel Viral Epitope in a Primed Host. Journal of Immunology, 171 (9), 4765-4772. doi: 10.4049/jimmunol.171.9.4765
Stewart, Trina J., Smyth, Mark J., Fernando, Germain J. P., Frazer, Ian H. and Leggatt, Graham R. (2003). Inhibition of early tumor growth requires Jα18-positive (natural killer T) cells. Cancer Research, 63 (12), 3058-3060.
Malcolm, K. M., Gill, J., Leggatt, G. R., Boyd, R., Lambert, P. and Frazer, I. H. (2003). Expression of the HPV16E7 oncoprotein by thymic epithelium is accompanied by disrupted T cell maturation and a failure of the thymus to involute with age. Clinical and Developmental Immunology, 10 (2-4), 91-103. doi: 10.1080/10446670310001626562
Khammanivong, Vithagna, Liu, Xiao Song, Liu, Wen Jun, Rodda, Stuart J., Leggatt, Graham R., Tindle, Robert W., Frazer, Ian H. and Fernando, Germain J. P. (2003). Paucity of functional CTL epitopes in the E7 oncoprotein of cervical cancer associated human papillomavirus type 16. Immunology and Cell Biology, 81 (1), 1-7. doi: 10.1046/j.1440-1711.2003.01130.x
Gao, Feng Guang, Khammanivong, Vithagna, Liu, Wen Jun, Leggatt, Graham R., Frazer, Ian H. and Fernando, Germain J. P. (2002). Antigen-specific CD4+ T-Cell Help Is Required to Activate a Memory CD8+ T Cell to a Fully Functional Tumor Killer Cell. Cancer Research, 62 (22), 6438-6441.
Leggatt, Graham R., Dunn, Linda A., De Kluyver, Rachel L., Stewart, Trina and Frazer, Ian H. (2002). Interferon-gamma enhances cytotoxic T lymphocyte recognition of endogenous peptide in keratinocytes without lowering the requirement for surface peptide. Immunology and Cell Biology, 80 (5), 415-424. doi: 10.1046/j.1440-1711.2002.01105.x
Dale, C. Jane, Liu, Xiao Song Song, De Rose, Robert, Purcell, Damian F. J., Anderson, Jenny, Xu, Yan, Leggatt, Graham R., Frazer, Ian H. and Kent, Stephen J. (2002). Chimeric human papilloma virus-simian/human immunodeficiency virus virus-like-particle vaccines: Immunogenicity and protective efficacy in macaques. Virology, 301 (1), 176-187. doi: 10.1006/viro.2002.1589
Fernando, G. J. P., Khammanivong, V., Leggatt, G. R., Liu, W. J. and Frazer, I. H. (2002). The number of long-lasting functional memory CD8(+) T cells generated depends on the nature of the initial nonspecific stimulation. European Journal of Immunology, 32 (6), 1541-1549. doi: 10.1002/1521-4141(200206)32:6<1541::AID-IMMU1541>3.0.CO;2-S
Liu, Xiao Song, Liu, Wen Jun, Zhao, Kong Nan, Liu, Yue Hua, Leggatt, Graham and Frazer, Ian H. (2002). Route of administration of chimeric BPV1VLP determines the character of the induced immune responses. Immunology and Cell Biology, 80 (1), 21-29. doi: 10.1046/j.1440-1711.2002.01051.x
Liu, Wen jun, Zhao, Kong-Nan, Gao, Feng Guang, Leggatt, Graham R., Fernando, Germain J. and Frazer, Ian H. (2001). Polynucleotide viral vaccines: codon optimisation and ubiquitin conjugation enhances prophylactic and therapeutic efficacy. Vaccine, 20 (5-6), 862-869. doi: 10.1016/S0264-410X(01)00406-6
Frazer, Ian H., De Kluyver, Rachel, Leggatt, Graham R., Guo, Hua Yang, Dunn, Linda, White, Olivia, Harris, Craig, Liem, Amy and Lambert, Paul (2001). Tolerance or immunity to a tumor antigen expressed in somatic cells can be determined by systemic proinflammatory signals at the time of first antigen exposure. Journal of Immunology, 167 (11), 6180-6187. doi: 10.4049/jimmunol.167.11.6180
Frazer, Ian H., De Kluyver, Rachel L., Leggatt, Graham R., Guo, Hua, Dunn, Linda A., White, Olivia J., Harris, Craig, Liem, Amy and Lambert, Paul F. (2001). Tolerance or immunity to a tumor antigen expressed in somatic cells can be determined by systemic proinflammatory signals at the time of first antigen exposure. The Journal of Immunology, 167 (11), 6180-6187.
Tindle, Robert W., Herd, Karen A., Doan, Tracy, Bryson, Greg, Leggatt, Graham R., Lambert, Paul, Ian H. Frazer, and Street, Michael D. (2001). Nonspecific down-regulation of CD8+ T-Cell responses in mice expressing human Papillomavirus Type 16 E7 oncoprotein from the keratin-14 promoter. Journal of Virology, 75 (13), 5985-5997. doi: 10.1128/JVI.75.13.5985-5997.2001
Liu, WJ, Liu, XS, Zhao, KN, Leggatt, GR and Frazer, IH (2000). Papillomavirus virus-like particles for the delivery of multiple cytotoxic T cell epitopes. Virology, 273 (2), 374-382. doi: 10.1006/viro.2000.0435
Leggatt, G. R. and Berzofsky, J. A. (2000). Cytotoxic T-cell adherence assay (CAA). Methods in molecular biology (Clifton, N.J.), 134, 277-281.
Frazer, Ian H., Thomas, Ranjeny, Zhou, Jian A., Leggatt, Graham R., Dunn, Linda, Mcmillan, Nigel A. J., Tindle, Robert W., Filgueira, Luis, Manders, Peter, Barnard, Paula and Sharkey, Michael (1999). Potential strategies utilised by papillomavirus to evade host immunity. Immunological Reviews, 168 (1), 131-142. doi: 10.1111/j.1600-065X.1999.tb01288.x
Leggatt, G. R., Hosmalin, A., Pendleton, C. D., Kumar, A., Hoffman, S. and Berzofsky, J. A. (1998). The importance of pairwise interactions between peptide residues in the delineation of TCR specificity. Journal of Immunology, 161 (9), 4728-4735.
Frazer, Ian H., Fernando, Germain J. P., Fowler, Nina, Leggatt, Graham R., Lambert, Paul F., Liem, Amy, Malcolm, Karen and Tindle, Robert W. (1998). Split tolerance to a viral antigen expressed in thymic epithelium and keratinocytes. European Journal of Immunology, 28 (9), 2791-2800. doi: 10.1002/(SICI)1521-4141(199809)28:09<2791::AID-IMMU2791>3.0.CO;2-B
Zhang, L. H., Leggatt, G. R., Kalinna, B. H., Piva, T. J. and McManus, D. P. (1997). Cloning and expression of a cDNA encoding a nonintegrin laminin-binding protein from Echinococcus granulosus with localization of the laminin-binding domain. Molecular and Biochemical Parasitology, 87 (2), 183-192. doi: 10.1016/S0166-6851(97)00066-2
Leggatt, G. R., Alexander-Miller, M. A., Kumar, A., Hoffman, S. L. and Berzofsky, J. A. (1997). Cytotoxic T lymphocyte (CTL) adherence assay (CAA): A non-radioactive assay for murine CTL recognition of peptide-MHC class I complexes. Journal of Immunological Methods, 201 (1), 1-10. doi: 10.1016/S0022-1759(96)00203-7
Jones, M. K., Zhang, L. H., Leggatt, G. R., Stenzel, D. J. and McManus, D. P. (1996). The ultrastructural localization of Echinococcus granulosus antigen 5. Parasitology, 113 (3), 213-222. doi: 10.1017/S0031182000081993
Alexander-Miller, M. A., Leggatt, G. R., Sarin, A. and Berzofsky, J. A. (1996). Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL. Journal of Experimental Medicine, 184 (2), 485-492. doi: 10.1084/jem.184.2.485
Alexander-Miller, M. A., Leggatt, G. R. and Berzofsky, J. A. (1996). Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy. Proceedings of the National Academy of Sciences of the United States of America, 93 (9), 4102-4107. doi: 10.1073/pnas.93.9.4102
Takahashi, H., Nakagawa, Y., Leggatt, G. R., Ishida, Y., Saito, T., Yokomuro, K. and Berzofsky, J. A. (1996). Inactivation of human immunodeficiency virus (HIV)-1 envelope-specific CD8+ cytotoxic T lymphocytes by free antigenic peptide: A self-veto mechanism?. Journal of Experimental Medicine, 183 (3), 879-889. doi: 10.1084/jem.183.3.879
Zhang, L. -H., Leggatt, G. R. and McManus, D. P. (1995). Further characterization of the 38 kDa antigen from Echinococcus granulosus (hydatid disease) cyst fluid: Evidence for antigenic heterogeneity and reactivity with anti-P1 antibodies. Parasite Immunology, 17 (6), 287-296. doi: 10.1111/j.1365-3024.1995.tb00894.x
Leggatt, G. R. and McManus, D. P. (1994). Identification and diagnostic value of a major antibody epitope on the 12 kDa antigen from Echinococcus granulosus (hydatid disease) cyst fluid. Parasite Immunology, 16 (2), 87-96.
McManus, D. P. and Leggatt, G. R. (1993). Hydatid immunoblot test and cross-reactivity with sera from patients with cysticercosis. Transactions of the Royal Society of Tropical Medicine and Hygiene, 87 (3), 350-350. doi: 10.1016/0035-9203(93)90162-J
Leggatt, G. R. and McManus, D. P. (1992). Sequence homology between two immunodiagnostic fusion proteins from Echinococcus multilocularis. International Journal For Parasitology, 22 (6), 831-833. doi: 10.1016/0020-7519(92)90134-7
Leggatt, G. R., Yang, W. and McManus, D. P. (1992). Serological evaluation of the 12 kDa subunit of antigen B in Echinococcus granulosus cyst fluid by immunoblot analysis. Transactions of the Royal Society of Tropical Medicine and Hygiene, 86 (2), 189-192. doi: 10.1016/0035-9203(92)90566-U
McManus, D. P., Bowles, J., Leggatt, G. and Garcia-Zepeda, E. (1991). Some recent advances in the molecular characterization of Echinococcus and Taenia solium. The Southeast Asian journal of tropical medicine and public health, 22 Suppl, 256-261.
Conference Papers
Wright, Q., Sinha, D., Gonzalez-Cruz, J., Frazer, I. and Leggatt, G. (2022). Targeting of immune regulatory proteins through locoregional delivery of mAbs augments CD8 T cell mediated anti-tumour responses in vivo. ESMO Immuno-Oncology Congress 2022, Geneva, Switzerland, 7-9 December 2022. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.iotech.2022.100289
Dang, T. V. T., Gillinder, K. G., Brooks, A. J., Asplett, K., Tolley, L. K., Hume, D. A., Leggatt, G. R., Frazer, I. H. and Chandra, J. (2022). Gene-therapy based modulation of antigen-presenting cells within hyperproliferative epithelium to restore immunity. 29th Annual Congress of the European-Society-of-Gene-and-Cell-Therapy (ESCGT), Edinburgh, United Kingdom, 11-14 October 2022. New Rochelle, NY United States: Mary Ann Liebert.
Leggatt, Graham R., Salim, Nazhifah and Mattarollo, Stephen (2020). Upregulated 4-1BB (CD137) expression on skin T cells from a mouse model of precancerous skin. IMMUNOLOGY2020, Honolulu, HI, United States, 8-12 May, 2020. Rockville, MD, United States: American Association of Immunologists.
Wright, Quentin, Minnie, Simone and Leggatt, Graham R. (2020). Intradermal delivery of a combination of immunomodulatory antibodies can promote rejection of hyperplastic skin in a mouse model of actinic keratosis. IMMUNOLOGY2020, Honolulu, HI, United States, 8-12 May 2020. Rockville, MD, United States: American Association of Immunologists.
McMillan, N., Fallaha, S., Martin, D., Leggatt, G. and Gabrielli, B. (2016). Inhibition of Aurora Kinases is curative for HPV-driven tumours. 16th Biennial Meeting of the International Gynecologic Cancer Society, Lisbon, Portugal, 28-31 October 2016. London, United Kingdom: Lippincott Williams & Wilkins. doi: 10.1097/01.IGC.0000503327.50238.5c
Leggatt, G., Veitch, M., Sheehan, B., McKee, S., Linedale, R., Jazayeri, S. D. and Mattarollo, S. (2016). Tissue resident CD103+CD69+ T cells develop rapidly and do not require cognate antigen within the epidermis of a mouse model of precancerous skin. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley.
Frazer, I, Mattarollo, S., Leggatt, G., Wells, J., Tuong, K., Kuo, P., Jazayeri, S., Lambert, P. and Chandra, J. (2016). Immunotherapy for persisting viral infection and associated cancer. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley.
Rearden, R., Sah, A., Doff, B., Kobayashi, T., McKee, S., Leggatt, G. and Mattarollo, S. (2016). The implications of vaccination-induced IFN-gamma signalling on the control of B-cell lymphoma and the acquisition of immune resistance. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley.
Kobayashi, T., Tuong, K., Man, K., Mckee, S., Leggatt, G., Kallies, A. and Mattarollo, S. (2016). Altered nutrient levels caused by B cell lymphoma leads to dysfunctional natural killer cells. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley.
Mattarollo, Stephen, Leggatt, Graham, Wells, James, Lambert, Paul and Frazer, Ian H. (2016). Modeling checkpoint blockade inhibitor resistant immunoregulation induced by squamous epithelial cancers. International Cancer Immunotherapy Conference: Translating Science into Survival, New York, United States, September 16-19, 2015. Philadelphia, United States: American Association for Cancer Research. doi: 10.1158/2326-6074.CRICIMTEATIAACR15-A064
Gabrielli, Brian G., Bokhari, Fawzi, Ranall, Max, Oo, Zay Yar, Stevenson, Alex, Wang, Weili, McKee, Sara, Leggatt, Graham, Leo, Paul, Gonda, Thomas J. and McMillan, Nigel A. J. (2015). Abstract 945: synthetic lethal screen identifies Aurora A as a selective target in HPV driven cervical cancer. 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Philadelphia, PA United States, 18-22 April 2015. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.AM2015-945
Gabrielli, B., Bokhari, F., Ranall, M., Stevenson, A., Murell, M., Kelly, M., McKee, S., Leggatt, G., Gonda, T. and McMillan, N. (2014). Synthetic lethal screen identifies Aurora A as a selective target in HPV driven cervical cancer. 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Barcelona Spain, 18-21 November 2014. Abingdon, Oxford, United Kingdom: Elsevier. doi: 10.1016/S0959-8049(14)70420-4
Leggatt, Graham, Mattarollo, Stephen, Yong, Michelle, Nissen, Michael and Frazer, Ian (2013). Systemic lymphopenia results in loss of suppressive lymphocytes from precancerous skin. 100th Annual Meeting of the American Association of Immunologists, Honolulu, Hawaii, 03-07 May 2013. Bethesda, MD United States: American Association of Immunologists.
Gu, W. Y., Leggatt, G., Payne, E., Wilson, D., Choyce, A. and McMillan, N. A. J. (2009). RNA interference for the treatment of cervical cancers: Solving the delivery and efficacy issues. 6th Meeting of the Australasian Gene Therapy Society, Sydney, Australia, 29 April - 01 May 2009. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/jgm.1375
Leggatt, G. R., Zhong, J., Mattarollo, S., Liu, X., De Kluyver, R., Fiorenza, S., Zhou, J., Hadis, U., Warif, N. A., Rahimpour, A., Broom, J. and Frazer, I. H. (2009). Immunotherapy for skin cancer. 6th Annual Scientific Meeting, Australasian Society for Dermatology Research, Surfers Paradise, QLD, Australia, 20-21 May 2009. Baltimore, MD, U.S.A.: Nature Publishing Group. doi: 10.1038/jid.2009.333
Frazer, Ian H., Leggatt, G. J., Matsumoto, K., De Kluyver, R., Quinn, M., Nicklin, J., Tan, J., Perrin, L., Ng, P., O'Connor, V., White, O., Wendt, N., Martin, J., Mitchelll, S.V., McKenzie, A., Crowley, J., Edwards, S. and Maher, D. (2003). Immunotherapy for HPV associated pre-cancer. Cancer Vaccine Collaborative 2002, Multiple locations, September 30 - October 1 2002. The Academy of Cancer Immunology.
Saito, J., Kanzaki, H., Leggatt, G. and Frazer, I. (2001). Mucosal and systemic immunization with BPVL1E7VLP vaccine induce effective cellular immunity. 53rd Annual Congress of the Japan Society of Obstetrics and Gynecology, Sapporo, Japan, 12-15 May 2001. 40128 BOLOGNA: Medimond S R L.
Alexander-Miller, M. A., Parker, K. C., Leggatt, G. R., Tsukui, T., Pendleton, C. D., Coligan, J. E. and Berzofsky, J. A. (1995). Similar presentation of a promiscuous HIV 1 peptide by human and murine class I MHC molecules, and ability of peptide induced murine CTL to clear virus infection in scid mice. -, -, -. LARCHMONT: MARY ANN LIEBERT INC PUBL.