Dr Vitaliya Sagulenko
Senior Scientific Officer - Protein
School of Chemistry and Molecular Biosciences
+61 7 334 67539
Vita oordinates and maintain the RealTime PCR and Flow Cytometry facilities in the school. She contributes to the training of staff and students in the use of equipment in the facilities, and provides advice on experimental design and interpretation of data.
Vita contributes to the development of funding applications to support the purchase of new equipment for these facilities as well as other general school scientific equipment. She supervises a HEW 5 Scientific Officer, serves as an IATA certified Dangerous Goods shipper for SCMB staff (advise, supervise, certify shipping of DG and biological goods), and is a fire warden for the Molecular Biosciences Building.
Book Chapter
Stacey, Katryn J., Idris, Adi, Sagulenko, Vitaliya, Vitak, Nazarii and Sester, David P. (2016). Methods for delivering DNA to intracellular receptors. Toll-like receptor detection and activation. (pp. 93-106) edited by Claire E. McCoy. New York, NY, United States: Springer Science+Business Media. doi: 10.1007/978-1-4939-3335-8_6
Journal Articles
Thygesen, Sara J., Burgener, Sabrina S., Mudai, Prerna, Monteleone, Mercedes, Boucher, Dave, Sagulenko, Vitaliya, Schroder, Kate and Stacey, Katryn J. (2024). Fluorochrome‐labeled inhibitors of caspase‐1 require membrane permeabilization to efficiently access caspase‐1 in macrophages. European Journal of Immunology, 54 (5) 2350515, e2350515. doi: 10.1002/eji.202350515
Afanasyeva, Elena A., Gartlgruber, Moritz, Ryl, Tatsiana, Decaesteker, Bieke, Denecker, Geertrui, Mönke, Gregor, Toprak, Umut H., Florez, Andres, Torkov, Alica, Dreidax, Daniel, Herrmann, Carl, Okonechnikov, Konstantin, Ek, Sara, Sharma, Ashwini Kumar, Sagulenko, Vitaliya, Speleman, Frank, Henrich, Kai-Oliver and Westermann, Frank (2021). Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastoma. Life Science Alliance, 4 (5) e201900332, e201900332. doi: 10.26508/LSA.201900332
Sagulenko, Vitaliya, Vitak, Nazarii, Vajjhala, Parimala, Vince, James E and Stacey, Katryn J (2017). Caspase-1 is an apical caspase leading to caspase-3 cleavage in the AIM2 inflammasome response, independent of caspase-8. Journal of Molecular Biology, 430 (2), 238-247. doi: 10.1016/j.jmb.2017.10.028
Sagulenko, Vitaliya, Lawlor, Kate E. and Vince, James E. (2016). New insights into the regulation of innate immunity by caspase-8. Arthritis Research and Therapy, 18 (1) 4, 4.1-4.3. doi: 10.1186/s13075-015-0910-0
Vajjhala, Parimala R., Lu, Alvin, Brown, Darren L., Pang, Siew Wai, Sagulenko, Vitaliya, Sester, David P., Cridland, Simon O., Hill, Justine M., Schroder, Kate, Stow, Jennifer L., Wu, Hao and Stacey, Katryn J. (2015). The inflammasome adaptor ASC induces procaspase-8 death effector domain filaments. Journal of Biological Chemistry, 290 (49), 29217-29230. doi: 10.1074/jbc.M115.687731
Sester, David P., Sagulenko, Vitaliya, Thygesen, Sara J., Cridland, Jasmyn A., Loi, Yen Siew, Cridland, Simon O., Masters, Seth L., Genske, Ulrich, Hornung, Veit, Andoniou, Christopher E., Sweet, Matthew J., Degli-Esposti, Mariapia A., Schroder, Kate and Stacey, Katryn J. (2015). Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice.. Journal of Immunology, 195 (3), 1233-1241. doi: 10.4049/jimmunol.1402859
Sester, David P., Thygesen, Sara J., Sagulenko, Vitaliya, Vajjhala, Parimala R., Cridland, Jasmyn A., Vitak, Nazarii, Chen, Kaiwen W., Osborne, Geoffrey W., Schroder, Kate and Katryn J. Stacey (2015). A novel flow cytometric method to assess inflammasome formation. The Journal of Immunology, 194 (1), 455-462. doi: 10.4049/jimmunol.1401110
Sagulenko, V., Thygesen, S. J., Sester, D. P., Idris, A., Cridland, J. A., Vajjhala, P. R., Roberts, T., Schroder, K., Vince, J. E., Hill, J. M., Silke, J. and Stacey, K. J. (2013). AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC. Cell Death and Differentiation, 20 (9), 1149-1160. doi: 10.1038/cdd.2013.37
Yin, Qian, Sester, David P., Tian, Yuan, Hsiao, Yu-Shan, Lu, Alvin, Cridland, Jasmyn A., Sagulenko, Vitaliya, Thygesen, Sara J., Choubey, Divaker, Hornung, Veit, Walz, Thomas, Stacey, Katryn J. and Wu, Hao (2013). Molecular mechanism for p202-mediated specific inhibition of aim2 inflammasome activation. Cell Reports, 4 (2), 327-339. doi: 10.1016/j.celrep.2013.06.024
Aachoui, Youssef, Sagulenko, Vitaliya, Miao, Edward A. and Stacey, Katryn J. (2013). Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection. Current Opinion in Microbiology, 16 (3), 319-326. doi: 10.1016/j.mib.2013.04.004
Schroder, Kate, Sagulenko, Vitaliya, Zamoshnikova, Alina, Richards, Ayanthi A., Cridland, Jasmyn A., Irvine, Katharine M., Stacey, Katryn J. and Sweet, Matthew J. (2012). Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction. Immunobiology, 217 (12), 1325-1329. doi: 10.1016/j.imbio.2012.07.020
Afanasyeva, E. A., Mestdagh, P., Kumps, C., Vandesompele, J., Ehemann, V., Theissen, J., Fischer, M., Zapatka, M., Brors, B., Savelyeva, L., Sagulenko, V., Speleman, F., Schwab, M. and Westermann, F. (2011). MicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survival. Cell Death and Differentiation, 18 (6), 974-984. doi: 10.1038/cdd.2010.164
Stacey, Katryn J. and Sagulenko, Vitaliya (2010). A clear link between endogenous retroviral LTR activity and Hodgkin's lymphoma. Cell Research, 20 (8), 869-871. doi: 10.1038/cr.2010.96
Schramm, Gunnar, Wiesberg, Stefan, Diessl, Nicolle, Kranz, Anna-Lena, Sagulenko, Vitalia, Oswald, Marcus, Reinelt, Gerhard, Westermann, Frank, Eils, Roland and Konig, Rainer (2010). PathWave: Discovering patterns of differentially regulated enzymes in metabolic pathways. Bioinformatics, 26 (9), 1225-1231. doi: 10.1093/bioinformatics/btq113
Sagulenko, Vitalia, Muth, Daniel, Sagulenko, Evgeny, Paffhausen, Tobias, Schwab, Manfred and Westermann, Frank (2008). Cathepsin D protects human neuroblastoma cells from doxorubicin-induced cell death. Carcinogenesis, 29 (10), 1869-1877. doi: 10.1093/carcin/bgn147
Sagulenko, Evgeny, Savelyeva, Larissa, Ehemann, Volker, Sagulenko, Vitaliya, Hofmann, Wera, Arnold, Katrin, Claas, Andreas, Scherneck, Siegfried and Schwab, Manfred (2007). Suppression of polyploidy by the BRCA2 protein. Cancer Letters, 257 (1), 65-72. doi: 10.1016/j.canlet.2007.07.003
Roumiantseva, M. L., Andronov, E. E., Sagulenko, V. V., Onishchuk, O. P., Provorov, N. A. and Simarov, B. V. (2004). [Instability of cryptic plasmids in strain Sinorhizobium meliloti P108 in the course of symbiosis with Alfalfa Medicago sativa]. Генетика [Genetika], 40 (4), 454-461. doi: 10.1023/B:RUGE.0000024971.91460.55
Sagulenko, Evgeniy, Sagulenko, Vitaliya, Chen, Jun and Christie, Peter J. (2001). Role of Agrobacterium VirB11 ATPase in T-pilus assembly and substrate selection. Journal of Bacteriology, 183 (20), 5813-5825. doi: 10.1128/JB.183.20.5813-5825.2001
Sagulenko, V., Sagulenko, E,, Jakubowski, S., Spudich, E. and Christie, P. J. (2001). VirB7 lipoprotein is exocellular and associates with the Agrobacterium tumefaciens T pilus.. Journal of Bacteriology, 183 (12), 3642-3651. doi: 10.1128/JB.183.12.3642-3651.2001
Conference Paper
Vajjhala, P., Lu, A., Brown, D., Sagulenko, V, Schroder, K., Stow, J., Wu, H. and Stacey, K. (2016). Molecular arrangement and activation of procaspases-1 and-8 at inflammasomes. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley.