School of Chemistry and Molecular Biosciences

Professor Bostjan Kobe

BSc (Ljubljana) Chemistry, PhD (Texas) Biochemistry/Biophysics
NHMRC Leadership Fellow
School of Chemistry and Molecular Biosciences
+61 7 336 52132
Molecular Biosciences Building (76), Room 329
View researcher profile

Primary research interest

Structural biology of infection and immunity

Additional roles

  • Leader, Protein Structure and Function Group

About me

I received my BSc (Hons) degree from the University of Ljubljana, Slovenia, and my PhD degree from the University of Texas Soutwestern Medical Center at Dallas, USA, under the supervision of Johann Deisenhofer. I worked as Postdoctoral Fellow at Howard Hughes Medical Institute in Dallas Texas, and at St Vincent's Institute of Medical Research in Melbourne, Australia. I have been at the University of Queensland since the year 2000. I have been awarded the Minister's Prize for Achievement in Life Sciences in 2001, the ASBMB Roche Medal in 2009 and the ASBMB Beckman Coulter Discovery Science Award in 2018. I was awarded the ARC Federation Fellowship in 2005 and the ARC Laureate Fellowship in 2017. I become Fellow of the Australian Academy of Science in 2018.

Research focus and collaborations

Protein structure and function

The group’s research theme is protein structure and function, with the emphasis on understanding the structural basis of intra- and intermolecular interactions formed by these macromolecules and inferring function from structure. The biological focus is on proteins involved in infection and immunity. The goal of the research is to use structural and molecular information to understand the molecular and cellular functions of proteins, validate proteins as therapeutic targets or biotechnological products, and to design new therapeutics and biotechnological applications. The primary techniques used in the laboratory are X-ray crystallography and cryo-electron microscopy, combined with a plethora of other molecular biology, biophysical and computational techniques.

Projects

  • Molecular and structural basis of innate immunity in animals, plants and bacteria
  • Molecular and structural basis of bacterial, fungal and viral pathogenesis

Funded projects

  • ARC Discovery Project 2022-2025
    Structural basis of plant immune receptor signaling
    Total value of grant: $500,253
  • ARC Laureate Fellowship 2019-2023
    Unifying mechanisms of innate immunity signaling in animals and plants
    Total value of grant: $2,682,165
  • NHMRC Project 2019-2021
    Molecular basis and inhibition of TIR-domain function in Toll-like receptor and neuronal cell-death pathways
    Total value of grant: $772,521
  • ARC Discovery Project 2019-2021
    Molecular mechanisms of signalling by plant immune receptors
    Total value of grant: $538,287
  • NHMRC Program 2015-2019
    Proteins and glycans in host-pathogen interactions: targets for novel drugs and vaccines
    $8,795,785

Teaching interests

  • Advanced Biochemistry and Molecular Biology (BIOC3000)
  • Cell Structure & Function (BIOL2200)
  • Foundations of Biophysics (BIPH2000)
  • Frontiers in Biophysics (BIPH3001)

Achievements and awards

Appointments

  • Academic Editor, Acta Crystallographica Section D Structural Biology
  • Academic Editor, PLoS One
  • Lorne Proteins Conference Organising Committee (2017-)
  • ARC Medical Research Advisory Group (2018-)
  • NHMRC Projects Grant Review Panel (2016-2018)
  • ARC College of Experts (2012-2015)

Awards

  • 2022 School of Chemistry and Molecular Biosciences High Impact Research Achievement Award
  • 2020 Slovenian Ambassador of Science
  • 2018 ASBMB Beckman Coulter Discovery Science Award
  • 2018  Fellow of the Australian Academy of Science
  • 2018 ARC Laureate Fellowship
  • 2017 School of Chemistry and Molecular Biosciences Higher Degree by Research Supervision Excellence Award
  • 2016 NHMRC Principal Research Fellowship
  • 2014 School of Chemistry and Molecular Biosciences High Impact Research Achievement Award
  • 2011 Q-Index Award for Postgraduate Supervision
  • 2011 NHMRC Senior Research Fellowship
  • 2009 ASBMB Roche Medal
  • 2005 ARC Federation Fellowship
  • 2003 NHMRC Senior Research Fellowship
  • 2001 Minister's Prize for Achievement in Life Sciences 
  • 2000 Erice Vaciago Award, International School of Crystallography
  • 1998 National Association of Research Fellows of NHMRC Post-Doctoral Award
  • 1997 Wellcome Senior Research Fellowship in Medical Science
  • 1996 ARC Postoctoral Fellowship
  • 1994 University of Texas Southwestern Nominata Award

Featured publications

Researcher biography

Dr Kobe's research interests are in protein structure and function, focussing particularly on proteins involved in the processes of infection and immunity.

The primary techniques used in the laboratory are X-ray crystallography and cryo-electron microscopy, combined with a plethora of other molecular biology, biophysical and computational techniques.

Current projects include:

  • Structural basis of signalling by cooperative assembly formation (SCAF) in innate immunity and cell-death pathways, in particular Toll-like receptors and interleukin-1 receptors
  • Structural basis of plant disease resistance - particularly plant NLRs and the correponding pathogen effector proteins
  • Molecular and structural basis of function of proteins from pathogens (fungal, bacterial and viral pathogens)

Publications

Book Chapters (19)
Journal Articles (280)
Conference Papers (58)

Book Chapters

Ellis, Jonathan J. and Kobe, Boštjan (2013). Protein phosphorylation. Encyclopedia of biophysics. (pp. 2037-2040) edited by Gordon C. K. Roberts. Berlin, Germany: Springer-Verlag. doi: 10.1007/978-3-642-16712-6_184
Kobe, Bostjan and Kemp, Bruce E. (2010). Principles of kinase regulation. Handbook of Cell Signaling, 2/e. (pp. 559-563) Elsevier Inc.. doi: 10.1016/B978-0-12-374145-5.00074-7
Mouradov, Dmitri, Kobe, Bostjan, Dixon, Nicholas E. and Huber, Thomas (2010). Hybrid methods for protein structure prediction. Introduction to protein structure prediction: Methods and algorithms. (pp. 265-277) edited by Huzefa Rangwala and George Karypis. Hoboken, New Jersey, USA: John Wiley and Sons, Inc.. doi: 10.1002/9780470882207.ch12
W. Saunders, Neil F., Brinkworth, Ross I., Kemp, Bruce E. and Kobe, Bostjan (2010). Substrates of Cyclic Nucleotide-Dependent Protein Kinases. Handbook of Cell Signaling. (pp. 1489-1495) Elsevier. doi: 10.1016/b978-0-12-374145-5.00182-0
Li, Sheng, Mouradov, Dmitri, King, Gordon, Liu, Tong, Ross, Ian, Kobe, Bostjan, Woods, Virgil L. and Huber, Thomas (2009). Study of protein three-dimensional structure and dynamics determination using peptide amide hydrogen/deuterium exchange mass spectrometry (DXMS) and chemical cross-linking with mass spectrometry to constrain molecular modeling. Structural Bioinformatics. (pp. 171-206) edited by Gu, Jenny and Bourne, Phillip E.. Hoboken, N.J.: Wiley-Blackwell.
Robin, G., Cowieson, N.P., Guncar, G., Forwood, J.K., Listwan, P., Hume, D.A., Kobe, B., Martin, J.L. and Huber, T.L. (2008). A general target selection method for crystallographic proteomics. Structural Proteomics: High-Throughput Methods. (pp. 27-35) edited by Kobe, B., Guss, M. and Huber, T.L.. Totowa, NJ, United States: Humana Press. doi: 10.1007/978-1-60327-058-8_2
Mouradov, Dmitri, King. Gordon, Ross, Ian L., Forwood, Jade K., Hume, David A., Sinz, Andrea, Martin, Jennifer L., Kobe, Bostjan and Huber, Thomas L. (2008). Protein structure determination using a combination of cross-linking, mass spectrometry, and molecular modeling. Structural Proteomics: High Throughput Methods. (pp. 459-474) edited by Bostjan Kobe, Mitchell Guss and Thomas L. Huber. Totowa, NJ, United States: Humana Press. doi: 10.1007/978-1-60327-058-8_31
Thakur, A. S., Newman, J., Martin, J. L. and Kobe, B. (2008). Increasing protein crystallization screening success with heterogeneous nucleating agents. Structural Proteomics: High-throughput Methods. (pp. 403-409) edited by B. Kobe, M. Guss and T. Huber. USA: Humana Press.
Meng, Weining, Forwood, Jade K., Guncar, Gregor, Robin, Gautier, Cowieson, Nathan P., Listwan, Pawel, Mouradov, Dmitri, King, Gordon, Ross, lan L., Robinson, Jodie, Puri, Munish, Hill, Justine M., Kellie, Stuart, Huber, Thomas, Hume, David A., Martin, Jennifer L. and Kobe, Bostjan (2008). Overview of the pipeline for structural and functional characterization of macrophage proteins at the University of Queensland. Structural proteomics: High-throughput methods. (pp. 577-587) edited by B. Kobe, M. Guss and T. L. Huber. Totowa, NJ, United States: Humana Press. doi: 10.1007/978-1-60327-058-8_38
Cowieson, N. P., Wensley, B., Robin, G., Guncar, G., Forwood, J. K., Hume, D. A., Kobe, B. and Martin, J. L. (2008). A medium or high throughput protein refolding assay. Structural Proteomics: High throughput Methods. (pp. 269-275) edited by Bostjan Kobe, Mitchell Guss and Thomas Huber. Totowa, NJ, United States: Humana Press. doi: 10.1007/978-1-60327-058-8_17
Brinkworth, R. I., Kobe, B. and Kemp, B.L.E. (2004). Peptide substrates of cyclic nucleotide-dependent protein kinases. Handbook of Cell Signaling. (pp. 495-499) edited by R. A. Bradshaw and E. A. Dennis. USA: Academic Press. doi: 10.1016/B978-012124546-7/50563-5
Kobe, B. and Kemp, B. E. (2004). Principles of kinase regulation. Handbook of Cell Signaling Vol 1. (pp. 539-542) edited by R. A. Bradshaw and E. A. Dennis. USA: Academic Press.
Kobe, Bostjan and Kemp, Bruce E. (2003). Principles of Kinase Regulation. Handbook of Cell Signaling. (pp. 539-542) Elsevier Inc.. doi: 10.1016/B978-012124546-7/50450-2
Brinkworth, R. I., Breinl, R. A. and Kobe, B. (2002). Conserved sequence motifs in protein kinase families. Recent Research Developments in Protein Folding Stability and Design. (pp. 67-77) edited by M Michael Gromiha and S Selvaraj. Trivandrum, India: Research Signpost.
Kobe, Bostjan, Jennings, Ian G. and Cotton, Richard G. H. (2002). Structure and Regulation of Phenylalanine Hydroxylase, and Implications for Related Enzymes. Chemistry and Biology of Pteridines and Folates. (pp. 79-84) Boston, MA: Springer US. doi: 10.1007/978-1-4615-0945-5_13
Heierhorst, Jorg, Pearson, Richard, Horne, James, Bozinovski, Steven, Kobe, Bostjan and Kemp, Bruce E. (2000). Protein serine/threonine kinases. Principles of Molecular Regulation. (pp. 297-310) edited by Michael Conn P. and Anthony R. Means. Totowa, N.J., USA: Humana Press. doi: 10.1007/978-1-59259-032-2_17
Kobe, Bostjan, Gleichmann, Thomas, Teh, Trazel, Heierhorst, Jorg and Kemp, Bruce E. (1999). Crystallization of protein kinases and phosphatases. Protein phosphorylation: A practical approach. (pp. 387-422) edited by D. Grahame Hardie. Oxford, UK: Oxford University Press.
Kobe, Boštjan, Heierhorst, Jörg and Kemp, Bruce E. (1997). 3 Intrasteric regulation of protein kinases. Advances in Second Messenger and Phosphoprotein Research. (pp. 29-40) Elsevier. doi: 10.1016/s1040-7952(97)80006-7
Rizo, Josep, Blanco, Francisco, Kobe, Bostjan, Bruch, Martha D., Hoyt, David W. and Gierasch, Lila M. (1992). Conformations of wild-type and mutant OmpA signal sequences in membrane mimetic environments. Peptides. (pp. 265-267) Dordrecht: Springer Netherlands. doi: 10.1007/978-94-011-2264-1_94

Journal Articles

Lv, You, Qi, Jianxun, Babon, Jeffrey J., Cao, Longxing, Fan, Guohuang, Lang, Jiajia, Zhang, Jin, Mi, Pengbing, Kobe, Bostjan and Wang, Faming (2024). Correction to: The JAK-STAT pathway: from structural biology to cytokine engineering (Signal Transduction and Targeted Therapy, (2024), 9, 1, (221), 10.1038/s41392-024-01934-w). Signal Transduction and Targeted Therapy, 9 (1) 290, 290. doi: 10.1038/s41392-024-01975-1
Li, Y., Pacoste, L. C., Gu, W., Thygesen, S. J., Stacey, K. J., Ve, T., Kobe, B., Xu, H. and Nanson, J. D. (2024). Microcrystal electron diffraction structure of Toll-like receptor 2 TIR-domain-nucleated MyD88 TIR-domain higher-order assembly. Acta Crystallographica Section D Structural Biology, 80 (9), 699-712. doi: 10.1107/s2059798324008210
Bhatt, Akansha, Mishra, Biswa P., Gu, Weixi, Sorbello, Mitchell, Xu, Hongyi, Ve, Thomas and Kobe, Bostjan (2024). Structural characterization of TIR-domain signalosomes through a combination of structural biology approaches. IUCrJ, 11 (5), 695-707. doi: 10.1107/s2052252524007693
Teng, Linhong, Sun, Yuhuan, Chen, Jiayi, Wang, Chenghui, Urbach, Jonathan M., Kobe, Bostjan, Ye, Naihao and Zeng, Qiangcheng (2024). Exon shuffling and alternative splicing of ROCO genes in brown algae enables a diverse repertoire of candidate immune receptors. Frontiers in Plant Science, 15 1445022. doi: 10.3389/fpls.2024.1445022
Lv, You, Qi, Jianxun, Babon, Jeffrey J., Cao, Longxing, Fan, Guohuang, Lang, Jiajia, Zhang, Jin, Mi, Pengbing, Kobe, Bostjan and Wang, Faming (2024). The JAK-STAT pathway: from structural biology to cytokine engineering. Signal Transduction and Targeted Therapy, 9 (1) 221, 221. doi: 10.1038/s41392-024-01934-w
McGuinness, Helen Y., Gu, Weixi, Shi, Yun, Kobe, Bostjan and Ve, Thomas (2024). SARM1-dependent axon degeneration: nucleotide signaling, neurodegenerative disorders, toxicity, and therapeutic opportunities. The Neuroscientist, 30 (4), 473-492. doi: 10.1177/10738584231162508
Shi, Yun, Masic, Veronika, Mosaiab, Tamim, Rajaratman, Premraj, Hartley-Tassell, Lauren, Sorbello, Mitchell, Goulart, Cassia C., Vasquez, Eduardo, Mishra, Biswa P., Holt, Stephanie, Gu, Weixi, Kobe, Bostjan and Ve, Thomas (2024). Structural characterization of macro domain–containing Thoeris antiphage defense systems. Science Advances, 10 (26) eadn3310, eadn3310. doi: 10.1126/sciadv.adn3310
Lv, You, Mi, Pengbing, Babon, Jeffrey J., Fan, Guohuang, Qi, Jianxun, Cao, Longxing, Lang, Jiajia, Zhang, Jin, Wang, Faming and Kobe, Bostjan (2024). Small molecule drug discovery targeting the JAK-STAT pathway. Pharmacological Research, 204 107217, 107217. doi: 10.1016/j.phrs.2024.107217
Rahaman, Md. Habibur, Thygesen, Sara J., Maxwell, Michael J., Kim, Hyoyoung, Mudai, Prerna, Nanson, Jeffrey D., Jia, Xinying, Vajjhala, Parimala R., Hedger, Andrew, Vetter, Irina, Haselhorst, Thomas, Robertson, Avril A. B., Dymock, Brian, Ve, Thomas, Mobli, Mehdi, Stacey, Katryn J. and Kobe, Bostjan (2024). o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2. Journal of Enzyme Inhibition and Medicinal Chemistry, 39 (1) 2313055, 2313055. doi: 10.1080/14756366.2024.2313055
Thynne, Elisha and Kobe, Bostjan (2024). Mixed-organism enzyme in plant defense. Science, 383 (6684), 707-708. doi: 10.1126/science.adn8306
Ganio, Katherine, Nasreen, Marufa, Yang, Zihao, Maunders, Eve A., Luo, Zhenyao, Hossain, Sheikh Imamul, Ngu, Dalton H. Y., Ellis, Daniel, Gu, Jin, Neville, Stephanie L., Wilksch, Jonathan, Gunn, Adam P., Whittall, Jonathan J., Kobe, Boštjan, Deplazes, Evelyne, Kappler, Ulrike and McDevitt, Christopher A. (2024). Hfe permease and Haemophilus influenzae manganese homeostasis. ACS Infectious Diseases, 10 (2), 436-452. doi: 10.1021/acsinfecdis.3c00407
Chen, Rachel M., Emming, Stefan, Cinnamon, Roseanna, Cameron, Jacob P., Schroder, Kate, Kobe, Bostjan and Robertson, Avril A. B. (2024). The design, synthesis, and biological evaluation of 5,6,7,8-tetrahydropteridines as anti-inflammatory compounds. Organic & Biomolecular Chemistry. doi: 10.1039/d4ob01453g
Maruta, Natsumi, Outram, Megan A. and Kobe, Bostjan (2023). Mildew RALPHs up in arms with cereals. Proceedings of the National Academy of Sciences, 120 (36) e2311817120, 1-3. doi: 10.1073/pnas.2311817120
Li, Sulin, Manik, Mohammad K., Shi, Yun, Kobe, Bostjan and Ve, Thomas (2023). Toll/interleukin-1 receptor domains in bacterial and plant immunity. Current Opinion in Microbiology, 74 102316, 1-10. doi: 10.1016/j.mib.2023.102316
McCombe, Carl L., Catanzariti, Ann‐Maree, Greenwood, Julian R., Desai, Anna M., Outram, Megan A., Yu, Daniel S., Ericsson, Daniel J., Brenner, Steven E., Dodds, Peter N., Kobe, Bostjan, Jones, David A. and Williams, Simon J. (2023). A rust‐fungus Nudix hydrolase effector decaps mRNA in vitro and interferes with plant immune pathways. New Phytologist, 239 (1), 222-239. doi: 10.1111/nph.18727
Maruta, Natsumi, Sorbello, Mitchell, Lim, Bryan Y. J., McGuinness, Helen Y., Shi, Yun, Ve, Thomas and Kobe, Bostjan (2023). TIR domain-associated nucleotides with functions in plant immunity and beyond. Current Opinion in Plant Biology, 73 102364, 102364. doi: 10.1016/j.pbi.2023.102364
Lang, Jia-Jia, Lv, You, Kobe, Bostjan, Chen, Hongfei, Tan, Yan, Chen, Limei, Wang, Xuechuan, Mi, Pengbing, Zheng, Xing and Lin, Ying-Wu (2023). Discovery of C-5 pyrazole-substituted pyrrolopyridine derivatives as potent and selective inhibitors for janus kinase 1. Journal of Medicinal Chemistry, 66 (10), 6725-6742. doi: 10.1021/acs.jmedchem.3c00050
Tao, Le, Yang, Guangyue, Sun, Tiantian, Tao, Jie, Zhu, Chan, Yu, Huimin, Cheng, Yalan, Yang, Zongguo, Xu, Mingyi, Jiang, Yuefeng, Zhang, Wei, Wang, Zhiyi, Ma, Wenting, Wu, Liu, Xue, Dongying, Wang, Dongxue, Yang, Wentao, Zhao, Yongjuan, Horsefield, Shane, Kobe, Bostjan, Zhang, Zhe, Tang, Zongxiang, Li, Qigen, Zhai, Qiwei, Dooley, Steven, Seki, Ekihiro, Liu, Ping, Xu, Jianrong, Chen, Hongzhuan and Liu, Cheng (2023). Capsaicin receptor TRPV1 maintains quiescence of hepatic stellate cells in the liver via recruitment of SARM1. Journal of Hepatology, 78 (4), 805-819. doi: 10.1016/j.jhep.2022.12.031
Teng, Linhong, Liang, Miao, Wang, Chenghui, Li, Yan, Urbach, Jonathan M., Kobe, Bostjan, Xing, Qikun, Han, Wentao and Ye, Naihao (2023). Exon shuffling potentiates a diverse repertoire of brown algal NB‐ARC‐TPR candidate immune receptor proteins via alternative splicing. The Plant Journal, 114 (2), 246-261. doi: 10.1111/tpj.16131
Bayless, Adam M., Chen, Sisi, Ogden, Sam C., Xu, Xiaoyan, Sidda, John D., Manik, Mohammad K., Li, Sulin, Kobe, Bostjan, Ve, Thomas, Song, Lijiang, Grant, Murray, Wan, Li and Nishimura, Marc T. (2023). Plant and prokaryotic TIR domains generate distinct cyclic ADPR NADase products. Science Advances, 9 (11) eade8487, 1-15. doi: 10.1126/sciadv.ade8487
Muusse, Timothy W., Lee, Morris Y.L., Kim, Hyoyoung, Parat, Marie-Odile, Nanson, Jeffrey D., Kobe, Bostjan, Vajjhala, Parimala R. and Stacey, Katryn J. (2022). Flow cytometric reporter assays provide robust functional analysis of signaling complexes. Journal of Biological Chemistry, 298 (12) 102666, 102666. doi: 10.1016/j.jbc.2022.102666
Foley, Gabriel, Mora, Ariane, Ross, Connie M., Bottoms, Scott, Sützl, Leander, Lamprecht, Marnie L., Zaugg, Julian, Essebier, Alexandra, Balderson, Brad, Newell, Rhys, Thomson, Raine E. S., Kobe, Bostjan, Barnard, Ross T., Guddat, Luke, Schenk, Gerhard, Carsten, Jörg, Gumulya, Yosephine, Rost, Burkhard, Haltrich, Dietmar, Sieber, Volker, Gillam, Elizabeth M. J. and Bodén, Mikael (2022). Engineering indel and substitution variants of diverse and ancient enzymes using Graphical Representation of Ancestral Sequence Predictions (GRASP). PL o S Computational Biology, 18 (10) e1010633, e1010633. doi: 10.1371/journal.pcbi.1010633
Wizrah, Maha S. I., Chua, Sheena M. H., Luo, Zhenyao, Manik, Mohammad K., Pan, Mengqi, Whyte, Jessica M. L., Robertson, Avril A. B., Kappler, Ulrike, Kobe, Bostjan and Fraser, James A. (2022). AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans. Journal of Biological Chemistry, 298 (10) 102453, 102453. doi: 10.1016/j.jbc.2022.102453
Manik, Mohammad K., Shi, Yun, Li, Sulin, Zaydman, Mark A., Damaraju, Neha, Eastman, Samuel, Smith, Thomas G., Gu, Weixi, Masic, Veronika, Mosaiab, Tamim, Weagley, James S., Hancock, Steven J., Vasquez, Eduardo, Hartley-Tassell, Lauren, Kargios, Nestoras, Maruta, Natsumi, Lim, Bryan Y. J., Burdett, Hayden, Landsberg, Michael J., Schembri, Mark A., Prokes, Ivan, Song, Lijiang, Grant, Murray, DiAntonio, Aaron, Nanson, Jeffrey D., Guo, Ming, Milbrandt, Jeffrey, Ve, Thomas and Kobe, Bostjan (2022). Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling. Science, 377 (6614) eadc8969, 1-11. doi: 10.1126/science.adc8969
Holmes, Susannah, Kirkwood, Henry J., Bean, Richard, Giewekemeyer, Klaus, Martin, Andrew V., Hadian-Jazi, Marjan, Wiedorn, Max O., Oberthür, Dominik, Marman, Hugh, Adriano, Luigi, Al-Qudami, Nasser, Bajt, Saša, Barák, Imrich, Bari, Sadia, Bielecki, Johan, Brockhauser, Sandor, Coleman, Mathew A., Cruz-Mazo, Francisco, Danilevski, Cyril, Dörner, Katerina, Gañán-Calvo, Alfonso M., Graceffa, Rita, Fanghor, Hans, Heymann, Michael, Frank, Matthias, Kaukher, Alexander, Kim, Yoonhee, Kobe, Bostjan, Knoška, Juraj ... Darmanin, Connie (2022). Megahertz pulse trains enable multi-hit serial femtosecond crystallography experiments at X-ray free electron lasers. Nature Communications, 13 (1) 4708, 1-13. doi: 10.1038/s41467-022-32434-6
Lv, You, Zheng, Shan, Goldenzweig, Adi, Liu, Fengjiang, Gao, Yan, Yang, Xiuna, Kandale, Ajit, McGeary, Ross P., Williams, Simon, Kobe, Bostjan, Schembri, Mark A., Landsberg, Michael J., Wu, Bin, Brück, Thomas B., Sieber, Volker, Boden, Mikael, Rao, Zihe, Fleishman, Sarel J., Schenk, Gerhard and Guddat, Luke W. (2022). Enhancing the Thermal and Kinetic Stability of Ketol-Acid Reductoisomerase, a Central Catalyst of a Cell-Free Enzyme Cascade for the Manufacture of Platform Chemicals. Applied Biosciences, 1 (2), 163-178. doi: 10.3390/applbiosci1020011
Hancock, Steven J., Lo, Alvin W., Ve, Thomas, Day, Christopher J., Tan, Lendl, Mendez, Alejandra A., Phan, Minh-Duy, Nhu, Nguyen Thi Khanh, Peters, Kate M., Richards, Amanda C., Fleming, Brittany A., Chang, Chyden, Ngu, Dalton H. Y., Forde, Brian M., Haselhorst, Thomas, Goh, Kelvin G. K., Beatson, Scott A., Jennings, Michael P., Mulvey, Matthew A., Kobe, Bostjan and Schembri, Mark A. (2022). Ucl fimbriae regulation and glycan receptor specificity contribute to gut colonisation by extra-intestinal pathogenic Escherichia coli. PLoS Pathogens , 18 (6) e1010582, e1010582. doi: 10.1371/journal.ppat.1010582
Alquethamy, Saleh, Ganio, Katherine, Luo, Zhenyao, Hossain, Sheikh I., Hayes, Andrew J., Ve, Thomas, Davies, Mark R., Deplazes, Evelyne, Kobe, Boštjan and McDevitt, Christopher A. (2022). Structural and biochemical characterization of Acinetobacter baumannii ZnuA. Journal of Inorganic Biochemistry, 231 111787, 1-11. doi: 10.1016/j.jinorgbio.2022.111787
Maunders, Eve A., Ngu, Dalton H. Y., Ganio, Katherine, Hossain, Sheikh I., Lim, Bryan Y. J., Leeming, Michael G., Luo, Zhenyao, Tan, Aimee, Deplazes, Evelyne, Kobe, Boštjan and McDevitt, Christopher A. (2022). The impact of chromate on Pseudomonas aeruginosa molybdenum homeostasis. Frontiers in Microbiology, 13 903146, 1-19. doi: 10.3389/fmicb.2022.903146
Shi, Yun, Kerry, Philip S., Nanson, Jeffrey D., Bosanac, Todd, Sasaki, Yo, Krauss, Raul, Saikot, Forhad K., Adams, Sarah E., Mosaiab, Tamim, Masic, Veronika, Mao, Xianrong, Rose, Faith, Vasquez, Eduardo, Furrer, Marieke, Cunnea, Katie, Brearley, Andrew, Gu, Weixi, Luo, Zhenyao, Brillault, Lou, Landsberg, Michael J., DiAntonio, Aaron, Kobe, Bostjan, Milbrandt, Jeffrey, Hughes, Robert O. and Ve, Thomas (2022). Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules. Molecular Cell, 82 (9), 1643-1659.e10. doi: 10.1016/j.molcel.2022.03.007
Liu, Liping, Lucas, Richard M., Nanson, Jeffrey D., Li, Yan, Whitfield, Jason, Curson, James E. B., Tuladhar, Neeraj, Alexandrov, Kirill, Mobli, Mehdi, Sweet, Matthew J., Kobe, Bostjan, Stow, Jennifer and Luo, Lin (2022). The transmembrane adaptor SCIMP recruits tyrosine kinase Syk to phosphorylate Toll-like receptors to mediate selective inflammatory outputs. Journal of Biological Chemistry, 298 (5) 101857, 101857. doi: 10.1016/j.jbc.2022.101857
Scholz, Jean L., Eleftherianos, Ioannis and Kobe, Bostjan (2022). Editorial: Evolution of Innate Immunity in Eukarya: Advances and Implications. Frontiers in Immunology, 13 879429, 879429. doi: 10.3389/fimmu.2022.879429
Nimma, Surekha, Gu, Weixi, Manik, Mohammad K., Ve, Thomas, Nanson, Jeffrey D. and Kobe, Bostjan (2022). Crystal structure of the Toll/interleukin‐1 receptor (TIR) domain of IL‐1R10 provides structural insights into TIR domain signaling. FEBS Letters, 596 (7), 886-897. doi: 10.1002/1873-3468.14288
Tran, Thao Thanh, Mathmann, Carmen D., Gatica-Andrades, Marcela, Rollo, Rachel F., Oelker, Melanie, Ljungberg, Johanna K., Nguyen, Tam T. K., Zamoshnikova, Alina, Kummari, Lalith K., Wyer, Orry J. K., Irvine, Katharine M., Melo-Bolívar, Javier, Gross, Annette, Brown, Darren, Mak, Jeffrey Y. W., Fairlie, David P., Hansford, Karl A., Cooper, Matthew A., Giri, Rabina, Schreiber, Veronika, Joseph, Shannon R., Simpson, Fiona, Barnett, Timothy C., Johansson, Jörgen, Dankers, Wendy, Harris, James, Wells, Timothy J., Kapetanovic, Ronan, Sweet, Matthew J. ... Blumenthal, Antje (2022). Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages. PLoS Pathogens, 18 (1) e1010166, e1010166. doi: 10.1371/journal.ppat.1010166
Maruta, Natsumi, Burdett, Hayden, Lim, Bryan Y. J., Hu, Xiahao, Desa, Sneha, Manik, Mohammad Kawsar and Kobe, Bostjan (2022). Structural basis of NLR activation and innate immune signalling in plants. Immunogenetics, 74 (1), 5-26. doi: 10.1007/s00251-021-01242-5
Loreto, Andrea, Angeletti, Carlo, Gu, Weixi, Osborne, Andrew, Nieuwenhuis, Bart, Gilley, Jonathan, Arthur-Farraj, Peter, Merlini, Elisa, Amici, Adolfo, Luo, Zhenyao, Hartley-Tassell, Lauren, Ve, Thomas, Desrochers, Laura M, Wang, Qi, Kobe, Bostjan, Orsomando, Giuseppe and Coleman, Michael P (2021). Neurotoxin-mediated ­­potent activation of the axon degeneration regulator SARM1. eLife, 10 e72823. doi: 10.7554/elife.72823
Nimma, Surekha, Gu, Weixi, Maruta, Natsumi, Li, Yan, Pan, Mengqi, Saikot, Forhad Karim, Lim, Bryan Y. J., McGuinness, Helen Ying, Zaoti, Zannati Ferdous, Li, Sulin, Desa, Sneha, Manik, Mohammad Kawsar, Nanson, Jeffrey D. and Kobe, Bostjan (2021). Structural evolution of TIR-domain signalosomes. Frontiers in Immunology, 12 784484, 1-10. doi: 10.3389/fimmu.2021.784484
Sasaki, Yo, Zhu, Jian, Shi, Yun, Gu, Weixi, Kobe, Bostjan, Ve, Thomas, DiAntonio, Aaron and Milbrandt, Jeffrey (2021). Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection. Experimental Neurology, 345 113842, 113842. doi: 10.1016/j.expneurol.2021.113842
Chua, Sheena M. H., Wizrah, Maha S. I., Luo, Zhenyao, Lim, Bryan Y. J., Kappler, Ulrike, Kobe, Bostjan and Fraser, James A. (2021). Structural features of Cryptococcus neoformans bifunctional GAR/AIR synthetase may present novel antifungal drug targets. Journal of Biological Chemistry, 297 (4) 101091. doi: 10.1016/j.jbc.2021.101091
Gu, Weixi, Luo, Zhenyao, Vonrhein, Clemens, Jia, Xinying, Ve, Thomas, Nanson, Jeffrey D. and Kobe, Bostjan (2021). Crystal structure determination of the armadillo repeat domain of Drosophila SARM1 using MIRAS phasing. Acta Crystallographica. Section F: Structural Biology Communications, 77 (10), 364-373. doi: 10.1107/s2053230x21006786
Župan, Marina L., Luo, Zhenyao, Ganio, Katherine, Pederick, Victoria G., Neville, Stephanie L., Deplazes, Evelyne, Kobe, Boštjan and McDevitt, Christopher A. (2021). Conformation of the solute-binding protein AdcAII influences zinc uptake in Streptococcus pneumoniae. Frontiers in Cellular and Infection Microbiology, 11 729981, 1-15. doi: 10.3389/fcimb.2021.729981
Hopkins, Eleanor L., Gu, Weixi, Kobe, Bostjan and Coleman, Michael P. (2021). A novel NAD signaling mechanism in axon degeneration and its relationship to innate immunity. Frontiers in Molecular Biosciences, 8 703532, 1-16. doi: 10.3389/fmolb.2021.703532
Outram, Megan A., Sung, Yi‐Chang, Yu, Daniel, Dagvadorj, Bayantes, Rima, Sharmin A., Jones, David A., Ericsson, Daniel J., Sperschneider, Jana, Solomon, Peter S., Kobe, Bostjan and Williams, Simon J. (2021). The crystal structure of SnTox3 from the necrotrophic fungus Parastagonospora nodorum reveals a unique effector fold and provides insight into Snn3 recognition and pro‐domain protease processing of fungal effectors. New Phytologist, 231 (6) nph.17516, 1-15. doi: 10.1111/nph.17516
Lee, Chin Hong, Hawker, Nathaniel P., Peters, Jonathan R., Lonhienne, Thierry G. A., Gursanscky, Nial R., Matthew, Louisa, Brosnan, Christopher A., Mann, Christopher W. G., Cromer, Laurence, Taochy, Christelle, Ngo, Quy A., Sundaresan, Venkatesan, Schenk, Peer M., Kobe, Bostjan, Borges, Filipe, Mercier, Raphael, Bowman, John L. and Carroll, Bernard J. (2021). Defective embryo and meristems genes are required for cell division and gamete viability in Arabidopsis. PL o S Genetics, 17 (5) e1009561, 1-31. doi: 10.1371/journal.pgen.1009561
Clabbers, Max T. B., Holmes, Susannah, Muusse, Timothy W., Vajjhala, Parimala R., Thygesen, Sara J., Malde, Alpeshkumar K., Hunter, Dominic J. B., Croll, Tristan I., Flueckiger, Leonie, Nanson, Jeffrey D., Rahaman, Md. Habibur, Aquila, Andrew, Hunter, Mark S., Liang, Mengning, Yoon, Chun Hong, Zhao, Jingjing, Zatsepin, Nadia A., Abbey, Brian, Sierecki, Emma, Gambin, Yann, Stacey, Katryn J., Darmanin, Connie, Kobe, Bostjan, Xu, Hongyi and Ve, Thomas (2021). MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography. Nature Communications, 12 (1) 2578, 1-14. doi: 10.1038/s41467-021-22590-6
Figley, Matthew D., Gu, Weixi, Nanson, Jeffrey D., Shi, Yun, Sasaki, Yo, Cunnea, Katie, Malde, Alpeshkumar K., Jia, Xinying, Luo, Zhenyao, Saikot, Forhad K., Mosaiab, Tamim, Masic, Veronika, Holt, Stephanie, Hartley-Tassell, Lauren, McGuinness, Helen Y., Manik, Mohammad K., Bosanac, Todd, Landsberg, Michael J., Kerry, Philip S., Mobli, Mehdi, Hughes, Robert O., Milbrandt, Jeffrey, Kobe, Bostjan, DiAntonio, Aaron and Ve, Thomas (2021). SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration. Neuron, 109 (7), 1-19. doi: 10.1016/j.neuron.2021.02.009
Sung, Yi‐Chang, Outram, Megan A., Breen, Susan, Wang, Chen, Dagvadorj, Bayantes, Winterberg, Britta, Kobe, Bostjan, Williams, Simon J. and Solomon, Peter S. (2021). PR1‐mediated defence via C‐terminal peptide release is targeted by a fungal pathogen effector. New Phytologist, 229 (6), 3467-3480. doi: 10.1111/nph.17128
Oyarzun, Patricio, Kashyap, Manju, Fica, Victor, Salas-Burgos, Alexis, Gonzalez-Galarza, Faviel F., McCabe, Antony, Jones, Andrew R., Middleton, Derek and Kobe, Bostjan (2021). A proteome-wide immunoinformatics tool to accelerate T-cell epitope discovery and vaccine design in the context of emerging infectious diseases: an ethnicity-oriented approach. Frontiers in Immunology, 12 598778, 1-25. doi: 10.3389/fimmu.2021.598778
Luo, Zhenyao, Morey, Jacqueline R., Deplazes, Evelyne, Motygullina, Alina, Tan, Aimee, Ganio, Katherine, Neville, Stephanie L., Eleftheriadis, Nikolaos, Isselstein, Michael, Pederick, Victoria G., Paton, James C., Cordes, Thorben, Harmer, Jeffrey R., Kobe, Bostjan and McDevitt, Christopher A. (2021). A trap-door mechanism for zinc acquisition by Streptococcus pneumoniae AdcA. mBio, 12 (1) e01958-20, 1-14. doi: 10.1128/mBio.01958-20
Struwe, Michel A., Kalimuthu, Palraj, Luo, Zhenyao, Zhong, Qifeng, Ellis, Daniel, Yang, Jing, Khadanand, K.C., Harmer, Jeffrey R., Kirk, Martin L., McEwan, Alastair G., Clement, Bernd, Bernhardt, Paul V., Kobe, Bostjan and Kappler, Ulrike (2021). Active site architecture reveals coordination sphere flexibility and specificity determinants in a group of closely related molybdoenzymes. Journal of Biological Chemistry, 296 100672, 1-16. doi: 10.1016/j.jbc.2021.100672
Zhong, Qifeng, Kobe, Bostjan and Kappler, Ulrike (2020). Molybdenum enzymes and how they support virulence in pathogenic bacteria. Frontiers in Microbiology, 11 615860, 1-23. doi: 10.3389/fmicb.2020.615860
Azar, Daniel F., Haas, Meryl, Fedosyuk, Sofiya, Rahaman, Md. Habibur, Hedger, Andrew, Kobe, Bostjan and Skern, Tim (2020). Vaccinia virus immunomodulator A46: destructive interactions with MAL and MyD88 shown by negative-stain electron microscopy. Structure, 28 (12), 1271-1287.e5. doi: 10.1016/j.str.2020.09.007
Sun, Chenghai, Luo, Zhenyao, Zhang, Wenlu, Tian, Wenya, Peng, Haidong, Lin, Zhi, Deng, Zixin, Kobe, Bostjan, Jia, Xinying and Qu, Xudong (2020). Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines. Nature Communications, 11 (1) 6251, 1-10. doi: 10.1038/s41467-020-20022-5
Sun, Yeping, Kobe, Bostjan and Qi, Jianxun (2020). Targeting multiple epitopes on the spike protein: a new hope for COVID-19 antibody therapy. Signal Transduction and Targeted Therapy, 5 (1) 208, 208. doi: 10.1038/s41392-020-00320-6
Hancock, Steven J., Phan, Minh-Duy, Luo, Zhenyao, Lo, Alvin W., Peters, Kate M., Nhu, Nguyen Thi Khanh, Forde, Brian M., Whitfield, Jason, Yang, Ji, Strugnell, Richard A., Paterson, David L., Walsh, Timothy R., Kobe, Bostjan, Beatson, Scott A. and Schembri, Mark A. (2020). Comprehensive analysis of IncC plasmid conjugation identifies a crucial role for the transcriptional regulator AcaB. Nature Microbiology, 5 (11), 1340-1348. doi: 10.1038/s41564-020-0775-0
Shewell, Lucy K., Day, Christopher J., Jen, Freda E.-C., Haselhorst, Thomas, Atack, John M., Reijneveld, Josephine F., Everest-Dass, Arun, James, David B. A., Boguslawski, Kristina M., Brouwer, Stephan, Gillen, Christine M., Luo, Zhenyao, Kobe, Bostjan, Nizet, Victor, von Itzstein, Mark, Walker, Mark J., Paton, Adrienne W., Paton, James C., Torres, Victor J. and Jennings, Michael P. (2020). All major cholesterol-dependent cytolysins use glycans as cellular receptors. Science Advances, 6 (21) EAAZ4926, eaaz4926. doi: 10.1126/sciadv.aaz4926
Lai, Jhih‐Siang, Rost, Burkhard, Kobe, Bostjan and Bodén, Mikael (2020). Evolutionary model of protein secondary structure capable of revealing new biological relationships. Proteins: Structure, Function, and Bioinformatics, 88 (9) prot.25898, 1251-1259. doi: 10.1002/prot.25898
Luo, Zhenyao, Neville, Stephanie L., Campbell, Rebecca, Morey, Jacqueline R., Menon, Shruti, Thomas, Mark, Eijkelkamp, Bart A., Ween, Miranda P., Huston, Wilhelmina M., Kobe, Bostjan and McDevitt, Christopher A. (2019). The structure and metal binding properties of Chlamydia trachomatis YtgA. Journal of Bacteriology, 202 (1) e00580. doi: 10.1128/jb.00580-19
Horsefield, Shane, Burdett, Hayden, Zhang, Xiaoxiao, Manik, Mohammad K., Shi, Yun, Chen, Jian, Qi, Tiancong, Gilley, Jonathan, Lai, Jhih-Siang, Rank, Maxwell X., Casey, Lachlan W., Gu, Weixi, Ericsson, Daniel J., Foley, Gabriel, Hughes, Robert O., Bosanac, Todd, von Itzstein, Mark, Rathjen, John P., Nanson, Jeffrey D., Boden, Mikael, Dry, Ian B., Williams, Simon J., Staskawicz, Brian J., Coleman, Michael P., Ve, Thomas, Dodds, Peter N. and Kobe, Bostjan (2019). NAD+ cleavage activity by animal and plant TIR domains in cell death pathways. Science, 365 (6455), 793-799. doi: 10.1126/science.aax1911
Burdett, Hayden, Bentham, Adam R., Williams, Simon J., Dodds, Peter N., Anderson, Peter A., Banfield, Mark J. and Kobe, Bostjan (2019). The plant “resistosome”: structural insights into immune signaling. Cell Host and Microbe, 26 (2), 193-201. doi: 10.1016/j.chom.2019.07.020
Burdett, Hayden, Kobe, Bostjan and Anderson, Peter A. (2019). Animal NLRs continue to inform plant NLR structure and function. Archives of Biochemistry and Biophysics, 670, 58-68. doi: 10.1016/j.abb.2019.05.001
Dowling, Jennifer K., Tate, Michelle E., Bourke, Nollaig M., Bitto, Natalie, Lauterbach, Mario A., Cheung, Shane, Ve, Thomas, Kobe, Bostjan, Golenbock, Douglas and Mansell, Ashley (2019). The single nucleotide polymorphism Mal-D96N mice provide new insights into functionality of Mal in TLR immune responses. The Journal of Immunology, 202 (8), ji1800501-2396. doi: 10.4049/jimmunol.1800501
Newman, Toby E., Lee, Jungmin, Williams, Simon J., Choi, Sera, Halane, Morgan K., Zhou, Jun, Solomon, Peter, Kobe, Bostjan, Jones, Jonathan D. G., Segonzac, Cécile and Sohn, Kee Hoon (2019). Autoimmunity and effector recognition in Arabidopsis thaliana can be uncoupled by mutations in the RRS1-R immune receptor. New Phytologist, 222 (2), 954-965. doi: 10.1111/nph.15617
Wan, Li, Koeck, Markus, Williams, Simon J., Ashton, Anthony R., Lawrence, Gregory J., Sakakibara, Hitoshi, Kojima, Mikiko, Böttcher, Christine, Ericsson, Daniel J., Hardham, Adrienne R., Jones, David A., Ellis, Jeffrey G., Kobe, Bostjan and Dodds, Peter N. (2019). Structural and functional insights into the modulation of the activity of a flax cytokinin oxidase by flax rust effector AvrL567-A. Molecular Plant Pathology, 20 (2), 211-222. doi: 10.1111/mpp.12749
Nanson, Jeffrey D., Kobe, Bostjan and Ve, Thomas (2019). Death, TIR, and RHIM: Self-assembling domains involved in innate immunity and cell-death signaling. Journal of Leukocyte Biology, 105 (2), 363-375. doi: 10.1002/JLB.MR0318-123R
Stewart, Louisa J., Thaqi, Denis, Kobe, Bostjan, McEwan, Alastair G., Waldron, Kevin J. and Djoko, Karrera Y. (2019). Handling of nutrient copper in the bacterial envelope. Metallomics, 11 (1), 50-63. doi: 10.1039/c8mt00218e
O'Carroll, Ailís, Chauvin, Brieuc, Brown, James W.P., Meagher, Ava, Coyle, Joanne, Schill, Jurgen, Bhumkhar, Akshay, Hunter, Dominic J.B., Ve, Thomas, Kobe, Bostjan, Sierecki, Emma and Gambin, Yann (2018). Pathological mutations differentially affect the self-assembly and polymerisation of the innate immune system signalling adaptor molecule MyD88. BMC Biology, 16 (149) 149, 149. doi: 10.1186/s12915-018-0611-7
Wiedorn, Max O., Oberthür, Dominik, Bean, Richard, Schubert, Robin, Werner, Nadine, Abbey, Brian, Aepfelbacher, Martin, Adriano, Luigi, Allahgholi, Aschkan, Al-Qudami, Nasser, Andreasson, Jakob, Aplin, Steve, Awel, Salah, Ayyer, Kartik, Bajt, Saša, Barák, Imrich, Bari, Sadia, Bielecki, Johan, Botha, Sabine, Boukhelef, Djelloul, Brehm, Wolfgang, Brockhauser, Sandor, Cheviakov, Igor, Coleman, Matthew A., Cruz-Mazo, Francisco, Danilevski, Cyril, Darmanin, Connie, Doak, R. Bruce, Domaracky, Martin ... Barty, Anton (2018). Megahertz serial crystallography. Nature Communications, 9 (1) 4025, 4025. doi: 10.1038/s41467-018-06156-7
Kummari, Lalith K., Butler, Mark S., Furlong, Emily, Blundell, Ross, Nouwens, Amanda, Silva, Alberto B., Kappler, Ulrike, Fraser, James A., Kobe, Bostjan, Cooper, Matthew A. and Robertson, Avril A.B. (2018). Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles. Bioorganic and Medicinal Chemistry, 26 (20), 5408-5419. doi: 10.1016/j.bmc.2018.09.004
Luo, Zhenyao, Pederick, Victoria G., Paton, James C., McDevitt, Christopher A. and Kobe, Bostjan (2018). Structural characterisation of the HT3 motif of the polyhistidine triad protein D from Streptococcus pneumoniae. FEBS letters, 592 (13), 2341-2350. doi: 10.1002/1873-3468.13122
Nanson, Jeffrey D., Rahaman, Habibur, Ve, Thomas and Kobe, Bostjan (2018). Regulation of signaling by cooperative assembly formation in mammalian innate immunity signalosomes by molecular mimics. Seminars in Cell and Developmental Biology, 99, 96-114. doi: 10.1016/j.semcdb.2018.05.002
Cotrim, Camila A., Soares, Jose Sergio M., Kobe, Bostjan and Menossi, Marcelo (2018). Crystal structure and insights into the oligomeric state of UDP-glucose pyrophosphorylase from sugarcane. PloS One, 13 (3) 0193667, 1-13. doi: 10.1371/journal.pone.0193667
Ryan, Timothy M., Trewhella, Jill, Murphy, James M., Keown, Jeremy R., Casey, Lachlan, Pearce, F. Grant, Goldstone, David C., Chen, Kelan, Luo, Zhenyao, Kobe, Bostjan, McDevitt, Christopher A., Watkin, Serena A., Hawley, Adrian M., Mudie, Stephen T., Boban, Vesna Samardzic and Kirby, Nigel (2018). An optimized SEC-SAXS system enabling high X-ray dose for rapid SAXS assessment with correlated UV measurements for biomolecular structure analysis. Journal of Applied Crystallography, 51 (1), 97-111. doi: 10.1107/S1600576717017101
Li, Jie, Watterson, Daniel, Chang, Chiung-Wen, Che, Xiao-Yan, Li, Xiao-Quan, Ericsson, Daniel J., Qiu, Li-Wen, Cai, Jian-Piao, Chen, Jing, Fry, Scott R., Cheung, Stacey T. M., Cooper, Matthew A., Young, Paul R. and Kobe, Bostjan (2018). Structural and functional characterization of a cross-reactive dengue virus neutralizing antibody that recognizes a cryptic epitope. Structure, 26 (1), 51-59. doi: 10.1016/j.str.2017.11.017
de Barros, Andrea C, Takeda, Agnes A S, Dreyer, Thiago R, Velazquez-Campoy, Adrian, Kobe, Boštjan and Fontes, Marcos R M (2017). DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway. Biochimie, 146, 87-96. doi: 10.1016/j.biochi.2017.11.013
Zhang, Xiaoxiao, Farah, Nadya, Rolston, Laura, Ericsson, Daniel J., Catanzariti, Ann-Maree, Bernoux, Maud, Ve, Thomas, Bendak, Katerina, Chen, Chunhong, Mackay, Joel P., Lawrence, Gregory J., Hardham, Adrienne, Ellis, Jeffrey G., Williams, Simon J., Dodds, Peter N., Jones, David A. and Kobe, Bostjan (2017). Crystal structure of the Melampsora lini effector AvrP reveals insights into a possible nuclear function and recognition by the flax disease resistance protein P. Molecular Plant Pathology, 19 (5), 1196-1209. doi: 10.1111/mpp.12597
Hughes, Mark M., Lavrencic, Peter, Coll, Rebecca C., Ve, Thomas, Ryan, Dylan G., Williams, Niamh C., Menon, Deepthi, Mansell, Ashley, Board, Philip G., Mobli, Mehdi, Kobe, Bostjan and O'Neill, Luke A. J. (2017). Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling. Proceedings of the National Academy of Sciences, 114 (32), E6480-E6489. doi: 10.1073/pnas.1701868114
Ve, Thomas, Vajjhala, Parimala, Hedger, Andrew, Croll, Tristan, DiMaio, Frank, Horsefield, Shane, Yu, Xiong, Lavrencic, Peter, Hassan, Zahid, Morgan, Garry P., Mansell, Ashley, Mobli, Mehdi, O'Carroll, Ailis, Chauvin, Brieuc, Gambin, Yann, Sierecki, Emma, Landsberg, Michael J., Stacey, Katryn, Egelman, Edward H. and Kobe, Bostjan (2017). Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling. Nature Structural and Molecular Biology, 24 (9), 743-751. doi: 10.1038/nsmb.3444
Breen, Susan, Williams, Simon J., Outram, Megan, Kobe, Bostjan and Solomon, Peter S. (2017). Emerging insights into the functions of pathogenesis-related protein 1. Trends in Plant Science, 22 (10), 871-879. doi: 10.1016/j.tplants.2017.06.013
Chitty, Jessica L., Blake, Kirsten L., Blundell, Ross D., Koh, Y. Q. Andre E., Thompson, Merinda, Robertson, Avril A. B., Butler, Mark S., Cooper, Matthew A., Kappler, Ulrike, Williams, Simon J., Kobe, Bostjan and Fraser, James A. (2017). Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design. Journal of Biological Chemistry, 292 (28), 11829-11839. doi: 10.1074/jbc.M117.787994
Vajjhala, Parimala R., Ve, Thomas, Bentham, Adam, Stacey, Katryn J. and Kobe, Bostjan (2017). The molecular mechanisms of signaling by cooperative assembly formation in innate immunity pathways. Molecular Immunology, 86, 23-37. doi: 10.1016/j.molimm.2017.02.012
Nimma, Surekha, Ve, Thomas, Williams, Simon J. and Kobe, Bostjan (2017). Towards the structure of the TIR-domain signalosome. Current Opinion In Structural Biology, 43, 122-130. doi: 10.1016/j.sbi.2016.12.014
Chitty, Jessica L., Tatzenko, Tayla L. , Williams, Simon J., Koh, Y. Q. Andre E., Corfield, Elizabeth C., Butler, Mark S., Robertson, Avril A. B., Cooper, Matthew A., Kappler, Ulrike, Kobe, Bostjan and Fraser, James A. (2017). GMP synthase is required for virulence factor production and infection by cryptococcus neoformans. Journal of Biological Chemistry, 292 (7), 3049-3059. doi: 10.1074/jbc.M116.767533
Patrick, Ralph, Kobe, Bostjan, Lê Cao, Kim-Anh and Bodén, Mikael (2017). PhosphoPICK-SNP: quantifying the effect of amino acid variants on protein phosphorylation. Bioinformatics, 33 (12), 1773-1781. doi: 10.1093/bioinformatics/btx072
Miljenović, Tomas, Jia, Xinying, Lavrencic, Peter, Kobe, Bostjan and Mobli, Mehdi (2017). A non-uniform sampling approach enables studies of dilute and unstable proteins. Journal of Biomolecular NMR, 68 (2), 1-9. doi: 10.1007/s10858-017-0091-z
Zhang, Xiaoxiao, Bernoux, Maud, Bentham, Adam R., Newman, Toby E., Ve, Thomas, Casey, Lachlan W., Raaymakers, Tom M., Hu, Jian, Croll, Tristan I., Schreiber, Karl J., Staskawicz, Brian J., Anderson, Peter A., Sohn, Kee Hoon, Williams, Simon J., Dodds, Peter N. and Kobe, Bostjan (2017). Multiple functional self-association interfaces in plant TIR domains. Proceedings of the National Academy of Sciences, 114 (10), E2046-E2052. doi: 10.1073/pnas.1621248114
De Oliveira, David M. P., Hartley-Tassell, Lauren, Everest-Dass, Arun, Day, Christopher J., Dabbs, Rebecca A., Ve, Thomas, Kobe, Bostjan, Nizet, Victor, Packer, Nicolle H., Walker, Mark J., Jennings, Michael P. and Sanderson-Smith, Martina L. (2017). Blood group antigen recognition via the group A Streptococcal M protein mediates host colonization. MBio, 8 (1) e02237-16, e02237-16. doi: 10.1128/mBio.02237-16
Williams, Simon J., Yin, Ling, Foley, Gabriel, Casey, Lachlan W., Outram, Megan A., Ericsson, Daniel J., Lu, Jiang, Boden, Mikael, Dry, Ian B. and Kobe, Bostjan (2016). Structure and function of the TIR domain from the grape NLR protein RPV1. Frontiers in Plant Science, 7 (DECEMBER2016) 1850, 1850. doi: 10.3389/fpls.2016.01850
Casey, Lachlan W., Lavrencic, Peter, Bentham, Adam R., Cesari, Stella, Ericsson, Daniel J., Croll, Tristan, Turk, Dušan, Anderson, Peter A., Mark, Alan E., Dodds, Peter N., Mobli, Mehdi, Kobe, Bostjan and Williams, Simon J. (2016). The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteins. Proceedings of the National Academy of Sciences, 113 (45), 12856-12861. doi: 10.1073/pnas.1609922113
Patrick, Ralph, Horin, Coralie, Kobe, Bostjan, Cao, Kim-Anh Le and Bodén, Mikael (2016). Prediction of kinase-specific phosphorylation sites through an integrative model of protein context and sequence. Biochimica et Biophysica Acta, 1864 (11), 1599-1608. doi: 10.1016/j.bbapap.2016.08.001
Breen, Susan, Williams, Simon J., Winterberg, Britta, Kobe, Bostjan and Solomon, Peter S. (2016). Wheat PR-1 proteins are targeted by necrotrophic pathogen effector proteins. Plant Journal, 88 (1), 13-25. doi: 10.1111/tpj.13228
Blundell, Ross D., Williams, Simon J., Arras, Samantha D. M., Chitty, Jessica L., Blake, Kirsten L., Ericsson, Daniel J., Tibrewal, Nidhi, Rohr, Jurgen, Koh, Y. Q. Andre, Kappler, Ulrike, Robertson, Avril A. B., Butler, Mark S., Cooper, Matthew A., Kobe, Bostjan and Fraser, James A. (2016). Disruption of de novo adenosine triphosphate (ATP) biosynthesis abolishes virulence in Cryptococcus neoformans. ACS Infectious Diseases, 2 (9), 651-663. doi: 10.1021/acsinfecdis.6b00121
Bentham, Adam, Burdett, Hayden, Anderson, Peter A., Williams, Simon J. and Kobe, Bostjan (2016). Animal NLRs provide structural insights into plant NLR function. Annals of Botany, 119 (5), 689-702. doi: 10.1093/aob/mcw171
Schreiber, Karl J., Bentham, Adam, Williams, Simon J., Kobe, Bostjan and Staskawicz, Brian J. (2016). Multiple domain associations within the Arabidopsis immune receptor RPP1 regulate the activation of programmed cell death. PLoS Pathogens, 12 (7) e1005769, e1005769. doi: 10.1371/journal.ppat.1005769
Couñago, Rafael M., Chen, Nathan H., Chang, Chiung-Wen, Djoko, Karrera Y., McEwan, Alastair G. and Kobe, Bostjan (2016). Structural basis of thiol-based regulation of formaldehyde detoxification in H. influenzae by a MerR regulator with no sensor region. Nucleic Acids Research, 44 (14), 6981-6993. doi: 10.1093/nar/gkw543
de Barros, Andrea C., Takeda, Agnes A.S., Dreyer, Thiago R., Velazquez-Campoy, Adrian, Kobe, Bostjan and Fontes, Marcos R.M. (2016). Structural and calorimetric studies demonstrate that Xeroderma pigmentosum type G (XPG) can be imported to the nucleus by a classical nuclear import pathway via a monopartite NLS sequence. Journal of Molecular Biology, 428 (10), 2120-2131. doi: 10.1016/j.jmb.2016.01.019
Christie, Mary, Chang, Chiung-Wen, Róna, Gergely, Smith, Kate M., Stewart, Alastair G, Takeda, Agnes A. S., Fontes, Marcos R. M., Stewart, Murray, Vértessy, Beáta G., Forwood, Jade K. and Kobe, Bostjan (2016). Structural biology and regulation of protein import into the nucleus. Journal of Molecular Biology, 428 (10), 2060-2090. doi: 10.1016/j.jmb.2015.10.023
Chang, Chiung-Wen, Counago, Rafael Miguez, Williams, Simon J., Boden, Mikael and Kobe, Bostjan (2016). Distinctive Conformation of Minor Site-Specific Nuclear Localization Signals Bound to Importin-alpha (vol 14, pg 1144, 2013). Traffic, 17 (6), 704-704. doi: 10.1111/tra.12395
Ullah, M. Obayed, Sweet, Matthew J., Mansell, Ashley, Kellie, Stuart and Kobe, Bostjan (2016). TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target. Journal of Leukocyte Biology, 100 (1), 27-45. doi: 10.1189/jlb.2RI1115-531R
Darmanin, Connie, Strachan, Jamie, Adda, Christopher G., Ve, Thomas, Kobe, Bostjan and Abbey, Brian (2016). Protein crystal screening and characterization for serial femtosecond nanocrystallography. Scientific Reports, 6 (1) 25345, 25345.1-25345.8. doi: 10.1038/srep25345
Zhang, Xiaoxiao, Nguyen, Neal, Breen, Susan, Outram, Megan A., Dodds, Peter N., Kobe, Bostjan, Solomon, Peter S. and Williams, Simon J. (2016). Production of small cysteine-rich effector proteins in Escherichia coli for structural and functional studies. Molecular Plant Pathology, 18 (1), 141-151. doi: 10.1111/mpp.12385
You, Lv, Kandale, Ajit, Wun, Shun Jie, McGeary, Ross P., Williams, Simon J., Kobe, Bostjan, Sieber, Volker, Schembri, Mark A., Schenk, Gerhard and Guddat, Luke W. (2016). Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution: A potential target for anti-tuberculosis drug discovery. Febs Journal, 283 (7), 1184-1196. doi: 10.1111/febs.13672
Oyarzun, Patricio and Kobe, Bostjan (2016). Recombinant and epitope-based vaccines on the road to the market and implications for vaccine design and production. Human Vaccines and Immunotherapeutics, 12 (3), 763-767. doi: 10.1080/21645515.2015.1094595
Bernoux, Maud, Burdett, Hayden, Williams, Simon J., Zhang, Xiaoxiao, Chen, Chunhong, Newell, Kim, Lawrence, Gregory J., Kobe, Bostjan, Ellis, Jeffrey G., Anderson, Peter A. and Dodds, Peter N. (2016). Comparative analysis of the flax immune receptors L6 and L7 suggests an equilibrium-based switch activation model. Plant Cell, 28 (1), 146-159. doi: 10.1105/tpc.15.00303
Luo, Zhenyao, Morey, Jacqueline R., McDevitt, Christopher A. and Kobe, Bostjan (2015). Heterogeneous nucleation is required for crystallization of the ZnuA domain of pneumococcal AdcA. Acta Crystallographica: Section F Structural Biology Communications, 71 (12), 1459-1464. doi: 10.1107/S2053230X15021330
Deplazes, Evelyne, Begg, Stephanie L., van Wonderen, Jessica H., Campbell, Rebecca, Kobe, Bostjan, Paton, James C., MacMillan, Fraser, McDevitt, Christopher A. and O'Mara, Megan L. (2015). Characterizing the conformational dynamics of metal-free PsaA usingmolecular dynamics simulations and electron paramagnetic resonance spectroscopy. Biophysical Chemistry, 207, 51-60. doi: 10.1016/j.bpc.2015.08.004
Oyarzun, P. and Kobe, B. (2015). Computer-aided design of T-cell epitope-based vaccines: addressing population coverage. International Journal of Immunogenetics, 42 (5), 313-321. doi: 10.1111/iji.12214
Chang, Chiung-Wen, Tran, Elizabeth N. H., Ericsson, Daniel J., Casey, Lachlan W., Lonhienne, Thierry, Benning, Friederike, Morona, Renato and Kobe, Bostjan (2015). Structural and biochemical analysis of a single amino-acid mutant of WzzBSF that alters Lipopolysaccharide O-antigen chain length in Shigella flexneri. PLoS One, 10 (9) e0138266, e0138266. doi: 10.1371/journal.pone.0138266
Kobe, Bostjan, Ve, Thomas and Williams, Simon J. (2015). Fusion-protein-assisted protein crystallization. Acta Crystallographica. Section F Structural Biology Communications, 71 (7), 861-869. doi: 10.1107/S2053230X15011061
Cork, Amanda J., Ericsson, Daniel J., Law, Ruby H. P., Casey, Lachlan W., Valkov, Eugene, Bertozzi, Carlo, Stamp, Anna, Jovcevski, Blagojce, Aquilina, J. Andrew, Whisstock, James C., Walker, Mark J. and Kobe, Bostjan (2015). Stability of the octameric structure affects plasminogen-binding capacity of Streptococcal enolase. PLoS One, 10 (3) e0121764, 1-18. doi: 10.1371/journal.pone.0121764
Begg, Stephanie L., Eijkelkamp, Bart A., Luo, Zhenyao, Couñago, Rafael M., Morey, Jacqueline R., Maher, Megan J., Ong, Cheryl-lynn Y., McEwan, Alastair G., Kobe, Bostjan, O'Mara, Megan L., Paton, James C. and McDevitt, Christopher A. (2015). Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae. Nature Communications, 6 (6418) 6418, 1-11. doi: 10.1038/ncomms7418
Williams, Simon J., Ve, Thomas and Kobe, Bostjan (2015). A linker strategy for the production and crystallization of Toll/interleukin-1 receptor/resistance protein domain complexes. Protein Engineering, Design and Selection, 28 (5), 137-145. doi: 10.1093/protein/gzv013
Bajaj, Megha, Mamidyala, Sreeman K., Zuegg, Johannes, Begg, Stephanie L., Ween, Miranda P., Luo, Zhenyao, Huang, Johnny Xiao, McEwan, Alastair G., Kobe, Bostjan, Paton, James C., McDevitt, Christopher A. and Cooper, Matthew A. (2015). Discovery of novel pneumococcal surface antigen A (PsaA) inhibitors using a fragment-based drug design approach. ACS Chemical Biology, 10 (6), 1511-1520. doi: 10.1021/cb501032x
Thakar, Nilay Y., Ovchinnikov, Dmitry A., Hastie, Marcus L., Kobe, Bostjan, Gorman, Jeffrey J. and Wolvetang, Ernst J. (2015). TRAF2 recruitment via T61 in CD30 drives NFκB activation and enhances hESC survival and proliferation.. Molecular Biology of the Cell, 26 (5), 993-1006. doi: 10.1091/mbc.E14-08-1290
Oyarzun, Patricio, Ellis, Jonathan J., Gonzalez-Galarza, Faviel F., Jones, Andrew R, Middleton, Derek, Boden, Mikael and Kobe, Bostjan (2015). A bioinformatics tool for epitope-based vaccine design that accounts for human ethnic diversity: Application to emerging infectious diseases.. Vaccine, 33 (10), 1267-1273. doi: 10.1016/j.vaccine.2015.01.040
Ve, Thomas, Williams, Simon J. and Kobe, Bostjan (2014). Structure and function of Toll/interleukin-1 receptor/resistance protein (TIR) domains.. Apoptosis, 20 (2), 250-261. doi: 10.1007/s10495-014-1064-2
Roona, Gergely, Borsos, Mate, Ellis, Jonathan J., Mehdi, Ahmed M., Christie, Mary, Koornyei, Zsuzsanna, Neubrandt, Mate, Tooth, Judit, Bozooky, Zoltan, Buday, Laszlo, Madaraasz, Emilia, Bodaen, Mikael, Kobe, Bostjan and Veertessy, Beata G. (2014). Dynamics of re-constitution of the human nuclear proteome after cell division is regulated by NLS-adjacent phosphorylation. Cell Cycle, 13 (22), 3551-3564. doi: 10.4161/15384101.2014.960740
Dyrka, Witold, Lamacchia, Marina, Durrens, Pascal, Kobe, Bostjan, Daskalov, Asen, Paoletti, Matthieu, Sherman, David J. and Saupe, Sven J. (2014). Diversity and variability of NOD-like receptors in fungi. Genome Biology and Evolution, 6 (12), 3137-3158. doi: 10.1093/gbe/evu251
Obayed Ullah, M., Valkov, Eugene, Ve, Thomas, Williams, Simon, Mas, Caroline, Mansell, Ashley and Kobe, Bostjan (2014). Recombinant production of functional full-length and truncated human TRAM/TICAM-2 adaptor protein involved in toll-like receptor and interferon signaling. Protein Expression and Purification, 106, 31-40. doi: 10.1016/j.pep.2014.09.019
Patrick, Ralph, Lê Cao, Kim-Anh, Kobe, Bostjan and Bodén, Mikael (2014). PhosphoPICK: modelling cellular context to map kinase-substrate phosphorylation events. Bioinformatics, 31 (3), 382-389. doi: 10.1093/bioinformatics/btu663
Róna, Gergely, Borsos, Máté, Kobe, Bostjan and Vértessy, Beáta G. (2014). Factors influencing nucleo-cytoplasmic trafficking: which matter? Response to Alvisi & Jans' comment on Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights. Acta Crystallographica. Section D: Biological Crystallography, 70 (10), 2777-2778. doi: 10.1107/S1399004714020501
Sohn, Kee Hoon, Segonzac, Cecile, Rallapalli, Ghanasyam, Sarris, Panagiotis F., Woo, Joo Yong, Williams, Simon J., Newman, Toby E., Paek, Kyung Hee, Kobe, Bostjan and Jones, Jonathan D. G. (2014). The nuclear immune receptor RPS4 is required for RRS1SLH1-dependent constitutive defense activation in Arabidopsis thaliana.. PLoS Genetics, 10 (10), e1004655. doi: 10.1371/journal.pgen.1004655
Verstak, Brett, Stack, Julianne, Ve, Thomas, Mangan, Matthew, Hjerrild, Kathryn, Jeon, Jannah, Stahl, Rainer, Latz, Eicke, Gay, Nick, Kobe, Bostjan, Bowie, Andrew G. and Mansell, Ashley (2014). The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4. Journal of Leukocyte Biology, 96 (3), 427-436. doi: 10.1189/jlb.2A0913-487R
Williams, Simon J., Sohn, Kee Hoon, Wan, Li, Bernoux, Maud, Sarris, Panagiotis, Segonzac, Cecile, Ve, Thomas, Ma, Yan, Saucet, Simon B., Ericsson, Daniel J., Casey, Lachlan W., Lonhienne, Thierry, Winzor, Donald J., Zhang, Xiaoxiao, Coerdt, Anne, Parker, Jane E., Dodds, Peter N., Kobe, Bostjan and Jones, Jonathan D. G. (2014). Structural basis for assembly and function of a heterodimeric plant immune receptor. Science, 344 (6181), 299-303. doi: 10.1126/science.1247357
Chang, Chiung-Wen, Williams, Simon J., Couñago, Rafael Miguez and Kobe, Bostjan (2014). Structural basis of interaction of bipartite nuclear localization signal from Agrobacterium VirD2 with rice importin-alpha. Molecular Plant, Advance Access (6), 1-10. doi: 10.1093/mp/ssu014
Plumptre, Charles D., Eijkelkamp, Bart A., Morey, Jacqueline R., Behr, Felix, Couñago, Rafael M., Ogunniyi, Abiodun D., Kobe, Bostjan, O'Mara, Megan L., Paton, James C. and McDevitt, Christopher A. (2014). AdcA and AdcAII employ distinct zinc acquisition mechanisms and contribute additively to zinc homeostasis in Streptococcus pneumoniae. Molecular Microbiology, 91 (4), 834–851-834–851. doi: 10.1111/mmi.12504
Batten, Stuart R., Kobe, Bostjan and Guddat, Luke (2014). International Year of Crystallography. Australian Journal of Chemistry, 67 (12), 1718-1719. doi: 10.1071/CH14557
Couñago, Rafael M., Ween, Miranda P., Begg, Stephanie L., Bajaj, Megha, Zuegg, Johannes, O'Mara, Megan L., Cooper, Matthew A., McEwan, Alastair G., Paton, James C., Kobe, Bostjan and McDevitt, Christopher A. (2014). Imperfect coordination chemistry facilitates metal ion release in the Psa permease. Nature Chemical Biology, 10 (1), 35-41. doi: 10.1038/nCHeMBIO.1382
Casey, Lachlan W., Mark, Alan E. and Kobe, Bostjan (2014). Small-Angle X-Ray Scattering for the Discerning Macromolecular Crystallographer. Australian Journal of Chemistry, 67 (12), 1786-1792. doi: 10.1071/CH14396
Roman, Noelia, Christie, Mary, Swarbrick, Crystall M. D., Kobe, Bostjan and Forwood, Jade K. (2013). Structural characterisation of the nuclear import receptor importin alpha in complex with the bipartite NLS of Prp20. PLoS One, 8 (12) e82038, e82038.1-e82038.6. doi: 10.1371/journal.pone.0082038
Rona, G., Marfori, M., Borsos, M., Scheer, I., Takacs, E., Toth, J., Babos, F., Magyar, A., Erdei, A., Bozoky, Z., Buday, L., Kobe, B. and Vertessy, B.G. (2013). Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: Structural and mechanistic insights. Acta Crystallographica Section D: Biological Crystallography, 69 (12), 2495-2505. doi: 10.1107/S0907444913023354
Ullah, M. Obayed, Ve, Thomas, Mangan, Matthew, Alaidarous, Mohammed, Sweet, Matthew J., Mansell, Ashley and Kobe, Bostjan (2013). The TLR signalling adaptor TRIF/TICAM-1 has an N-terminal helical domain with structural similarity to IFIT proteins. Acta Crystallographica Section D: Biological Crystallography, 69 (12), 2420-2430. doi: 10.1107/S0907444913022385
Alaidarous, Mohammed Abdullah, Ve, Thomas, Casey, Lachlan, Valkov, Eugene, Ericsson, Daniel, Obayed, Ullah, M., Schembri, Mark A., Mansell, Ashley, Sweet, Matthew J. and Kobe, Bostjan (2013). Mechanism of bacterial interference with TLR4 signaling by Brucella TIR-domain-containing protein TcpB. Journal of Biological Chemistry, 289 (2), 654-668. doi: 10.1074/jbc.M113.523274
Wan, Li, Zhang, Xiaoxiao, Williams, Simon J., Ve, Thomas, Bernoux, Maud, Sohn, Kee Hoon, Jones, Jonathan D. G., Dodds, Peter N. and Kobe, Bostjan (2013). Crystallization and preliminary X-ray diffraction analyses of the TIR domains of three TIR-NB-LRR proteins that are involved in disease resistance in Arabidopsis thaliana. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 69 (11), 1275-1280. doi: 10.1107/S1744309113026614
Chang, Chiung-Wen, Counago, Rafael Miguez, Williams, Simon J., Boden, Mikael and Kobe, Bostjan (2013). Distinctive conformation of minor site-specific nuclear localization signals bound to importin-α. Traffic, 14 (11), 1144-1154. doi: 10.1111/tra.12098
Ve, Thomas, Williams, Simon J., Catanzariti, Ann-Maree, Rafiqi, Maryam, Rahman, Motiur, Ellis, Jeffrey G., Hardham, Adrienne R., Jones, David A., Anderson, Peter A., Dodds, Peter N. and Kobe, Bostjan (2013). Structures of the flax-rust effector AvrM reveal insights into the molecular basis of plant-cell entry and effector-triggered immunity. Proceedings of the National Academy of Sciences of the United States of America, 110 (43), 17594-17599. doi: 10.1073/pnas.1307614110
Alaidarous, Mohammed, Ve, Thomas, Ullah, M. Obayed, Valkov, Eugene, Mansell, Ashley, Schembri, Mark A., Sweet, Matthew J. and Kobe, Bostjan (2013). Cloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of the TIR domain from the Brucella melitensis TIR-domain-containing protein TcpB. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 69 (10), 1167-1170. doi: 10.1107/S1744309113024408
Wan, Li, Williams, Simon J., Zhang, Xiaoxiao, Ericsson, Daniel J., Koeck, Markus, Dodds, Peter N., Ellis, Jeffrey G. and Kobe, Bostjan (2013). Crystallization and preliminary X-ray diffraction analysis of the flax cytokinin oxidase LuCKX1.1. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 69 (10), 1094-1096. doi: 10.1107/S1744309113023142
Blundell, Ross D., Williams, Simon J., Morrow, Carl A., Ericsson, Daniel J., Kobe, Bostjan and Fraser, James A. (2013). Purification, crystallization and preliminary X-ray analysis of adenylosuccinate synthetase from the fungal pathogen Cryptococcus neoformans. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 69 (Pt. 9), 1033-1036. doi: 10.1107/S1744309113021921
Henningham, Anna, Ericsson, Daniel J., Langer, Karla, Casey, Lachlan W., Jovcevski, Blagojce, Singh Chhatwal, G., Aquilina, J. Andrew, Batzloff, Michael R., Kobe, Bostjan and Walker, Mark J. (2013). Structure-informed design of an enzymatically inactive vaccine component for group A Streptococcus. mBio, 4 (4) e00509-13. doi: 10.1128/mBio.00509-13
Ullah, M. Obayed, Ve, Thomas, Dkhar, Jameris, Alaidarous, Mohammed, Ericsson, Daniel J., Sweet, Matthew J., Mansell, Ashley and Kobe, Bostjan (2013). Crystallization and X-ray diffraction analysis of the N-terminal domain of the Toll-like receptor signalling adaptor protein TRIF/TICAM-1. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 69 (7), 766-770. doi: 10.1107/S174430911301419X
Chen, Nathan H., Couñago, Rafael M., Djoko, Karrera Y., Jennings, Michael P., Apicella, Michael A., Kobe, Bostjan and McEwan, Alastair G. (2013). A glutathione-dependent detoxification system is required for formaldehyde resistance and optimal survival of Neisseria meningitidis in biofilms. Antioxidants and Redox Signaling, 18 (7), 743-755. doi: 10.1089/ars.2012.4749
Oyarzun, Patricio, Ellis, Jonathan J., Boden, Mikael and Kobe, Bostjan (2013). PREDIVAC: CD4+T-cell epitope prediction for vaccine design that covers 95% of HLA class II DR protein diversity. BMC Bioinformatics, 14 (1) 52, 52. doi: 10.1186/1471-2105-14-52
Chen, Kai-En, Richards, Ayanthi A., Caradoc-Davies, Tom T., Vajjhala, Parimala R., Robin, Gautier, Lua, Linda H. L., Hill, Justine M., Schroder, Kate, Sweet, Matthew J., Kellie, Stuart, Kobe, Bostjan and Martin, Jennifer (2013). The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized. Acta Crystallographica Section D: Biological Crystallography, 69 (5), 774-784. doi: 10.1107/S0907444913001558
Chang, Chiung-Wen, Counago, Rafael Miguez, Williams, Simon J., Boden, Mikael and Kobe, Bostjan (2013). The distribution of different classes of nuclear localization signals (NLSs) in diverse organisms and the utilization of the minor NLS-binding site in plant nuclear import factor importin-α. Plant Signaling and Behavior, 8 (10), e25976.1-e25976.6. doi: 10.4161/psb.25976
Mehdi, Ahmed M., Sehgal, Muhammad Shoaib B., Kobe, Bostjan, Bailey, Timothy L. and Boden, Mikael (2013). DLocalMotif: a discriminative approach for discovering local motifs in protein sequences. Bioinformatics, 29 (1), 39-46. doi: 10.1093/bioinformatics/bts654
Chang, Chiung-Wen, Counago, Rafael Lemos Miguez, Williams, Simon J., Boden, Mikael and Kobe, Bostjan (2012). Crystal structure of rice importin-alpha and structural basis of its interaction with plant-specific nuclear localization signals. Plant Cell, 24 (12), 5074-5088. doi: 10.1105/tpc.112.104422
Ravensdale, Michael, Bernoux, Maud, Ve, Thomas, Kobe, Bostjan, Thrall, Peter H., Ellis, Jeffrey G. and Dodds, Peter N. (2012). Intramolecular interaction influences binding of the flax L5 and L6 resistance proteins to their AvrL567 ligands. PloS Pathogens, 8 (11) e1003004, e1003004. doi: 10.1371/journal.ppat.1003004
Morrow, Carl A., Valkov, Eugene, Stamp, Anna, Chow, Eve W. L., Lee, I. Russel, Wronski, Ania, Williams, Simon J., Hill, Justine M., Djordjevic, Julianne T., Kappler, Ulrke, Kobe, Bostjan and Fraser, James A. (2012). De novo GTP biosynthesis is critical for virulence of the fungal pathogen cryptococcus neoformans. PLoS Pathogens, 8 (10) e1002957, e1002957. doi: 10.1371/journal.ppat.1002957
Counago, Rafael M., McDevitt, Christopher A., Ween, Miranda P. and Kobe, Bostjan (2012). Prokaryotic substrate-binding proteins as targets for antimicrobial therapies. Current Drug Targets, 13 (11), 1400-1410. doi: 10.2174/138945012803530170
Ve, Thomas, Gay, Nicholas J., Mansell, Ashley, Kobe, Bostjan and Kellie, Stuart (2012). Adaptors in toll-like receptor signaling and their potential as therapeutic targets. Current Drug Targets, 13 (11), 1360-1374. doi: 10.2174/138945012803530260
Ericsson, Daniel J., Standish, Alistair, Kobe, Bostjan and Morona, Renata (2012). Wzy-dependent bacterial capsules as potential drug targets. Current Drug Targets, 13 (11), 1421-1431. doi: 10.2174/138945012803530279
de Barros, Andrea C., Takeda, Agnes A. S., Chang, Chiung-Wen, Kobe, Bostjan and Fontes, Marcos R. M. (2012). Structural basis of nuclear import of flap endonuclease 1 (FEN1). Acta Crystallographica Section D: Biological Crystallography, 68 (7), 743-750. doi: 10.1107/S0907444912010281
Kobe, Bostjan and Boden, Mikael (2012). Computational modelling of linear motif-mediated protein interactions. Current Topics in Medicinal Chemistry, 12 (14), 1553-1561. doi: 10.2174/156802612802652439
Patrick, Ralph, Cao, Kim-Anh L., Davis, Melissa, Kobe, Bostjan and Bodén, Mikael (2012). Mapping the stabilome: a novel computational method for classifying metabolic protein stability. BMC Systems Biology, 6 (1) 60, 60.1-60.15. doi: 10.1186/1752-0509-6-60
Chen, Kai-En, Richards, Ayanthi A., Arrifin, Juliana K., Ross, Ian L., Sweet, Matthew J., Kellie, Stuart, Kobe, Bostjan and Martin, Jennifer L. (2012). The mammalian DUF59 protein Fam96a forms two distinct types of domain-swapped dimer. Acta Crystallographica Section D: Biological Crystallography, 68 (6), 637-648. doi: 10.1107/S0907444912006592
Marfori, Mary, Lonhienne, Thierry G., Forwood, Jade K. and Kobe, Bostjan (2012). Structural basis of high-affinity nuclear localization signal interactions with importin-alpha. Traffic, 13 (4), 532-548. doi: 10.1111/j.1600-0854.2012.01329.x
Stark, Mitchell S., Woods, Susan L., Gartside, Michael G., Bonazzi, Vanessa F., Dutton-Regester, Ken, Aoude, Lauren G., Chow, Donald, Sereduk, Chris, Niemi, Natalie M., Tang, Nanyun, Ellis, Jonathan J., Reid, Jeffrey, Zismann, Victoria, Tyagi, Sonika, Muzny, Donna, Newsham, Irene, Wu, YuanQing, Palmer, Jane M., Pollak, Thomas, Youngkin, David, Brooks, Bradford R., Lanagan, Catherine, Schmidt, Christopher W., Kobe, Bostjan, MacKeigan, Jeffrey P., Yin, Hongwei, Brown, Kevin M., Gibbs, Richard, Trent, Jeffrey and Hayward, Nicholas K. (2012). Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing. Nature Genetics, 44 (2), 165-169. doi: 10.1038/ng.1041
Henningham, Anna, Chiarot, Emiliano, Gillen, Christine M., Cole, Jason N., Rohde, Manfred, Fulde, Marcus, Ramachandran, Vidiya, Cork, Amanda J., Hartas, Jon, Magor, Graham, Djordjevic, Steven P., Cordwell, Stuart J., Kobe, Bostjan, Sriprakash, Kabada S., Nizet, Victor, Chhatwal, G. S., Margarit, Immaculada Y. R., Batzloff, Michael R. and Walker, Mark J. (2012). Conserved anchorless surface proteins as group A streptococcal vaccine candidates. Journal of Molecular Medicine, 90 (10), 1197-1207. doi: 10.1007/s00109-012-0897-9
Watterson, Daniel, Kobe, Bostjan and Young, Paul R. (2012). Residues in domain III of the dengue virus envelope glycoprotein involved in cell-surface glycosaminoglycan binding. Journal of General Virology, 93 (1), 72-82. doi: 10.1099/vir.0.037317-0
Ve, Thomas, Williams, Simon J., Stamp, Anna, Valkov, Eugene, Dodds, Peter N., Anderson, Peter A. and Kobe, Bostjan (2011). Crystallization and X-ray diffraction analysis of the C-terminal domain of the flax rust effector protein AvrM. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 67 (12), 1603-1607. doi: 10.1107/S1744309111037675
McDevitt, Christopher A., Ogunniyi, Abiodun D., Valkov, Eugene, Lawrence, Michael C., Kobe, Bostjan, McEwan, Alastair G. and Paton, James C. (2011). A molecular mechanism for bacterial susceptibility to zinc. PLoS Pathogens, 7 (11) e1002357, e1002357.1-e1002357.9. doi: 10.1371/journal.ppat.1002357
Kobe, Bostjan (2011). Structural mix-n-match reveals molecular secrets of platelets. Blood, 118 (19), 5065-5066. doi: 10.1182/blood-2011-09-379859
Marfori, Mary, Kobe, Bostjan and Forwood, Jade K. (2011). Ligand-induced conformational changes within a hexameric acyl-CoA thioesterase. Journal of Biological Chemistry, 286 (41), 35643-35649. doi: 10.1074/jbc.M111.225953
Valkov, Eugene, Stamp, Anna, DiMaio, Frank, Baker, David, Verstak, Brett, Roversi, Pietro, Kellie, Stuart, Sweet, Matthew J., Mansell, Ashley, Gay, Nicholas J., Martin, Jennifer L. and Kobe, Bostjan (2011). Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection. Proceedings of the National Academy of Sciences of the United States of America, 108 (36), 14879-14884. doi: 10.1073/pnas.1104780108
Takeda, Agnes A. S., de Barros, Andrea C., Chang, Chiung-Wen, Kobe, Boštjan and Fontes, Marcos R. M. (2011). Structural basis of importin-alpha-mediated nuclear transport for Ku70 and Ku80. Journal of Molecular Biology, 412 (2), 226-234. doi: 10.1016/j.jmb.2011.07.038
Marfori, Mary, Mynott, Andrew, Ellis, Jonathan J., Mehdi, Ahmed M., Saunders, Neil F. W., Curmi, Paul M., Forwood, Jade K., Bodén, Mikael and Kobe, Bostjan (2011). Molecular basis for specificity of nuclear import and prediction of nuclear localization. Biochimica et Biophysica Acta (BBA): Molecular Cell Research, 1813 (9), 1562-1577. doi: 10.1016/j.bbamcr.2010.10.013
Williams, Simon J., Sornaraj, Pradeep, deCourcy-Ireland, Emma, Menz, R. Ian, Kobe, Bostjan, Ellis, Jeffrey G., Dodds, Peter N. and Anderson, Peter A. (2011). An autoactive mutant of the M flax rust resistance protein has a preference for binding ATP, whereas wild-type M protein binds ADP. Molecular Plant-Microbe Interactions, 24 (8), 897-906. doi: 10.1094/MPMI-03-11-0052
Ellis, Jonathan J. and Kobe, Bostjan (2011). Predicting protein kinase specificity : Predikin update and performance in the DREAM4 challenge. PLoS One, 6 (7) e21169, e21169-1-e21169-7. doi: 10.1371/journal.pone.0021169
Maco, B, Ross, IL, Landsberg, MJ, Mouradov, D, Saunders, NFW, Hankamer, B and Kobe, B (2011). Proteomic and electron microscopy survey of large assemblies in macrophage cytoplasm. Molecular and Cellular Proteomics, 10 (6) M111.008763, M111.008763. doi: 10.1074/mcp.M111.008763
Mehdi, Ahmed M., Sehgal, Muhammad Shoaib B., Kobe, Bostjan, Bailey, Timothy L. and Boden, Mikael (2011). A probabilistic model of nuclear import of proteins. Bioinformatics, 27 (9) btr121, 1239-1246. doi: 10.1093/bioinformatics/btr121
Mynott, Andrew V., Harrop, Stephen J., Brown, Louise J., Breit, Samuel N., Kobe, Bostjan and Curmi, Paul M. G. (2011). Crystal structure of importin-alpha bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4. The FEBS Journal, 278 (10), 1662-1675. doi: 10.1111/j.1742-4658.2011.08086.x
Bemoux, Maud, Ve, Thomas, Williams, Simon, Warren, Christopher, Hatters, Danny, Valkov, Eugene, Zhang, Xiaoxiao, Ellis, Jeffrey G., Kobe, Bostjan and Dodds, Peter N. (2011). Structural and functional analysis of a plant resistance protein TIR Domain reveals interfaces for self-association, signaling, and autoregulation. Cell Host and Microbe, 9 (3), 200-211. doi: 10.1016/j.chom.2011.02.009
Ve, Thomas, Williams, Simon, Valkov, Eugene, Ellis, Jeffrey G., Dodds, Peter N. and Kobe, Bostjan (2011). Crystallization, X-ray diffraction analysis and preliminary structure determination of the TIR domain from the flax resistance protein L6. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, 67 (2), 237-240. doi: 10.1107/S1744309110051006
Pitson, S. and Kobe, B. (2010). Science meets Parliament 2010. Australian Biochemist, 41 (2), 40-41.
Kirkby, Brenda, Roman, Noelia, Kobe, Bostjan, Kellie, Stuart and Forwood, Jade K. (2010). Functional and structural properties of mammalian acyl-coenzyme A thioesterases. Progress in Lipid Research, 49 (4), 366-377. doi: 10.1016/j.plipres.2010.04.001
Forwood, JK, Lange, A, Zachariae, U, Marfori, M, Preast, C, Grubmuller, H, Stewart, M, Corbett, AH and Kobe, B (2010). Quantitative structural analysis of Importin-β flexibility: Paradigm for solenoid protein structures. Structure, 18 (9), 1171-1183. doi: 10.1016/j.str.2010.06.015
Morrow, CA, Stamp, A, Valkov, E, Kobe, B and Fraser, JA (2010). Crystallization and preliminary X-ray analysis of mycophenolic acid-resistant and mycophenolic acid-sensitive forms of IMP dehydrogenase from the human fungal pathogen Cryptococcus. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 66 (9), 1104-1107. doi: 10.1107/S1744309110031659
Yang, Sny, Takeda, AAS, Fontes, MRM, Harris, JM, Jans, DA and Kobe, B (2010). Probing the specificity of binding to the major nuclear localization sequence-binding site of importin-alpha using oriented peptide library screening. Journal of Biological Chemistry, 285 (26), 19935-19946. doi: 10.1074/jbc.M109.079574
Allsopp, Luke P., Totsika, Makrina, Tree, Jai J., Ulett, Glen C., Mabbett, Amanda N., Wells, Timothy J., Kobe, Bostjan, Beatson, Scott A. and Schembri, Mark A. (2010). UpaH is a newly identified autotransporter protein that contributes to biofilm formation and bladder colonization by uropathogenic Escherichia coli CFT073. Infection and Immunity, 78 (4), 1659-1669. doi: 10.1128/IAI.01010-09
Catanzariti, Ann-Maree, Dodds, Peter N., Ve, Thomas, Kobe, Bostjan, Ellis, Jeffrey G. and Staskawicz, Brian J. (2010). The AvrM Effector from flax rust has a structured C-terminal domain and interacts directly with the M resistance protein. Molecular Plant-Microbe Interactions, 23 (1), 49-57. doi: 10.1094/MPMI-23-1-0049
Kobe, B., Guncar, G., Buchholz, R., Huber, T. L. and Maco, B. (2009). The many faces of platelet glycoprotein Ib alpha - thrombin interaction. Current Protein and Peptide Science, 10 (6), 551-558. doi: 10.2174/138920309789630570
Kampmann, T., Yennamalli, R., Campbell, P., Stoermer, M. J., Fairlie, D. P., Kobe, B. and Young, P. R. (2009). In silico screening of small molecule libraries using the dengue virus envelope E protein has identified compounds with antiviral activity against multiple flaviviruses. Antiviral Research, 84 (3), 234-241. doi: 10.1016/j.antiviral.2009.09.007
King, Gordon J., Chen, Kai-En, Robin, Gautier, Forwood, Jade K., Heras, Begoña, Thakur, Anil S., Kobe, Bostjan, Blomberg, Simon P. and Martin, Jennifer L. (2009). Interaction between plate make and protein in protein crystallisation screening. PLoS One, 4 (11) e7851, x-x. doi: 10.1371/journal.pone.0007851
O'Connell, A, Robin, G, Kobe, B and Botella, JR (2009). Biochemical characterization of arabidopsis developmentally regulated G-proteins (DRGs). PROTEIN EXPRESSION AND PURIFICATION, 67 (2), 88-95. doi: 10.1016/j.pep.2009.05.009
Lonhienne, Thierry G., Forwood, Jade K., Marfori, Mary, Robin, Gautier, Kobe, Bostjan and Carroll, Bernard J. (2009). Importin-B is a GDP-to-GTP exchange factor of Ran: Implications for the mechanism of nuclear import. Journal of Biological Chemistry, 284 (34), 22549-22558. doi: 10.1074/jbc.M109.019935
Cork, A. J., Jergic, S., Hammerschmidt, S., Kobe, B., Pancholi, V., Benesch, J. L. P., Robinson, C. V., Dixon, N. E., Aquilina, J. A. and Walker, M. J. (2009). Defining the structural basis of human plasminogen binding by streptococcal surface enolase. Journal of Biological Chemistry, 284 (25), 17129-17137. doi: 10.1074/jbc.M109.004317
Roman, Noelia, Kirkby, Brenda, Marfori, Mary, Kobe, Bostjan and Forwood, Jade K. (2009). Crystallization of the flexible nuclear import receptor importin-beta in the unliganded state. Acta Crystallographica Section F: Structural Biology and Crystallization Communications Online, 65 (6), 625-628. doi: 10.1107/S1744309109016820
Yennamalli, Ragothaman, Subbarao, Naidu, Kampmann, Thorsten, McGeary, Ross P., Young, Paul R. and Kobe, Bostjan (2009). Identification of novel target sites and an inhibitor of the dengue virus E protein. Journal of Computer-Aided Molecular Design, 23 (6), 333-341. doi: 10.1007/s10822-009-9263-6
Kobe, Bostjan, Guncar, Gregor, Buchholz, Rebecca, Huber, Thomas, Maco, Bohumil, Cowieson, Nathan, Martin, Jennifer L., Marfori, Mary and Forwood, Jade K. (2008). Crystallography and protein-protein interactions: Biological interfaces and crystal contacts. Biochemical Society Transactions, 36 (6), 1438-1441. doi: 10.1042/BST0361438
Forwood, Jade K., Lonhienne, Thierry G., Marfori, Mary, Robin, Gautier, Meng, Weining, Guncar, Gregor, Liu, Sai M., Stewart, Murray, Carroll, Bernard J. and Kobe, Bostjan (2008). Kap95p binding induces the switch loops of RanGDP to adopt the GTP-bound conformation: Implications for nuclear import complex assembly dynamics. Journal of Molecular Biology, 383 (4), 772-782. doi: 10.1016/j.jmb.2008.07.090
Cowieson, Nathan P., Kobe, Bostjan and Martin, Jennifer L. (2008). United we stand: combining structural methods. Current Opinion in Structural Biology, 18 (5), 617-622. doi: 10.1016/j.sbi.2008.07.004
Miyahara, A., Hirani, T., Oakes, M., Kereszt, A., Kobe, B., Djordjevic, M.A. and Gresshoff, P. M. (2008). Soybean Nodule Autoregulation Receptor Kinase Phosphorylates Two Kinase-associated Protein Phosphatases in Vitro. Journal of Biological Chemistry, 283 (37), 25381-25391. doi: 10.1074/jbc.M800400200
Thakur, Anil S, Newman, Janet, Martin, Jennifer L and Kobe, Bostjan (2008). Increasing protein crystallization screening success with heterogeneous nucleating agents. Methods in molecular biology (Clifton, N.J.), 426, 403-409. doi: 10.1007/978-1-60327-058-8_26
Androulakis, S., Schmidberger, J., Bate, M. A., DeGori, R., Beitz, A., Keong, C., Cameron, B., McGowan, S., Porter, C. J., Harrison, A., Hunter, J., Martin, J. L., Kobe, B., Dobson, R. C. J., Parker, M. W., Whisstock, J. C., Gray, J., Treloar, A., Groenewegen, D., Dickson, N. and Buckle, A. M. (2008). Federated repositories of X-ray diffraction images. Acta Crystallographica Section D: Biological Crystallography, 64 (7), 810-814. doi: 10.1107/S0907444908015540
King, G. J., Jones, A., Kobe, B., Huber, T., Mouradov, D., Hume, D. A. and Ross, I. L. (2008). Identification of Disulfide-containing chemical cross-links in proteins using MALDI-TOF/TOF-MAss spectrometry. Analytical Chemistry, 80 (13), 5036-5043. doi: 10.1021/ac702277q
Cowieson, Nathan P., King, Gordon, Cookson, David, Ross, Ian, Huber, Thomas, Hume, David A., Kobe, Bostjan and Martin, Jennifer L. (2008). Cortactin adopts a globular conformation and bundles actin into sheets. The Journal of Biological Chemistry, 283 (23), 16187-16193. doi: 10.1074/jbc.M708917200
Saunders, N., Brinkworth, R.I., Huber, T. L., Kemp, B.E. and Kobe, B. (2008). Predikin and PredikinDB: a computational framework for the prediction of protein kinase peptide specificity and an associated database of phosphorylation sites. BMC Bioinformatics, 9 (245) 245, 1-11. doi: 10.1186/1471-2105-9-245
Frith, Martin C., Saunders, Neil F. W., Kobe, Bostjan and Bailey, Timothy L. (2008). Discovering sequence motifs with arbitrary insertions and deletions. PLoS Computational Biology, 4 (5) e1000071, e1000071.1-e1000071.12. doi: 10.1371/journal.pcbi.1000071
Lonic, A., Barry, E.F., Quach, C., Kobe, B., Saunders, N. and Guthridge, M.A. (2008). Fibroblast growth factor receptor 2 phosphorylation on Serine 779 couples to 14-3-3 and regulates cell survival and proliferation. Molecular & Cellular Biology, 28 (10), 3372-3385. doi: 10.1128/MCB.01837-07
Cowieson, Nathan P., Miles, Andrew J., Robin, Gautier, Forwood, Jade K., Kobe, Bostjan, Martin, Jennifer L. and Wallace, B. A. (2008). Evaluating protein: Protein complex formation using synchrotron radiation circular dichroism spectroscopy. Proteins: Structure Function Bioinformatics, 70 (4), 1142-1146. doi: 10.1002/prot.21631
Saunders, Neil F. W. and Kobe, Bostjan (2008). The Predikin webserver: improved prediction of protein kinase peptide specificity using structural information. Nucleic Acids Research, 36 (suppl 2), W286-W290. doi: 10.1093/nar/gkn279
Mueller, D., Kampmann, T., Yennamalli, R., Young, P.R., Kobe, B. and Mark, A. E. (2008). Histidine protonation and the activation of viral fusion proteins. Biochemical Society Transactions, 36 (1), 43-45. doi: 10.1042/BST0360043
Kobe, Bostjan, Guss, Mitchell and Huber, Thomas (2008). Structural proteomics: high-throughput methods. Preface. Methods in molecular biology (Clifton, N.J.), 426, v-vi. doi: 10.1007/978-1-60327-058-8
Thakur, A., Robin, G., Guncar, G., Saunders, N., Newman, J., Martin, J. L. and Kobe, B. (2007). Improved Success of Sparse Matrix Protein Crystallization Screening with Heterogeneous Nucleating Agents. PLoS ONE, 2 (10) e1091, e1091-1-e1091-6. doi: 10.1371/journal.pone.0001091
Wang, C., Guncar, G., Forwood, J., Teh, T., Catanzariti, A., Lawrence, G., Loughlin, F., Mackay, J., Schirra, H., Anderson, P., Ellis, J., Dodds, P. and Kobe, B. (2007). Crystal structures of flax rust avirulence proteins AvrL567-A and -D reveal details of the structural basis for flax disease resistance specificity. Plant Cell, 19 (9), 2898-2912. doi: 10.1105/tpc.107.053611
Forwood, J., Thakur, A., Guncar, G., Marfori, M., Mouradov, D., Meng, W., Robinson, J., Huber, T., Kellie, S., Martin, J. L., Hume, D. and Kobe, B. (2007). Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation. Proceedings of The National Academy of Sciences of The United States of America, 104 (25), 10382-10387. doi: 10.1073/pnas.0700974104
Guncar, G., Wang, C., Forwood, J., Teh, T., Catanzariti, A., Ellis, J., Dodds, P. and Kobe, B (2007). The use of Co2+ for crystallization and structure determination, using a conventional monochromatic X-ray source, of flax rust avirulence protein. Acta Crystallographica Section F-structural Biology And Crystallization Communications, 63 (3), 209-213. doi: 10.1107/S1744309107004599
Schmidt, S., Williams, S., Wang, C., Sornaraj, P., James, B., Kobe, B., Dodds, P., Ellis, J. and Anderson, P. (2007). Purification of the M flax-rust resistance protein expressed in Pichia pastoris. Plant Journal, 50 (6), 1107-1117. doi: 10.1111/j.1365-313X.2007.03104.x
Bogoyevitch, Marie A. and Kobe, Bostjan (2006). Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases. Microbiology and Molecular Biology Reviews, 70 (4), 1061-1095. doi: 10.1128/MMBR.00025-06
Dodds, P. N., Lawrence, G. J., Cantanzariti, A. M., Teh, T., Wang, C. I. A., Ayliffe, M. A., Kobe, B. and Ellis, J. G. (2006). Direct protein interaction underlies gene-for-gene specificity and coevolution of the flax resistance genes and flax rust avirulence genes. Proceedings of the National Academy of Science of the United States of America, 103 (23), 8888-8893. doi: 10.1073/pnas.0602577103
Kurz, M., Cowieson, N. P., Robin, G., Hume, D. A., Martin, J. L., Kobe, B. and Listwan, P. (2006). Incorporating a TEV cleavage site reduces the solubility of nine recombinant mouse proteins. Protein Expression And Purification, 50 (1), 68-73. doi: 10.1016/j.pep.2006.05.006
Serek, R., Forwood, J. K., Hume, D. A., Martin, J. L. and Kobe, B. (2006). Crystallization of the C-terminal domain of the mouse brain cytosolic long-chain acyl-CoA thioesterase. Acta Crystallographica Section F-structural Biology And Crystallization Communications, 62, 133-135. doi: 10.1107/S17443091060000030
Brinkworth, Ross I., Munn, Alan L. and Kobe, Bostjan (2006). Protein kinases associated with the yeast phosphoproteome. Bmc Bioinformatics, 7 (47) 47, 47. doi: 10.1186/1471-2105-7-47
Puri, M., Robin, G., Cowieson, N., Forwood, J. K., Listwan, P., Hu, S. H., Guncar, G., Huber, T., Kellie, S., Hume, D. A., Kobe, B. and Martin, J. L. (2006). Focusing in on structural genomics: The University of Queensland structural biology pipeline. Biomolecular Engineering, 23 (6), 281-289. doi: 10.1016/j.bioeng.2006.09.002
Kampmann, Thorsten, Meuller, Daniela S., Mark, Alan E., Young, Paul R. and Kobe, Bostjan (2006). The role of histidine residues in low-pH-mediated viral membrane fusion. Structure, 14 (10), 1481-1487. doi: 10.1016/j.str.2006.07.011
Mouradov, D., Craven, A., Forwood, J. K., Flanagan, J. U., Garcia-Castellanos, R., Gomis-Ruth, F. X., Hume, D. A., Martin, J. L., Kobe, B. and Huber, T. (2006). Modelling the structure of latexin-carboxypeptidase A complex based on chemical cross-linking and molecular docking. Protein Engineering Design & Selection, 19 (1), 9-16. doi: 10.1093/protein/gzi070
Cowieson, Nathan P., Wensley, Beth, Listwan, Pawel, Hume, David A., Kobe, Bostjan and Martin, Jennifer L. (2006). An automatable screen for the rapid identification of proteins amenable to refolding. Proteomics, 6 (6), 1750-1757. doi: 10.1002/pmic.200500056
Kobe, Bostjan, Kampmann, Thorsten, Forwood, Jade K., Listwan, Pawel and Brinkworth, Ross I. (2005). Substrate specifity of protein kinases and computational prediction of substrates. Biochimica et Biophysica Acta, 1754 (1-2), 200-209. doi: 10.1016/j.bbapap.2005.07.036
Listwan, P, Cowieson, N, Kurz, M, Hume, DA, Martin, JL and Kobe, B (2005). Modification of recombinatorial cloning for small affinity tag fusion protein construct generation. Analytical Biochemistry, 346 (2), 327-329. doi: 10.1016/j.ab.2005.06.016
Cowieson, N. P., Listwan, P., Kurz, M., Aagaard, A., Ravasi, T., Wells, C. A., Huber, T. L., Hume, D. A., Kobe, B. and Martin, J. L. (2005). Pilot studies on the parallel production of soluble mouse proteins in a bacterial expression system. Journal of Structural and Functional Genomics, 6 (1), 13-20. doi: 10.1007/s10969-005-0462-7
Aagaard, A., Listwan, P., Cowieson, N. P., Huber, T. L., Ravasi, T., Wells, C. A., Flanagan, J. U., Kellie, S., Hume, D. A., Kobe, B. and Martin, J. L. (2005). An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: Relationship to cystatins and the tumor suppressor TIG1. Structure, 13 (2), 309-317. doi: 10.1016/j.str.2004.12.013
Fontes, M. R. M., Teh, T., Riell, R. D., Park, S. B., Standaert, R. E. and Kobe, B. (2005). Crystallization and preliminary X-ray diffraction analysis of importin-alpha acomplexed with NLS peptidomimetics. Biochimica Et Biophysica Acta-proteins And Proteomics, 1750 (1), 9-13. doi: 10.1016/j.bbapap.2005.03.014
Ren, Gang, Wang, Juan, Brinkworth, Ross, Winsor, Barbara, Kobe, Bostjan and Munn, Alan L. (2005). Verprolin cytokinesis function mediated by the Hof one trap domain. Traffic, 6 (7), 575-593. doi: 10.1111/j.1600-0854.2005.00300.x
Listwan, P., Martin, J. L., Kobe, B. and Cowieson, N. P. (2004). Methods for high-throughput protein expression, purification and structure determination adapted for structural genomics. Australian Biochemist, 35 (2), 43-46.
Kobe, Bostjan (2004). Structural and Functional Genomics. Australian Biochemist, 35 (2)
Huber, T. L. and Kobe, B. (2004). Comment on 'Protein isoelectric point as a predictor for increased crystallization screening efficiency'. Bioinformatics, 20 (14), 2169-2170. doi: 10.1093/bioinformatics/bth452
Lay, C. S., Wilson, K. A., Kobe, B., Kemp, B. E., Drummer, H. E. and Poumbourios, P. (2004). Expression and biochemical analysis of the entire HIV-2 gp41 ectodomain: determinants of stability map to N- and C-terminal sequences outside the 6-helix bundle core. Febs Letters, 567 (2-3), 183-188. doi: 10.1016/j.febslet.2004.04.054
Fontes, R. M., Teh, T., Toth, G., John, A.I., Pavo, I. D. A., Jans, D. A. and Kobe, B. (2003). Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-a. Biochemical Journal, 375 (2), 339-349. doi: 10.1042/BJ20030510
Wooh, J. W., Kidd, R. D., Martin, J. L. and Kobe, B. (2003). Comparison of three commercial sparse-matrix crystallization screens. Acta Crystallographica Section D: Biological Crystallography, 59 (4), 769-772. doi: 10.1107/S0907444903002919
Brinkworth, R. I., Breinl, R. A. and Kobe, B. (2003). Structural basis and prediction of substrate specificity in protein serine/threonine kinases. Proceedings of The National Academy of Sciences of The United States of America, 100 (1), 74-79. doi: 10.1073/pnas.0134224100
Kobe, B. (2003). Great Expectations: Structural Biology Amidst World Politics. Australian Biochemist, 34 (1), 24-27.
Smyth, Douglas R., Mrozkiewicz, Marek K., McGrath, William J., Listwan, Pawel and Kobe, Bostjan (2003). Crystal structures of fusion proteins with large-affinity tags. Protein Science, 12 (7), 1313-1322. doi: 10.1110/ps.0243403
Fontes, R. Marcos, Teh, Trazel, Jans, David A., Brinkworth, Ross I. and Kobe, Bostjan (2003). Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-α. Journal of Biological Chemistry, 278 (30), 27981-27987. doi: 10.1074/jbc.M303275200
Kobe, Bostjan (2002). Intramolecular autoregulatory sequences in proteins. Croatica Chemica Acta, 75 (3), 805-816.
Brinkworth, R. I., Horne, J. and Kobe, B. (2002). A computational analysis of substrate binding strength by phosphorylase kinase and protein kinase A. Journal of Molecular Recognition, 15 (2), 104-111. doi: 10.1002/jmr.563
Horne, J., Jennings, I. G., Teh, T., Gooley, P. R. and Kobe, B. (2002). Structural characterization of the N-terminal autoregulatory sequence of phenylalanine hydroxylase. Protein Science, 11 (8), 2041-2047. doi: 10.1110/ps.4560102
Kajava, A. V. and Kobe, B. (2002). Assessment of the ability to model proteins with leucine-rich repeats in light of the latest structural information. Protein Science, 11 (5), 1082-1090. doi: 10.1110/ps.4010102
Kobe, Bostjan and Kajava, Andrey V. (2001). The leucine-rich repeat as a protein recognition motif. Current Opinion In Structural Biology, 11 (6), 725-732. doi: 10.1016/S0959-440X(01)00266-4
Blanchard, H., Fontes, R. M, Hammet, A., Pike, B. L., Teh, T., Gleichmann, T., Gooley, P. R., Kobe, B. and Heierhorst, J. (2001). Crystallization and preliminary X-ray diffraction studies of FHA domains of Dun1 and Rad53 protein kinases. Acta Crystallographica Section D: Biological Crystallography, 57 (3), 459-461. doi: 10.1107/S0907444901002116
Kobe, B. (2001). Crystallization and crystal structure determination of ribomuclease A-ribonuclease inhibitor protein complex. Methods in Molecular Biology, 160, 201-211. doi: 10.1385/1-59259-233-3:201
Jennings, I. G., Teh, T. and Kobe, B. (2001). Essential role of the N-terminal autoregulatory sequence in the regulation of phenylalanine hydroxylase. Febs Letters, 488 (3), 196-200. doi: 10.1016/S0014-5793(00)02426-1
Catimel, B., Teh, T., Fontes, M. R. M., Jennings, I. G., Jans, D. A., Howlett, G. J., Nice, E. C. and Kobe, B. (2001). Biophysical characterization of interactions involving importin-alpha during nuclear import. Journal of Biological Chemistry, 276 (36), 34189-34198. doi: 10.1074/jbc.M103531200
Walsh, C. R., Hume, D. A., Kobe, B. and Martin, J. L. (2001). Structural genomics: Protein structures for the masses?. Australian Biochemist, 32 (2), 13-16.
Maerz, Anne L., Center, Rob J., Kemp, Bruce E., Kobe, Bostjan and Poumbourios, Pantelis (2000). Functional implications of the human T-lymphotropic virus type 1 transmembrane glycoprotein helical hairpin structure. Journal of Virology, 74 (14), 6614-6621. doi: 10.1128/JVI.74.14.6614-6621.2000
Jennings, IG, Cotton, RGH and Kobe, B (2000). Structural interpretation of mutations in phenylalanine hydroxylase protein aids in identifying genotype-phenotype correlations in phenylketonuria. European Journal of Human Genetics, 8 (9), 683-696. doi: 10.1038/sj.ejhg.5200518
Jennings, IG, Cotton, RGH and Kobe, B (2000). Functional analysis, using in vitro mutagenesis, of amino acids located in the phenylalanine hydroxylase active site. Archives of Biochemistry And Biophysics, 384 (2), 238-244. doi: 10.1006/abbi.2000.2111
Kobe, B and Kajava, AV (2000). When protein folding is simplified to protein coiling: the continuum of solenoid protein structures. Trends in Biochemical Sciences, 25 (10), 509-515. doi: 10.1016/S0968-0004(00)01667-4
Montgomery, J, Ilg, T, Thompson, JK, Kobe, B and Handman, E (2000). Identification and predicted structure of a leucine-rich repeat motif shared by Leishmania major proteophosphoglycan and Parasite Surface Antigen 2. Molecular And Biochemical Parasitology, 107 (2), 289-295. doi: 10.1016/S0166-6851(00)00186-9
Hammet, A, Pike, BL, Mitchelhill, KI, Teh, T, Kobe, B, House, CM, Kemp, BE and Heierhorst, J (2000). FHA domain boundaries of the Dun1p and Rad53p cell cycle checkpoint kinases. Febs Letters, 471 (2-3), 141-146. doi: 10.1016/S0014-5793(00)01392-2
Fontes, MRM, Teh, T and Kobe, B (2000). Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha. Journal of Molecular Biology, 297 (5), 1183-1194. doi: 10.1006/jmbi.2000.3642
Teh, T, Tiganis, T and Kobe, B (1999). Crystallization of importin alpha, the nuclear-import receptor. Acta Crystallographica Section D: Biological Crystallography, 55 (2), 561-563. doi: 10.1107/S0907444998012943
Kobe, B, Jennings, IG, House, CM, Michell, BJ, Goodwill, KE, Santarsiero, BD, Stevens, RC, Cotton, RGH and Kemp, BE (1999). Structural basis of autoregulation of phenylalanine hydroxylase. Nature Structural Biology, 6 (5), 442-448. doi: 10.1038/8247
Kobe, B (1999). Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha. Nature Structural Biology, 6 (4), 388-397. doi: 10.1038/7625
Kobe, B, Gleichmann, T, Horne, J, Jennings, IG, Scotney, PD and Teh, T (1999). Turn up the HEAT. Structure, 7 (5), R91-R97. doi: 10.1016/S0969-2126(99)80060-4
Kobe, B, Center, RJ, Kemp, BE and Poumbourios, P (1999). Crystal structure of human T cell leukemia virus type 1 gp21 ectodomain crystallized as a maltose-binding protein chimera reveals structural evolution of retroviral transmembrane proteins. Proceedings of The National Academy of Sciences of The United States of America, 96 (8), 4319-4324. doi: 10.1073/pnas.96.8.4319
Poumbourios, P, Center, RJ, Wilson, KA, Kemp, BE and Kobe, B (1999). Evolutionary conservation of the membrane fusion machine. Iubmb Life, 48 (2), 151-156. doi: 10.1080/713803503
Kobe, B and Kemp, BE (1999). Active site-directed protein regulation. Nature, 402 (6760), 373-376. doi: 10.1038/46478
Smith, Barbara S., Kobe, Bostjan, Kurumbail, Ravi, Buchanan, Susan K., Venkatramani, Lalitha, van der Helm, Dick and Deisenhofer, Johann (1998). Crystallization and preliminary X-ray analysis of ferric enterobactin receptor FepA, an integral membrane protein from Escherichia coli. Acta crystallographica: Section D, Biological crystallography, 54 (4), 697-699. doi: 10.1107/S0907444997020222
Kemp, B. E., Kobe, B. and Heierhorst, J. (1998). Protein phosphorylation: In-charge and networking!. Australian Biochemist, 29, 11-13.
Kobe, B (1998). Open up review system. Nature, 396 (6711), 509-509. doi: 10.1038/24969
Center, RJ, Kobe, B, Wilson, KA, Teh, T, Howlett, GJ, Kemp, BE and Poumbourios, P (1998). Crystallization of a trimeric human T cell leukemia virus type 1 gp21 ectodomain fragment as a chimera with maltose-binding protein. Protein Science, 7 (7), 1612-1619. doi: 10.1002/pro.5560070715
Kobe, B. (1997). Erratum: Leucines on a roll (Nature Structural Biology (1996) 3:12 (977- 980)). Nature Structural Biology, 4 (4). doi: 10.1038/nsb0497-327
Kobe, B, Jennings, IG, House, CM, Feil, SC, Michell, BJ, Tiganis, T, Parker, MW, Cotton, RGH and Kemp, BE (1997). Regulation and crystallization of phosphorylated and dephosphorylated forms of truncated dimeric phenylalanine hydroxylase. Protein Science, 6 (6), 1352-1357. doi: 10.1002/pro.5560060626
Xu, P, Mitchelhill, KI, Kobe, B, Kemp, BE and Zot, HG (1997). The myosin-I-binding protein Acan125 binds the SH3 domain and belongs to the superfamily of leucine-rich repeat proteins. Proceedings of The National Academy of Sciences of The United States of America, 94 (8), 3685-3690. doi: 10.1073/pnas.94.8.3685
Kobe, B, Heierhorst, J and Kemp, BE (1997). Intrasteric regulation of protein kinases. Signal Transduction In Health And Disease, 31, 29-40.
Heierhorst, Jörg, Kobe, Bostjan, Feil, Susanne C., Parker, Michael W., Benian, Guy M., Weiss, Klaudiusz R. and Kemp, Bruce E. (1996). Ca2+ /S100 regulation of giant protein kinases. Nature, 380 (6575), 636-639. doi: 10.1038/380636a0
Kobe, Bostjan (1996). Leucines on a roll. Nature Structural Biology, 3 (12), 977-980. doi: 10.1038/nsb1296-977
Kobe, B, Heierhorst, J, Feil, SC, Parker, MW, Benian, GM, Weiss, KR and Kemp, BE (1996). Giant protein kinases: Domain interactions and structural basis of autoregulation. Embo Journal, 15 (24), 6810-6821. doi: 10.1002/j.1460-2075.1996.tb01072.x
Kobe, B and Deisenhofer, J (1996). Mechanism of ribonuclease inhibition by ribonuclease inhibitor protein based on the crystal structure of its complex with ribonuclease A. Journal of Molecular Biology, 264 (5), 1028-1043. doi: 10.1006/jmbi.1996.0694
Kemp, B. E., Barden, J. A., Kobe, B., House, C. and Parker, M. W. (1996). Intrasteric regulation of calmodulin-dependent protein kinases. Advances in Pharmacology, 36 (C), 221-249. doi: 10.1016/S1054-3589(08)60584-0
Kobe, Bostjan and Deisenhofer, Johann (1995). Proteins with leucine-rich repeats. Current Opinion in Structural Biology, 5 (3), 409-416. doi: 10.1016/0959-440X(95)80105-7
Kobe, Bostjan and Deisenhofer, Johann (1995). A structural basis of the interactions between leucine-rich repeats and protein ligands. Nature, 374 (6518), 183-186. doi: 10.1038/374183a0
Kobe, Bestjan, Ma, Zhiquan and Deisenhofer, Johann (1994). Complex between bovine ribonuclease A and porcine ribonuclease inhibitor crystallizes in a similar unit cell as free ribonuclease inhibitor. Journal of Molecular Biology, 241 (2), 288-291. doi: 10.1006/jmbi.1994.1502
Kobe, Bostjan and Deisenhofer, Johann (1994). The leucine-rich repeat: a versatile binding motif. Trends In Biochemical Sciences, 19 (10), 415-421. doi: 10.1016/0968-0004(94)90090-6
Rizo, Josep, Blanco, Francisco J., Kobe, Bostjan, Bruch, Martha D. and Gierasch, Lila M. (1993). Conformational behavior of Escherichia coli OmpA signal peptides in membrane mimetic environments. Biochemistry, 32 (18), 4881-4894. doi: 10.1021/bi00069a025
Kobe, Bostjan and Deisenhofer, Johann (1993). Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats. Nature, 366 (6457), 751-756. doi: 10.1038/366751a0
Kobe, Bostjan and Deisenhofer, Johann (1993). Crystallization and preliminary X-ray analysis of porcine ribonuclease inhibitor, a protein with leucine-rich repeats. Journal of Molecular Biology, 231 (1), 137-140. doi: 10.1006/jmbi.1993.1263
Kobe, B., Kobe, J., Smee, D. F., Jerman-Blazic-Dzonova, B. and Solmajer, T. (1992). Use of distance geometry approach for the in vitro antiviral activity evaluation of N-bridgehead C-nucleosides. European Journal of Medicinal Chemistry, 27 (3), 259-266. doi: 10.1016/0223-5234(92)90010-X
Faming, Z., Kobe, B., Stewart, C. B., Rutter, W. J. and Goldsmith, E. J. (1991). Structural evolution of an enzyme specificity. The structure of rat carboxypeptidase A2 at 1.9-A resolution. The Journal of Biological Chemistry, 266 (36), 24606-24612.

Conference Papers

Kobe, Bostjan, Nanson, Jeffrey D., Manik, Mohammad K., Li, Sulin, Gu, Weixi, Pan, Mengqi, Li, Yan, Muusse, Timothy W., Vajjhala, Parimala R, Stacey, Katryn J., Holmes, Susannah, Darmanin, Connie, Clabbers, Max T. B., Xu, Hongyi, Shi, Yun and Ve, Thomas (2023). Structural evolution of TIR-domain signalosomes in mammalian, plant and bacterial immunity characterized by integrative structural biology. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323093658
Nanson, J. D., Muusse, T. W., Li, Y., Pan, M., Landsberg, M. J., Vajjhala, P. R., Ve, T., Stacey, K. J. and Kobe, B. (2023). TLR4 TIR domain higher-order assemblies reveal the structural basis of adaptor recruitment in Toll-like receptor signaling pathways. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323086631
Li, Y., Nanson, J. D., Pacoste, L. C., Xu, H. and Kobe, B. (2023). Structure determination of TLR2 TIR domain induced MyD88 TIR domain higher-order assembly revealed by microcrystal electron diffraction (microED). XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323093993
Ngu, Dalton H. Y., Maunders, Eve. A., Lim, Bryan Y. J., Luo, Zhenyao, McDevitt, Christopher A. and Kobe, Boštjan (2023). Characterisation of the solute-binding protein ModA from Pseudomonas aeruginosa and its role in molybdenum homeostasis. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323089477
Gu, W., Luo, Z., Nanson, J. D., Ve, T. and Kobe, B. (2023). Allosteric regulation of SARM1, the executioner of axon degeneration. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323089398
Maruta, Natsumi, Burdett, Hayden, Sorbello, Mitchell, Lim, Bryan Ying Jie, Ngu, Dalton and Kobe, Bostjan (2023). Structural and functional characterisation of plant innate immune receptors. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323087764
McGuinness, Helen Ying, Rosell, Arnau Llobert, Gu, Weixi, Nanson, Jeffrey, Ve, Thomas and Kobe, Bostjan (2023). Characterisation of Axundead, a novel downstream regulator of Wallerian degeneration. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323087661
Arachchige, K. S. A., Koifman, N., Gu, W., Kobe, B., Clegg, J. K., Xu, H. and Wepf, R. (2023). Development of 3D-ED/MicroED facility at the University of Queensland. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323086461
Kwah, Kayden, Gu, Weixi, Arachchige, Kasun S. A., He, Yaowu, Landsberg, Michael, Kobe, Bostjan and Hooper, John (2023). Structural basis of an anti-cancer biological warhead bound to its target CDCP1 for the diagnosis and treatment of epithelial cancers. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323084449
Li, Sulin, Manik, Mohammad Kawsar, Ve, Thomas, Nanson, Jeffrey D. and Kobe, Bostjan (2023). Activated bacterial TIR proteins: NADase activity and filamentous assemblies. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323086904
Lim, Bryan Y. J., Sorbello, Mitchell, Ngu, Dalton H. Y., Burdett, Hayden, Maruta, Natsumi and Kobe, Boštjan (2023). Structural and functional characterisation of plant TIR domains and their role in plant innate immunity. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323087752
Alenzi, Athyah, Nimma, Surekha and Kobe, Bostjan (2023). Structural and functional characterization of interleukin-1 receptor 8. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323086667
Qian, Xiaoqi, Nanson, Jeffrey and Kobe, Boštjan (2023). Structural and functional analysis of the TIR-domain in Toll-like receptors 7, 8 and 9 signaling and the interactions with adaptor proteins. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s205327332308662x
Shi, Y., Nanson, J., Gu, W., Masic, V., Mosaiab, T., Landsberg, M., Kobe, B. and Ve, T. (2023). Structural basis for activation and inhibition of the pro-neurodegenerative NADase SARM1. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323087776
Pan, M., Hedger, A., Nanson, J., Pospich, S., Ve, T. V. E. A., Raunser, S., Landsberg, M. and Kobe, B. (2022). Structural basis of TIR-domain assembly formation in TRAM- and TRIF- dependent TLR signalling. 2022 American Crystallographic Association Meeting, Portland, OR USA, 29 July-3 August 2022. Hoboken, NJ USA: Wiley-Blackwell Publishing. doi: 10.1107/s2053273322093196
Rank, M. X., Kobe, B., Burdett, H., Horsefield, S., Manik, M. K., Zhang, X. and Shi, Y. (2019). Interaction and structural study between plant TIR-containing NLRs and EDS1 immune regulatory complex. 18th Congress of International Society for Molecular Plant Microbe Interactions (IS-MPMI), Glasgow, Scotland, 14-18 July, 2019. St. Paul, MN, United States: American Phytopathological Society. doi: 10.1094/MPMI-32-10-S1.1
Burdett, H., Rank, M. X., Chen, J., Zhang, X., Shi, Y., Ve, T., Dodds, P. N. and Kobe, B. (2019). Structural and Biochemical Analysis of Plant TIR NAD plus Cleavage Activity. 18th Congress of International Society for Molecular Plant Microbe Interactions (IS-MPMI), Glasgow, Scotland, 14-18 July, 2019. St. Paul, MN, United States: American Phytopathological Society. doi: 10.1094/MPMI-32-10-S1.213
Kobe, B., Burdett, H., Zhang, X., Chen, J., Rank, M. X., Horsefield, S., Manik, M. K., Shi, Y., Qi, T., Dry, I. B., Williams, S. J., Staskawicz, B. J., Ve, T. and Dodds, P. N. (2019). Animal TIR domains inform the molecular and structural basis of signaling by plant NLR TIR domains. 18th Congress of International Society for Molecular Plant Microbe Interactions (IS-MPMI), Glasgow, Scotland, 14-18 July, 2019. St. Paul, MN, United States: American Phytopathological Society. doi: 10.1094/MPMI-32-10-S1.1
Chen, J., Zhang, X., Burdett, H., Rank, M. X., Ve, T., Rathjen, J., Kobe, B. and Dodds, P. N. (2019). Self-association and an intact NADase active site are required for plant TIR domain immune signaling. 18th Congress of International Society for Molecular Plant Microbe Interactions (IS-MPMI), Glasgow, Scotland, 14-18 July, 2019. St. Paul, MN, United States: American Phytopathological Society. doi: 10.1094/MPMI-32-10-S1.1
de Mattos Fontes, Marcos Roberto, de Barros, Andrea, Bernardes, Natalia, Takeda, Agnes, Dreyer, Thiago, Bertolini, Maria Celia and Kobe, Bostjan (2018). Crystallographic and calorimetric studies with nuclear transport of DNA repair proteins. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1107/S2053273318092434
O'Carroll, Ailis, Ve, Thomas, Moustaqil, Mehdi, Giles, Nichole, Bhumkar, Akshay, Hunter, Dominic, Kobe, Bostjan, Sierecki, Emma and Gambin, Yann (2017). Prion ‐ like protein polymerisation underlies signal transduction in innate immunity: The emergence of a universal mechanism ?. Experimental Biology 2017 Meeting, Chicago, IL United States, 22-26 April 2017. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1096/fasebj.31.1_supplement.937.1
Jeon, Yujung, Ross, Ian, Landsberg, Michael, Hankamer, Ben and Kobe, Bostjan (2017). Structural characterization of pseudo-dihyroorotase domain in yeast URA2. XXIV IUCr Congress, Hyderabad, India, 21-28 August 2017. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1107/s2053273317090325
Horsefield, Shane Michael, Ve, Thomas, Zhang, Xiaoxiao, Casey, Lachlan and Kobe, Bostjan (2017). Structural characterisation of SARM in axon degeneration and cell death. IUCr Congress, Hyderabad, India, 21-28 August 2017. Hoboken, NJ, United States: Wiley-Blackwell. doi: 10.1107/S205327331708740X
O'Carroll, Allis, Ve, Thomas, Moustaqil, Mehdi, Giles, Nichole, Bhumkar, Akshay, Hunter, Dominic, Kobe, Bostjan, Sierecki, Emma and Gambin, Yann (2017). Prion - like protein polymerisation underlies signal transduction in innate immunity: the emergence of a universal mechanism ?. Annual Meeting of the American-Society-for-Pharmacology-and-Experimental-Therapeutics (ASPET) at Experimental Biology Meeting, Chicago, IL USA, Apr 22-26, 2017. Bethesda, MD, USA: Federation of American Societies for Experimental Biology.
Jeon, Yujung, Ross, Ian, Landsberg, Michael, Schultz, Ben, Hankamer, Ben and Kobe, Bostjan (2016). Structural characterization of dihydroorotase domain in yeast CAD multienzyme. 30th European Crystallographic Meeting, Basel, Switzerland, 28 August - 1 September 2016. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273316096807
O'Carroll, Ailis, Ve, Thomas, Lau, Derrick, Giles, Nichole, Moustaqil, Mehdi, Bhumkar, Akshay, Hunter, Dominic, Kobe, Bostjan, Boecking, Till, Sierecki, Emma and Gambin, Yann (2016). Prion ‐ like protein polymerisation underlies signal transduction in innate immunity: the emergence of a universal mechanism ?. Experimental Biology 2016 Meeting, San Diego, CA United States, 1-5 April 2016. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1096/fasebj.30.1_supplement.814.3
Gresshoff, P. M., Indrasumunar, A., Miyahara, A., Nontachaiyapoom, S., Biswas, B., Lin, Y-H., Lin, M-H, Reid, D., Callahan, D., Capon, R., Zhang, H., Jiang, Q., Hirani, T., Kobe, B., Men, A., Scott, P., Kereszt, A., Miyagi, M., Li, D., Chan, P-K., Roessner, U., Djordjevic, M. A., Kinkema, M. and Ferguson, B. (2009). Functional genomic analysis of systemic cell division regulation in legumes. International Symposium on Induced Mutations in Plants, Vienna, Austria, 2–15 August 2008. Vienna, Austria: Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture.
Brooking, Charles, Shouldice, Stephen R., Robin, Gautier, Kobe, Bostjan, Martin, Jennifer L. and Hunter, Jane (2009). Comparing METS and OAI-ORE for encapsulating scientific data products: A protein crystallography case study. IEEE International Conference on e-Science and Grid Computing [e-Science], Oxford, U.K., 9-11 December 2009. Los Alamitos, CA, U.S.A.: Institute for Electrical and Electronic Engineers (IEEE). doi: 10.1109/e-Science.2009.29
Yennamalli, RM, Kobe, B, Mark, AE, Young, PR and Subbarao, N (2009). Dengue viral envelope protein and histidine protonation. XVIII National Conference of Indian Virological Society, Post Graduate Institute of Medical Education and Research, Chandigarh, India., 11–13 December 2008. HISAR: Indian Virological Society.
Forwood, J K, Mouradov, D. A., Guncar, G, Mafori, M., Serek, R. A., Martin, J L, Huber, T L and Kobe, B (2006). Two hot dogs are better than one: Structural and biochemical insights into mammalian long-chain acyl-COA hydrolase. ComBio 2006, Brisbane, 24-28 Sept, 2006.
Guncar, G, Forwood, J K, Mouradov, D. A., Serek, R. A., Mafori, M., Huber, T L, Martin, J L and Kobe, B (2006). Exit on the other side please; crystal structure of the ACOT7 C-terminal domain. ComBio 2006, Brisbane, 24-28 Sept, 2006.
King, G. F., Jones, A., Cowieson, N. P., Huber, T. L., Kobe, B. and Ross, I. L. (2006). Rapid identification of DTSSP crosslinked peptides using LCMALDI Tof-Tof mass spectrometry. ComBio 2006, Brisbane, Australia, 24-28 Sept, 2006. Kent Town, Australia: Australian Society for Biochemistry and Molecular Biology.
Yennamalli Madhava R, R., Kampmann, T., Subbarao, N., Kobe, B. and Young, P. R. (2006). In silico screening and structure based drug design for the envelope protein of flaviviruses. 5th International Conference on Bioinformatics, New Delhi, India, 18-20 Dec, 2006.
Yennamalli Madhava R, R., Kampmann, T., Subbarao, N., Kobe, B and Young, P R (2006). In silico screening and structure based drug design for the envelope protein of flaviviruses. 7th Asia Pacific Congress of Virology, New Delhi, 13-15 Nov, 2006.
Young, P. R., Chappell, K. J., Stoermer, M. J., Fairlie, D., Kampmann, T. and Kobe, B. (2006). Multiple targets for antiviral inhibitors. 7th Asia Pacific Congress of Virology, New Delhi, 13-15 Nov, 2006.
Kampmann, T., Muller,, Robinson, J., Mark, A, Young, P R and Kobe, B (2006). The mechanism of vira membrane fusion and identification of novel antiviral lead compounds. 31st Lorne Conference on Protein Structure & Function, Lorne, Victoria, Australia, 5-9 Feb, 2006.
Robin, G, Cowieson, N P, Forwood, J K, Guncar, G, Listwan, P., Huber, T L, Kobe, B and Martin, J L (2006). University of Queensland structural genomics pipeline. ComBio 2006, Brisbane, 24-28 Sept, 2006.
Saunders, F W, Brinkworth, R. I., Huber, T L and Kobe, B (2006). Prediction of protein kinase substrates using sequence-structure information. ComBio 2006, Brisbane, 24-28 Sept, 2006.
Mouradov, D. A., Forwood, J. K., Ross, I. L., King, G. F., Sinz, A., Kobe, B. and Huber, T. L. (2006). Application of bioinformatic/biochemical hybrid approach to determine the structure of protein complexes and multi-domain proteins. ComBio 2006, Brisbane, Australia, 24-28 September, 2006. Kent Town, Australia: Australian Society for Biochemistry and Molecular Biology.
Kampmann, T., Muller, D. A., Robinson, J., Mark, A., Young, P. R. and Kobe, B. (2005). A structural model for low pH mediated viral fusion: The role of histidine protonation. 3rd Australian Virology Group Meeting, Phillip Island, 9-12 Dec, 2005.
Yennamalli Madhava R. R., Kampmann, T., Rao, N. S., Kobe, B. and Young, P. R. (2005). In silico screening and structure based drug design for the envelope protein of flaviviruses. 3rd Australian Virology Group Meeting, Phillip Island, Vic, 9-12 December, 2005.
Young, P. R., Robinson, J., Kampmann, T. and Kobe, B. (2005). Dengue virus mediated fusion as a target for antiviral drug design. 2nd Asian Dengue Meeting, Singapore, 28-30 Sept, 2005.
Kampmann, T., Yennamalli Madhava R, R., Stoermer, M. J., Kobe, B. and Young, P. R. (2005). Discovery of antiviral inhibitors targeting the fusion mechanism of the flavivirus family members Dengue, Kunjin and Yellow fever. 30th FEBS Congress - 9th Int Union of Biochem & Molecular Biof, Budapest, 2-7 July, 2005.
Kampmann, T., Yennamalli Madhava R, R., Stoermer, M. J., Kobe, B. and Young, P. R. (2005). Development of antiviral drugs targeting the flavivirus fusion mechanism. 30th Lorne Conference on Protein Structure & Function, Lorne, 6-10 Feb, 2005.
Kobe, B. and Brinkworth, R. I. (2005). Prediction of substrate specificities of protein kinases. 4th International Conference Inhibitors of Protein Kinases, Warsaw, 25-29 June, 2005. Cell Mol Biol Lett.
Kampmann, T., Yennamalli, R., Stoermer, M., Kobe, B. and Young, P. (2005). Development of antiviral drugs targeting the flaviviruses fusion mechanism. 30th FEBS Congress - 9th IUBMB Conference, Budapest, Hungary, 2-7tJuly 2005. Oxford, England: Blackwell Publishing. doi: 10.1111/j.1742-4658.2005.4739_15.x
Fontes, M. R. M., Takeda, A. A. S., Teh, T., Standaert, R. F. and Kobe, B. (2005). Structural studies with the importin alpha complexed with nuclear localization sequence peptidomimetics. Int Union Biochem Molecular Biol 50th Anniversary Symposium, Budapest, Hungary, 2nd - 7th July, 2005. Oxford, U.K.: Blackwell. doi: 10.1111/j.1742-4658.2005.4739_14.x
Kobe, Bostjan (2003). Protein regulation, protein-protein interactions and structural genomics. Ljubljana, Slovenia: Slovensko Kemijsko Drus.
Kobe, B., Jennings, I.G. and Cotton, R.G.H. (2002). Structure and regulation of phenylalanine hydroxylase, and implications for related enzymes. 12th Int Symposium on Pteridines and Folates, Bethesda, USA, 17-22 June, 2001. USA: Kluwer Academic Publishers.
Walsh, C. R., Listwan, P., Serek, R. A., Cowieson, N. P., Gee, C. L., Barry, G., Ross, I. L., Ravasi, T., Wells, C. A., Jerala, R., Martin, J. L., Hume, D. A. and Kobe, B. (2002). Structure and functions analysis of leucine rich repeat containing proteins involved in the macrophage response to bacterial lipopolysaccharide. Australian Society for Immunology Meeting, Brisbane, 1-5 December, 2002.
Listwan, P., Walsh, C. R., Ravasi, T., Wells, C. A., Cowieson, N. P., Hume, D. A., Martin, J. L. and Kobe, B. (2002). Structural genomics of novel macrophage proteins associated with inflammatory disease and cancer. International Conference on Structural Genomics, Berlin, 10-13 October, 2002.
Kobe, B., Breinl, R. A. and Brinkworth, R. I. (2002). Prediction of substrate specificity in protein kinases. ComBio 2002, Sydney, 29 September - 3 October, 2002.
Kobe, B. (2002). Protein regulation, protein-protein interactions and structural genomics. First Central European Conference Chemistry Towards Biology, Portoroz, Slovenia, 8-12 September, 2002.
Kobe, B. (2002). The scope of intrasteric (active site-directed) protein regulation. First Wellcome Trust Conference for International Snr Fellows, London, 30 April - 1 May, 2002.
Walsh, C. R., Listwan, P., Serek, R. A., Cowieson, N. P., Barry, G., Ross, I. L., Ravasi, T., Wells, C. A., Jerala, R., Martin, J. L., Kobe, B. and Hume, D. A. (2002). Structural genomics of novel proteins induced in macrophages in response to lipopolysaccharide. ComBio2002, Darling Harbour Convention Centre, Sydney, Australia, 29 September -3 October, 2002.
Hamwood, T., Kobe, B., Smythe, M. L. and Hume, D. A. (2002). Clues to interaction between CSF-1 and CSF-1R from specificity and structure. Australian Society of Immunologists Meeting, Brisbane, 1-5 December, 2002.
Cotton, R. H., Jennings, I. G. and Kobe, B. (1999). Structural basis of phenylketonuria. xx, October, 1999. Chicago, IL: University of Chicago Press.
Rizo, J., Blanco, F., Kobe, B., Bruch, M. D., Hoyt, D. W. and Gierasch, L. M. (1992). Conformations of wild type and mutant OmpA signal sequences in membrane mimetic environments. 12th American Peptide Symposium, Cambridge, Massachusetts, U.S.A., 16-21 June, 1991. Leiden, The Netherlands: ESCOM.

Areas of research

Biochemistry and molecular biology discipline
Biomolecular chemistry theme
Biotechnology discipline
Microbiology discipline
Structural biology and biochemistry theme