School of Chemistry and Molecular Biosciences

Professor Craig Williams

BSc (Flinders) PhD (Flinders)
Professor
School of Chemistry and Molecular Biosciences
+61 7 336 53530
Chemistry Building (68), Room 1102
View researcher profile

Primary research interest

Organic chemistry – organic synthesis (complex - hardcore), method development (catalysis), medicinal chemistry (tools for drug design and development), agricultural chemistry (herbicide discovery), microelectronics (monomers, insulators), physical organic chemistry (fundamental molecules), impact sensitive molecules (flares) and isolation of complex natural products (Australian rainforest and desert).

About me

After completing my B.Sc (Hons) and Ph.D (1997, under Rolf Prager) at Flinders University of South Australia (Adelaide) I was an Alexander von Humboldt Fellow at the Georg-August-Universität, Göttingen (with Armin de Meijere), Germany from 1997-1999, and an Australian National University Post-doctoral Fellow (with Lewis Mander) at the Research School of Chemistry (1999-2000), Canberra, Australia. I was then appointed to my first academic position in 2000 at the University of Queensland, and now hold the position of Professor.

Research focus 

My group’s research interests are broad, and very collaborative throughout academia and industry, but are grounded on advanced and extensive fundamental organic chemistry knowledge.

Representative areas of interest :

  1.  investigating strategies towards the synthesis of complex natural products (diterepenes, diterpene alkaloids, and tetranortriterpenes);
  2.  designing and discovering novel biologically active molecules for potential use as medicines (antifungals, analgesics, anticancer, neurodegeneration, scabies, anticoagulants) and agrichemicals (herbicides);
  3.  design and develop new synthetic methods for new modes of constructing chemical bonds that are synthetically useful (catalysts and general synthetic methodology);
  4.  physical organic chemistry (fundamental molecules, computational chemistry, impact sensitive molecules);
  5.  micro- and nanoelectronics (photolithography monomers); and
  6.  natural product isolation/elucidation of structurally intriguing novel molecules from the Australian desert, and (sub)tropical rainforests.

Projects and patents

Funded projects

  • ARC Discovery Project (2021-2024), Pioneering stable copper carbanions for new C-C bond forming paradigms. Total value of grant: $390,000
  • NHMRC Ideas Grant (2021-2023), Cryo-EM inspired drug discovery to treat human fungal pathogenic infections. Total value of grant: $988,000
  • ARC Discovery Project (2018-2021), Chemical Building Block Size Principles for Discovery Chemists.  Total value of grant: $411,000
  • Commonwealth Department of Agriculture, Water and the Environment (2020–2022) Herbicide discovery for Australian WONS based on developments in the bioisostere concept - Phase 2. Total value of grant: $300,000

Patents

  • Smith, M.T., Brown, L., Harvey, M.B.P. and Williams, C.M. (2003) ‘Methods and compositions including nitric oxide donors and opioid analgesics for pain relief’, PCT Int. Appl.

Featured publications

Research Collaborators

International co-authors

  • Prof. Tim Clarke (Uni Erlangen, Germany) DFT Calculations
  • Prof. Andrei Kutateladze (University of Denver, USA) Structure elucidation
  • Prof. Huw Davies (Emory, USA) Synthetic methods
  • Prof.s Dennis Liotta and Mark Goodman (Emory, USA) Drug development and PET
  • Prof. Charles Zercher (Uni New Hampshire, USA) Organometallic reagents
  • Prof. Stefan Bräse (Karlsruhe Institute of Technology, Germany) Synthetic methodology
  • Prof. Giovanni Appendino (Università del Piemonte Orientale, Italy) Natural products
  • Dr. Gary Yanik (PDR-Separations, USA) Chiral Chromatography
  • Em. Prof. François Terrier and Prof. Regis Goumont (University of Versailles, France) Physical organic chemistry
  • Prof. Marc Maudit (Ecole Nationale Superieure de Chemie de Rennes, France) Organometallic reagents
  • Prof. Josef Michl (University of Colorado, USA) Carboranes
  • Em. Prof. Ernst Anders (Friedrich-Schiller-Universitaet, Germany) Calculations
  • Prof. Peter Schreiner (Justus-Liebig-Universität, Germany) Calculations
  • Prof. Steven Ley (University of Cambridge, UK) Reaction development
  • Prof. Raymond Poirier (Memorial University, Canada) Calculations
  • Prof. Claudio Alves (Universidade Federal do Pará, Brazil) Tyrosinase inhibitors
  • Dr. Reinhard Effenberger and Dr. Joseph Zilberman (IMI-TAMI, Israel) Sustainable engineering
  • Prof. Eric W. McFarland (University of California−Santa Barbara) Sustainable engineering
  • Prof. Seijiro Matsubara (Kyoto University, Japan) Synthetic methodology
  • A/Prof. Ahmed Chadli (Augusta University, USA) Cancer
  • A/Prof. Jian-Ke Tie (University of North Carolina at Chapel Hill, USA) Anticoagulants
  • Prof. C. N. R. Rao (Jawaharlal Nehru Centre for Advanced Scientific Research, India) x-ray crystallography
  • A/Prof. Jogendra Behera (National Institute of Science Education and Research, India) x-ray crystallography
  • Prof. Thomas Shellhammer (Oregon State University, USA) Hops research
  • Prof. Daniel Romo (Baylor University, USA) Natural products
  • Prof. Matthew Todd (University College London, UK) Medicinal chemistry
  • Em. Prof. Armin de Meijere (Georg-August-Universität, Germany) Organometallics

Domestic - co-authors

  • Drs Paul Savage, John Tsanaktsidis and Susan Nilsson (CSIRO, Melbourne) Drug development and synthetic methodology
  • Prof. Richard O'Hair (Uni Melbourne) Mass spectrometry
  • Prof. George Koutsantonis (Uni Western Australia) Inorganic NMR
  • A/Prof. Jason Harper (Uni New South Wales) Physical organic chemistry
  • Prof. Michelle Coote (Australian National University) Calculations
  • Em. Lewis Mander (Australian National University) Synthetic organic chemistry
  • Em. Rolf Prager (Flinders University) Synthetic organic chemistry
  • Profs Michael Kassiou and Louis Rendina (Uni Sydney) Cubane chemistry
  • Dr. Jason Brusnahan (Defence Science and Technology Group, Adelaide) Impact sensitivity
  • A/Prof. Martin Johnston (Flinders University) Impact sensitivity
  • A/Prof. Stephen Bell (Uni Adelaide) Enzymology
  • Dr. Anastasios Polyzos (Uni Melbourne-CSIRO) Flow chemistry

Local - co-authors

  • A/Prof. Elizabeth Krenske (SCMB) DFT Calculations
  • Profs. Lawrence Gahan and Paul Bernhardt (SCMB) Metal corodination, catalysis and x-ray crystallographic analysis
  • Dr.s Victoria Gordon and Paul Reddell (EcoBiotics and QBiotics)
  • Prof. Glen Boyle and Em. Prof. Peter Parsons (Berghofer Queensland Institute of Medical Research) Cancer
  • Prof. James McCarthy (Berghofer Queensland Institute of Medical Research) Scabies
  • Prof. Paul Young and A/Prof. Daniel Watterson (SCMB) Virology
  • Prof. Helen Cooper and A/Prof. Thomas Burne (Queensland Brain Institute, UQ) Neurodegenerative disease and developmental neurobiology
  • Prof. Maree Smith (Centre for Integrated Preclinical Drug Development, UQ) Pain and analgesia
  • Prof. Luke Guddat (SCMB) Anti-fungal and herbicide discovery
  • Prof. Nick West (SCMB) Tuberculosis
  • Em. Prof. Gimme Walter (School of Biological Sciences, UQ) Herbicide and Pesticide discovery
  • Prof. James Fraser (SCMB) Pathogenic fungi  
  • Prof. Gary Schenk (SCMB) Enzymology
  • Prof. James de Voss (SCMB) Enzymology
  • A/Prof. Evan Moore (SCMB) Flash laser spectroscopy
  • A/Prof. Heather Smyth (Queensland Alliance for Agriculture and Food Innovation, UQ) Flavours
  • A/Prof. Jeffrey Harmer and Dr. Gregory Pierens (Centre for Advanced Imaging, UQ) EPR and NMR spectroscopy
  • A/Prof. Simon Smart (Dow Centre for Sustainable Engineering Innovation) Sustainable engineering
  • Dr. Amanda Nouwens (SCMB) Mass spectroscopy
  • Prof. Vicky Avery (Griffith Institute for Drug Discovery, Griffith University) Chagas Disease
  • Prof. Jack Clegg (SCMB) x-ray crystallography
  • A/Prof. Michael Landsberg (SCMB) cryo-EM
  • Em. Prof. Mary Garson (SCMB) anti-fouling agents

Teaching interests

  • Organic chemistry
  • Synthesis and retrosynthesis in organic chemistry
  • Advanced synthesis and retrosynthesis in organic chemistry

Achievements and awards 

  • A. J. Birch Medal (Royal Australian Chemical Institute, 2021)
  • ARC Future Fellow
  • Alexander von Humbolt Fellow
  • Award for Outstanding Contribution to Research (SCMB, 2019).
  • Thieme Chemistry Journals Award in 2007
  • Member of the Higher Degree Research (HDR) Committee
  • Faculty OH&S Committee member
  • Past Chair and Committee member of the School OH&S Committee
  • Overseer of the Dangerous (potentially) Experiments laboratory
  • Consulting to local biotechnology industry

Researcher biography

Craig M. Williams was born in Adelaide, Australia. He received his B.Sc. (Hons) degree in chemistry in 1994 from Flinders University. In 1997, he was awarded his Ph.D. in organic chemistry from the same institution under the supervision of Professor Rolf H. Prager. He undertook post-doctoral studies as an Alexander von Humboldt Fellow working with Professor Armin de Meijere at the Georg-August-Universität, Göttingen, Germany, from 1997 to 1999. In early 1999, he accepted a second post-doctoral fellowship at the Australian National University with Professor Lewis N. Mander.

Professor Williams has held an academic position at the University of Queensland since 2000, and during this time has won a number of awards including a Thieme Chemistry Journals Award in 2007, an Australian Research Council Future Fellowship award in 2011, and the Award for Outstanding Contribution to Research (SCMB, UQ, 2019). The Williams research group explores numerous interests within the discipline of organic chemistry (e.g. medicinal chemistry, fundamental molecules, natural productisolation, microelectronics, drug and agrichemical development, impact sensitive molecules) enabled by organic synthesis refined through the construction of biologically active complex natural products (diterpenes, polyketides, alkaloids), and designs synthetic methodology to assist in this endeavour (synthetic transformations and reagents). Professor Williams especially enjoys teaching whole molecule retrosynthesis to undergraduate and post-graduate students.

Publications

Book Chapters (5)
Journal Articles (216)
Conference Papers (4)
Data Collections (2)
Patents (2)

Book Chapters

Williams, Craig M. (2014). Sleepless nights: The total synthesis of the anticancer australian rainforest polyketide EBC-23. Strategies and Tactics in Organic Synthesis. (pp. 249-270) edited by Michael Harmata. Maryland Heights, MO United States: Academic Press. doi: 10.1016/B978-0-12-417185-5.00011-9
Williams, Craig M. (2012). The story behind the total synthesis of Vibsanin E and 5-epi-Vibsanin E. Strategies and tactics in organic synthesis. (pp. 395-412) edited by M. Harmata. San Diego, CA, United States: Academic Press (Elsevier). doi: 10.1016/B978-0-12-386540-3.00017-4
Pouwer, Rebecca H. and Williams, Craig M. (2010). Silver alkyls, alkenyls, aryls, and alkynyls in organic synthesis. Silver in organic chemistry. (pp. 1-41) edited by Michael Harmata. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/9780470597521.ch1
Prager, R.H. and Williams, C.M. (2005). Product Class 10: Acridin-9(10H)-ones and Related Systems. Science of Synthesis: Category 2, Hetarenes and Related Ring Systems. (pp. 1029-1064) edited by Black, D. StC.. New York: Thieme. doi: 10.1055/sos-SD-015-01714
Prager, R.H. and Williams, C.M. (2005). Product Class 9: Acridines. Science of Synthesis: Category 2, Hetarenes and Related Ring Systems. (pp. 987-1028) edited by Black, D. StC.. New York: Thieme. doi: 10.1055/sos-SD-015-01674

Journal Articles

Naher, Masnun, Su, Chuyi, Harmer, Jeffrey R., Williams, Craig M. and Bernhardt, Paul V. (2024). Macrocyclic Copper(II) Complexes as Catalysts for Electrochemically Mediated Atom Transfer. Inorganic Chemistry, 63 (14), 6453-6464. doi: 10.1021/acs.inorgchem.4c00311
Su, Chuyi, Dallaston, Madeleine A., Watson, Renée D., Fahrenhorst-Jones, Tyler, Cameron, Jacob P., Pierens, Gregory K., Bernhardt, Paul V., Savage, G. Paul and Williams, Craig M. (2024). The (±)-5-Aza[1.0]triblattane Skeleton via Azetine Cycloaddition. Organic Letters, 26 (14), 2827-2831. doi: 10.1021/acs.orglett.3c03655
Kong, Dehui, Fahrenhorst-Jones, Tyler, Kuo, Andy, Simmons, Jacinta L., Tan, Lendl, Burns, Jed M., Pierens, Gregory K., Li, Rui, West, Nicholas P., Boyle, Glen M., Smith, Maree T., Savage, G. Paul and Williams, Craig M. (2023). seco-1-Azacubane-2-carboxylic acid: derivative scope and comparative biological evaluation. The Journal of Organic Chemistry, 89 (1), 798-803. doi: 10.1021/acs.joc.3c02333
Bates, Roderick W., Elyashberg, Mikhail, Kutateladze, Andrei G. and Williams, Craig M. (2023). Reassignment of the Structure of Janthinolide A. European Journal of Organic Chemistry, 26 (44) e202300910. doi: 10.1002/ejoc.202300910
Deepak, Nashvin Mikhail Singh, Kutateladze, Andrei G., Elyashberg, Mikhail, Williams, Craig M. and Bates, Roderick W. (2023). Arneroma B: Structure reassignment and total synthesis. Tetrahedron, 147 133670, 133670. doi: 10.1016/j.tet.2023.133670
Novitskiy, Ivan M., Elyashberg, Mikhail, Bates, Roderick W., Kutateladze, Andrei G. and Williams, Craig M. (2023). Penicitone: Structural Reassignment of a Proposed Natural Product Acid Chloride. Organic Letters, 25 (43), 7796-7799. doi: 10.1021/acs.orglett.3c02859
Fahrenhorst-Jones, Tyler, Marshall, David L., Burns, Jed M., Pierens, Gregory K., Van Meurs, Derek P., Kong, Dehui, Bernhardt, Paul V., Blanksby, Stephen J., Savage, G. Paul, Eaton, Philip E. and Williams, Craig M. (2023). 9-Azahomocubane. Chemistry: A European Journal, 30 (3) e202303133, e202303133. doi: 10.1002/chem.202303133
Naher, Masnun, Su, Chuyi, Harmer, Jeffrey R., Williams, Craig M. and Bernhardt, Paul V. (2023). Electrocatalytic atom transfer radical addition with turbocharged organocopper(II) complexes. Inorganic Chemistry, 62 (38), 15575-15583. doi: 10.1021/acs.inorgchem.3c02106
Fahrenhorst-Jones, Tyler, Kong, Dehui, Burns, Jed M., Pierens, Gregory K., Bernhardt, Paul V., Savage, G. Paul and Williams, Craig M. (2023). seco-1-Azacubane-2-carboxylic acid–Amide Bond Comparison to Proline. The Journal of Organic Chemistry, 88 (18), 12867-12871. doi: 10.1021/acs.joc.3c01264
Liu, Yizhou, Wen Liang, Benjamin Jian, Modhiran, Naphak, Savage, G. Paul, Watterson, Daniel and Williams, Craig M. (2023). Cubane and cyclooctatetraene pirfenidones – synthesis and biological evaluation. Asian Journal of Organic Chemistry, 12 (8) e202300238, 1-7. doi: 10.1002/ajoc.202300238
Cheng, Yan, Lonhienne, Thierry, Garcia, Mario. D., Williams, Craig M., Schenk, Gerard and Guddat, Luke W. (2023). Crystal structure of the commercial herbicide, amidosulfuron, in complex with Arabidopsis thaliana acetohydroxyacid synthase. Journal of Agricultural and Food Chemistry, 71 (13), 5117-5126. doi: 10.1021/acs.jafc.2c08528
Fahrenhorst-Jones, Tyler, Marshall, David L., Burns, Jed. M., Pierens, Gregory K., Hormann, Robert E., Fisher, Allison M., Bernhardt, Paul V., Blanksby, Stephen J., Savage, G. Paul, Eaton, Philip E. and Williams, Craig M. (2023). 1-azahomocubane. Chemical Science, 14 (11), 2821-2825. doi: 10.1039/d3sc00001j
Gonzálvez, Miguel A., Williams, Craig M., Martínez, Manuel and Bernhardt, Paul V. (2023). Kinetico-mechanistic studies on a reactive organocopper(II) complex: Cu–C bond homolysis versus heterolysis. Inorganic Chemistry, 62 (11), 4662-4671. doi: 10.1021/acs.inorgchem.3c00127
Smith, Maree T., Kong, Dehui, Kuo, Andy, Imam, Mohammad Z. and Williams, Craig M. (2023). Multitargeted opioid ligand discovery as a strategy to retain analgesia and reduce opioid-related adverse effects. Journal of Medicinal Chemistry, 66 (6), 3746-3784. doi: 10.1021/acs.jmedchem.2c01695
Xue, Yongbo, Savchenko, Andrei I., Agnew-Francis, Kylie A., Miles, Jared A., Holt, Tina, Lu, Hieng, Chow, Sharon, Forster, Paul I., Boyle, Glen M., Ross, Benjamin P., Fischer, Katja, Kutateladze, Andrei G. and Williams, Craig M. (2023). seco-pregnane glycosides from Australian caustic vine (Cynanchum viminale subsp. australe). Journal of Natural Products, 86 (3), 490-497. doi: 10.1021/acs.jnatprod.2c01037
Jin, Da-Yun, Chen, Xuejie, Liu, Yizhou, Williams, Craig M., Pedersen, Lars C., Stafford, Darrel W. and Tie, Jian-Ke (2023). A genome-wide CRISPR-Cas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase. Nature Communications, 14 (1) 828, 1-14. doi: 10.1038/s41467-023-36446-8
Kutateladze, Andrei G., Bates, Roderick W., Elyashberg, Mikhail and Williams, Craig M. (2023). Structural Reassignment of Two Polyenol Natural Products. European Journal of Organic Chemistry, 26 (9) e202201316. doi: 10.1002/ejoc.202201316
Takebe, Hiyori, Yoshino, Nana, Shimada, Yukako, Williams, Craig M. and Matsubara, Seijiro (2023). Chiral auxiliary-directed site-selective deprotonation of the cubane skeleton. Organic Letters, 25 (1), 27-30. doi: 10.1021/acs.orglett.2c03659
Bettencourt, Christian J., Krainz, Tanja, Chow, Sharon, Parr, Brendan T., Tracy, William F., Bernhardt, Paul V., Davies, Huw M. L. and Williams, Craig M. (2022). Unearthing the subtleties of rhodium(II)-catalyzed carbenoid cycloadditions to furans with an N-sulfonyl-1,2,3-triazole probe. Organic Letters, 24 (50), 9290-9295. doi: 10.1021/acs.orglett.2c03869
Lonhienne, Thierry, Cheng, Yan, Garcia, Mario D., Hu, Shu Hong, Low, Yu Shang, Schenk, Gerhard, Williams, Craig M. and Guddat, Luke W. (2022). Structural basis of resistance to herbicides that target acetohydroxyacid synthase. Nature Communications, 13 (1) 3368, 3368. doi: 10.1038/s41467-022-31023-x
Thomaz, Fernanda Santos, Tan, Yuen P., Williams, Craig M., Ward, Leigh C., Worrall, Simon and Panchal, Sunil K. (2022). Wasabi (Eutrema japonicum) reduces obesity and blood pressure in diet-induced metabolic syndrome in rats. Foods, 11 (21) 3435, 1-12. doi: 10.3390/foods11213435
Elyashberg, Mikhail, Novitskiy, Ivan M., Bates, Roderick W., Kutateladze, Andrei G. and Williams, Craig M. (2022). Reassignment of improbable natural products identified through chemical principle screening. European Journal of Organic Chemistry, 2022 (34) e202200572, 1-9. doi: 10.1002/ejoc.202200572
Kong, Dehui, Saqer, Alaa A., Carpinelli de Jesus, Matheus, Khan, Nemat, Jones, Alun, Blanchfield, Joanne T., Smith, Maree T. and Williams, Craig M. (2022). Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain. Bioorganic and Medicinal Chemistry, 69 116889, 1-10. doi: 10.1016/j.bmc.2022.116889
Fahrenhorst-Jones, Tyler, Savage, G. Paul and Williams, Craig M. (2022). Photochemical generation of the 2-azabicyclo[4.2.0]octa-4,7-diene skeleton. Australian Journal of Chemistry, 75 (11), 884-887. doi: 10.1071/ch22139
Shah, Sarah, Lonhienne, Thierry, Murray, Cody-Ellen, Chen, Yibi, Dougan, Katherine E., Low, Yu Shang, Williams, Craig M., Schenk, Gerhard, Walter, Gimme H., Guddat, Luke W. and Chan, Cheong Xin (2022). Genome-guided analysis of seven weed species reveals conserved sequence and structural features of key gene targets for herbicide development. Frontiers in Plant Science, 13 909073. doi: 10.3389/fpls.2022.909073
Buccini, Marco, Tham, Louisa, Dhoro, Francis, Skelton, Brian W., Williams, Craig M. and Piggott, Matthew J. (2022). Toward the total synthesis of alpkinidine: synthesis of haloquinone CE ring system synthons and attempted nucleophilic bisannulation. ACS Omega, 7 (23), 19080-19092. doi: 10.1021/acsomega.2c02116
Buccini, Marco, Dhoro, Francis, Tham, Louisa, Skelton, Brian W., Williams, Craig M. and Piggott, Matthew J. (2022). Toward the total synthesis of alpkinidine: Michael addition to isoquinolinetrione CE ring-system synthons. ACS Omega, 7 (23), 19093-19105. doi: 10.1021/acsomega.2c02117
Chen, Xuejie, Furukawa, Natsuko, Jin, Da‐Yun, Liu, Yizhou, Stafford, Darrel W., Williams, Craig M., Suhara, Yoshitomo and Tie, Jian‐Ke (2022). Naturally occurring UBIAD1 mutations differentially affect menaquinone biosynthesis and vitamin K‐dependent carboxylation. The FEBS Journal, 289 (9), 2613-2627. doi: 10.1111/febs.16291
Fahrenhorst-Jones, Tyler, Bernhardt, Paul V., Savage, G. Paul and Williams, Craig M. (2022). The (±)-6-Aza[1.0]triblattane skeleton: contraction beyond the Wilder–Culberson ring system. Organic Letters, 24 (3) acs.orglett.1c04240, 903-906. doi: 10.1021/acs.orglett.1c04240
Smith, Maree T., Kong, Dehui, Kuo, Andy, Imam, Mohammad Z. and Williams, Craig M. (2022). Analgesic opioid ligand discovery based on nonmorphinan scaffolds derived from natural sources. Journal of Medicinal Chemistry, 65 (3) acs.jmedchem.0c01915, 1612-1661. doi: 10.1021/acs.jmedchem.0c01915
Gonzálvez, Miguel A., Su, Chuyi, Williams, Craig M. and Bernhardt, Paul V. (2022). Organocopper(II) complexes: new catalysts for carbon–carbon bond formation via electrochemical atom transfer radical addition (eATRA). Chemical Science, 13 (35), 10506-10511. doi: 10.1039/d2sc03418b
Cullen, Jason K., Boyle, Glen M., Yap, Pei-Yi, Elmlinger, Stefan, Simmons, Jacinta L., Broit, Natasa, Johns, Jenny, Ferguson, Blake, Maslovskaya, Lidia A., Savchenko, Andrei I., Mirzayans, Paul Malek, Porzelle, Achim, Bernhardt, Paul V., Gordon, Victoria A., Reddell, Paul W., Pagani, Alberto, Appendino, Giovanni, Parsons, Peter G. and Williams, Craig M. (2021). Activation of PKC supports the anticancer activity of tigilanol tiglate and related epoxytiglianes. Scientific Reports, 11 (1) 207, 207. doi: 10.1038/s41598-020-80397-9
Bettencourt, Christian J., Chow, Sharon, Moore, Peter W., Read, Christopher D. G., Jiao, Yanxiao, Bakker, Jan Peter, Zhao, Sheng, Bernhardt, Paul V. and Williams, Craig M. (2021). Tandem oxidation-dehydrogenation of (hetero)arylated primary alcohols via perruthenate catalysis. Australian Journal of Chemistry, 74 (9), 652-659. doi: 10.1071/ch21137
Yoshino, Nana, Kato, Yumi, Shimada, Yukako, Williams, Craig M. and Matsubara, Seijiro (2021). Unmasking inherent chirality within the cubane skeleton. Israel Journal of Chemistry, 61 (7-8), 380-386. doi: 10.1002/ijch.202100013
Burns, Jed M., Clark, Timothy and Williams, Craig M. (2021). Comprehensive computational investigation of the Barton–Kellogg reaction for both alkyl and aryl systems. The Journal of Organic Chemistry, 86 (11) acs.joc.1c00506, 1-14. doi: 10.1021/acs.joc.1c00506
Canavieira, Luciana Morais, Brasil, Edikarlos Macedo, Silva, Thiago de Melo e, Borges, Rosivaldo dos Santos, Silva, José Rogério Araújo, Lameira, Jerônimo, Bernhardt, Paul V., Williams, Craig M. and Alves, Cláudio Nahum (2021). Experimental and theoretical approaches for the development of 4H-Chromene derivatives as inhibitors of tyrosinase. Molecular Simulation, 47 (9), 762-770. doi: 10.1080/08927022.2021.1926455
Williams, Craig M. and Dallaston, Madeleine A. (2021). The future of retrosynthesis and synthetic planning: algorithmic, humanistic or the interplay?. Australian Journal of Chemistry, 74 (5), 291-326. doi: 10.1071/ch20371
Chen, Xuejie, Liu, Yizhou, Furukawa, Natsuko, Jin, Da‐Yun, Paul Savage, G., Stafford, Darrel W., Suhara, Yoshitomo, Williams, Craig M. and Tie, Jian‐Ke (2021). A novel vitamin K derived anticoagulant tolerant to genetic variations of vitamin K epoxide reductase. Journal of Thrombosis and Haemostasis, 19 (3), 689-700. doi: 10.1111/jth.15209
Pilkington, Rowan L., Dallaston, Madeleine A., Savage, G. Paul, Williams, Craig M. and Polyzos, Anastasios (2021). Enone-promoted decarboxylation of trans-4-hydroxy-l-proline in flow: a side-by-side comparison to batch. Reaction Chemistry and Engineering, 6 (3), 486-493. doi: 10.1039/d0re00442a
Dallaston, Madeleine A., Bettencourt, Christian J., Chow, Sharon, Gebhardt, Joshua, Spangler, Jordan, Johnston, Martin R., Wall, Craig, Brusnahan, Jason S. and Williams, Craig M. (2020). Corrigendum to: Ranking Oxidant Sensitiveness: A Guide for Synthetic Utility (Chemistry – A European Journal, (2019), 25, 41, (9614-9618), 10.1002/chem.201902036). Chemistry - A European Journal, 26 (59) chem.202004223, 13532-13532. doi: 10.1002/chem.202004223
Tse, Edwin G., Houston, Sevan D., Williams, Craig M., Savage, G. Paul, Rendina, Louis M., Hallyburton, Irene, Anderson, Mark, Sharma, Raman, Walker, Gregory S., Obach, R. Scott and Todd, Matthew H. (2020). Nonclassical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open-Source Antimalarials. Journal of Medicinal Chemistry, 63 (20) acs.jmedchem.0c00746, 11585-11601. doi: 10.1021/acs.jmedchem.0c00746
Chow, Sharon, Krainz, Tanja, Bettencourt, Christian J., Broit, Natasa, Ferguson, Blake, Zhu, Mingzhao, Hull, Kenneth G., Pierens, Gregory K., Bernhardt, Paul V., Parsons, Peter G., Romo, Daniel, Boyle, Glen M. and Williams, Craig M. (2020). Synthetic tigliane intermediates engage thiols to induce potent cell line selective anti‐cancer activity. Chemistry: A European Journal, 26 (59) chem.202003221, 13372-13377. doi: 10.1002/chem.202003221
Agnew-Francis, Kylie A., Tang, Yu Cheng, Lin, Xin, Low, Yu Shang, Wun, Shun Jie, Kuo, Andy, Elias, S. M. A. Sayeed Ibn, Lonhienne, Thierry G., Condon, Nicholas, Pimentel, Bruna Natalia Alves da Silva, Vergani, Carlos, Smith, Maree T., Fraser, James A., Williams, Craig M. and Guddat, Luke W (2020). Herbicides that target acetohydroxyacid synthase are potent inhibitors of the growth of drug resistant Candida auris. ACS infectious diseases, 6 (11) acsinfecdis.0c00229, 2901-2912. doi: 10.1021/acsinfecdis.0c00229
Agnew-Francis, Kylie A. and Williams, Craig M. (2020). Squaramides as bioisosteres in contemporary drug design. Chemical Reviews, 120 (20) acs.chemrev.0c00416, 11616-11650. doi: 10.1021/acs.chemrev.0c00416
Maslovskaya, Lidia A., Savchenko, Andrei I., Krenske, Elizabeth H., Chow, Sharon, Holt, Tina, Gordon, Victoria A., Reddell, Paul W., Pierce, Carly J., Parsons, Peter G., Boyle, Glen M., Kutateladze, Andrei G. and Williams, Craig M. (2020). EBC‐232 and 323: a structural conundrum necessitating unification of five in silico prediction and elucidation methods. Chemistry – A European Journal, 26 (51) chem.202001884, 11862-11867. doi: 10.1002/chem.202001884
Dallaston, Madeleine A., Houston, Sevan D. and Williams, Craig M. (2020). Cubane, Bicyclo[1.1.1]pentane and Bicyclo[2.2.2]octane: Impact and Thermal Sensitiveness of Carboxyl-, Hydroxymethyl- and Iodo-substituents. Chemistry - A European Journal, 26 (52) chem.202001658, 11966-11970. doi: 10.1002/chem.202001658
Lonhienne, Thierry, Low, Yu Shang, Garcia, Mario D., Croll, Tristan, Gao, Yan, Wang, Quan, Brillault, Lou, Williams, Craig M., Fraser, James A., McGeary, Ross P., West, Nicholas P., Landsberg, Michael J., Rao, Zihe, Schenk, Gerhard and Guddat, Luke W. (2020). Structures of fungal and plant acetohydroxyacid synthases. Nature, 586 (7828), 317-321+. doi: 10.1038/s41586-020-2514-3
Yoshino, Nana, Kato, Yumi, Mabit, Thibaud, Nagata, Yuuya, Williams, Craig M., Harada, Mei, Muranaka, Atsuya, Uchiyama, Masanobu and Matsubara, Seijiro (2020). Cubane chirality via substitution of a “hidden” regular tetrahedron. Organic Letters, 22 (11) acs.orglett.0c01142, 4083-4087. doi: 10.1021/acs.orglett.0c01142
Tan, Yuen Ping, Savchenko, Andrei I., Agnew-Francis, Kylie A., Boyle, Glen M., Bernhardt, Paul V., Fraser, James A. and Williams, Craig M. (2020). Kalparinol, a Salvialane (Isodaucane) sesquiterpenoid derived from native Australian dysphania species that suggests a putative biogenetic link to zerumbone. Journal of Natural Products, 83 (5) acs.jnatprod.9b01039, 1473-1479. doi: 10.1021/acs.jnatprod.9b01039
Maslovskaya, Lidia A., Savchenko, Andrei I., Krenske, Elizabeth H., Chow, Sharon, Gordon, Victoria A., Reddell, Paul W., Pierce, Carly J., Parsons, Peter G., Boyle, Glen M. and Williams, Craig M. (2020). EBC-342: A novel tetrahydrofuran moiety containing casbane from the Australian rainforest. European Journal of Organic Chemistry, 2020 (8), 1042-1045. doi: 10.1002/ejoc.202000017
Tan, Yuen Ping, Agnew‐Francis, Kylie A., Hofmann, Julian, Savchenko, Andrei I., Lafontaine, Scott R., Boyle, Glen M., Bernhardt, Paul V., Fraser, James A., Shellhammer, Thomas H. and Williams, Craig M. (2020). Humulene diepoxides from the Australian arid zone herb Dysphania: assignment of aged hops constituents. Chemistry: A European Journal, 26 (7) chem.201904420, 1653-1660. doi: 10.1002/chem.201904420
Sarkar, Md. Raihan, Houston, Sevan D., Savage, G. Paul, Williams, Craig M., Krenske, Elizabeth H., Bell, Stephen G. and De Voss, James J. (2019). Rearrangement-free hydroxylation of methylcubanes by a cytochrome P450: the case for dynamical coupling of C–H abstraction and rebound. Journal of the American Chemical Society, 141 (50) jacs.9b08064, 19688-19699. doi: 10.1021/jacs.9b08064
Chow, Sharon, Krainz, Tanja, Bernhardt, Paul V. and Williams, Craig M. (2019). En route to D-ring inverted phorbol esters. Organic Letters, 21 (21) acs.orglett.9b03379, 8761-8764. doi: 10.1021/acs.orglett.9b03379
Tan, Yuen P., Xue, Yongbo, Savchenko, Andrei I., Houston, Sevan D., Modhiran, Naphak, McMillan, Christopher L. D., Boyle, Glen M., Bernhardt, Paul V., Young, Paul R., Watterson, Daniel and Williams, Craig M. (2019). Basimarols A, B, and C, Highly Oxygenated Pimarane Diterpenoids from Basilicum polystachyon. Journal of Natural Products, 82 (10) acs.jnatprod.9b00522, 2828-2834. doi: 10.1021/acs.jnatprod.9b00522
Arachchige, Kasun S. Athukorala, Fahrenhorst-Jones, Tyler, Burns, Jed M., AL-Fayaad, Hydar A., Behera, Jogendra N., Rao, C. N. R., Clegg, Jack K. and Williams, Craig M. (2019). 1,4-Diazacubane crystal structure rectified as piperazinium. Chemical Communications, 55 (78), 11751-11753. doi: 10.1039/c9cc06272f
Xie, Sida, Bernhardt, Paul V., Gahan, Lawrence R. and Williams, Craig M. (2019). Contemplating 1,2,4-thiadiazole-inspired cyclic peptide mimics: a computational investigation. Australian Journal of Chemistry, 72 (11), 894-899. doi: 10.1071/CH19248
Dallaston, Madeleine A., Bettencourt, Christian J., Chow, Sharon, Gebhardt, Joshua, Spangler, Jordan, Johnston, Martin R., Wall, Craig, Brusnahan, Jason S. and Williams, Craig M. (2019). Ranking oxidant sensitiveness: a guide for synthetic utility. Chemistry - A European Journal, 25 (41), 9614-9618. doi: 10.1002/chem.201902036
Houston, Sevan D., Fahrenhorst-Jones, Tyler, Xing, Hui, Chalmers, Benjamin A., Sykes, Melissa L., Stok, Jeanette E., Farfan Soto, Clementina, Burns, Jed M., Bernhardt, Paul V., De Voss, James J., Boyle, Glen M., Smith, Maree T., Tsanaktsidis, John, Savage, G. Paul, Avery, Vicky M. and Williams, Craig M. (2019). The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement. Organic and Biomolecular Chemistry, 17 (28), 6790-6798. doi: 10.1039/c9ob01238a
Dallaston, Madeleine A., Brusnahan, Jason S., Wall, Craig and Williams, Craig M. (2019). Thermal and sensitiveness determination of cubanes: towards cubane‐based fuels for infrared countermeasures. Chemistry: A European Journal, 25 (35) chem.201901086, 8344-8352. doi: 10.1002/chem.201901086
Kutateladze, Andrei G., Krenske, Elizabeth H. and Williams, Craig M. (2019). Reassignments and corroborations of oxo-bridged natural products directed by OSE and DU8+ NMR computation. Angewandte Chemie International Edition, 58 (21), 7107-7112. doi: 10.1002/anie.201902777
Xing, Hui, Houston, Sevan D., Chen, Xuejie, Jin, Da-Yun, Savage, G. Paul, Tie, Jian-Ke and Williams, Craig M. (2019). Determining the necessity of phenyl ring π-character in warfarin. Bioorganic and Medicinal Chemistry Letters, 29 (15), 1954-1956. doi: 10.1016/j.bmcl.2019.05.039
Huang, Lillian, Wyse, Bruce D., Williams, Craig M. and Smith, Maree T. (2019). Nitric oxide modulates μ‐opioid receptor function in vitro. Clinical and Experimental Pharmacology and Physiology, 46 (7) 1440-1681.13091, 676-685. doi: 10.1111/1440-1681.13091
Tan, Yuen P., Houston, Sevan D., Modhiran, Naphak, Savchenko, Andrei I., Boyle, Glen M., Young, Paul R., Watterson, Daniel and Williams, Craig M. (2019). Stachyonic acid: a dengue virus inhibitor from Basilicum polystachyon. Chemistry – A European Journal, 25 (22) chem.201900591, 5664-5667. doi: 10.1002/chem.201900591
Xing, Hui, Houston, Sevan D., Chen, Xuejie, Ghassabian, Sussan, Fahrenhorst-Jones, Tyler, Kuo, Andy, Murray, Cody-Ellen P., Conn, Kyna-Anne, Jaeschke, Kara N., Jin, Da-Yun, Pasay, Cielo, Bernhardt, Paul V., Burns, Jed M., Tsanaktsidis, John, Savage, G. Paul, Boyle, Glen M., De Voss, James J., McCarthy, James, Walter, Gimme H., Burne, Thomas H. J., Smith, Maree T., Tie, Jian-Ke and Williams, Craig M. (2019). Cyclooctatetraene: a bioactive cubane paradigm complement. Chemistry: A European Journal, 25 (11), 2729-2734. doi: 10.1002/chem.201806277
Houston, Sevan D., Xing, Hui, Bernhardt, Paul V., Vanden Berg, Timothy J., Tsanaktsidis, John, Savage, G. Paul and Williams, Craig M. (2019). Cyclooctatetraenes through valence isomerization of cubanes: scope and limitations. Chemistry: A European Journal, 25 (11), 2735-2739. doi: 10.1002/chem.201805124
Reekie, Tristan A., Williams, Craig M., Rendina, Louis M. and Kassiou, Michael (2019). Cubanes in medicinal chemistry. Journal of Medicinal Chemistry, 62 (3) acs.jmedchem.8b00888, 1078-1095. doi: 10.1021/acs.jmedchem.8b00888
Houston, Sevan D., Chalmers, Benjamin A., Savage, G. Paul and Williams, Craig M. (2019). Enantioselective synthesis of (R)-2-cubylglycine including unprecedented rhodium mediated C–H insertion of cubane. Organic & Biomolecular Chemistry, 17 (5), 1067-1070. doi: 10.1039/c8ob02959h
Maslovskaya, Lidia A., Savchenko, Andrei I., Gordon, Victoria A., Reddell, Paul W., Pierce, Carly J., Boyle, Glen M., Parsons, Peter G. and Williams, Craig M. (2019). New Halimanes from the Australian rainforest plant Croton Insularis. European Journal of Organic Chemistry, 2019 (5), 1058-1060. doi: 10.1002/ejoc.201801548
Pinkerton, David M., Chow, Sharon, Eisa, Nada H., Kainth, Kashish, Vanden Berg, Timothy J., Burns, Jed M., Guddat, Luke W., Savage, G. Paul, Chadli, Ahmed and Williams, Craig M. (2019). Synthesis of the seco-limonoid BCD ring system identifies a Hsp90 chaperon machinery (p23) inhibitor. Chemistry - A European Journal, 25 (6), 1451-1455. doi: 10.1002/chem.201805420
Maslovskaya, Lidiya A., Savchenko, Andrei I., Pierce, Carly J., Boyle, Glen M., Gordon, Victoria A., Reddell, Paul W., Parsons, Peter G. and Williams, Craig M. (2019). New casbanes and the first trans‐cyclopropane seco‐casbane from the Australian rainforest plant croton insularis. Chemistry - A European Journal, 25 (6), 1525-1534. doi: 10.1002/chem.201804904
Moore, Peter W., Zerk, Timothy J., Burns, Jed M., Bernhardt, Paul V. and Williams, Craig M. (2019). Hydrogen-bonding interactions in the Ley-Griffith oxidation: practical considerations for the synthetic chemist. European Journal of Organic Chemistry, 2019 (2-3), 303-308. doi: 10.1002/ejoc.201800860
Kato, Yumi, Williams, Craig M., Uchiyama, Masanobu and Matsubara, Seijiro (2019). A protocol for an iodine-metal exchange reaction on cubane using lithium organozincates. Organic Letters, 21 (2), 473-475. doi: 10.1021/acs.orglett.8b03721
McAlpine, James B., Chen, Shao-Nong, Kutateladze, Andrei, MacMillan, John B., Appendino, Giovanni, Barison, Andersson, Beniddir, Mehdi A., Biavatti, Maique W., Bluml, Stefan, Boufridi, Asmaa, Butler, Mark S., Capon, Robert J., Choi, Young H., Coppage, David, Crews, Phillip, Crimmins, Michael T., Csete, Marie, Dewapriya, Pradeep, Egan, Joseph M., Garson, Mary J., Genta-Jouve, Grégory, Gerwick, William H., Gross, Harald, Harper, Mary Kay, Hermanto, Precilia, Hook, James M., Hunter, Luke, Jeannerat, Damien, Ji, Nai-Yun ... Pauli, Guido F. (2019). Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Natural Product Reports, 36 (1), 248-249. doi: 10.1039/c8np90041h
Moore, Peter W., Zerk, Timothy J., Burns, Jed M., Bernhardt, Paul V. and Williams, Craig M. (2018). Cover Feature: Hydrogen-Bonding Interactions in the Ley-Griffith Oxidation: Practical Considerations for the Synthetic Chemist (Eur. J. Org. Chem. 2-3/2019). European Journal of Organic Chemistry, 2019 (2-3), 230-230. doi: 10.1002/ejoc.201801822
Garcia, Mario D., Chua, Sheena M. H., Low, Yu-Shang, Lee, Yu-Ting, Agnew-Francis, Kylie, Wang, Jian-Guo, Nouwens, Amanda, Lonhienne, Thierry, Williams, Craig M., Fraser, James A. and Guddat, Luke W. (2018). Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections. Proceedings of the National Academy of Sciences of the United States of America, 115 (41), E9649-E9658. doi: 10.1073/pnas.1809422115
McAlpine, James B., Chen, Shao-Nong, Kutateladze, Andrei, MacMillan, John B., Appendino, Giovanni, Barison, Andersson, Beniddir, Mehdi A., Biavatti, Maique W., Bluml, Stefan, Boufridi, Asmaa, Butler, Mark S., Capon, Robert J., Choi, Young H., Coppage, David, Crews, Phillip, Crimmins, Michael T., Csete, Marie, Dewapriya, Pradeep, Egan, Joseph M., Garson, Mary J., Genta-Jouve, Grégory, Gerwick, William H., Gross, Harald, Harper, Mary Kay, Hermanto, Precilia, Hook, James M., Hunter, Luke, Jeannerat, Damien, Ji, Nai-Yun ... Pauli, Guido F. (2018). The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Natural Product Reports, 36 (1), 35-107. doi: 10.1039/c7np00064b
Chalmers, Benjamin A., Xing, Hui, Houston, Sevan, Clark, Charlotte, Ghassabian, Sussan, Kuo, Andy, Cao, Benjamin, Reitsma, Andrea, Murray, Cody-Ellen P., Stok, Jeanette E., Boyle, Glen M., Pierce, Carly J., Littler, Stuart W., Winkler, David A., Bernhardt, Paul V., Pasay, Cielo, De Voss, James J., McCarthy, James, Parsons, Peter G., Walter, Gimme H., Smith, Maree T., Cooper, Helen M., Nilsson, Susan K., Tsanaktsidis, John, Savage, G. Paul and Williams, Craig M. (2018). Corrigendum to: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere (Angewandte Chemie International Edition, (2016), 55, 11, (3580-3585), 10.1002/anie.201510675). Angewandte Chemie - International Edition, 57 (28), 8359-8359. doi: 10.1002/anie.201711161
Xie, Sida, Savchenko, Andrei I., Krenske, Elizabeth H., Grange, Rebecca L., Gahan, Lawrence R. and Williams, Craig M. (2018). Front cover: developing cyclic peptide heteroatom interchange: synthesis and DFT modelling of a HI-ascidiacyclamide isomer (Eur. J. Org. Chem. /2018). European Journal of Organic Chemistry, 2018 (25), 3246-3246. doi: 10.1002/ejoc.201800902
Xie, Sida, Savchenko, Andrei I., Krenske, Elizabeth H., Grange, Rebecca L., Gahan, Lawrence R. and Williams, Craig M. (2018). Developing cyclic peptide heteroatom interchange: synthesis and DFT modelling of a HI-ascidiacyclamide isomer. European Journal of Organic Chemistry, 2018 (25), 3265-3270. doi: 10.1002/ejoc.201800449
Xie, Sida, Savchenko, Andrei I., Kerscher, Marion, Grange, Rebecca L., Krenske, Elizabeth H., Harmer, Jeffrey R., Bauer, Michelle J., Broit, Natasa, Watters, Dianne J., Boyle, Glen M., Bernhardt, Paul V., Parsons, Peter G., Comba, Peter, Gahan, Lawrence R. and Williams, Craig M. (2018). Heteroatom-Interchanged Isomers of Lissoclinamide 5: Copper(II) Complexation, Halide Binding, and Biological Activity. European Journal of Organic Chemistry, 2018 (12), 1465-1476. doi: 10.1002/ejoc.201701659
Moore, Peter W., Read, Christopher D. G., Bernhardt, Paul V. and Williams, Craig M. (2018). ATP3 and MTP3: easily prepared stable perruthenate salts for oxidation applications in synthesis. Chemistry: A European Journal, 24 (18), 4556-4561. doi: 10.1002/chem.201800531
Lonhienne, Thierry, Garcia, Mario D., Noble, Chris, Harmer, Jeffrey, Fraser, James A., Williams, Craig M. and Guddat, Luke W. (2017). High resolution crystal structures of the acetohydroxyacid synthase-pyruvate complex provide new insights into its catalytic mechanism. Chemistryselect, 2 (36), 11981-11988. doi: 10.1002/slct.201702128
Zerk, Timothy J., Moore, Peter W., Harbort, Joshua S., Chow, Sharon, Byrne, Lindsay, Koutsantonis, George A., Harmer, Jeffrey R., Martinez, Manuel, Williams, Craig M. and Bernhardt, Paul V. (2017). Elucidating the mechanism of the Ley-Griffith (TPAP) alcohol oxidation. Chemical Science, 8 (12), 8435-8442. doi: 10.1039/c7sc04260d
Vuong, Khuong Q. , Effenberger, Reinhard, Zilberman, Joseph, Smart, Simon, Williams, Craig M. and McFarland, Eric W. (2017). Dialkyl carbonate synthesis via in situ generated carbonyl dibromide on porous glass. ACS Sustainable Chemistry & Engineering, 5 (9), 7492-7495. doi: 10.1021/acssuschemeng.7b01487
Vanden Berg, Timothy J., Pinkerton, David M. and Williams, Craig M. (2017). 7-Step total synthesis of (+)-EBC-329: Photoisomerisation reveals new seco-casbane family member. Organic & Biomolecular Chemistry, 15 (34), 7102-7105. doi: 10.1039/c7ob01400g
Pagani, Alberto, Gaeta, Simone, Savchenko, Andrei I., Williams, Craig M. and Appendino, Giovanni (2017). An improved preparation of phorbol from croton oil. Beilstein Journal of Organic Chemistry, 13 (1), 1361-1367. doi: 10.3762/bjoc.13.133
Tan, Y. P., Savchenko, A. I., Broit, N., Boyle, G. M., Parsons, P. G. and Williams, C. M. (2017). Furofuran lignans from the Simpson Desert species Eremophila macdonnellii. Fitoterapia, 126, 93-97. doi: 10.1016/j.fitote.2017.06.004
Blons, Charlie, Morin, Marie S. T., Schmid, Thibault E., Vives, Thomas, Colombel-Rouen, Sophie, Basle, Olivier, Reynaldo, Thibault, Covington, Cody L., Halbert, Stephanie, Cuskelly, Sean N., Bernhardt, Paul V., Williams, Craig M., Crassous, Jeanne, Polavarapu, Prasad L., Crevisy, Christophe, Gerard, Helene and Mauduit, Marc (2017). Asymmetric sequential Cu-catalyzed 1,6/1,4-conjugate additions of hard nucleophiles to cyclic dienones: determination of absolute configurations and origins of enantioselectivity. Chemistry-A European Journal, 23 (31), 7515-7525. doi: 10.1002/chem.201606034
Pinkerton, David M., Bernhardt, Paul V., Savage, G. Paul and Williams, Craig M. (2017). Cover Picture: Towards the Total Synthesis of Gedunin: Construction of the Fully Elaborated ABC Ring System (Asian J. Org. Chem. 5/2017). Asian Journal of Organic Chemistry, 6 (5), 475-475. doi: 10.1002/ajoc.201700182
San, Anh T., Joyce, Daryl C., Hofman, Peter J., Macnish, Andrew J., Webb, Richard I., Matovic, Nicolas J., Williams, Craig M., De Voss, James J., Wong, Siew H. and Smyth, Heather E. (2017). Stable isotope dilution assay (SIDA) and HS-SPME-GCMS quantification of key aroma volatiles for fruit and sap of Australian mango cultivars. Food Chemistry, 221, 613-619. doi: 10.1016/j.foodchem.2016.11.130
Brasil, Edikarlos M., Canavieira, Luciana M., Cardoso, Érica T. C., Silva, Edilene O., Lameira, Jeronimo, Nascimento, Jose L. M., Eifler-Lima, Vera L., de Matos Macchi, Barbarella, Sriram, Dharmarajan, Bernhardt, Paul V., Silva, Jose Rogerio Araujo, Williams, Craig M. and Alves, Claudio N. (2017). Inhibition of Tyrosinase by 4H-Chromene Analogues: Synthesis, Kinetic Studies and Computational Analysis. Chemical Biology and Drug Design, 90 (5), 804-810. doi: 10.1111/cbdd.13001
Tan, Yuen P. , Savchenko, Andrei I. , Broit, Natasa , Boyle, Glen M. , Parsons, Peter G. and Williams, Craig M. (2017). The first plant 5,6-secosteroid from the Australian arid zone species Frankenia foliosa. European Journal of Organic Chemistry, 2017 (11), 1498-1501. doi: 10.1002/ejoc.201700035
Pinkerton, David M., Bernhardt, Paul V., Savage, G. Paul and Williams, Craig M. (2017). Towards the total synthesis of gedunin: construction of the fully elaborated ABC ring system. Asian Journal of Organic Chemistry, 6 (5), 583-597. doi: 10.1002/ajoc.201700013
Lonhienne, Thierry, Garcia, Mario D., Fraser, James A., Williams, Craig M. and Guddat, Luke W. (2017). The 2.0 Å X-ray structure for yeast acetohydroxyacid synthase provides new insights into its cofactor and quaternary structure requirements. PLoS One, 12 (2) e0171443, e0171443.1-e0171443.13. doi: 10.1371/journal.pone.0171443
Pinkerton, David M., Vanden Berg, Timothy J., Bernhardt, Paul V. and Williams, Craig M. (2017). Gaining synthetic appreciation for the gedunin ABC ring system. Chemistry - A European Journal, 23 (10), 2282-2285. doi: 10.1002/chem.201605751
Maslovskaya, Lidiya A., Savchenko, Andrei I., Gordon, Victoria A., Reddell, Paul W., Pierce, Carly J., Parsons, Peter G. and Williams, Craig M. (2017). The first casbane hydroperoxides EBC-304 and EBC-320 from the Australian rainforest. Chemistry: A European Journal, 23 (3), 537-540. doi: 10.1002/chem.201604674
Moore, Peter W., Hooker, Jordan P., Zavra, Athanasios, Khairallah, George N., Krenske, Elizabeth H., Bernhardt, Paul V., Quach, Gina, Moore, Evan G., O’Hair, Richard A. J. and William, Craig M. (2017). Hydroxyl radicals via collision-induced dissociation of trimethylammonium benzyl alcohols. Australian Journal of Chemistry, 70 (4), 397-406. doi: 10.1071/CH16602
Moore, Peter W., Jiao, Yanxiao, Mirzayans, Paul M., Sheng, Lexter Ng Qi, Hooker, Jordan P. and Williams, Craig M. (2016). ChemInform abstract: selectivity modulation of the Ley-Griffith TPAP oxidation with N-oxide salts. ChemInform, 47 (41). doi: 10.1002/chin.201641044
Moore, Peter W., Jiao, Yanxiao, Mirzayans, Paul M., Sheng, Lexter Ng Qi, Hooker, Jordan P. and Williams, Craig M. (2016). Selectivity modulation of the Ley–Griffith TPAP oxidation with N-oxide salts. European Journal of Organic Chemistry, 2016 (20), 3401-3407. doi: 10.1002/ejoc.201600453
Pippin, Adam B., Mohd Arshad, Zaira Hidayah, Vol, Ronald J., Nye, Jonathon A., Ghassabian, Sussan, Williams, Craig M., Mancini, Alessandra, Liotta, Dennis C., Smith, Maree T. and Goodman, Mark M. (2016). In Vitro Metabolic Stability and in Vivo Biodistribution of 3‑Methyl-4- furoxancarbaldehyde Using PET Imaging in Rats. ACS Medicinal Chemistry Letters, 7 (6), 563-567. doi: 10.1021/acsmedchemlett.5b00410
Mander, Lewis N. and Williams, Craig M. (2016). Chromatography with silver nitrate: part 2. Tetrahedron, 72 (9), 1133-1150. doi: 10.1016/j.tet.2016.01.004
Maslovskaya, Lidia A., Savchenko, Andrei I., Gordon, Victoria A., Reddell, Paul W., Pierce, Carly J., Parsons, Peter G. and Williams, Craig M. (2016). EBC-318 and 339: Bicyclo[10.2.1]alkanes from Croton insularis. RSC Advances, 6 (30), 25110-25113. doi: 10.1039/c6ra02599d
Agnew-Francis, Kylie A. and Williams, Craig M. (2016). Catalysts containing the adamantane scaffold. Advanced Synthesis and Catalysis, 358 (5), 675-700. doi: 10.1002/adsc.201500949
Maslovskaya, Lidia A., Savchenko, Andrei I., Gordon, Victoria A., Reddell, Paul W., Pierce, Carly J., Parsons, Peter G. and Williams, Craig M. (2016). seco-Casbanes from the Australian rainforest: ECD predictions key for determining remote absolute configuration. European Journal of Organic Chemistry, 2016 (9), 1673-1677. doi: 10.1002/ejoc.201501605
Chalmers, Benjamin A., Xing, Hui, Houston, Sevan, Clark, Charlotte, Ghassabian, Sussan, Kuo, Andy, Cao, Benjamin, Reitsma, Andrea, Murray, Cody-Ellen P., Stok, Jeanette E., Boyle, Glen M., Pierce, Carly J., Littler, Stuart W., Winkler, David A., Bernhardt, Paul V., Pasay, Cielo, De Voss, James J., McCarthy, James, Parsons, Peter G., Walter, Gimme H., Smith, Maree T., Cooper, Helen M., Nilsson, Susan K., Tsanaktsidis, John, Savage, G. Paul and Williams, Craig M. (2016). Frontispiece: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere. Angewandte Chemie International Edition, 55 (11), 8359-8359. doi: 10.1002/anie.201681161
Lonhienne, Thierry, Nouwens, Amanda, Williams, Craig M., Fraser, James A., Lee, Yu-Ting, West, Nicholas P. and Guddat, Luke W. (2016). Commercial herbicides can trigger the oxidative inactivation of acetohydroxyacid synthase. Angewandte Chemie, 128 (13), 4319-4323. doi: 10.1002/ange.201511985
Agnew-Francis, Kylie and Williams, Craig M. (2016). Adamantane: the heavy weight in catalysis. Advanced Synthesis and Catalysis, 358 (5), 673-673. doi: 10.1002/adsc.201501018
Stok, Jeanette E., Chow, Sharon, Krenske, Elizabeth H., Farfan Soto, Clementina, Matyas, Csongor, Poirier, Raymond A., Williams, Craig M. and De Voss, James J. (2016). Direct observation of an oxepin from a bacterial cytochrome P450-catalyzed oxidation. Chemistry: A European Journal, 22 (13), 4408-4412. doi: 10.1002/chem.201600246
Chalmers, Benjamin A., Xing, Hui, Houston, Sevan, Clark, Charlotte, Ghassabian, Sussan, Kuo, Andy, Cao, Benjamin, Reitsma, Andrea, Murray, Cody-Ellen P., Stok, Jeanette E., Boyle, Glen M., Pierce, Carly J., Littler, Stuart W., Winkler, David A., Bernhardt, Paul V., Pasay, Cielo, De Voss, James J., McCarthy, James, Parsons, Peter G., Walter, Gimme H., Smith, Maree T., Cooper, Helen M., Nilsson, Susan K., Tsanaktsidis, John, Savage, G. Paul and Williams, Craig M. (2016). Validating Eaton's hypothesis: cubane as a benzene bioisostere. Angewandte Chemie (International Edition), 55 (11), 3580-3585. doi: 10.1002/anie.201510675
Zerk, Timothy J., Moore, Peter W., Williams, Craig M. and Bernhardt, Paul V. (2016). N-Oxides rescue Ru(v) in catalytic Griffith-Ley (TPAP) alcohol oxidations. Chemical Communications, 52 (67), 10301-10304. doi: 10.1039/C6CC05440D
Read, Christopher D. G., Moore, Peter W. and Williams, Craig M. (2016). ChemInform Abstract: N,N,N′,N′-Tetramethylenediamine Dioxide (TMEDAO2) Facilitates Atom Economical/Open Atmosphere Ley-Griffith (TPAP) Tandem Oxidation-Wittig Reactions. ChemInform, 47 (5), no-no. doi: 10.1002/chin.201605041
Lonhienne, Thierry, Nouwens, Amanda, Williams, Craig M., Fraser, James A., Lee, Yu-Ting, West, Nicholas P. and Guddat, Luke W. (2016). Commercial Herbicides Can Trigger the Oxidative Inactivation of Acetohydroxyacid Synthase. Angewandte Chemie - International Edition, 55 (13), 4247-4251. doi: 10.1002/anie.201511985
Krainz, Tanja, Chow, Sharon, Korica, Natasa, Bernhardt, Paul V., Boyle, Glen M., Parsons, Peter G., Davies, Huw M. L. and Williams, Craig M. (2015). Rhodium-Catalyzed [4+3] Cycloaddition to Furans: Direct Access to Functionalized Bicyclo[5.3.0]decane Derivatives. European Journal of Organic Chemistry, 2016 (1), 41-44. doi: 10.1002/ejoc.201501271
Krenske, Elizabeth H. and Williams, Craig M. (2015). Do anti-Bredt natural products exist? Olefin strain energy as a predictor of isolability. Angewandte Chemie International Edition, 54 (36), 10608-10612. doi: 10.1002/anie.201503822
Read, Christopher D. G., Peter W. Moore and Williams, Craig M. (2015). N,N,N’,N’-Tetramethylenediamine dioxide (TMEDAO2) facilitates atom economical/open atmosphere Ley–Griffith (TPAP) tandem oxidation-Wittig reactions. Green Chemistry, 17 (9), 4537-4540. doi: 10.1039/C5GC01346A
Stockdale, Tegan P. and Williams, Craig M. (2015). Pharmaceuticals that contain polycyclic hydrocarbon scaffolds. Chemical Society Reviews, 44 (21), 7737-7763. doi: 10.1039/C4CS00477A
Moore, Peter W., Mirzayans, Paul M. and Williams, Craig M. (2015). ChemInform Abstract: NMO·TPB: A Selectivity Variation on the Ley-Griffith TPAP Oxidation. ChemInform, 46 (29), no-no. doi: 10.1002/chin.201529041
Huang, Lillian Y., Tsui, Debbie Y., Williams, Craig M., Wyse, Bruce D. and Smith, Maree T. (2015). The Furoxan Nitric Oxide Donor, PRG150, Evokes Dose-Dependent Analgesia in a Rat Model of Painful Diabetic Neuropathy (PDN). Clinical and Experimental Pharmacology and Physiology, 42 (9), 921-929. doi: 10.1111/1440-1681.12442
Moore, Peter W., Mirzayans, Paul M. and Williams, Craig M. (2015). NMO TPB: a selectivity variation on the Ley–Griffith TPAP oxidation. Chemistry - A European Journal, 21 (9), 3567-3571. doi: 10.1002/chem.201406256
Maslovskaya, Lidia A., Savchenko, Andrei I., Gordon, Victoria A., Reddell, Paul W., Pierce, Carly J., Parsons, Peter G. and Williams, Craig M. (2015). EBC-316, 325-327, and 345: new pimarane diterpenes from Croton insularis found in the Australian rainforest. Australian Journal of Chemistry, 68 (4), 652-659. doi: 10.1071/CH14550
Mak, Jeffrey Y. W., Pouwer, Rebecca H. and Williams, Craig M. (2014). Natural Products with Anti-Bredt and Bridgehead Double Bonds. Angewandte Chemie International Edition, 53 (50), 13664-13688. doi: 10.1002/anie.201400932
Maslovskaya, Lidiya A., Savchenko, Andrei I., Pierce, Carly J., Gordon, Victoria A., Reddell, Paul W., Parsons, Peter G. and Williams, Craig M. (2014). Unprecedented 1,14-seco-Crotofolanes from Croton insularis: oxidative cleavage of crotofolin C by a putative homo-Baeyer–Villiger rearrangement. Chemistry: A European Journal, 20 (44), 14226-14230. doi: 10.1002/chem.201404250
Maslovskaya, Lidiya A., Savchenko, Andrei I., Krenske, Elizabeth H., Gordon, Victoria A., Reddell, Paul W., Pierce, Carly J., Parsons, Peter G. and Williams, Craig M. (2014). Croton insularis introduces the seco-casbane class with EBC-329 and the first casbane endoperoxide EBC-324. Chemical Communications, 50 (82), 12315-12317. doi: 10.1039/C4CC05413J
Maslovskaya, Lidiya A., Savchenko, Andrei I., Krenske, Elizabeth H., Pierce, Carly J., Gordon, Victoria A., Reddell, Paul W., Parsons, Peter G. and Williams, Craig M. (2014). EBC-219: A new diterpene skeleton, crotinsulidane, from the Australian rainforest containing a bridgehead double bond. Angewandte Chemie - International Edition, 53 (27), 7006-7009. doi: 10.1002/anie.201310923
Eger, Wilhelm A., Anders, Ernst and Williams, Craig M. (2014). Mechanistic aspects of the lycopodine Michael-Claisen domino cyclization. Journal of Molecular Modeling, 20 (Online First) (4) 2173, 2173.1-2173.8. doi: 10.1007/s00894-014-2173-0
Wentrup, Curt and Williams, Craig (2014). 6th Heron Island conference on reactive intermediates and unusual molecules. Australian Journal of Chemistry, 67 (3), 317-319. doi: 10.1071/CH14041
Mirzayans, Paul Malek, Krenske, Elizabeth H. and Williams, Craig M. (2014). Nonstabilised azomethine ylids from n-oxides: unravelling the deprotonation of n-methylmorpholine n-oxide. Australian Journal of Chemistry, 67 (8-9), 1309-1317. doi: 10.1071/CH14217
Savchenko, Andrei I. and Williams, Craig M. (2013). The anti-Bredt red flag! Reassignment of neoveratrenone. European Journal of Organic Chemistry, Early View (32), 7263-7265. doi: 10.1002/ejoc.201301308
Khairallah, George N., Williams, Craig M., Chow, Sharon and O'Hair, Richard A. J. (2013). sp-sp(3) Coupling reactions of alkynylsilver cations, RC (equivalent to) CAg2+ (R = Me and Ph) with allyliodide. Dalton Transactions, 42 (26), 9462-9467. doi: 10.1039/c2dt32143b
Ho, Junming, Zheng, Jingling, Meana-Pañeda, Rubén, Truhlar, Donald G., Ko, Eun Jung, Savage, G. Paul, Williams, Craig M., Coote, Michelle L. and Tsanaktsidis, John (2013). Chloroform as a hydrogen atom donor in Barton reductive decarboxylation reactions. Journal of Organic Chemistry, 78 (13), 6677-6687. doi: 10.1021/jo400927y
Linsenmeier, Anna M., Williams, Craig M. and Brase, Stefan (2013). Photochemical synthesis of phenanthridines: exploring fluoro and protected catechol substitution. European Journal of Organic Chemistry, 18 (18), 3847-3856. doi: 10.1002/ejoc.201300218
Khairallah, George N., Saleeba, Kirsty A., Chow, Sharon, Eger, Wilhelm, Williams, Craig M. and O'Hair, Richard A. J. (2013). CH and CC bond activation reactions in silver alkynyl cluster cations, RCCAg2+. International Journal of Mass Spectrometry, 354-355, 229-234. doi: 10.1016/j.ijms.2013.07.010
Mak, Jeffrey Y. W. and Williams, Craig M. (2012). Erratum: Enantioselective total synthesis of ()-neovibsanin G and ()-14-epi-neovibsanin G (Chemical Communications (2012) (287-289) DOI: 10.1039/c1cc15995j)). Chemical Communications, 48 (100) doi: 10.1039/c2cc90426h
Aiken, Karelle S., Eger, Wilhelm A., Williams, Craig M., Spencer, Carley M. and Zercher, Charles K. (2012). A combined DFT and NMR investigation of the zinc organometallic intermediate proposed in the syn-selective tandem chain extension-aldol reaction of β-keto esters. Journal of Organic Chemistry, 77 (14), 5942-5955. doi: 10.1021/jo3004925
Pouwer, Rebecca H. and Williams, Craig M. (2012). Method in the madness - Methodology from total synthesis. Synlett, 23 (10) ST-2011-A0782-A, 1446-1458. doi: 10.1055/s-0031-1290967
Ko, Eun Jung, Williams, Craig M., Savage, G. Paul and Tsanaktsidis, John (2012). Reductive Radical Decarboxylation of Aliphatic Carboxylic Acids. Organic Syntheses, 89, 471-479. doi: 10.15227/orgsyn.089.0471
Mak, Jeffrey Y. W. and Williams, Craig M. (2012). Total synthesis of (-)-neovibsanin G and (-)-14-epi-neovibsanin G: Towards the synthesis of 15-O-methylneovibsanin F and 14-epi-15-O-methylneovibsanin F. European Journal of Organic Chemistry, 2012 (10), 2001-2012. doi: 10.1002/ejoc.201101796
Mak, Jeffrey Y. W. and Williams, Craig M. (2012). Key achievements in the total synthesis of vibsane-type diterpenoids. Natural Product Reports, 29 (4), 440-448. doi: 10.1039/c2np00067a
Mirzayans, Paul Malek, Pouwer, Rebecca H., Williams, Craig M. and Bernhardt, Paul V. (2012). Stereocontrolled Synthesis of the cis-Hydroxydecalin System: Towards Biologically Active 19-nor-Clerodanes. European Journal of Organic Chemistry, 8 (8), 1633-1638. doi: 10.1002/ejoc.201101807
Mak, Jeffrey Y.W. and Williams, Craig M. (2012). Enantioselective total synthesis of (-)-neovibsanin G and (-)-14-epi-neovibsanin G. Chemical Communications, 48 (2), 287-289. doi: 10.1039/c1cc15995j
Faber, Jonathan M., Eger, Wilhelm A. and Williams, Craig M. (2012). Enantioselective total synthesis of the mexicanolides: khayasin, proceranolide, and mexicanolide. Journal of Organic Chemistry, 77 (20), 8913-8921. doi: 10.1021/jo301182f
Williams, Craig (2012). 2nd international collaborative and cooperative chemistry symposium. Australian Journal of Chemistry, 65 (9), 1260-1261. doi: 10.1071/CH12231
Linsenmeier, Anna M., Williams, Craig M. and Brase, Stefan (2011). Synthesis of phenanthridine derivatives via photolysis. Journal of Organic Chemistry, 76 (21), 9127-9132. doi: 10.1021/jo201542x
Chow, Sharon, Kress, Christoph, Albaek, Nanna, Jessen, Carsten and Williams, Craig M. (2011). Determining a synthetic approach to pierisformaside C. Organic Letters, 13 (19), 5286-5289. doi: 10.1021/ol202147r
Merritt, Andrew T., Pouwer, Rebecca H., Williams, David J., Williams, Craig M. and Ley, Steven V. (2011). The clerodane ring system: investigating the viability of a direct Diels-Alder approach. Organic and Biomolecular Chemistry, 9 (13), 4745-4747. doi: 10.1039/c1ob05422h
Eger, Wilhelm A., Grange, Rebecca L, Schill, Heiko, Goumont, Régis, Clark, Timothy and Williams, Craig M. (2011). Understanding the reactivity of acyl anion equivalents: The epoxide ring opening case. European Journal of Organic Chemistry, 2011 (13), 2548-2553. doi: 10.1002/ejoc.201001680
Ko, Eun Jung, Savage, G. Paul, Williams, Craig M. and Tsanaktsidis, John (2011). Reducing the cost, smell, and toxicity of the Barton reductive decarboxylation: Chloroform as the hydrogen atom source. Organic Letters, 13 (8), 1944-1947. doi: 10.1021/ol200290m
Maslovskaya, LA, Savchenko, AI, Gordon, VA, Reddell, PW, Pierce, CJ, Parsons, PG and Williams, CM (2011). Isolation and confirmation of the proposed cleistanthol biogentic link from Croton insularis. Organic Letters, 13 (5), 1032-1035. doi: 10.1021/ol103083m
Rooshenas, Parham, Hof, Kira, Schreiner, Peter R. and Williams, Craig M. (2011). 1,2,4-triazine vs. 1,3- and 1,4-oxazinones in normal- and inverse-electron-demand hetero-diels-alder reactions: Establishing a status quo by computational analysis. European Journal of Organic Chemistry, 2011 (5), 983-992. doi: 10.1002/ejoc.201001365
Silvestri, Ilaria Proietti, Andemarian, Fikre, Khairallah, George N., Yap, Su Wan, Quach, Tim, Tsegay, Sammi, Williams, Craig M., O'Hair, Richard A. J., Donnelly, Paul S. and Williams, Spencer J. (2011). Copper(I)-catalyzed cycloaddition of silver acetylides and azides: Incorporation of volatile acetylenes into the triazole core. Organic and Biomolecular Chemistry, 9 (17), 6082-6088. doi: 10.1039/c1ob05360d
Faber, Jonathan M. and Williams, Craig M. (2011). A concise total synthesis of (+/-)-cipadonoid B from synthetic azedaralide. Chemical Communications, 47 (8), 2258-2260. doi: 10.1039/c0cc04698a
Wentrup, C and Williams, C (2010). 5th Heron Island conference on reactive intermediates and unusual molecules. Australian Journal of Chemistry, 63 (12), 1597-1597. doi: 10.1071/CH10389
Eger, WA, Zercher, CK and Williams, CM (2010). A mechanistic investigation into the zinc carbenoid-mediated homologation reaction by DFT methods: Is a classical donor-acceptor cyclopropane intermediate involved?. Journal of Organic Chemistry, 75 (21), 7322-7331. doi: 10.1021/jo101590t
Grange, RL, Gallen, MJ, Schill, H, Johns, JP, Dong, L, Parsons, PG, Reddell, PW, Gordon, VA, Bernhardt, PV and Williams, CM (2010). [4+2] Cycloaddition reactions between 1,8-disubstituted cyclooctatetraenes and diazo dienophiles: Stereoelectronic effects, anticancer properties and application to the synthesis of 7,8-substituted bicyclo [4.2.0] octa-2,4-dienes. Chemistry - A European Journal, 16 (29), 8894-8903. doi: 10.1002/chem.200903454
Chen, Apj, Muller, CC, Cooper, HM and Williams, CM (2010). Synthetic neovibsanes and their ability to induce neuronal differentiation in PC12 cells. Tetrahedron, 66 (34), 6842-6850. doi: 10.1016/j.tet.2010.06.056
O'Hair, Richard A. J., Williams, Craig M. and Clark, Timothy (2010). Neighboring group stabilization by sigma-holes. Journal of Molecular Modeling, 16 (3), 559-565. doi: 10.1007/s00894-009-0567-1
Grange, Rebecca L. and Williams, Craig M. (2010). A convenient new route to enantiopure 3-hydroxy-5-oxo esters and 5,6-dihydropyran-2-ones: intricacies of the trithioorthoester protecting group. Tetrahedron Letters, 51 (8), 1158-1160. doi: 10.1016/j.tetlet.2009.12.058
Chalmers, Benjamin A., Chen, Annette P.-J., Savage, G. Paul and Williams, Craig M. (2010). Cubane: A new NMR Internal Standard. Australian Journal Of Chemistry, 63 (7), 1108-1110. doi: 10.1071/CH10107
Schwartz, Brett D., Denton, Justin R., Davies, Huw M. L. and Williams, Craig M. (2009). Total synthesis of (+) vibsanin E. Australian Journal of Chemistry, 62 (9), 980-982. doi: 10.1071/CH09267
Dong, Lin, Schill, Heiko, Grange, Rebecca L., Porzelle, Achim, Johns, Jenny P., Parsons, Peter G., Gordon, Victoria A., Reddell, Paul W. and Williams, Craig M. (2009). Anticancer agents from the Australian tropical rainforest: Spiroacetals EBC-23, 24, 25, 72, 73, 75 and 76. Chemistry: A European Journal, 15 (42), 11307-11318. doi: 10.1002/chem.200901525
Schwartz, Brett D., Denton, Justin R., Bernhardt, Paul V., Davies, Huw M. L. and Williams, Craig M. (2009). Towards the total synthesis of 3-hydroxyvibsanin E. Synthesis, 2009 (17), 2840-2846. doi: 10.1055/s-0029-1216912
Chen, Annette P. -J., Müller, C. Catharina, Cooper, Helen M. and Williams, Craig M. (2009). Total synthesis of (+/-)-4,5-Bis-epi-neovibsanin A and B: A neurite outgrowth comparison study. Organic Letters, 11 (16), 3758-3761. doi: 10.1021/ol901406j
Mirzayans, Paul Malek, Pouwer, Rebecca H., Williams, Craig M. and Bernhardt, Paul V. (2009). Synthesis of cis-vinyltrimethylstannanes and cis-vinylpinacolboronates in a two-step highly regio and stereoselective process. Tetrahedron, 65 (39), 8297-8305. doi: 10.1016/j.tet.2009.06.092
Schwartz, Brett D., Denton, Justin R., Lian, Yajing, Davies, Huw M. L. and Williams, Craig M. (2009). Asymmetric [4+3] cycloadditions between vinylcarbenoids and dienes: Application to the total synthesis of the natural product (-)-5-epi-Vibsanin E. Journal of the American Chemical Society, 131 (23), 8329-8332. doi: 10.1021/ja9019484
Schwartz, B.D., Porzelle, A., Jack, K.S., Faber, J. M., Gentle, I.R. and Williams, C. M. (2009). Cyclic enones as substrates in the Morita-Baylis-Hillman reaction: Surfactant interactions, scope and scalability with an emphasis on formaldehyde. Advanced Synthesis & Catalysis, 351 (7-8), 1148-1154. doi: 10.1002/adsc.200800739
Wang, Farrah Qiuyun, Khairallah, George N., Koutsantonis, George A., Williams, Craig M., Callahan, Damien L. and O'Hair, Richard A. J. (2009). Competition between cluster fragmentation, C-C bond coupling and C-X bond activation in silver hexynyl cluster cations, [(C4H9CCAg)(n)Ag](+). Size does matter!. Physical Chemistry Chemical Physics, 11 (21), 4132-4135. doi: 10.1039/b904687a
Williams, Craig (2009). University of Queensland-National University of Singapore Joint Symposium. Australian Journal of Chemistry, 62 (62), 949-950. doi: 10.1071/CH09389
Chen, A.P. and Williams, C.M. (2008). Total Synthesis of (+)-2-O-Methylneovibsanin H. Organic Letters, 10 (16), 3441-3443. doi: 10.1021/ol801117e
Dong, Lin, Gordon, Victoria A., Grange, Rebecca L., Johns, Jenny, Parsons, Peter G., Porzelle, Achim, Reddell, Paul, Schill, Heiko and Williams, Craig M. (2008). Structure and absolute stereochemistry of the anticancer agent EBC-23 from the Australian rainforest. Journal of American Chemical Society, 130 (46), 15262-15263. doi: 10.1021/ja807133p
Schwartz, Brett D., Williams, Craig M. and Bernhardt, Paul V. (2008). End game strategies towards the total synthesis of vibsanin E, 3-hydroxyvibsanin E, furanovibsanin A, and 3-O-methylfuranovibsanin A. Beilstein Journal of Organic Chemistry, 4 (1) 34, 1-9. doi: 10.3762/bjoc.4.34
Grange, Rebecca L., Williams, Craig M., Dong, Lin and Gordon, Victoria A. (2008). A general procedure to access methylene ether isonitrile derivatives. Synthesis, 2008 (20), 3326-3330. doi: 10.1055/s-0028-1083143
Malek Mirzayans, P., Pouwer, R. and Williams, C.M. (2008). Two-Step Regio- and Stereoselective Synthesis of cis-Vinylstannanes. Organic Letters, 10 (17), 3861-3863. doi: 10.1021/ol801251m
Gallen, Michael J. and Williams, Craig M. (2008). Towards the total synthesis of Spirovibsanin A: Total synthesis of (±)-5,14-Bis-epi-spirovibsanin A. European Journal of Organic Chemistry, 2008 (27), 4697-4705. doi: 10.1002/ejoc.200800574
Schwartz, Brett D., Williams, Craig M., Anders, Ernst and Bernhardt, Paul V. (2008). Exploiting the Anders-Gassner variant on the Wittig reaction: new methodology for the synthesis of 3,3-dimethylacroyl enol esters. Tetrahedron, 64 (27), 6482-6487. doi: 10.1016/j.tet.2008.04.068
Waters, Tom, Boulton, Jack, Clark, Timothy, Gallen, Michael J., Williams, Craig M. and O'Hair, Richard A. J. (2008). Experimental determination of the gas phase proton affinities of the conjugate base anions of 2-iodoxybenzoic acid (IBX) and 2-iodosobenzoic acid (IBA). Organic & Biomolecular Chemistry, 6 (6), 2530-2533. doi: 10.1039/b803452d
Gallen, M. and Williams, C.M. (2008). Total synthesis of (+)-5, 14-bis-epi-Spirovibsanin A. Organic Letters, 10 (5), 713-715. doi: 10.1021/ol702827x
Pouwer, Rebecca H., Schill, Heiko, Williams, Craig M. and Bernhardt, Paul V. (2007). Investigating direct access to 2-oxospiro[4.5]decanones via 6 pi-electrocyclisation. European Journal of Organic Chemistry, 2007 (28), 4699-4705. doi: 10.1002/ejoc.200700367
Porzelle, A, Gordon, VA and Williams, CM (2007). Rapid access to in situ generated (R)- and (S)-2-furyloxirane and associated regioselective nucleophilic ring-opening studies. Synlett, 2007 (10), 1619-1621. doi: 10.1055/s-2007-980381
Pouwer, R. H., Harper, J. B., Vyakaranam, K., Michl, J., Williams, C. M., Jessen, C. H. and Bernhardt, P. V. (2007). Investigating direct alkynylation at the bridgehead of bicyclic cages using silver(I) acetylides. European Journal of Organic Chemistry, 2007 (2), 241-248. doi: 10.1002/ejoc.200600701
Gallen, Michael J., Goummont, Regis, Clark, Timothy, Terrier, Francois and Williams, Craig M. (2006). o-iodoxybenzoic acid (IBX): pK(a) and proton-affinity analysis. Angewandte Chemie-international Edition, 45 (18), 2929-2934. doi: 10.1002/anie.200504156
Baker, L. A., Williams, C. M., Bernhardt, P. V. and Yanik, G. W. (2006). Azedaralide: total synthesis, relative and absolute stereochemical assignment. Tetrahedron, 62 (31), 7355-7360. doi: 10.1016/j.tet.2006.05.030
Porzelle, Achim and Williams, Craig M. (2006). Direct access to functionalized cyclic enones using Mannich, Morita-Baylis-Hillman and elimination reactions. Synthesis, 18 (18), 3025-3030. doi: 10.1055/s-2006-942539
Schwartz, B. D., Tilly, D. P., Heim, R., Wiedemann, S., Williams, C. M. and Bernhardt, P. V. (2006). Towards the total synthesis of vibsanin E, 15-O-methylcyclovibsanin B, 3-hydroxyvibsanin E, furanovibsanin A, and 3-O-methylfuranovibsanin A. European Journal of Organic Chemistry, 2006 (14), 3181-3192. doi: 10.1002/ejoc.200600246
Williams, C. M., Heim, R. and Bernhardt, P. V. (2005). Nitrogen is a requirement for the photochemical induced 3-azabicyclo[3.3.1]nonane skeletal rearrangement!. Tetrahedron, 61 (15), 3771-3779. doi: 10.1016/j.tet.2005.02.013
Tilly, David P., Williams, Craig M. and Bernhardt, Paul V. (2005). Construction of the cyclovibsanin core via a biogenetically modeled approach. Organic Letters, 7 (23), 5155-5157. doi: 10.1021/ol051897d
Williams, C. M., Mander, L. N., Bernhardt, P. V. and Willis, A. C. (2005). Investigating direct routes to an advanced intermediate for the synthesis of C-20 diterpene alkaloids. Tetrahedron, 61 (15), 3759-3769. doi: 10.1016/j.tet.2005.02.014
Pouwer, R. H., Williams, C. M., Raine, A. L. and Harper, J. B. (2005). "One-Step" alkynylation of adamantyl iodide with Silver(I) acetylides. Organic Letters, 7 (7), 1323-1325. doi: 10.1021/ol050121+
Heim, Ralf, Wiedemann, Stefan, Williams, Craig M. and Bernhardt, Paul V. (2005). Expedient construction of the vibsanin E core without the use of protecting groups. Organic Letters, 7 (7), 1327-1329. doi: 10.1021/ol0501222
Porzelle, A., Williams, C. M., Schwartz, B. D. and Gentle, I. R. (2005). Evaluating the Baylis-Hillman reaction of cyclic enones using surfactants in water. Synlett, 19 (19) D25505ST, 2923-2926. doi: 10.1055/s-2005-921890
Williams, Craig M. and Mander, Lewis N. (2004). Guaiacol transprotection: replacement of the phenoxy isopropyl protecting function by acetyl. Tetrahedron Letters, 45 (4), 667-669. doi: 10.1016/j.tetlet.2003.11.065
Williams, Craig M., Heim, Ralf, Brecknell, Douglas J. and Bernhardt, Paul V. (2004). Unprecedented photochemical induced cascading rearrangement of the 3-azabicyclo[3.3.1] nonane skeleton. Organic and Biomolecular Chemistry, 2 (6), 806-807. doi: 10.1039/b402200a
Williams, C. M., Bernhardt, P. V., Wiedemann, S. and Barden, M. C. (2003). The synthesis and X-ray crystal structure of 9-carboxyhexahydro-7-methoxy-4a,7-ethano-benzopyran-5-en-1-one. Journal of Chemical Research (S), 12 (12), 784-785. doi: 10.3184/030823403322840387
Williams, Craig M., Mander, Lewis N. and Bernhardt, Paul V. (2003). 1-Ethynyl-2-isopropoxy-3-methoxybenzene. Acta Crystallographica Section E, 59 (4), 0561-0563. doi: 10.1107/S1600536803006585
Baker, L. A. and Williams, C. M. (2003). Synthesis of novel 2-amino-1,3-thiazole-5-carboxylates utilising ultrasonic and thermally mediated aminolysis. Journal of Heterocyclic Chemistry, 40 (2), 353-356. doi: 10.1002/jhet.5570400225
Williams, C. M. and Bernhardt, P. V. (2003). The synthesis and X-ray crystal structure of 6-bromo-2,4,4-trimethyl-cyclohex-2-enone. Journal of Chemical Research-s, 2003 (7), 410-411. doi: 10.3184/030823403103174326
Tebben, G. D., Rauch, K., Stratmann, C., Williams, C. M. and de Meijere, A. (2003). Intramolecular titanium-mediated aminocyclopropanation of terminal alkenes: Easy access to various substituted azabicyclo[n.1.0]alkanes. Organic Letters, 5 (4), 483-485. doi: 10.1021/ol027352q
Lang, R. C., Williams, C. M. and Garson, M. J. (2003). An improved preparation of 4-amino-3-mercaptobenzoic acid. Organic Preparations And Procedures International, 35 (3), 520-524. doi: 10.1080/00304940309355864
Williams, C. M. and Mander, L. N. (2003). Bridgehead arylation: A direct route to advanced intermediates for the synthesis of C-20 diterpene alkaloids. Organic Letters, 5 (19), 3499-3502. doi: 10.1021/ol0353060
Mander, L. N. and Williams, C. M. (2003). Oxidative degradation of benzene rings. Tetrahedron, 59 (8), 1105-1136. doi: 10.1016/S0040-4020(02)01492-8
de Meijere, A, Williams, CM, Kourdioukov, A, Sviridov, SV, Chaplinski, V, Kordes, M, Savchenko, AI, Stratmann, C and Noltemeyer, M (2002). Mono- and disubstituted Nu,Nu-dialkylcyclopropylamines from dialkylformamides via ligand-exchanged titanium-alkene complexes. Chemistry: A European Journal, 8 (16), 3789-3801. doi: 10.1002/1521-3765(20020816)8:16<3789::AID-CHEM3789>3.0.CO;2-R
Raine, A. L., Williams, C. M. and Bernhardt, P. V. (2002). 1-(Phenylethynyl)adamantane. Acta Crystallographica Section E - Structure Reports, E58 (12), 1439-1440. doi: 10.1107/S1600536802021542
Kibbler, H., Williams, C. M., Williams, R. R. and Johnston, M. E. (2002). Inhibition of adventitious rooting in Backhousia citriodora F. Muell cuttings correlate with the concentration of essential oil. Journal of Horticultural Science & Biotechnology, 77 (6), 705-711. doi: 10.1080/14620316.2002.11511560
Williams, C. M. and Mander, L. N. (2001). Chromatography with silver nitrate. Tetrahedron, 57 (3), 425-447. doi: 10.1016/S0040-4020(00)00927-3
de Meijere, A, Stecker, B, Kourdioukov, A and Williams, CM (2000). An unprecedented stereoselective titanium-mediated dihydrodimerization of allyl ethers and allylamines. Synthesis-Stuttgart (7), 929-934. doi: 10.1055/s-2000-6297
Prager, RH and Williams, CM (1999). Base-catalysed rearrangements of 5-oxodihydroisoxazoles. Heterocycles, 51 (12), 3013-3030.
Khalafy, J, Prager, RH and Williams, CM (1999). The synthesis of almazoles A and B. Australian Journal of Chemistry, 52 (1), 31-36. doi: 10.1071/C98093
Williams, CM and de Meijere, A (1998). Easy access to various substituted 4-aminocyclopentenes by rearrangement of 2-ethenyl-substituted cyclopropylamines. Journal of the Chemical Society-Perkin Transactions 1 (22), 3699-3702. doi: 10.1039/a807012a
Williams, CM, Chaplinski, V, Schreiner, PR and de Meijere, A (1998). Unexpected titanium shifts during cyclopropanation of N,N-dibenzylformamide with ligand-exchanged titanium-alkadiene complexes. Tetrahedron Letters, 39 (42), 7695-7698. doi: 10.1016/S0040-4039(98)01665-7
Khalafy, J, Svensson, CE, Prager, RH and Williams, CM (1998). A new synthesis of chiral aminoalkyloxazolecarboxylate esters from isoxazol-5(2H)-ones: the synthesis of almazoles A and B. Tetrahedron Letters, 39 (30), 5405-5408. doi: 10.1016/S0040-4039(98)01014-4
Prager, RH, Smith, JA, Weber, B and Williams, CM (1997). Chemistry of 5-oxodihydroisoxazoles .17. Acylation of 5-oxodihydroisoxazoles. Journal of The Chemical Society-perkin Transactions 1 (17), 2659-2664. doi: 10.1039/a700133i
Prager, RH, Taylor, MR and Williams, CM (1997). The chemistry of 5-oxodihydroisoxazoles .19. The synthesis and photolysis of N-thioacylisoxazol-5(2H)-ones. Journal of The Chemical Society-perkin Transactions 1 (17), 2673-2678. doi: 10.1039/a700646b
Prager, RH, Smith, JA, Weber, B and Williams, CM (1997). Chemistry of 5-oxodihydroisoxazoles .18. Synthesis of oxazoles by the photolysis and pyrolysis of 2-acyl-5-oxo-2,5-dihydroisoxazoles. Journal of The Chemical Society-perkin Transactions 1 (17), 2665-2672. doi: 10.1039/a700134g
Ang K.H., Prager R.H., Smith J.A., Weber B. and Williams C.M. (1996). The synthesis of oxazoles by thermolysis or photolysis of 2-acylisoxazol-5-ones. Tetrahedron Letters, 37 (5), 675-678. doi: 10.1016/0040-4039(95)02240-6
Prager, RH and Williams, CM (1996). The chemistry of 5-oxodihydroisoxazoles .16. A new synthesis of pyrroles, furans, thiophens and their benzo analogues. Australian Journal of Chemistry, 49 (12), 1315-1323. doi: 10.1071/CH9961315
Ang, KH, Prager, RH and Williams, CM (1995). The Chemistry of 5-Oxodihydroisoxazoles .12. Trapping of Derived Ketenimines with Lithium Amides and Alkyllithiums. Australian Journal of Chemistry, 48 (1), 55-63. doi: 10.1071/CH9950055
Ang, KH, Prager, RH and Williams, CM (1995). The Chemistry of 5-Oxodihydroisoxazoles .13. Reactions of the Imino Carbene Derived From Photolysis of Ethyl 5-Oxo-2-Phenyl-2,5-Dihydroisoxazole-4-Carboxylate. Australian Journal of Chemistry, 48 (3), 567-575. doi: 10.1071/CH9950567

Conference Papers

Appendino, G., Pagani, A., Williams, C., Cullen, J., Boyle, G., Parsons, P., Campbell, J., Gordon,, Schmidt, P. and Reddell, P. (2019). Chemistry, mode of action and clinical efficacy of the anticancer diterpenoid tigilanol tigliate (EBC-46). 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), Innsbruck, Austria, 1-5 September, 2019. Stuttgart, Germany: Georg Thieme Verlag. doi: 10.1055/s-0039-3399676
Bahr, Constance, Moore, Peter, Shanahan, Erin R., Burn, Paul, Williams, Craig, Holtmann, Gerald J., deVoss, James and Morrison, Mark (2018). Mass spectrometric analysis of volatile organic compounds produced by duodenal microbiota. Annual Meeting of the American Society for Gastrointestinal Endoscopy / Digestive Disease Week, Washington, DC, United States, 2-5 June, 2018. Philadelphia, PA, United States: Elsevier. doi: 10.1016/s0016-5085(18)32307-2
Wentrup, Curt and Williams, Craig M. (2017). 7th Heron Island conference on reactive intermediates and unusual molecules. Clayton, VIC, Australia: CSIRO. doi: 10.1071/CH17065
Aoude, L., Ferguson, B., Gordon, V., Johns, J., Maslovskaya, L., Parsons, P., Pierce, C., Reddell, P., Savchenko, A. and Williams, C. (2008). Cell culture-based assays identify edible rainforest fruits with potential for chemoprevention of cancer. 4th Australian Health and Medical Research Congress, Brisbane, Australia, 16-21 November 2008. Sydney, Australia: AHMRC.

Data Collections

Shah, Sarah, Lonhienne, Thierry, Murray, Cody-Ellen, Chen, Yibi, Dougan, Katherine E., Low, Yu Shang, Williams, Craig M., Schenk, Gerhard, Walter, Gimme H., Guddat, Luke W. and Chan, Cheong Xin (2022). Genomic resources of seven Australian weed species of national significance. The University of Queensland. (Dataset) doi: 10.48610/c22c10c
Krenske, Elizabeth H. and Williams, Craig M. (2016). Olefin strain energy as a predictor of isolability. The University of Queensland. (Dataset) doi: 10.14264/uql.2016.208

Patents

Smith, Maree and Williams, Craig (2006). Methods of treating pain. PCT/AU2005/001976.
Smith, M. T., Brown, L. C., Harvey, M. and Williams, C. M. (2003). Compositions comprising nitric oxide donors and opioid analgesics. PCT/AU03/00335.

Areas of research

Biomolecular chemistry theme
Organic chemistry discipline