Natural production total synthesis and molecular design research group

Dr Craig WilliamsDr Craig Williams

Chemistry Building (68), Room 1102 
Phone: +61 7 3365 3530
Fax: +61 7 3365 4299
Email: c.williams3@uq.edu.au

Research group photo

 

 

Current Group Members

Post Docs

  • Sharon Chow
    Sharon Chow
  • Angela Ko
    Angela Ko
  • Andrei Savchenko
    Andrei Savchenko
  • Charlotte Madsen
    Charlotte Madsen

PhD Students

  • Jonathan Faber
    Jonathan Faber
  • Jeffrey Mak
    Jeffrey Mak
  • Sida Xie
    Sida Xie
  • Tanja Krainz
    Tanja Krainz
  • Benjamin Chalmers
    Benjamin Chalmers
  • Anna Linsenmeier
    Anna Linsenmeier
  • Kylie Agnew-Francis
    Kylie Agnew-Francis
    (Honours student)

Former Group Members

  • BSc (Hons) & Masters

    • Michael Balfour
    • Luke Baker
    • Mikkel Jessing
    • Kent Heeiah
    • Hilke Wolf (visiting)
    • Daniela Behn (visiting)
    • Ann Lam
    • Rebecca Pouwer
    • Sonia Arwadi
    • Colin Skepper
    • Michael Gallen
    • Linda Reeh
    • Pinus Jumaryatno
    • Stuart Fritz
    • Annette Chen
    • Michael Auld (Undergraduate)
    • Christopher Turner (Undergraduate)
    • Ryan Layden
  • PhD Students

    • Luke Baker
    • Nanna Albeak (visiting)
    • Carsten Jessen (visiting)
    • Rebecca Pouwer
    • Michael Gallen
    • Annette Chen
    • Charlotte Madsen (visiting)
    • Paul Malek Mirzayans
  • Post Doc

    • Wilhelm Eger
    • Rebecca Grange
    • Sunnhild Salmen
    • Stefan Wiedemann
    • Ralf Heim
    • Rob Lang
    • David Tilly
    • Achim Porzelle
    • Heiko Schill
    • Michael Gallen
    • Brett Schwartz

Our research focus concentrates on two areas: 

  1. Investigating strategies towards the total synthesis of complex natural products which contain caged bicyclic moieties within the carbon skeleton, these include the vibsanin family, diterpene alkaloids and tetranortriterpenes.
  2. Design, discovery and synthesis of novel biologically active molecules as lead candidates for the development of new medicines (e.g. anticancer and Alzheimers).


Patents

(1) Smith, M.T., Brown, L., Harvey, M.B.P. and Williams, C.M. (2003) : “Methods and compositions including nitric oxide donors and opioid analgesics for pain relief”, PCT Int. Appl. (Chem. Abstr. 139:271069).

Book Chapters

(2) Prager, R.H. and Williams, C.M. (2005) : Science of Synthesis, Houben-Weyl, Methods for Molecular Transformations, Volume 15, Product Class 9, Acridines.

(3) Prager, R.H., Williams, C.M. (2005) : Science of Synthesis, Houben-Weyl, Methods for Molecular Transformations, Volume 15, Product Class 10, Acridones.

(4) Pouwer, R.H., Williams, C.M. (2010) in Silver Cation-Catalyzed Transformations in Organic Synthesis, “Silver Alkyls, Alkenyls, Aryls and Alkynyls in Organic Synthesis”, edited by Michael Harmata, Wiley.

(5) Williams, C.M. (2012) : The Story Behind the Total Synthesis of Vibsanin E and5-epi-Vibsanin E. In M. Harmata, editors: Strategies and Tactics in Organic Synthesis, 8, STOS, UK: Academic Press, pp. 395-412.

(6) Williams, C.M. (2014) : Sleepless Nights: The Total Synthesis of the Anticancer Australian Rainforest Polyketide EBC-23. In M. Harmata, editors: Strategies and Tactics in Organic Synthesis, 10, STOS, UK: Academic Press, pp. 249-270.

Review Articles

(7) Prager, R.H. and Williams, C.M. (1999) : Base-Catalysed Rearrangements of 5-Oxodihydroisoxazolones. Heterocycles, 51, 3013.

(8) Williams, C.M. and Mander, L.N. (2001) : Chromatography with Silver Nitrate. Tetrahedron57, 425.

(9) Mander, L.N. and Williams, C.M. (2003) : Oxidative degradation of benzene rings. Tetrahedron59, 1105.

(10) COVER issue Mak, J. Y. W.; Williams, C. M. (2012) : Key achievements in the total synthesis of vibsane-type diterpenoids. Nat. Prod. Rep., 29, 440.

(11) Pouwer, R.H.; Williams, C.M. (2012) : Method in the madness - Methodology from total synthesis. Synlett, 1446. Invited personal account of Williams group research over the last 10 years.

(12) J. Y. W. Mak, R. H. Pouwer, C. M. Williams (2014) : Natural Products with Anti-Bredt and Bridgehead Double Bonds. Angew. Chem. Int. Ed., 53, 13664.

(13) T. P. Stockdale, C. M. Williams (2015) : Pharmaceuticals that contain polycyclic hydrocarbon scaffolds. Chem. Soc. Rev., 44, 7737.

(14) K. A. Agnew-Francis, C. M. Williams (2016) : Catalysts Containing the Adamantane Scaffold. Adv. Synth. Catal. On-line early view.

(15) L. N. Mander, C. M. Williams (2016) : Chromatography with Silver Nitrate: Part 2. Tetrahedron, 72, 1133-1150. .

Journal Articles

(16) Ang, K.H., Prager, R.H. and Williams, C.M. (1995) : The Chemistry of 5-Oxodihydro isoxazoles. XIII Reactions of the Imino Carbene Derived from Photolysis of Ethyl 5-Oxo3 2-phenyl-2,5-dihydroisoxazole-4-carboxylate. Aust. J. Chem., 48, 567-575.

(17) Ang, K.H., Prager, R.H. and Williams, C.M. (1995) : The Chemistry of 5-Oxodihydroisoxazoles. XII Trapping of Derived Ketenimines with Lithium Amides and Alkyllithiums. Aust. J. Chem.48, 55-63.

(18) Prager, R.H. and Williams, C.M. (1996) : The Chemistry of 5-Oxodihydroisoxazoles. XVI A New Synthesis of Pyrroles, Furans, Thiophens and their Benzo Analogues. Aust. J. Chem., 49, 1315-1323.

(19) Ang, K.H., Prager, R.H., Smith, J.A., Weber, B. and Williams, C.M. (1996) : The Synthesis of Oxazoles by Thermolysis of Pyrolysis of 2-Acylisoxazol-5-ones. Tetrahedron Lett.37, 675-678.

(20) Prager, R.H., Smith, J.A., Weber, B. and Williams, C.M. (1997) : The Chemistry of 5-Oxodihydroisoxazoles. XVII Acylation of 5-Oxodihydroisoxazoles. J. Chem. Soc., Perkins Trans. 1, 2659.

(21) Prager, R.H., Smith, J.A., Weber, B. and Williams, C.M. (1997) : The Chemistry of 5-Oxodihydroisoxazoles. XVIII The Synthesis of Oxazoles by the Photolysis and Pyrolysis of 2-Acyl-5-oxo-2,5-dihydroisoxazoles. J. Chem. Soc., Perkins Trans. 1, 2665.

(22) Prager, R.H., Taylor, M.R. and Williams, C.M. (1997) : The Chemistry of 5-Oxodihydroisoxazoles. XIX The Synthesis and Photolysis of N-Thioacylisoxazol-5(2H)-ones. J.Chem.Soc., Perkins Trans. 1, 2673.

(23) Khalafy, J., Svensson, C.E., Prager, R.H. and Williams, C.M. (1998) : A new Synthesis of chiral Aminoalkyloxazolecarboxylate Esters from Isoxazol-5(2H)-ones: The Synthesis of Almazoles A and B. Tetrahedron Lett.39, 5405.

(24) Williams, C.M., Chaplinski, V., Schreiner, P.R. and de Meijere, A. (1998) : Unexpected Titanium Shifts during Cyclopropanation of N,N-Dibenzylformaide with Ligand-Exchanged Titanium-Alkadiene Complexs. Tetrahedron Lett.39, 7695.

(25) de Meijere, A. and Williams, C.M. (1998) : Easy access to various substituted 4-aminocyclopentenes by rearrangement of 2-ethenyl-substituted cyclopropylamines. J. Chem. Soc., Perkin Trans. 1., 3699.

(26) Khalafy, J., Prager, R.H. and Williams, C.M. (1999) : The Synthesis of Almazoles A and B. Aust. J. Chem.52, 31.

(27) de Meijere, A., Stecker, B., Kordioukou, A., and Williams, C.M. (2000) : An Unprecedented Stereoselective Titanium-Mediated Dihydrodimerization of Allyl Ethers and Allylamines. Synthesis, 929.

(28) de Meijere, A., Williams, C.M., Kordioukou, A., Sviridov, S.V., Chaplinski, V., Kordes, M., Savchenko, A.I., Stratmann, C., and Noltemeyer, M. (2002) : Mono- and Disubstituted N,Ndialkylcyclopropylamines from dialkylformamides via ligand-exchange titanium-alkene complexes. Chem. Eur. J.8, 3789.

(29) Kibbler, H., Williams, C.M., Williams, R.R, Johnston, M.E. (2002) : Inhibition of adventitious rooting in Backhousia citriodora F. Muell. cuttings correlate with the concentration of essential oil, J. Hort. Sci. Biotech.77, 705.

(30) Raine, A.L., Williams, C.M., and Bernhardt, P.V., (2002) : 1-(Phenylethynyl)adamantane, Acta Cryst.E58, o1439.

(31) Tebben, G.-D., Rauch, K., Stratmann, C., Williams, C.M. and de Meijere, A. (2003) : Intramolecular Titanium-Mediated aminocyclopropanation of Terminal Alkenes: Easy access to various substituted azabicyclo[n.1.0]alkanes, Organic Letters5, 483.

(32) Baker, L.A. and Williams, C.M. (2003) : Synthesis of Novel 2-Amino-1,3-thiazole-5-

carboxylates Utilising Ultrasonic and Thermally Mediated Aminolysis, J. Heterocyclic Chem.40, 353-356.

(33) Williams*, C.M. and Mander, L.N. (2003) : Bridgehead arylation: A direct route to advanced intermediates for the synthesis of C-20 diterpene alkaloids, Organic Letters5, 3499-3502.

(34) Williams, C.M., Mander, L.N., Bernhardt, P.V., 1-Ethynyl-2-isopropoxy-3-methoxybenzene, Acta Cryst.E59, o561-o563.

(35) Lang, R., Williams, C.M. and Garson, M.J. (2003) : An improved preparation of 4-amino-3-mercaptobenzoic acid, Org. Prep. Proced. Int., 35, 520-524.

(36) Williams, C.M. and Bernhardt, P.V. (2003) : The synthesis and x-ray crystal structure of 6-bromo-2,4,4-trimethyl-cyclohex-2-enone, J. Chem. Res. (S), 410-411.

(37) Williams, C.M., Bernhardt, P.V., Wiedemann, S. and Barden, M.C. (2003) : The synthesis and x-ray crystal structure of 9-carboxyhexahydro-7-methoxy-4a,7-ethano-benzopyran-5-en-1-one, J. Chem. Res. (S), 784-785.

(38) Williams, C.M. and Mander, L.N. (2004) : Guaiacol transprotection. Replacement of the phenoxy isopropyl protecting function by acetyl, Tetrahedron Lett.45, 667-669.

(39) Williams, C.M., Heim, R., Brecknell, D.J. and Bernhardt, P.V. (2004) : Unprecedented

photochemical cascading rearrangement of the 3-azabicyclo[3.3.1]nonane skeleton, Org.

Biomol. Chem.2, 806-807.

(40) Williams, C.M., Mander, L.N., Bernhardt, P.V. and Willis, A.C. (2005) : Investigating a direct route to advanced intermediates for the synthesis of C-20 diterpene alkaloids, Tetrahedron61, 3759-3769.

(41) Williams, C.M., Heim, R., Bernhardt, P.V. (2005) : Nitrogen is a requirement for the photochemical induced 3-azabicyclo[3.3.1]nonane skeletal rearrangement, Tetrahedron61, 3771-3779.

(42) Heim, R., Wiedemann, S., Williams, C.M., and Bernhardt, P.V. (2005) : Expedient Construction of the Vibsanin E Core Without the use of Protecting Groups, Organic Letters 7, 1327-1329.

(43) Pouwer, R.H.; Williams, C.M.; Raine, A.L.; Harper, J.B. (2005) : “One-Step” Alkynylation of Adamantyl Iodide with Silver-(I) Acetylides, Organic Letters 7, 1323-1325.

(44) Porzelle, A.; Williams, C.M.; Schwartz, B.D.; Gentle, I.R. (2005) : Evaluating the Baylis–Hillman Reaction of Cyclic Enones Using Surfactants in Water, SynLett 2923-2926.

(45) Tilly, D.P.; Williams, C.M.; Bernhardt, P.V. (2005) : Construction of the cyclovibsanin core via a biogenetically modeled approach, Organic Letters 7, 5155-5157.

(46) Gallen, M.J.; Goumont, R.; Clark, T.; Terrier, F.; Williams, C.M. (2006) : IBX: pKa and Proton affinity analysis, Angew. Chem. Int. Ed. 45, 2929-2934.

(47) Baker, L.A.; Williams, C.M.; Bernhardt, P.V.; Yanik, G. (2006) : Azedaralide: Total Synthesis, Relative and Absolute Stereochemical Assignment, Tetrahedron62, 7355-7360.

(48) Schwartz, B.D.; Tilly, D.P.; Heim, R.; Wiedemann, S.; Williams, C.M.; Bernhardt, P.V. (2006): Towards the total synthesis of vibsanin E, 15-O-methylcyclovibsanin B, 3-hydroxyvibsanin E, furanovibsanin A, and 3-O-methylfuranovibsanin A. Eur. J. Org. Chem., 3181-3192.

(49) Porzelle, A.; Williams, C.M. (2006): Direct access to functionalized cyclic enones using Mannich, Morita-Baylis-Hillman and elimination reactions. Synthesis, 3025-3030.

(50) COVER ISSUE Pouwer, R.H.; Harper, J.B.; Vyakaranam, K.; Michl, J.; Williams, C.M.; Jessen, C.H.; Bernhardt, P.V. (2007): Investigating direct alkynylation at the bridgehead of bicyclic cages using silver(I) acetylides. Eur. J. Org. Chem. 241-248.

(51) Porzelle, A. Gordon, V. Williams, C. M. (2007). Rapid Access to in situ Generated (R) and (S)-2-Furyloxirane and Associated Regioselective Nucleophilic Ring Opening Studies. SynLett, 1619.

(52) R. H. Pouwer, H. Schill, C. M. Williams, and P. V. Bernhardt (2007): Investigating Direct Access to 2-Oxospiro[4.5]decanones via 6π-Electrocyclisation. Eur. J. Org. Chem. 4699-4705.

(53) Gallen, M.J.; Williams, C.M. (2008): Total Synthesis of (±)-5,14-bis-epi-Spirovibsanin A. Organic Letters. 10, 713.

(54) Schwartz, B.D.; Williams, C.M.; Anders, E.; and Bernhardt, P.V. (2008): Exploiting the Anders-Gaßner variant on the Wittig Reaction: New Methodology for the Synthesis of 3,3-Dimethylacroyl Enol Esters. Tetrahedron64, 6482 .

(55) T. Waters, J. Boulton, T. Clark, M. J. Gallen, C. M. Williams and R. A. J. O'Hair (2008), Experimental determination of the gas phase proton affinities of the conjugate base anions of 2-iodoxybenzoic acid (IBA) and 2-iodosobenzoic acid (IBX),  Org. Biomol. Chem.6, 2530.

(56) A. P.-J. Chen, C. M. Williams, (2008) Total Synthesis of (±)-2-O-Methylneovibsanin H, Organic Letters,  10, 3441.

(57) P. Malek Mirzayans, R. H. Pouwer and C. M. Williams, Two-step regio and stereoselective synthesis of cis-vinylstannanes, Organic Letters, 2008, 10, 3861.

(58) Gallen, M.J.; Williams, C.M. (2008): Towards the Total Synthesis of Spirovibsanin A: Total Synthesis of (±)-5,14-Bis-epi-Spirovibsanin A. Eur. J. Org. Chem. 4697.

(59) Schwartz, B.D.; Williams, C.M.; and Bernhardt, P.V. (2008): End Game Strategies Towards the Total Synthesis of Vibsanin E, 3-Hydroxy-vibsanin E, Furanovibsanin A, and 3-O-Methylfuranovibsanin A. Beilstein J. Org. Chem. 4 (Oct.).

(60) Grange, R. L., Williams, C. M.; Dong, L.; Gordon, V. A. (2008) : A general procedure to access methylene ether isonitrile derivatives Synthesis 3326-3330.

(61) Dong, L.; Gordon, V. A.; Grange, R. L.; Johns, J.; Parsons, P. G.; Porzelle, A.; Reddell, P.; Schill, H.; Williams, C. M (2008) : Structure and Absolute Stereochemistry of the Anticancer Agent EBC-23 from the Australian Rainforest J. Am. Chem. Soc. 130, 15262-15263.

(62) F. Q. Wang, G. N. Khairallah, G. A. Koutsantonis, C. M. Williams, D. L. Callahan and R. A. J. O’Hair (2009): Competition between cluster fragmentation, C–C bond coupling and C–X bond activation in silver hexynyl cluster cations, [(C4H9CCAg)nAg]+. Size does matter!, Physical Chemistry Chemical Physics11, 4132.

(63) B. D. Schwartz, J. R. Denton, Y. Lian, H. M. L. Davies, C. M. Williams (2009): Asymmetric [4 + 3] Cyloadditions between Vinylcarbenoids and Dienes: Application to the Total Synthesis of the NaturalProduct (-)-5-epi-Vibsanin E, J. Am. Chem. Soc. 131, 8329.

(64) Schwartz, B. D.; Porzelle, A.; Jack, K. S.; Faber, J. M.; Gentle, I. R. and Williams, C. M. (2009): Cyclic Enones as Substrates in the Morita-Baylis-Hillman Reaction: Surfactant Interactions, Scope and Scalability with an Emphasis on Formaldehyde Adv. Synth. Catal. 351, 1148

(65) P. Malek Mirzayans, R. H. Pouwer, C. M. Williams, P.V. Bernhardt (2009): Synthesis of Cis-Vinyltrimethylstannanes and Cis-Vinylpinacolboronates in a Two-Step Highly Regio and Stereoselective Process, Tetrahedron65, 8297.

(66) Schwartz, B. D.; Denton, J. R.; Bernhardt, P. V.; Davies, H. M. L.; Williams, C. M. (2009):

Towards the total synthesis of 3-hydroxyvibsanin E. Synthesis 2840.

(67) B. D. Schwartz, J. R. Denton, H. M. L. Davies and C. M. Williams (2009): Total Synthesis of (±)-Vibsanin E, Aust. J. Chem. 62, 980.

(68) C.M. Williams. University of Queensland National University of Singapore Joint Symposium (2009). Aust. J. Chem. (2009), 62, 949.

(69) Chen, A. P.-J.; Muller, C. C.; Cooper, H. M.; Williams, C. M. (2009) Total Synthesis of (±)-4,5-Bis-epi-Neovibsanin A and B: A Neurite Outgrowth Comparison Study. Organic Letters 11, 3758-3761.

(70) Dong, L.; Schill, H.; Grange, R. L.; Porzelle, A.; Johns, J. P.; Parsons, P. G.; Gordon, V. A.; Reddell, P. W.; Williams, C. M. (2009). Anticancer Agents from the Australian Tropical Rainforest: Spiroacetals EBC-23, 24, 25, 72, 73, 75 and 76. Chem. Eur. J. 15, 11307.

(71) R. L. Grange, C.M. Williams (2010): A convenient new route to enantiopure 3-hydroxy-5-oxo esters and 5,6-dihydropyran-2-ones; intricacies of the trithioorthoester protecting group, Tetrahedron Lett.51, 1158.

(72) R. A. J. O’Hair, C. M. Williams, T. Clark (2010): Neighboring Group Stabilization by σ-Holes, J. Mol. Model 16559.

(73) B. A. Chalmers, A. P.–J. Chen, G. P. Savage, C. M. Williams (2010): Cubane: A New NMR Internal Standard, Aust. J. Chem., 2010, 63, 1108.

(74) A. P.-J. Chen, C. C. Müller, H. M. Cooper, C. M. Williams (2010): Synthetic neovibsanes and their ability to induce neuronal differentiation in PC12 cells, Tetrahedron, 66, 6842.

(75) R. L. Grange, M. J. Gallen, H. Schill, J. P. Johns, L. Dong, P. G. Parsons, P. W. Reddell, V. A. Gordon, P. V. Bernhardt, C. M. Williams (2010): [4+2] Cycloaddition Reactions Between 1,8-Disubstituted Cyclooctatetraenes and Diazo Dienophiles: Stereoelectronic Effects, Anticancer Properties and Application to the Synthesis of 7,8-Substituted Bicyclo [4.2.0]octa-2,4-dienes, Chem. Eur. J., 16, 8894.

(76) W. A. Eger, C. K. Zercher, C. M. Williams (2010): A Mechanistic Investigation into the Zinc Carbenoid-mediated Homologation Reaction by DFT methods: Is a Classical Donor-Acceptor Cyclopropane Intermediate Involved? J. Org. Chem.75, 7322.

(77) Wentrup, Curt; Williams, Craig (2010) 5th Heron Island Conference on Reactive Intermediates and Unusual Molecules. Aust. J. of Chem. 63, 1597.

(78) P. Rooshenas, K. Hof, P. R. Schreiner, C. M. Williams (2011): 1,2,4-Triazine vs. 1,3- and 1,4-Oxazinones in Normal- and Inverse-Electron-Demand Hetero-Diels-Alder Reactions: Establishing a Status Quo by Computational Analysis Eur. J. Org. Chem., 983.

(79) Ko, E. J.; Savage, G. P.; Williams, C. M.; Tsanaktsidis, J. (2011)  Reducing the Cost, Smell, and Toxicity of the Barton Reductive Decarboxylation: Chloroform as the Hydrogen Atom Source Org. Lett. 13, 1944.

(80) Maslovskaya, L. A.; Savchenko, A. I.; Gordon, V. A.; Reddell, P. W.; Pierce, C. J.; Parsons, P. G.; Williams, C. M. (2011)  Isolation and Confirmation of the Proposed Cleistanthol Biogenetic Link from Croton insularis Org. Lett. 13, 1032.

(81) Eger, W.A.; Grange, R.L.; Schill, H.; Goumont, R.; Clark, T.; Williams, C.M. (2011) Understanding the Reactivity of Acyl Anion Equivalents: The Epoxide Ring Opening Case. Eur. J. Org. Chem. 2548.

(82) Merritt, A. T.; Pouwer, R. H.; Williams, D. J.; Williams, C. M.; Ley, S. V. (2011) The Clerodane Ring System: Investigating the Viability of a Direct Diels-Alder Approach. Org. Biomol. Chem. 9, 4745.

(83) Silvestri, I. P.; Andemarian, F.; Kharaillah, G. N.; Yap, S. W.; Quach, T.; Williams, C.M.; O'Hair, R. A. J.; Donnelly, P. S.; Williams, S. J. (2011) Copper(I)-catalyzed cycloaddition of silver acetylides and azides: Incorporation of volatile acetylenes into the triazole core. Org. Biomol. Chem. 9, 6082.

(84) Linsenmeier, A.M.; Williams, C.M.; Bräse, S. (2011) Synthesis of Phenanthridine Derivatives via Photolysis. J. Org. Chem. 76, 9127.

(85) Chow, S.; Kreß, C.; Albæk, N.; Jessen, C.; Williams, C.M. (2011) Determining a Synthetic Approach to Pierisformaside C. Org. Lett. 13, 5286.

(86) Faber, J. M.; Williams, C. M. (2011) A concise total synthesis of (±)-cipadonoid B from synthetic azedaralide. Chem. Commun. 47, 2258.

(87) Mak, J. Y. W.;Williams, C. M. (2012) Enantioselective total synthesis of (-)-neovibsanin G and (-)-14-epi-neovibsanin G. Chem. Commun. 48, 287.

(88) Mirzayans, P.M.; Pouwer, R.H.; Williams, C.M.; Bernhardt, P.V. (2012) Stereocontrolled 1 Synthesis of the cis-Hydroxydecalin System: Towards Biologically Active 19-nor-Clerodanes. Eur. J. Org. Chem.1633–1638.

(89) Mak, J. Y. W.;Williams, C. M. (2012) Total Synthesis of (-)-Neovibsanin G and (-)-14-epi-Neovibsanin G: Towards the Total Synthesis of 15-O-Methylneovibsanin F and 14-epi-15-O-Methylneovibsanin F. Eur. J. Org. Chem. 2001-2012.

(90) Ko, E. J.; Williams, C. M.; Savage, G. P.; Tsanaktsidis, J. (2012) Reductive Radical Decarboxylation of Aliphatic Carboxylic Acids  Org. Synth. 89, 471-479.

(91) Aiken, K.; Eger, W.; Williams, C.M.; Spencer, C.; Zercher, C. (2012) A Combined DFT and NMR Investigation of the Zinc Organometallic Intermediate Proposed in the Syn-Selective Tandem Chain Extension-Aldol Reaction of beta-Keto Esters. J. Org. Chem. 77, 5942–5955.

(92) Williams, C.M. (2012) 2nd International Collaborative and Cooperative Chemistry Symposium. Aust. J. Chem. 65, 1260.

(93) Faber, J. M.; Eger, W.A.; Williams, C.M. (2012) Enantioselective Total Synthesis of the Mexicanolides: Khayasin, Proceranolide, and Mexicanolide. J. Org. Chem. 77, 8913.

(94) COVER Article Khairallah, G.N.; Williams, C. M.; Chow, S.; O Hair. R. A. J. (2013) spsp3 Coupling reactions of alkynylsilver cations, RCuCAg2+ (R = Me and Ph) with allyliodide. Dalton Trans. 42, 9462-9467.

(95) Khairallah, G. N.; Saleeba, K. A.; Chow, S.; Eger, W.; Williams, C. M.; O'Hair, R. A. J. (2013) CH and CC bond activation reactions in silver alkynyl cluster cations, RCCAg2+ Int. J. Mass Spect. , 354-355, 229-234.

(96) Ho, J.; Zheng, J.; Meana-Paneda, R.; Truhlar, D. G.; Ko, E. J.; Savage, G. P.; Williams, C. M.; Coote, M. L.; Tsanaktsidis, J. (2013) Chloroform as a Hydrogen Atom Donor in Barton Reductive Decarboxylation Reactions. J. Org. Chem. 78, 6677-6687.

(97) Savchenko, A. I.; Williams, C. M. (2013) The Anti-Bredt Red Flag! Reassignment of Neoveratrenone. Eur. J. Org. Chem. 7263-7265.

(98) Linsenmeier, A. M.; Williams, C. M.; Brase, S. (2013) Photochemical Synthesis of Phenanthridines: Exploring Fluoro and Protected Catechol Substitution. Eur. J. Org. Chem. 3847-3856.

(99) W. Eger, E. Anders, C. M. Williams, (2014) Mechanistic Aspects of the Lycopodine Michael-Claisen Domino Cyclisation. J. Mol. Model 20, 2173.

(100) Williams, C.M.; Wentrup, C. (2014) 6th Heron Island Conference on Reactive Intermediates and Unusual Molecules. Aust. J. Chem. 67, 317–319.

(101) L. A. Maslovskaya, A. I. Savchenko, E. H. Krenske, C. J. Pierce, V. A. Gordon, P. W. Reddell, P. G. Parsons, C. M. Williams (2014) EBC-219: A New Diterpene Skeleton – Crotinsulidane – from the Australian Rainforest Containing a Bridgehead Double Bond. Angew. Chem. Int. Ed. 53, 7006 –7009.

(102) P. M. Mirzayans, E. H. Krenske, Williams, C.M. (2014) Nonstabilized Azomethine Ylids from N-Oxides: Unraveling the Deprotonation of N-Methylmorpholine N-Oxide. Aust. J. Chem. 67, 1309.

(103) Maslovskaya, L., Savchenko, A.; Parsons, P.; Pierce, C.; Gordon, V.; Reddell, P.; Williams, C.M. (2014) : Unprecedented 1,14-seco-crotofolanes from Croton insularis: Oxidative Cleavage of Crotofolin C via Putative homo-Baeyer-Villiger Rearrangement. Chem. Eur. J., 20, 14226.

(104) Maslovskaya, L. A.; Savchenko, A. I.; Krenske, E. H.; Gordon, V. A.; Reddell, P. W.; Pierce, C. J.; Parsons, P. G.; Williams, C. M. (2014), Croton insularis Introduces the seco-Casbane class with EBC-329 and the First Casbane Endoperoxide EBC-324 Chem. Comm. 50, 12315.

(105) Maslovskaya, L. A.; Savchenko, A. I.; Gordon, V. A.; Reddell, P. W.; Pierce, C. J.; Parsons, P. G.; Williams, C.M. (2015), EBC-316, 325–327, and 345: New Pimarane Diterpenes from Croton insularis Found in the Australian Rainforest. Aust. J. Chem., 68, 652–659.

(106) Moore, P. W.; Mirzayans, P. M.; Williams, C. M. (2015), NMO·TPB: A Selectivity Variation on the Ley-Griffith TPAP Oxidation. Chem. Eur. J. 2015, 21, 3567 – 3571.

(107) C. D. G. Read, P. W. Moore, C. M. Williams (2015): TMEDAO2 Facilitates Atom Economical/Open Atmosphere Ley–Griffith (TPAP) Tandem Oxidation‐Wittig Reactions. Green Chem. 17, 4537.

(108) E. H. Krenske, C. M. Williams (2015): Do Anti-Bredt Natural Products Exist? Olefin Strain Energy as a Predictor of Isolability. Angew. Chem. Int. Ed. 54, 10608-10612.

(109) L. Y. Huang, D. Y Tsui, C. M. Williams, B. D. Wyse, M. T. Smith (2015): The Furoxan Nitric Oxide Donor, PRG150, Evokes Dose-Dependent Analgesia in a Rat Model of Painful Diabetic Neuropathy (PDN). Clin. Exp. Pharmacol. Physiol. 42, 921-929.

(110) T. Krainz, S. Chow, N. Korica, P. V. Bernhardt, G. M. Boyle, P. G. Parsons, H. M. L. Davies, C. M. Williams (2016): Rhodium-Catalysed [4+3] Cycloaddition to Furans: Direct Access to Functionalised Bicyclo[5.3.0]decane Derivatives. Eur. J. Org. Chem. 41-44.

(111) L. A. Maslovskaya, A. I. Savchenko, V. A. Gordon, P. W. Reddell, C. J. Pierce, P. G. Parsons, C. M. Williams (2016) : New Seco-Casbanes from the Australian Rainforest: ECD Predictions Key for Determining Remote Absolute Configuration. Eur. J. Org. Chem. on-line early view.

(112) B. A. Chalmers, H. Xing, S. Houston, C. Clark, S. Ghassabian, A. Kuo, B. Cao, A. Reitsma, C.-E. P. Murray, J. E. Stok, G. M. Boyle, C. J. Pierce, S. W. Littler, D. A. Winkler, P. V. Bernhardt, C. Pasay, J. J. DeVoss, J. McCarthy, P. G. Parsons, G. H. Walter, M. T. Smith, H. M. Cooper, S. K. Nilsson, J. Tsanaktsidis, G. P. Savage, C. M. Williams (2016) : Validation of Eaton’s Cubane for Benzene Bioisostere Conjecture. Angew. Chem. Int. Ed. on-line early view.

(113) J. E. Stok, S. Chow, E. H. Krenske, C. Farfan Soto, C. Matyas, R. A. Poirier, C. M. Williams, J. J. De Voss (2016) : Direct Observation of an Oxepin from a Bacterial Cytochrome P450 Catalyzed Oxidation. Chem. Eur. J. on-line early view.

(114) L. A. Maslovskaya, A. I. Savchenko, V. A. Gordon, P. W. Reddell, C. J. Pierce, P. G. Parsons, C. M. Williams (2016) : EBC-318 and 339: Bicyclo[10.2.1]alkanes from Croton insularisRSC Adv6, 25110.

(115) P. W. Moore, Y. Jiao, P. M. Mirzayans, Q. S. L. Ng, J. P. Hooker, C. M. Williams (2016) : Selectivity Modulation of the Ley–Griffith TPAP Oxidation with N-Oxide Salts. Submitted

(116) T. Lonhienne, A. Nouwens, C. M. Williams, J. A. Fraser, Y.-T. Lee, N. P. West, L. W. Guddat (2016) : Commercial Herbicides Can Trigger the Oxidative Inactivation of Their Target, Acetohydroxyacid Synthase. Angew. Chem. Int. Ed. on-line early view.

(117) San, A.; Joyce, D.; Hofman, P.; Macnish, A.; Webb, R.; Matovic, N.; Williams, C. M.; De Voss, J. J.; Smyth, H. (2016) : Stable isotope dilution assay (SIDA) and HS-SPME-GCMS quantification of key aroma volatiles for fruit of two Australian mango cultivars. Submitted.

(118) Pippin, A.; Mohd Arshad, Z.; Voll, R.; Nye, J.; Ghassabian, S.; Williams, C.M.; Mancini, A.; Liotta, D.; Smith, M.; Goodman, M. (2016) Vitro Metabolic Stability and In Vivo Biodistribution of 3-Methyl-4-Furoxancarbaldehyde Using PET Imaging in Rats” Submitted.