A semisynthetic approach has been used for the preparative formation of eight dimeric procyanidins from B-type. As starting material for the semisynthesis, polymeric procyanidins from industrial by-products were applied. Under acidic conditions the interflavanoid linkages of the polymeric procyanidins are cleaved and the liberated (-)-epicatechin can react with nucleophiles, such as (+)- catechin or (-)-epicatechin. In this way, dimeric procyanidins are formed. The reaction mixtures of the semisynthesis can be successfully fractionated with high-speed countercurrent chromatography (HSCCC), and the structure elucidation was done by NMR spectroscopy. Moreover, a first approach to semisynthesize A-Type procyanidins from B-types will be shown.

About School research seminars

Seminars cover all aspects of chemistry and molecular biosciences and are delivered by visiting national and international academics. PhD completion seminars are also incorporated into the program.

Seminars are usually held in person and via zoom. All are welcome to attend.  



Sir James Foots Building, Seminar Room (47A-141)