Bowl-Shaped Catalysts for Site-Selective C-H Functionalization
Abstract
For some time, we have been interested in developing chiral dirhodium catalysts for site-selective C-H functionalization by means of rhodium carbene-induced C-H insertion.1,2 This presentation will describe a series of new bowl-shaped catalysts, which are capable of distinguishing between very similar C-H bonds in a highly selective manner. This approach for C-H functionalization offers new strategic opportunities to access natural products and targets of pharmaceutical interest, and some of our recent accomplishments in these areas will be described.
References
- Dirhodium Tetracarboxylates: Privileged Catalysts for Selective Intermolecular C-H Functionalization, Davies, H. M. L.; Liao K. Nature Rev. Chem. 2019, 3, 347-360.
- Finding Opportunities from Surprises and Failures. Development of Rhodium-Stabilized Donor/Acceptor Carbenes and their Application to Catalyst-Controlled C-H Functionalization, Davies, H. M L. J. Org. Chem. 2019, 84, 12722-12745.
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