Dr Milos Tanurdzic
Senior Lecturer
School of Chemistry and Molecular Biosciences
+61 7 336 52045
Researcher biography
My research interests are at the intersection of plant developmental genetics, functional genomics, and molecular and systems biology, following my doctoral and postdoctoral training in the USA. The research effort in my group is focused on harnessing transformative genomics technology to understand the genetics of plant development, and to discover regulatory mechanisms coordinating plant growth and development. We utilize a variety of plant species in our research, from the model plant organism Arabidopsis to grain and horticultural crops like wheat, mango, avocado and macadamia. We employ a range of techniques based on high throughout DNA sequencing to explore gene expression, chromatin accessibility and modifications from single cell to whole plant levels, bioinformatics and computational biology tools to infer genetic components of gene regulatory networks, as well as gene editing technology to evaluate phenotipic consequences of perturbations in gene regulatory networks.
Book Chapters
Kerr, Stephanie C., Gaiti, Federico and Tanurdzic, Milos (2019). De novo plant transcriptome assembly and annotation using illumina RNA-seq reads. Plant long non-coding RNAs: methods and protocols. (pp. 265-275) edited by Julia A. Chekanova and Hsiao-Lin V. Wang. New York, NY, United States: Springer Nature. doi: 10.1007/978-1-4939-9045-0_16
Finigan, Patrick, Tanurdzic, Milos and Martienssen, Robert A. (2012). Origins of novel phenotypic variation in polyploids. Polyploidy and Genome Evolution. (pp. 57-76) edited by Pamela S. Soltis and Douglas E. Soltis. Heidelberg, Germany: Springer. doi: 10.1007/978-3-642-31442-1_4
Rutherford, George, Tanurdzic, Milos, Hasebe, Mitsuyasu and Banks, Jo Ann (2012). Reverse Genetic Analyses of Gene Function in Fern Gametophytes. Vascular Plants and Paleobotany. (pp. 54-66) edited by Philip Stewart and Sabine Globig. Point Pleasant, NJ, United States: CRC Press. doi: 10.1201/b12226-6
Journal Articles
Humphreys, Jazmine L., Beveridge, Christine A. and Tanurdžić, Miloš (2024). Strigolactone induces D14 ‐dependent large‐scale changes in gene expression requiring SWI /SNF chromatin remodellers. The Plant Journal, 119 (3), 1526-1542. doi: 10.1111/tpj.16873
Kerr, Stephanie C., Shehnaz, Saiyara, Paudel, Lucky, Manivannan, Mekaladevi S., Shaw, Lindsay M., Johnson, Amanda, Velasquez, Jose Teodoro J., Tanurdžić, Miloš, Cazzonelli, Christopher I., Varkonyi-Gasic, Erika and Prentis, Peter J. (2024). Advancing tree genomics to future proof next generation orchard production. Frontiers in Plant Science, 14 1321555, 1-23. doi: 10.3389/fpls.2023.1321555
Hellens, Alicia M., Humphreys, Jazmine L., Fichtner, Franziska, Tanurdžić, Miloš, Beveridge, Christine A. and Barbier, François F. (2023). Genome-wide identification of accessible chromatin regions by ATAC-seq upon induction of the transcription factor bZIP11 in Arabidopsis. Scientific Data, 10 (1) 490, 490. doi: 10.1038/s41597-023-02395-6
Zhang, Yan, Andrews, Haylie, Eglitis-Sexton, Judith, Godwin, Ian, Tanurdžić, Miloš and Crisp, Peter A. (2022). Epigenome guided crop improvement: current progress and future opportunities. Emerging Topics in Life Sciences, 6 (2), 141-151. doi: 10.1042/etls20210258
Paudel, Lucky, Kerr, Stephanie, Prentis, Peter, Tanurdžić, Miloš, Papanicolaou, Alexie, Plett, Jonathan M. and Cazzonelli, Christopher I. (2022). Horticultural innovation by viral-induced gene regulation of carotenogenesis. Horticulture Research, 9 uhab008, 1-19. doi: 10.1093/hr/uhab008
Tanurdžić, Miloš (2021). Profiling the endosperm, one nucleus at a time. Nature Plants, 7 (6), 710-711. doi: 10.1038/s41477-021-00945-7
Borges, Filipe, Donoghue, Mark T.A., LeBlanc, Chantal, Wear, Emily E., Tanurdžić, Milos, Berube, Benjamin, Brooks, Ashley, Thompson, William F., Hanley-Bowdoin, Linda and Martienssen, Robert A. (2021). Loss of small-RNA-directed DNA methylation in the plant cell cycle promotes germline reprogramming and somaclonal variation. Current Biology, 31 (3), 591-600.e4. doi: 10.1016/j.cub.2020.10.098
Ranawaka, Buddhini, Tanurdzic, Milos, Waterhouse, Peter and Naim, Fatima (2020). An optimised chromatin immunoprecipitation (ChIP) method for starchy leaves of Nicotiana benthamiana to study histone modifications of an allotetraploid plant. Molecular Biology Reports, 47 (12), 9499-9509. doi: 10.1007/s11033-020-06013-1
Popovic, Iva, Bierne, Nicolas, Gaiti, Federico, Tanurdžić, Miloš and Riginos, Cynthia (2020). Pre‐introduction introgression contributes to parallel differentiation and contrasting hybridization outcomes between invasive and native marine mussels. Journal of Evolutionary Biology, 34 (1) jeb.13746, 175-192. doi: 10.1111/jeb.13746
Chabikwa, Tinashe G., Barbier, Francois F., Tanurdzic, Milos and Beveridge, Christine A. (2020). De novo transcriptome assembly and annotation for gene discovery in avocado, macadamia and mango. Scientific Data, 7 (1) 9, 9. doi: 10.1038/s41597-019-0350-9
Li, Ying, Brooks, Matthew, Yeoh-Wang, Jenny, McCoy, Rachel M, Rock, Tara M, Pasquino, Angelo, Moon, Chang In, Patrick, Ryan M, Tanurdzic, Milos, Ruffel, Sandrine, Widhalm, Joshua R, McCombie, W Richard and Coruzzi, Gloria M (2020). SDG8-mediated histone methylation and RNA processing function in the response to nitrate signaling. Plant Physiology, 182 (1), 215-227. doi: 10.1104/pp.19.00682
Barbier, François F., Chabikwa, Tinashe G., Ahsan, Muhammad U., Cook, Stacey E., Powell, Rosanna, Tanurdzic, Milos and Beveridge, Christine A. (2019). A phenol/chloroform-free method to extract nucleic acids from recalcitrant, woody tropical species for gene expression and sequencing. Plant Methods, 15 (1) 62, 62. doi: 10.1186/s13007-019-0447-3
Ahsan, Muhammad Umair, Hayward, Alice, Irihimovitch, Vered, Fletcher, Stephen, Tanurdzic, Milos, Pocock, Alexander, Beveridge, Christine Anne and Mitter, Neena (2019). Juvenility and vegetative phase transition in tropical/subtropical tree crops. Frontiers in Plant Science, 10 729, 729. doi: 10.3389/fpls.2019.00729
Medici, Anna, Szponarski, Wojciech, Dangeville, Pierre, Safi, Alaeddine, Dissanayake, Indeewari Madhubhashini, Saenchai, Chorpet, Emanuel, Amélie, Rubio, Vicente, Lacombe, Benoît, Ruffel, Sandrine, Tanurdzic, Milos, Rouached, Hatem and Krouk, Gabriel (2019). Identification of molecular integrators shows that nitrogen actively controls the phosphate starvation response in plants. The Plant Cell, 31 (5), 1171-1184. doi: 10.1105/tpc.18.00656
Atallah, Nadia M., Vitek, Olga, Gaiti, Federico, Tanurdzic, Milos and Banks, Jo Ann (2018). Sex determination in is accompanied by transcriptome changes that drive epigenetic reprogramming of the young gametophyte. G3: Genes, Genomes, Genetics, 8 (7), 2205-2214. doi: 10.1534/g3.118.200292
Gaiti, Federico, Degnan, Bernard M and Tanurdžić, Miloš (2018). Long non-coding regulatory RNAs in sponges and insights into the origin of animal multicellularity. RNA Biology, 15 (6), 1-22. doi: 10.1080/15476286.2018.1460166
Gaiti, Federico, Hatleberg, William L., Tanurdžić, Miloš and Degnan, Bernard M. (2018). Sponge Long Non-Coding RNAs Are Expressed in Specific Cell Types and Conserved Networks. Non-Coding RNA, 4 (1) 6, 6. doi: 10.3390/ncrna4010006
Arras, Samantha D. M., Ormerod, Kate L., Erpf, Paige E., Espinosa, Monica I., Carpenter, Alex C., Blundell, Ross D., Stowasser, Samantha R., Schulz, Benjamin L., Tanurdzic, Milos and Fraser, James A. (2017). Convergent microevolution of Cryptococcus neoformans hypervirulence in the laboratory and the clinic. Scientific Reports, 7 (1) 17918, 1-14. doi: 10.1038/s41598-017-18106-2
Gaiti, Federico, Calcino, Andrew D., Tanurdzic, Miloš and Degnan, Bernard M. (2017). Origin and evolution of the metazoan non-coding regulatory genome. Developmental Biology, 427 (2), 193-202. doi: 10.1016/j.ydbio.2016.11.013
Arras, Samantha D. M., Chitty, Jessica L., Wizrah, Maha S. I., Erpf, Paige E., Schulz, Benjamin L., Tanurdzic, Milos and Fraser, James A. (2017). Sirtuins in the phylum Basidiomycota: A role in virulence in Cryptococcus neoformans. Scientific Reports, 7 (1) 46567, 46567.1-46567.14. doi: 10.1038/srep46567
Gaiti, Federico, Jindrich, Katia, Fernandez-Valverde, Selene L., Roper, Kathrein E., Degnan, Bernard M. and Tanurdzic, Milos (2017). Landscape of histone modifications in a sponge reveals the origin of animal cis-regulatory complexity. Elife, 6 e22194. doi: 10.7554/eLife.22194
Kerr, Stephanie C., Gaiti, Federico, Beveridge, Christine A. and Tanurdzic, Milos (2017). De novo transcriptome assembly reveals high transcriptional complexity in Pisum sativum axillary buds and shows rapid changes in expression of diurnally regulated genes. BMC Genomics, 18 (1) 221, 221. doi: 10.1186/s12864-017-3577-x
Gaiti, Federico, Fernandez-Valverde, Selene L., Nakanishi, Nagayasu, Calcino, Andrew D., Yanai, Itai, Tanurdzic, Milos and Degnan, Bernard M. (2015). Dynamic and Widespread lncRNA Expression in a Sponge and the Origin of Animal Complexity. Molecular Biology and Evolution, 32 (9), 2367-2382. doi: 10.1093/molbev/msv117
Li, Ying, Mukherjee, Indrani, Thum, Karen E., Tanurdzic, Milos, Katari, Manpreet S., Obertello, Mariana, Edwards, Molly B., McCombie, W. Richard, Martienssen, Robert A. and Coruzzi, Gloria M. (2015). The histone methyltransferase SDG8 mediates the epigenetic modification of light and carbon responsive genes in plants. Genome Biology, 16 (79) 79, 1-15. doi: 10.1186/s13059-015-0640-2
Thiebaut, Flavia, Grativol, Clı´cia, Tanurdzic, Milos, Carnavale-Bottino, Mariana, Vieira, Tauan, Motta, Mariana Romeiro, Rojas, Cristian, Vincentini, Renato, Chabregas, Sabrina Moutinho, Hemerly, Adriana Silva, Martienssen, Robert A. and Ferreira, Paulo Cavalcanti Gomes (2014). Differential sRNA regulation in leaves and roots of sugarcane under water depletion. PLoS One, 9 (4) e93822, e93822.1-e93822.17. doi: 10.1371/journal.pone.0093822
Vidal, Elena A., Moyano, Tomás C., Krouk, Gabriel, Katari, Manpreet S., Tanurdzic, Milos, McCombie, W. Richard, Coruzzi, Gloria M. and Gutierrez, Rodrigo A. (2013). Integrated RNA-seq and sRNA-seq analysis identifies novel nitrate-responsive genes in Arabidopsis thaliana roots. BMC Genomics, 14 (1) 701, 701.1-701.15. doi: 10.1186/1471-2164-14-701
Thiebaut, Flavia, Grativol, Clicia, Carnavale-Bottino, Mariana, Rojas, Cristian Antonio, Tanurdzic, Milos, Farinelli, Laurent, Martienssen, Robert A., Hemerly, Adriana Silva and Gomes Ferreira, Paulo Cavalcanti (2012). Computational identification and analysis of novel sugarcane microRNAs. BMC Genomics, 13 (1) 290, 290.1-290.14. doi: 10.1186/1471-2164-13-290
Banks, Jo Ann, Nishiyama, Tomoaki, Hasebe, Mitsuyasu, Bowman, John L., Gribskov, Michael, dePamphilis, Claude, Albert, Victor A., Aono, Naoki, Aoyama, Tsuyoshi, Ambrose, Barbara A., Ashton, Neil W., Axtell, Michael J., Barker, Elizabeth, Barker, Michael S., Bennetzen, Jeffrey L., Bonawitz, Nicholas D., Chapple, Clint, Cheng, Chaoyang, Correa, Luiz Gustavo Guedes, Dacre, Michael, DeBarry, Jeremy, Dreyer, Ingo, Elias, Marek, Engstrom, Eric M., Estelle, Mark, Feng, Liang, Finet, Cedric, Floyd, Sandra K., Frommer, Wolf B. ... Grigoriev, Igor V. (2011). The Selaginella Genome Identifies Genetic Changes Associated with the Evolution of Vascular Plants. Science, 332 (6032), 960-963. doi: 10.1126/science.1203810
Lee, Tae-Jin, Pascuzzi, Pete E., Settlage, Sharon B., Shultz, Randall W., Tanurdzic, Milos, Rabinowicz, Pablo D., Menges, Margit, Zheng, Ping, Main, Dorrie, Murray, James A. H., Sosinski, Bryon, Allen, George C., Martienssen, Robert A., Hanley-Bowdoin, Linda, Vaughn, Matthew W. and Thompson, William F. (2010). Arabidopsis thaliana chromosome 4 replicates in two phases that correlate with chromatin state. PLoS Genetics, 6 (6) ARTN e1000982, e1000982.1-e1000982.18. doi: 10.1371/journal.pgen.1000982
Slotkin, R. Keith, Vaughn, Matthew, Borges, Filipe, Tanurdzic, Milos, Becker, Joerg D., Feijo, Jose A. and Martienssen, Robert A. (2009). Epigenetic reprogramming and small RNA silencing of transposable elements in pollen. Cell, 136 (3), 461-472. doi: 10.1016/j.cell.2008.12.038
Tanurdzic, Milos, Vaughn, Matthew W., Jiang, Hongmei, Lee, Tae-Jin, Slotkin, R. Keith, Sosinski, Bryon, Thompson, William F., Doerge, R. W. and Martienssen, Robert A. (2008). Epigenomic consequences of immortalized plant cell suspension culture. PLoS Biology, 6 (12), 2880-2895. doi: 10.1371/journal.pbio.0060302
Masuda, Hana Paula, Cabral, Luiz Mors, De Veylder, Lieven, Tanurdzic, Milos, Engler, Janice de Almeida, Geelen, Danny, Inze, Dirk, Martienssen, Robert A., Ferreira, Paulo C. G. and Hemerly, Adriana S. (2008). ABAP1 is a novel plant Armadillo BTB protein involved in DNA replication and transcription. EMBO Journal, 27 (20), 2746-2756. doi: 10.1038/emboj.2008.191
Gutierez, Rodrigo A., Stokes, Trevor L., Thum, Karen, Xu, Xiaodong, Obertello, Mariana, Katari, Manpreet S., Tanurdzic, Milos, Dean, Alexis, Nero, Dannion C., McClung, C. Robertson and Coruzzi, Gloria M. (2008). Systems approach identifies an organic nitrogen-responsive gene network that is regulated by the master clock control gene CCA1. Proceedings of the National Academy of Sciences of the United States of America, 105 (12), 4939-4944. doi: 10.1073/pnas.0800211105
Vaughn, Matthew W., Tanurdzic, Milos, Lippman, Zachary, Jiang, Hongmei, Carrasquillo, Robert, Rabinowicz, Pablo D., Dedhia, Neilay, McCombie, W. Richard, Agier, Nicolas, Bulski, Agnes, Colot, Vincent, Doerge, R. W. and Martienssen, Robert A. (2007). Epigenetic natural variation in Arabidopsis thaliana. PloS Biology, 5 (7), 1617-1629. doi: 10.1371/journal.pbio.0050174
Vaughn, Matthew W., Tanurdzic, Milos and Martienssen, Rob (2005). Replication, repair, and reactivation. Developmental Cell, 9 (6), 724-725. doi: 10.1016/j.devcel.2005.11.011
Weng, Jing-Ke, Tanurdzic, Milos and Chapple, Clint (2005). Functional analysis and comparative genomics of expressed sequence tags from the lycophyte Selaginella moellendorffii. BMC Genomics, 6 (7-8) 85, 85.1-85.13. doi: 10.1186/1471-2164-6-85
Wang, Wenming, Tanurdzic, Milos, Luo, Meizhong, Sisneros, Nicholas, Kim, Hye Ran, Weng, Jing-Ke, Kudrna, Dave, Mueller, Christopher, Arumuganathan, K., Carlson, John, Chapple, Clint, de Pamphilis, Claude, Mandoli, Dina, Tomkins, Jeff, Wing, Rod A. and Banks, Jo Ann (2005). Construction of a bacterial artificial chromosome library from the spikemoss Selaginella moellendorffii: a new resource for plant comparative genomics. BMC Plant Biology, 5 (1) 10, 10.1-10.8. doi: 10.1186/1471-2229-5-10
Rutherford, George, Tanurdzic, Milos, Hasebe, Mitsuyasu and Banks, Jo Ann (2004). A systemic gene silencing method suitable for high throughput, reverse genetic analyses of gene function in fern gametophytes. BMC Plant Biology, 4 (1) 6. doi: 10.1186/1471-2229-4-6
Tanurdzic, Milos and Banks, Jo Ann (2004). Sex-determining mechanisms in land plants. Plant Cell, 16 (Supplement 1), S61-S71. doi: 10.1105/tpc.016667
Tanurdzic, M., Obreht, D., Vapa, L. and Davidovic, M. (2004). Polyglutamine-encoding microsatellite contributes to LMW GS diversity in Triticum monococcum. Cereal Research Communications, 32 (3), 301-308.
Conference Papers
Martienssen, R. A., Kloc, A., Slotkin, R. K. and Tanurdzic, M. (2008). Epigenetic inheritance and reprogramming in plants and fission yeast. 73rd Cold Spring Harbor Symposium on Quantitative Biology, Cold Spring Harbor, NY, New York, 28 May - 2 June 2008. Woodbury, NY, United States: Cold Spring Harbor Laboratory Press. doi: 10.1101/sqb.2008.73.062
Martienssen, Rob, Zaratiegui, Mikel, Irvine, Danielle, Goto, Derek, Slotkin, Keith, Tanurdzic, Milos, Lippman, Zach, Vaughn, Matt, May, Bruce, Cande, Zac, Colot, Vincent and Doerge, R. W. (2007). Silent running: RNA interference and heterochromatic modification. 16th International Chromosome Conference (ICC 16), Amsterdam, Netherlands, 25-29 August 2007. Dordrecht, Netherlands: Springer. doi: 10.1007/s10577-007-1912-9
Tanurdžić, Miloš, Doerge, Rebecca and Martienssen, Robert (2005). Microarrays: Design, analysis, and applications in functional genomics. doi: 10.2298/A000503124T
Craig, B. A., Vitek, O., Black, M. A., Tanurdzic, M. and Doerge, R. W. (2001). Designing microarrays. 13th Annual Conference on Applied Statistics in Agriculture, Manhattan, Kansas, United States, April 29 - May 1, 2001. Manhattan, Kansas, United States: New Prairie Press. doi: 10.4148/2475-7772.1223