School of Chemistry and Molecular Biosciences

Professor Vito Ferro

BSc (Hons), PhD (W.Aust.) Chemistry, GCertMgt (TechMgt) (Deakin) Technology Management
Professor & Chair, Health, Safety and Wellness Committee
School of Chemistry and Molecular Biosciences
+61 7 334 69598
Chemistry Building (68), Room 1014
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Primary research interest

Carbohydrate chemistry, medicinal chemistry, drug discovery

Additional roles

Medicinal Chemistry Theme Leader
Chair, Health Safety and Wellness Committee

About me

After completing my undergraduate and PhD studies at the University of WA I was a postdoctoral fellow at the Carlsberg Laboratory in Denmark (1992-94) with 2022 Nobel Laureate Morten Meldal, and then at the University of British Columbia in Canada (1994-96) with Steve Withers. I then returned to Australia and spent 12 years in the biotechnology industry with Progen Pharmaceuticals Ltd where I held various positions including Director of Drug Discovery. In 2008 I moved to QUT as a Principal Research Fellow and Deputy Program Leader in the CRC for Polymers before joining The University of Queensland in 2010.

Research focus and collaborations

My research interests are in carbohydrate and medicinal chemistry, with a focus on the synthesis of compounds to probe and/or inhibit carbohydrate-protein interactions. Of particular interest is heparan sulfate (HS) and the development of HS mimetics as potential drugs for a range of diseases. Previous work in this area resulted in the discovery of pixatimod (PG545), a potent inhibitor of angiogenesis and metastasis that is currently in Phase I clinical trials in cancer patients and has shown promise as a treatment for COVID-19.

Current research interests include: pharmacological chaperone therapy for lysosomal storage diseases such as Sanfilippo syndrome; HS mimetics as antiviral agents; glycoconjugates as antibacterial agents and vaccine adjuvants; and new synthetic routes to rare L-sugars.

Projects

  • Pharmacological chaperone therapy for lysosomal storage diseases
  • Synthetic heparin/HS mimetics as inhibitors of virus-cell attachment
  • Synthesis of heparanase inhibitors with improved specificity
  • Antibiotic conjugates: joining together to fight antimicrobial resistance
  • Radical new routes to rare L-sugars

Collaborators

International

  • Prof Israel Vlodavsky (Technion, Israel)
  • Prof Gideon Davies (University of York, UK)
  • Prof David Vocadlo (Simon Fraser University, Canada)
  • Prof Gerd Bendas (University of Bonn, Germany)
  • Prof Jin-ping Li (Uppsala University, Sweden)
  • Dr Edwin Yates (University of Liverpool, UK)
  • Prof Jeremy Turnbull, Mark Skidmore (Keele University, UK)
  • Dr Marco Guerrini (Ronzoni Institute, Italy)

National

  • Prof Kim Hemsley, Dr Adeline Lau (Flinders University)
  • Dr Neha Gandhi (QUT)
  • A/Prof Jan Kaslin (Monash University)
  • A/Prof Jennifer Wilson (Griffith University Gold Coast)
  • Prof Murray Baker (University of WA)

Local 

Funded projects

  • ARC Discovery Grant (2022-2024). Opening Up Access to L-Sugars through a Synergy of Experiment and Theory. Total value of the grant: $366,000
  • NHMRC IDEAS Grant (2021-2023). Antibiotic Conjugates: Joining Together to Fight Antimicrobial Resistance. Total value of grant: $697,674
  • Sanfilippo Children's Foundation Incubator Grant (2021). Development of pharmacological chaperones for MPS IIIB. Total value of grant: $94,500
  • National MPS Society (2021-2022). Towards pharmacological chaperone therapy for MPS II. Total value of grant: $161,755.00
  • Sanfilippo Children’s Foundation Incubator Grant (2021). Targeting purinergic pathways in the brain to ameliorate inflammation and restore synaptic health in Sanfilippo syndrome. Total value of grant: $90,000
  • AID Seed Grant (2021) Next generation COVID-19 vaccines and antivirals. Total value of grant: $50,000
  • Sanfilippo Children's Foundation Translational Grant (2020-2021). Small molecule drug therapy for MPS IIIA. Total value of grant: $482,932
  • Sanfilippo IIIB Syndrome Research (2020). Philanthropic Donation. Total value of donation: $81,000
  • Sanfilippo Children's Foundation Incubator Grant/UQ SWIF Grant (2018-2019). Pharmacological chaperones for MPS IIIA. Total value of grant: $159,926.30
  • ARC Discovery Grant (2017-2019). Heparan sulfate mimetics: versatile tools for chemical biology. Total value of grant: $435,000

Teaching interests

  • CHEM2050/2901 - Intermediate Chemistry 1/Advanced Intermediate Chemistry 1
  • CHEM3001 - Organic Chemistry
  • CHEM3020 - Medicinal Chemistry & Chemical Biology 
  • CHEM1221 - General, Organic & Biological Chemistry 

Achievements and awards

  • Fellow of the Royal Australian Chemical Institute
  • Member of the Australian Infectious Diseases Research Centre
  • Member of the Australian Glycoscience Society
  • Member of the American Chemical Society
  • 2014 SCMB Award for Outstanding Contributions to Engagement

Featured publications

Researcher biography

Carbohydrate chemistry, medicinal chemistry, drug discovery

Vito Ferro is a Professor in the School of Chemistry & Molecular Biosciences. His research interests are in the area of synthetic carbohydrate chemistry, and drug design and development.

Publications

Book Chapters (4)
Journal Articles (125)
Conference Papers (5)
Patents (4)

Book Chapters

Hammond, Edward and Ferro, Vito (2023). An enzymatic activity assay for heparanase that is useful for evaluating clinically relevant inhibitors and studying kinetics. Methods in molecular biology. (pp. 227-238) edited by Nikos K. Karamanos. New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-2946-8_16
Mohamed, Shifaza, He, Qi Qi, Singh, Arti A. and Ferro, Vito (2020). Mucopolysaccharidosis type II (Hunter syndrome): clinical and biochemical aspects of the disease and approaches to its diagnosis and treatment. Advances in carbohydrate chemistry and biochemistry. (pp. 71-118) edited by David C. Baker. Cambridge, MA, United States: Academic Press. doi: 10.1016/bs.accb.2019.09.001
Mohamed, Shifaza and Ferro, Vito (2015). Synthetic approaches to l-Iduronic Acid and l-Idose: key building blocks for the preparation of glycosaminoglycan oligosaccharides. Advances in carbohydrate chemistry and biochemistry. (pp. 21-61) edited by David C. Baker and Derek Horton. Waltham, MA, United States: Academic Press. doi: 10.1016/bs.accb.2015.07.001
Hammond, E., Bytheway, I. and Ferro, V. (2006). Heparanase as a Target for Anticancer Therapeutics: New Developments and Future Prospects. New Developments in Therapeutic Glycomics. (pp. 251-282) edited by Maryse Delehedde and Hugues Lortat-Jacob. Trivandrum, India: Research Signpost.

Journal Articles

See, Nicholas W., Roseli, Ras Baizureen, Wimmer, Norbert, Le, Tri T., Krenske, Elizabeth H. and Ferro, Vito (2024). Origins of temperature‐dependent anomeric selectivity in glycosylations with an L‐idose thioglycoside. Chemistry – A European Journal, 30 (52) e202400331, e202400331. doi: 10.1002/chem.202400331
Pan, Yuchen, He, Qi Qi, Wimmer, Norbert and Ferro, Vito (2024). Synthesis of a Deuterated Disaccharide Internal Standard for LC-MS/MS Quantitation of Heparan Sulfate in Biological Samples. Carbohydrate Research, 545 109270, 109270. doi: 10.1016/j.carres.2024.109270
Mutch, Alexandra L., Yang, Jiankun, Ferro, Vito, A, Anitha and Grøndahl, Lisbeth (2024). Sulfated Alginate for Biomedical Applications. Macromolecular Bioscience, 24 (11), e2400237. doi: 10.1002/mabi.202400237
Chhabra, Mohit, Shanthamurthy, Chethan D., Kumar, Nanjudaswamy Vijendra, Mardhekar, Sandhya, Vishweshwara, Sharath S., Wimmer, Norbert, Modhiran, Naphak, Watterson, Daniel, Amarilla, Alberto A., Cha, Jonathan S., Beckett, James R., De Voss, James J., Kayal, Yasmin, Vlodavsky, Israel, Dorsett, Lauren R., Smith, Raymond A. A., Gandhi, Neha S., Kikkeri, Raghavendra and Ferro, Vito (2024). Amphiphilic heparinoids as potent antiviral agents against SARS-CoV-2. Journal of Medicinal Chemistry, 67 (14), 11885-11916. doi: 10.1021/acs.jmedchem.4c00487
Zhang, Guoqing, See, Nicholas W., Wimmer, Norbert, Godinez, Michael J., Cameron, Scott A., Furneaux, Richard H. and Ferro, Vito (2024). Site-Selective Photobromination of O-Acetylated Carbohydrates in Benzotrifluoride. Organic Letters, 26 (28), 5956-5960. doi: 10.1021/acs.orglett.4c01898
Nahain, Abdullah Al, Li, Jinlin, Modhiran, Naphak, Watterson, Daniel, Li, Jin-ping, Ignjatovic, Vera, Monagle, Paul, Tsanaktsidis, John, Vamvounis, George and Ferro, Vito (2024). Antiviral Activities of Heparan Sulfate Mimetic RAFT Polymers Against Mosquito-borne Viruses. ACS Applied Bio Materials, 7 (5), 2862-2871. doi: 10.1021/acsabm.3c01223
Mutch, Alexandra L., Ferro, Vito, A, Anitha and Grøndahl, Lisbeth (2024). Synthesis of sulfated alginate from its tributylammonium salt: Comparing the sulfating agents H2SO4-DCC and SO3·py. Carbohydrate Polymers, 324 121488, 1-9. doi: 10.1016/j.carbpol.2023.121488
Li, Binjie, Zhang, Tianji, Cao, Hui, Ferro, Vito, Li, Jinping and Yu, Mingjia (2023). Identification of a pentasaccharide lead compound with high affinity to the SARS-CoV-2 spike protein via in silico screening. International Journal of Molecular Sciences, 24 (22) 16115, 1-16. doi: 10.3390/ijms242216115
See, Nicholas W., Pierens, Gregory K., Krenske, Elizabeth and Ferro, Vito (2023). C-5 epimerisation of D-mannopyranosyl fluorides: the influence of anomeric configuration on radical reactivity. Synthesis, 56 (06), 966-974. doi: 10.1055/a-2149-4586
Rayner, Beth, Verderosa, Anthony D., Ferro, Vito and Blaskovich, Mark A. T. (2023). Siderophore conjugates to combat antibiotic-resistant bacteria. RSC Medicinal Chemistry, 14 (5), 800-822. doi: 10.1039/d2md00465h
Doherty, Gareth G., Ler, Geraldine Jia Ming, Wimmer, Norbert, Bernhardt, Paul V., Ashmus, Roger A., Vocadlo, David J., Armstrong, Zach W. B., Davies, Gideon J., Maccarana, Marco, Li, Jin-ping, Kayal, Yasmin and Ferro, Vito (2023). Synthesis of uronic acid 1‐Azasugars as putative inhibitors of α‐Iduronidase, β‐glucuronidase and heparanase. ChemBioChem, 24 (4) e202200619, 1-7. doi: 10.1002/cbic.202200619
Hemsley, Kim M., Beard, Helen, Doherty, Gareth G., Mubarokah, Siti, Nazri, Nazzmer and Ferro, Vito (2023). A prohibitin-targeting drug modifies aspects of disease in a mouse model of Sanfilippo syndrome. Molecular Genetics and Metabolism, 138 (2) 107145, 59-59. doi: 10.1016/j.ymgme.2022.107145
Boittier, Eric D., Wimmer, Norbert, Harris, Alexandria K., Schembri, Mark A. and Ferro, Vito (2022). Synthesis of a Gal-β-(1→4)-Gal disaccharide as a ligand for the fimbrial adhesin UcaD. Australian Journal of Chemistry, 76 (1), 30-36. doi: 10.1071/ch22158
Parafioriti, Michela, Ni, Minghong, Petitou, Maurice, Mycroft‐West, Courtney J., Rudd, Timothy R., Gandhi, Neha S., Ferro, Vito, Turnbull, Jeremy E., Lima, Marcelo A., Skidmore, Mark A., Fernig, David G., Yates, Edwin A., Bisio, Antonella, Guerrini, Marco and Elli, Stefano (2022). Evidence for multiple binding modes in the initial contact between SARS‐CoV‐2 spike S1 protein and cell surface glycans**. Chemistry – A European Journal, 29 (1) e202202599, e202202599. doi: 10.1002/chem.202202599
See, Nicholas W, Xu, Xiaowen and Ferro, Vito (2022). An improved protocol for the stereoselective synthesis of β-D-glycosyl fluorides from 2-O-acyl thioglycosides. The Journal of Organic Chemistry, 87 (21), 14230-14240. doi: 10.1021/acs.joc.2c01748
Lo, Martin W., Amarilla, Alberto A., Lee, John D., Albornoz, Eduardo A., Modhiran, Naphak, Clark, Richard J., Ferro, Vito, Chhabra, Mohit, Khromykh, Alexander A., Watterson, Daniel and Woodruff, Trent M. (2022). SARS-CoV-2 triggers complement activation through interactions with heparan sulfate. Clinical and Translational Immunology, 11 (8) e1413, e1413. doi: 10.1002/cti2.1413
Guimond, Scott E., Mycroft-West, Courtney J., Gandhi, Neha S., Tree, Julia A., Le, Thuy T., Spalluto, C. Mirella, Humbert, Maria V., Buttigieg, Karen R., Coombes, Naomi, Elmore, Michael J., Wand, Matthew, Nyström, Kristina, Said, Joanna, Setoh, Yin Xiang, Amarilla, Alberto A., Modhiran, Naphak, Sng, Julian D. J., Chhabra, Mohit, Young, Paul R., Rawle, Daniel J., Lima, Marcelo A., Yates, Edwin A., Karlsson, Richard, Miller, Rebecca L., Chen, Yen-Hsi, Bagdonaite, Ieva, Yang, Zhang, Stewart, James, Nguyen, Dung ... Turnbull, Jeremy E. (2022). Synthetic heparan sulfate mimetic pixatimod (PG545) potently inhibits SARS-CoV-2 by disrupting the spike–ACE2 interaction. ACS Central Science, 8 (5) acscentsci.1c01293, 527-545. doi: 10.1021/acscentsci.1c01293
Gockel, Lukas M., Nekipelov, Katrin, Ferro, Vito, Bendas, Gerd and Schlesinger, Martin (2022). Tumour cell-activated platelets modulate the immunological activity of CD4+, CD8+, and NK cells, which is efficiently antagonized by heparin. Cancer Immunology, Immunotherapy, 71 (10), 2523-2533. doi: 10.1007/s00262-022-03186-5
Al‐Buthabhak, Hawraa S., Falasca, Valerio, Yu, Yu, Sobolev, Alexandre N., Skelton, Brian W., Moggach, Stephen A., Ferro, Vito, Al‐Salami, Hani and Baker, Murray V. (2022). Au‐NHC complexes with thiocarboxylate ligands: synthesis, structure, stability, thiol exchange and in vitro anti‐cancer activity. Applied Organometallic Chemistry, 38 (10) ARTN e6645. doi: 10.1002/aoc.6645
Chhabra, Mohit, Wilson, Jennifer C., Wu, Liang, Davies, Gideon J., Gandhi, Neha S. and Ferro, Vito (2022). Structural insights into pixatimod (PG545) inhibition of heparanase, a key enzyme in cancer and viral infections. Chemistry – A European Journal, 28 (11) e202104222, e202104222. doi: 10.1002/chem.202104222
Chhabra, Mohit, Wimmer, Norbert, He, Qi Qi and Ferro, Vito (2021). Development of improved synthetic routes to pixatimod (PG545), a sulfated oligosaccharide-steroid conjugate. Bioconjugate Chemistry, 32 (11) acs.bioconjchem.1c00453, 2420-2431. doi: 10.1021/acs.bioconjchem.1c00453
Chhabra, Mohit, Doherty, Gareth G., See, Nicholas W., Gandhi, Neha S. and Ferro, Vito (2021). From cancer to COVID‐19: a perspective on targeting heparan sulfate‐protein interactions. The Chemical Record, 21 (11) tcr.202100125, 3087-3101. doi: 10.1002/tcr.202100125
Huang, Xuan, Reye, Gina, Momot, Konstantin I., Blick, Tony, Lloyd, Thomas, Tilley, Wayne D., Hickey, Theresa E., Snell, Cameron E., Okolicsanyi, Rachel K., Haupt, Larisa M., Ferro, Vito, Thompson, Erik W. and Hugo, Honor J. (2021). Corrigendum: Heparanase Promotes Syndecan-1 Expression to Mediate Fibrillar Collagen and Mammographic Density in Human Breast Tissue Cultured ex vivo (Front. Cell Dev. Biol., (2020), 8, 599, 10.3389/fcell.2020.00599). Frontiers in Cell and Developmental Biology, 9 678589. doi: 10.3389/fcell.2021.678589
See, Nicholas W., Wimmer, Norbert, Krenske, Elizabeth H. and Ferro, Vito (2021). A substituent‐directed strategy for the selective synthesis of L‐hexoses: an expeditious route to L‐idose. European Journal of Organic Chemistry, 2021 (10), 1575-1584. doi: 10.1002/ejoc.202100042
Gockel, Lukas M., Heyes, Martin, Li, Honglian, Al Nahain, Abdullah, Gorzelanny, Christian, Schlesinger, Martin, Holdenrieder, Stefan, Li, Jin-Ping, Ferro, Vito and Bendas, Gerd (2021). Inhibition of tumor-host cell interactions using synthetic heparin mimetics. ACS Applied Materials and Interfaces, 13 (6), 7080-7093. doi: 10.1021/acsami.0c20744
Schuurs, Zachariah P., Hammond, Edward, Elli, Stefano, Rudd, Timothy R., Mycroft-West, Courtney J., Lima, Marcelo A., Skidmore, Mark A., Karlsson, Richard, Chen, Yen-Hsi, Bagdonaite, Ieva, Yang, Zhang, Ahmed, Yassir A., Richard, Derek J., Turnbull, Jeremy, Ferro, Vito, Coombe, Deirdre R. and Gandhi, Neha S. (2021). Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domain. Computational and Structural Biotechnology Journal, 19, 2806-2818. doi: 10.1016/j.csbj.2021.05.002
Boittier, Eric D., Burns, Jed M., Gandhi, Neha S. and Ferro, Vito (2020). GlycoTorch Vina: docking designed and tested for glycosaminoglycans. Journal of Chemical Information and Modeling, 60 (12), 6328-6343. doi: 10.1021/acs.jcim.0c00373
Mycroft-West, Courtney J., Su, Dunhao, Pagani, Isabel, Rudd, Timothy R., Elli, Stefano, Gandhi, Neha S., Guimond, Scott E., Miller, Gavin J., Meneghetti, Maria C. Z., Nader, Helena B., Li, Yong, Nunes, Quentin M., Procter, Patricia, Mancini, Nicasio, Clementi, Massimo, Bisio, Antonella, Forsyth, Nicholas R., Ferro, Vito, Turnbull, Jeremy E., Guerrini, Marco, Fernig, David G., Vicenzi, Elisa, Yates, Edwin A., Lima, Marcelo A. and Skidmore, Mark A. (2020). Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the spike S1 receptor-binding domain with heparin. Thrombosis and Haemostasis, 120 (12), 1700-1715. doi: 10.1055/s-0040-1721319
Nahain, Abdullah Al, Ignjatovic, Vera, Monagle, Paul, Tsanaktsidis, John, Vamvounis, George and Ferro, Vito (2020). Sulfonated RAFT copolymers as heparin mimetics: synthesis, reactivity ratios, and anticoagulant activity. Macromolecular Bioscience, 20 (9) 2000110, e2000110. doi: 10.1002/mabi.202000110
Huang, Xuan, Reye, Gina, Momot, Konstantin I., Blick, Tony, Lloyd, Thomas, Tilley, Wayne D., Hickey, Theresa E., Snell, Cameron E., Okolicsanyi, Rachel K., Haupt, Larisa M., Ferro, Vito, Thompson, Erik W. and Hugo, Honor J. (2020). Heparanase promotes syndecan-1 expression to mediate fibrillar collagen and mammographic density in human breast tissue cultured ex vivo. Frontiers in Cell and Developmental Biology, 8 599, 599. doi: 10.3389/fcell.2020.00599
Chhabra, Mohit and Ferro, Vito (2020). PI-88 and related heparan sulfate mimetics. Advances in Experimental Medicine and Biology, 1221, 473-491. doi: 10.1007/978-3-030-34521-1_19
Wu, Liang, Wimmer, Norbert, Davies, Gideon J. and Ferro, Vito (2020). Structural insights into heparanase activity using a fluorogenic heparan sulfate disaccharide. Chemical Communications, 56 (89), 13780-13783. doi: 10.1039/d0cc05932c
Nguyen, Huong, Pan, Yuchen, Nahain, Abdullah Al, Clarke, Daniel, McMillan, Nigel A. and Ferro, Vito (2020). Synthesis of cholesterol glycoconjugates for targeted liposomal drug delivery. Trends in Carbohydrate Research, 12 (3), 1-9.
Nahain, Abdullah Al, Ignjatovic, Vera, Monagle, Paul, Tsanaktsidis, John, Vamvounis, George and Ferro, Vito (2019). Anticoagulant heparin mimetics via RAFT Polymerization. Biomacromolecules, 21 (2), 1009-1021. doi: 10.1021/acs.biomac.9b01688
Modhiran, Naphak, Gandhi, Neha S., Wimmer, Norbert, Cheung, Stacey, Stacey, Katryn, Young, Paul R., Ferro, Vito and Watterson, Daniel (2019). Dual targeting of dengue virus virions and NS1 protein with the heparan sulfate mimic PG545. Antiviral Research, 168, 121-127. doi: 10.1016/j.antiviral.2019.05.004
He, Qi Qi, Trim, Paul James, Lau, Adeline A., King, Barbara M., Hopwood, John J., Hemsley, Kim M., Snel, Marten Francis and Ferro, Vito (2019). Synthetic disaccharide standards enable quantitative analysis of stored heparan sulfate in MPS IIIA murine brain regions. ACS Chemical Neuroscience, 10 (8) acschemneuro.9b00328, 3847-3858. doi: 10.1021/acschemneuro.9b00328
Supramaniam, Aroon, Bielefeldt-Ohmann, Helle, Rudd, Penny A., Webster, Julie, Ferro, Vito and Herrero, Lara J. (2019). PG545 treatment reduces RRV-induced elevations of AST, ALT with secondary lymphoid organ alterations in C57BL/6 mice. PLoS ONE, 14 (6) e0217998, e0217998. doi: 10.1371/journal.pone.0217998
Islam, Nazrul, Wang, Hui, Maqbool, Faheem and Ferro, Vito (2019). In vitro enzymatic digestibility of glutaraldehyde-crosslinked chitosan nanoparticles in lysozyme solution and their applicability in pulmonary drug delivery. Molecules, 24 (7) 1271, 1271. doi: 10.3390/molecules24071271
Boittier, Eric, Gandhi, Neha, Ferro, Vito and Coombe, Deirdre (2019). Cross-species analysis of glycosaminoglycan binding proteins reveals some animal models are “more equal” than others. Molecules, 24 (5) 924, 924. doi: 10.3390/molecules24050924
He, Qi Qi, Trim, Paul J., Snel, Marten F., Hopwood, John J. and Ferro, Vito (2018). Synthesis and mass spectrometric analysis of disaccharides from methanolysis of heparan sulfate. Organic & Biomolecular Chemistry, 16 (45), 8791-8803. doi: 10.1039/c8ob02225a
Chhabra, Mohit and Ferro, Vito (2018). The development of assays for heparanase enzymatic activity: towards a gold standard. Molecules, 23 (11) 23112971, 2971. doi: 10.3390/molecules23112971
Mu, Yuqing, Schulz, Benjamin L. and Ferro, Vito (2018). Applications of ion mobility-mass spectrometry in carbohydrate chemistry and glycobiology. Molecules, 23 (10) 2557, 2557. doi: 10.3390/molecules23102557
Elli, Stefano, Stancanelli, Eduardo, Handley, Paul N, Carroll, Anthony, Urso, Elena, Guerrini, Marco and Ferro, Vito (2018). Structural and conformational studies of the heparan sulfate mimetic PI-88. Glycobiology, 28 (10), 731-740. doi: 10.1093/glycob/cwy068
Mohamed, Shifaza, He, Qi Qi, Lepage, Romain J., Krenske, Elizabeth H. and Ferro, Vito (2018). Glycosylations of simple acceptors with 2-O-acyl L-idose or L-iduronic acid donors reveal only a minor role for neighbouring-group participation. European Journal of Organic Chemistry, 2018 (19), 2214-2227. doi: 10.1002/ejoc.201800318
Nahain, Abdullah Al, Ignjatovic, Vera, Monagle, Paul, Tsanaktsidis, John and Ferro, Vito (2018). Heparin mimetics with anticoagulant activity. Medicinal Research Reviews, 38 (5), 1582-1613. doi: 10.1002/med.21489
Supramaniam, Aroon, Lui, Xiang, Ferro, Vito and Herrero, Lara (2018). Prophylactic anti-heparanase activity by PG545 is anti-viraland protects against Ross River virus disease in mice. Antimicrobial Agents and Chemotherapy, 62 (4) e01959-17, e01959-17. doi: 10.1128/AAC.01959-17
Handley, Paul N., Carroll, Anthony and Ferro, Vito (2017). New structural insights into the oligosaccharide phosphate fraction of Pichia (Hansenula) holstii NRRL Y2448 phosphomannan. Carbohydrate Research, 446-447, 68-75. doi: 10.1016/j.carres.2017.05.008
Zhao, Weihao, Ferro, Vito and Baker, Murray V. (2017). Carbohydrate–N-heterocyclic carbene metal complexes: synthesis, catalysis and biological studies. Coordination Chemistry Reviews, 339, 1-16. doi: 10.1016/j.ccr.2017.03.005
Ferro, Vito (2017). Glycosaminoglycans and their mimetics. Molecules, 22 (1) 20, 20. doi: 10.3390/molecules22010020
Islam, Nazrul and Ferro, Vito (2016). Recent advances in chitosan-based nanoparticulate pulmonary drug delivery. Nanoscale, 8 (30), 14341-14358. doi: 10.1039/c6nr03256g
Muhsin, Mohammad D. A., George, Graeme, Beagley, Kenneth, Ferro, Vito, Wang, Hui and Islam, Nazrul (2016). Effects of chemical conjugation of L‑leucine to chitosan on dispersibility and controlled release of drug from a nanoparticulate dry powder inhaler formulation. Molecular Pharmaceutics, 13 (5), 1455-1466. doi: 10.1021/acs.molpharmaceut.5b00859
Mohamed, Shifaza, Krenske, Elizabeth H. and Ferro, Vito (2016). The stereoselectivities of tributyltin hydride-mediated reductions of 5-bromo-D-glucuronides to L-iduronides are dependent on the anomeric substituent: syntheses and DFT calculations. Organic and Biomolecular Chemistry, 14 (10), 2950-2960. doi: 10.1039/C6OB00283H
Nguyen, Huong, Katavic, Peter, Bashah, Nur Atikah Halim and Ferro, Vito (2016). Synthesis of mannose-cholesterol conjugates for targeted liposomal drug delivery. ChemistrySelect, 1 (1), 31-35. doi: 10.1002/slct.201600007
Ferro, Vito (2016). Meet our editorial board member. Current Medicinal Chemistry, 23 (1), 1. doi: 10.2174/092986732301151230160254
Konara, Chamindika S., Barnard, Ross T., Hine, Damian, Siegel, Evan and Ferro, Vito (2015). The Tortoise and the hare: evolving regulatory landscapes for biosimilars. Trends in Biotechnology, 34 (1), 70-83. doi: 10.1016/j.tibtech.2015.10.009
Shawky, Michael S., Ricciardelli, Carmela, Lord, Megan, Whitelock, John, Ferro, Vito, Britt, Kara and Thompson, Erik W. (2015). Proteoglycans: Potential Agents in Mammographic Density and the Associated Breast Cancer Risk.. Journal of Mammary Gland Biology and Neoplasia, 20 (3-4), 121-131. doi: 10.1007/s10911-015-9346-z
He, Q. Q., Wimmer, N., Verquin, G., Meutermans, W. and Ferro, V. (2015). Investigations into the decomposition of aminoacyl-substituted monosaccharide scaffolds from a drug discovery library. Organic and Biomolecular Chemistry, 13 (13), 4070-4079. doi: 10.1039/C5OB00122F
Ferro, Vito (2015). Meet the editorial board. Current Medicinal Chemistry, 22 (4), 405-405. doi: 10.2174/092986732204141226144632
Muhsin, Mohammad D. A., George, Graeme, Beagley, Kenneth, Ferro, Vito, Armitage, Charles and Islam, Nazrul (2014). Synthesis and toxicological evaluation of a chitosan-l-leucine conjugate for pulmonary drug delivery applications. Biomacromolecules, 15 (10), 3596-3607. doi: 10.1021/bm5008635
Mohamed, Shifaza, Bernhardt, Paul V. and Ferro, Vito (2014). Attempted synthesis of the imidazylate of an α-hydroxylactone results in unexpected chlorination: Synthesis and X-ray crystal structure of 5-Chloro-5-deoxy-1,2- O -isopropylidene-β- l -idurono-6,3-lactone. Journal of Carbohydrate Chemistry, 33 (4), 197-205. doi: 10.1080/07328303.2014.907908
Nandurkar, H., Chong, B., Salem, H., Gallus, A., Ferro, V. and McKinnon, R. (2014). Low-molecular-weight heparin biosimilars: potential implications for clinical practice. Internal Medicine Journal, 44 (5), 497-500. doi: 10.1111/imj.12417
Wilson, Jennifer C., Laloo, Andrew Elohim, Singh, Sanjesh and Ferro, Vito (2014). 1H NMR spectroscopic studies establish that heparanase is a retaining glycosidase. Biochemical and Biophysical Research Communications, 443 (1), 185-188. doi: 10.1016/j.bbrc.2013.11.079
Katavic, Peter L., Yong, Ken W. L., Herring, Joel N., Deseo, Myrna A., Blanchfield, Joanne T., Ferro, Vito and Garson, Mary J. (2013). Structure and stereochemistry of an anti-inflammatory anhydrosugar from the Australian marine sponge Plakinastrella clathrata and the synthesis of two analogues. Tetrahedron, 69 (37), 8074-8079. doi: 10.1016/j.tet.2013.06.079
Ferro, Vito (2013). Heparan sulfate inhibitors and their therapeutic implications in inflammatory illnesses. Expert Opinion on Therapeutic Targets, 17 (8), 965-975. doi: 10.1517/14728222.2013.811491
Plummer, Prue N., Freeman, Ruth, Taft, Ryan, Vider, Jelena, Sax, Michael, Umer, Brittany, Gao, Dingcheng, Johns, Christopher A., Mattick, John S., Wilton, Stephen D., Ferro, Vito, McMillan, Nigel A, Swarbrick, Alex, Mittal, Vivek and Mellick, Albert S. (2013). MicroRNAs regulate tumor angiogenesis modulated by endothelial progenitor cells. Cancer Research, 73 (1), 341-352. doi: 10.1158/0008-5472.CAN-12-0271
Liu, Ligong, Li, Caiping, Cochran, Siska, Feder, Daniel, Guddat, Luke W. and Ferro, Vito (2012). A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors. Bioorganic & Medicinal Chemistry Letters, 22 (19), 6190-6194. doi: 10.1016/j.bmcl.2012.08.001
Fairweather, Jon K., Liu, Ligong, Karoli, Tomislav and Ferro, Vito (2012). Synthesis of disaccharides containing 6-Deoxy-α-L-talose as potential heparan sulfate mimetics. Molecules, 17 (8), 9790-9802. doi: 10.3390/molecules17089790
Liu, Ligong, Li, Caiping, Cochran, Siska, Jimmink, Shane and Ferro, Vito (2012). Synthesis of a heparan sulfate mimetic library targeting FGF and VEGF via click chemistry on a monosaccharide template. ChemMedChem, 7 (7), 1267-1275. doi: 10.1002/cmdc.201200151
Ferro, Vito, Liu, Ligong, Johnstone, Ken D., Wimmer, Norbert, Karoli, Tomislav, Handley, Paul, Rowley, Jessica, Dredge, Keith, Li, Cai Ping, Hammond, Edward, Davis, Kat, Sarimaa, Laura, Harenberg, Job and Bytheway, Ian (2012). Discovery of PG545: A highly potent and simultaneous inhibitor of angiogenesis, tumor growth, and metastasis. Journal of Medicinal Chemistry, 55 (8), 3804-3813. doi: 10.1021/jm201708h
Lundin, Anna, Bergstrom, Tomas, Andrighetti-Fröhner, Carla R., Bendrioua, Loubna, Ferro, Vito and Trybala, Edward (2012). Potent anti-respiratory syncytial virus activity of a cholestanol-sulfated tetrasaccharide conjugate. Antiviral Research, 93 (1), 101-109. doi: 10.1016/j.antiviral.2011.11.002
Dredge, K, Hammond, E, Handley, P, Gonda, TJ, Smith, MT, Vincent, C, Brandt, R, Ferro, V and Bytheway, I (2011). PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models. British Journal of Cancer, 104 (5), 635-642. doi: 10.1038/bjc.2011.11
Pearson, Andrew G., Kiefel, Milton J., Ferro, Vito and von Itzstein, Mark (2011). Synthesis of simple heparanase substrates. Organic and Biomolecular Chemistry, 9 (12), 4614-4625. doi: 10.1039/c1ob05165b
Said, J, Trybala, E, Andersson, E, Johnstone, K, Liu, LG, Wimmer, N, Ferro, V and Bergstrom, T (2010). Lipophile-conjugated sulfated oligosaccharides as novel microbicides against HIV-1. Antiviral Research, 86 (3), 286-295. doi: 10.1016/j.antiviral.2010.03.011
Dredge, K., Hammond, E., Davis, K., Li, C. P., Liu, L., Johnstone, K., Handley, P., Wimmer, N., Gonda, T. J., Gautam, A., Ferro, V. and Bytheway, I. (2010). The PG500 series: Novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy. Investigational New Drugs, 28 (3), 276-283. doi: 10.1007/s10637-009-9245-5
Ekblad, M, Adamiak, B, Bergstrom, T, Johnstone, KD, Karoli, T, Liu, LG, Ferro, V and Trybala, E (2010). A highly lipophilic sulfated tetrasaccharide glycoside related to muparfostat (PI-88) exhibits virucidal activity against herpes simplex virus. Antiviral Research, 86 (2), 196-203. doi: 10.1016/j.antiviral.2010.02.318
Johnstone, Ken D., Karoli, Tomislav, Liu, Ligong, Dredge, Keith, Copeman, Elizabeth, Li, Cai Ping, Davis, Kat, Hammond, Edward, Bytheway, Ian, Kostewicz, Edmund, Chiu, Francis C. K., Shackleford, David M., Charman, Susan A., Charman, William N., Harenberg, Job, Gonda, Thomas J. and Ferro, Vito (2010). Synthesis and biological evaluation of polysulfated oligosaccharide glycosides as inhibitors of angiogenesis and tumor growth. Journal of Medicinal Chemistry, 53 (4), 1686-1699. doi: 10.1021/jm901449m
Hammond, Edward, Li, Cai Ping and Ferro, Vito (2010). Development of a colorimetric assay for heparanase activity suitable for kinetic analysis and inhibitor screening. Analytical Biochemistry, 396 (396), 112-116. doi: 10.1016/j.ab.2009.09.007
Fairweather, J.K., Karoli, T., Liu, L., Bytheway, I. and Ferro, V. (2009). Synthesis of a heparan sulfate mimetic disaccharide with a conformationally locked residue from a common intermediate. Carbohydrate Research, 344 (17), 2394-2398. doi: 10.1016/j.carres.2009.09.012
Cochran, S., Ping Li, C. and Ferro, V. (2009). A surface plasmon resonance-based solution affinity assay for heparan sulfate-binding proteins. Glycoconjugate Journal, 26 (5), 577-587. doi: 10.1007/s10719-008-9210-0
Liu, LG, Johnstone, KD, Fairweather, JK, Dredge, K and Ferro, V (2009). An improved synthetic route to the potent angiogenesis inhibitor benzyl manα(1→3)-Manα(1→3)-Manα(1→3) -Manα(1→2)-Man Hexadecasulfate. Australian Journal of Chemistry, 62 (6), 546-552. doi: 10.1071/CH09015
Fairweather, J.K., Hammond, E., Johnstone, K.D. and Ferro, V. (2008). Synthesis and heparanase inhibitory activity of sulfated mannooligosaccharides related to the antiangiogenic agent PI-88. Bioorganic & Medicinal Chemistry, 16 (2), 699-709. doi: 10.1016/j.bmc.2007.10.044
Liu, Ligong, Bytheway, Ian, Karoli, Tomislav, Fairweather, Jon K., Cochran, Siska, Li, Caiping and Ferro, Vito (2008). Design, synthesis, FGF-1 binding, and molecular modeling studies of conformationally flexible heparin mimetic disaccharides. Bioorganic & Medicinal Chemistry Letters, 18 (1), 344-349. doi: 10.1016/j.bmcl.2007.10.071
Adamiak, Beata, Ekblad, Maria, Bergström, Tomas, Ferro, Vito and Trybala, Edward (2007). Herpes simplex virus type 2 glycoprotein G is targeted by the sulfated oligo- and polysaccharide inhibitors of virus attachment to cells. Journal of Virology, 81 (24), 13424-13434. doi: 10.1128/JVI.01528-07
Ekblad, Maria, Adamiak, Beata, Bergefall, Kicki, Nenonen, Hannah, Roth, Anette, Bergstrom, Tomas, Ferro, Vito and Trybala, Edward (2007). Molecular basis for resistance of herpes simplex virus type 1 mutants to the sulfated oligosaccharide inhibitor PI-88. Virology, 367 (2), 244-252. doi: 10.1016/j.virol.2007.05.040
Ferro, Vito, Dredge, Keith, Liu, Ligong, Hammond, Edward, Bytheway, Ian, Li, Caiping, Johnstone, Ken, Karoli, Tomislav, Davis, Kat, Copeman, Elizabeth and Gautam, Anand: (2007). PI-88 and novel heparan sulfate mimetics inhibit angiogenesis. Seminars in Thrombosis and Hemostasis, 33 (5), 557-562. doi: 10.1055/s-2007-982088
Zammit, S. C., Ferro, V., Hammond, E. and Rizzacasa, M. A. (2007). Enantiospecific synthesis of the heparanase inhibitor (+)-trachyspic acid and stereoisomers from a common precursor. Organic and Biomolecular Chemistry, 5 (17), 2826-2834. doi: 10.1039/b708594j
Ekblad, M., Adamiak, B., Bergefall, K., Nenonen, H., Roth, A., Bergstrom, T, Ferro, V. and Trybala, E. (2007). Molecular basis for resistance of herpes simplex virus type 1 with glycoprotein H coding sequences deleted.. Virology (367), 244-252.
Adams, Y., Freeman, C., Schwartz-Albiez, R., Ferro, V., Parish, C.R. and Andrews, K.T. (2006). Inhibition of Plasmodium falciparum growth in vitro and adhesion to chondroitin-4-sulfate by the heparan sulfate mimetic PI-88 and other sulfated oligosaccharides. Antimicrobial Agents and Chemotherapy, 50 (8), 2850-2852. doi: 10.1128/AAC.00313-06
Bonnet, Muriel, Banwell, Martin G., Willis, Anthony C. and Ferro, Vito (2006). Spectroscopic and structural characterization of products arising from the base-promoted benzylation of 3-sulfolene. Arkivoc, 2006 (x), 35-41. doi: 10.3998/ark.5550190.0007.a05
Ekblad, M., Bergström, T., Banwell, M. G., Bonnet, M., Renner, J., Ferro, V. and Trybala, E. (2006). Anti-herpes simplex virus activities of two novel disulphated cyclitols. Antiviral Chemistry and Chemotherapy, 17 (2), 97-106. doi: 10.1177/095632020601700205
Pearson, A.G., Kiefel, M.J.., Ferro, V. and von Itzstein, M. (2005). Towards the synthesis of aryl glucuronides as potential heparanase probes. An interesting outcome in the glycosidation of glucuronic acid with 4-hydroxycinnamic acid. Carbohydrate Research, 340 (13), 2077-2085. doi: 10.1016/j.carres.2005.06.029
Freeman, Craig, Liu, Ligong, Banwell, Martin G., Brown, Kathryn J., Bezos, Anna, Ferro, Vito and Parish, Christopher R. (2005). Use of Sulfated Linked Cyclitols as Heparan Sulfate Mimetics to Probe the Heparin/Heparan Sulfate Binding Specificity of Proteins. Journal of Biological Chemistry, 280 (10), 8842-8849. doi: 10.1074/jbc.M410769200
Karoli, Tomislav, Liu, Ligong, Fairweather, Jon K., Hammond, Edward, Li, Cai Ping, Cochran, Siska, Bergefall, Kicki, Trybala, Edward, Addison, Russell S. and Ferro, Vito (2005). Synthesis, biological activity, and preliminary pharmacokinetic evaluation of analogues of a phosphosulfomannan angiogenesis inhibitor (PI-88). Journal of Medicinal Chemistry, 48 (26), 8229-8236. doi: 10.1021/jm050618p
Renner, J., Kruszelnicki, I., Adamiak, B., Willis, A.C., Hammond, E., Su, S., Burns, C., Trybala, E., Ferro, V. and Banwell, M.G. (2005). The synthesis and biological evaluation of two analogues of the C-riboside showdomycin. Australian Journal of Chemistry, 58 (2), 86-93. doi: 10.1071/CH04273
Fairweather, Jon K., Karoli, Tomislav and Ferro, Vito (2004). The synthesis of phosphorylated disaccharide components of the extracellular phosphomannan of Pichia (Hansenula) holstii NRRL Y-2448. Bioorganic & Medicinal Chemistry, 12 (23), 6063-6075. doi: 10.1016/j.bmc.2004.09.005
Levidiotis, V., Freeman, C., Punler, M., Martinello, P., Creese, B., Ferro, V., van der Vlag, J., Berden, Jo H.M., Parish, C.R. and Power, D.A. (2004). A synthetic heparanase inhibitor reduces proteinuria in passive heymann nephritis. Journal of the American Society of Nephrology, 15 (11), 2882-2892. doi: 10.1097/01.ASN.0000142426.55612.6D
Ferro, V., Hammond, E. and Fairweather, J. K. (2004). The development of inhibitors of heparanase, a key enzyme involved in tumour metastasis, angiogenesis and inflammation. Mini Reviews in Medicinal Chemistry, 4 (6), 693-702. doi: 10.2174/1389557043403729
Nyberg, K., Ekblad, M., Bergström, T., Freeman, C., Parish, C.R., Ferro, V. and Trybal, E. (2004). The low molecular weight heparan sulfate-mimetic, PI-88, inhibits cell-to-cell spread of herpes simplex virus. Antiviral Research, 63 (1), 15-24. doi: 10.1016/j.antiviral.2004.01.001
Liu, L., Li, C.P., Cochran, S. and Ferro, V. (2004). Application of the four-component Ugi condensation for the preparation of sulfated glycoconjugate libraries. Bioorganic & Medicinal Chemistry Letters, 14 (9), 2221-2226. doi: 10.1016/j.bmcl.2004.02.017
Fairweather, J.K., Karoli, T. and Ferro, V. (2004). The synthesis of phosphorylated disaccharide components of the extracellular phosphomannan of Pichia (Hansenula) holstii NRRL Y-2448.. Bioorganic & Medicinal Chemistry (12), 6063-6075.
Cochran, S., Li, C., Fairweather, J.K., Kett, W.C., Coombe, D.R. and Ferro, V. (2003). Probing the interactions of phosphosulfomannans with angiogenic growth factors by surface plasmon resonance. Journal of Medicinal Chemistry, 46 (21), 4601-4608. doi: 10.1021/jm030180y
Ferro, V. and Don, R. (2003). The development of the novel angiogenesis inhibitor PI-88 as an anticancer drug. Australasian Biotechnology, 13 (1), 38-39.
Yu, GL, Gunay, NS, Linhardt, RJ, Toida, T, Fareed, J, Hoppensteadt, DA, Shadid, H, Ferro, V, Li, CP, Fewings, K, Palermo, MC and Podger, D (2002). Preparation and anticoagulant activity of the phosphosulfomannan PI-88. European Journal of Medicinal Chemistry, 37 (10), 783-791. doi: 10.1016/S0223-5234(02)01347-8
Ferro, V, Li, CP, Wang, B, Fewings, K, King, AR, Hammond, E and Creese, BR (2002). Synthesis of [C-14]- and [S-35]-labelled PI-88 for pharmacokinetic and tissue distribution studies. Journal of Labelled Compounds & Radiopharmaceuticals, 45 (9), 747-754. doi: 10.1002/jlcr.591
Ferro, V, Li, CP, Fewings, K, Palermo, MC, Linhardt, RJ and Toida, T (2002). Determination of the composition of the oligosaccharide phosphate fraction of Pichia (Hansenula) holstii NRRL Y-2448 phosphomannan by capillary electrophoresis and HPLC. Carbohydrate Research, 337 (2), 139-146. doi: 10.1016/S0008-6215(01)00300-7
Ferro, V., Li, C., Wang, B., Fewings, K., King, A.R., Hammond, E. and Creese, B.R. (2002). Synthesis of [14C]- and [35S]-labelled PI-88 for pharmacokinetic and tissue distribution studies. Journal of Labelled Compounds and Radio-pharmaceuticals (45), 747-754.
Yu, G., Gunay, N.S., Linhardt, R.J., Toida, T., Fareed, J., Hoppensteadt, D.A., Shadid, H., Ferro, V., Li, C., Fewings, K., Palermo, M.C. and Podger, D. (2002). Preparation and anticoagulant activity of the phosphosulfomannan PI-88. European Journal of Medicinal Chemistry (37), 783-791.
Ferro, V., Li, C.P., Fewings, K., Palermo, M.C., Linhardt, R.J. and Toida, T. (2002). Determination of the composition of the oligosaccharide phosphate fraction of Pichia (Hansenula) holstii NRRL Y-2448 phosphomannan by capillary electrophoresis and HPLC.. Carbohydrate Research (337), 139-146.
Ferro, V, Fewings, K, Palermo, MC and Li, CP (2001). Large-scale preparation of the oligosaccharide phosphate fraction of Pichia holstii NRRL Y-2448 phosphomannan for use in the manufacture of PI-88. Carbohydrate Research, 332 (2), 183-189. doi: 10.1016/S0008-6215(01)00061-1
Ferro, V. and Devine, P. (2001). Targeting glycosaminoglycan-protein interactions. Chemistry in Australia (68), 18-21.
Wall, D., Douglas, S., Ferro, V., Cowden, W. and Parish, C. (2001). Characterisation of the anticoagulant properties of a range of structurally diverse sulfated oligosaccharides. Thrombosis Research, 103 (103), 325-335. doi: 10.1016/S0049-3848(01)00314-0
Ferro, V., Fewings, V., Palermo, M.C. and Li, C.P. (2001). Large-scale preparation of the oligosaccharide phosphate fraction of Pichia holstii NRRL Y-2448 phosphomannan for use in the manufacture of PI-88. Carbohydrate Research (332), 183-189.
Ferro, V, Weiler, L and Withers, SG (1998). Convergent synthesis of a fluorescence-quenched glycopeptide as a potential substrate for peptide: N-glycosidases. Carbohydrate Research, 306 (4), 531-538. doi: 10.1016/S0008-6215(98)00011-1
Ferro, V., Weiler, L., Withers, S.G. and Ziltener, H. (1998). N-Glycosyl phosphonamidates: potential transition-state analogue inhibitors of glycopeptidases. Canadian Journal of Chemistry, 76 (76), 313-318. doi: 10.1139/cjc-76-3-313
Ferro, V., Weiler, L. and Withers, S.G. (1998). Convergent synthesis of a fluorescence-quenched glycopeptide as a potential substrate for peptide: N-glycosidases. Carbohydrate Research (306), 531-538.
Mehta, S., Meldal, M., Ferro, V., Duus, J.O. and Bock, K. (1997). Internally quenched fluorogenic, alpha-helical dimeric peptides and glycopeptides for the evaluation of the effect of glycosylation on the conformation of peptides. Journal of the Chemical Society: Perkin Transactions I (1), 1365-1374. doi: 10.1039/a607624f
Best, W.M., Ferro, V., Harle, J., Stick, R.V. and Tilbrook, D.M.G. (1997). The synthesis of some epoxyalkyl Beta-C-Glycosides as potential inhibitors of Beta-Glucan hydrolases. Australian Journal of Chemistry, 50 (5), 463-472. doi: 10.1071/C97015
Damude, H.G., Ferro, V,, Withers, S.G. and Warren, R.A. (1996). Substrate specificity of endoglucanase A from Cellulomonas fimi: fundamental differences between endoglucanases and exoglucanases from family 6. Biochemistry Journal, 315 (315), 467-472. doi: 10.1042/bj3150467
Byrne, LT, Ferro, V, Stevenson, S and Stick, RV (1994). Analysis of the H-1-Nmr Spectra of Some Diethyl Phosphonates. Magnetic Resonance in Chemistry, 32 (12), 749-752. doi: 10.1002/mrc.1260321209
Ferro, V, Meldal, M and Bock, K (1994). Synthesis of 2'-Acylated and 2''-O-Acylated Maltotriosides as Potential Fluorescence-Quenched Substrates for Alpha-Amylase. Journal of the Chemical Society-Perkin Transactions 1 (15), 2169-2176. doi: 10.1039/p19940002169
Byrne L.T., Ferro, V., Stevenson, S. and Stick, R.V. (1994). Analysis of the 1H NMR spectra of some diethyl phosphonates. Magnetic Resonance in Chemistry (32), 749-752.
Ferro, V., Meldal, M. and Bock, K. (1994). Synthesis of 2'- and 2"-O-acylated maltotriosides as potential fluorescence-quenched substrates for alpha-amylase. Journal of the Chemical Society Perkin Transactions I, 2169-2176.
Clare, B.W., Ferro, V., Skelton, B.W., Stick, R.V. and White, A.H. (1993). Approaches to the synthesis of retronecine from some pyrrolidine precursors. Australian Journal of Chemistry, 46 (46), 805-824. doi: 10.1071/CH9930805
Ferro, V., Skelton, B.W., Stick, R.V. and White, A.H. (1993). The synthesis of some pyrrolidines as potential precursors to retronecine. Australian Journal of Chemistry, 46 (46), 787-803. doi: 10.1071/CH9930787
Ferro, V., Mocerino, M., Stick, R.V. and Tilbrook, D.M.G. (1988). An improvement in the preparation of some carbohydrate benzylidene acetals. Australian Journal of Chemistry, 41 (5), 813-815. doi: 10.1071/CH9880813

Conference Papers

Plummer, Prue N., Balsara, Spenta, Umer, Brittany, Taft, Ryan, Ferro, Vito, Mattick, John S., Swarbrick, Alex, McMillan, Nigel, Mittal, Vivek and Mellick, Albert S. (2013). Micrornas as novel anti-angiogenesis therapeutic targets. 8th Meeting of the Australasian GeneTherapy-Society, Sydney, NSW Australia, 08-10 May 2013. Hoboken, NJ United States: John Wiley and Sons Inc.. doi: 10.1002/jgm.2740
Plummer, Prue N., Balsara, Spenta, Ferro, Vito, Mittal, Vivek and Mellick, Albert S. (2013). Nanoparticle Delivery of Rna-Based Therapy to Modulate Tumour Vasculature: as a Next Generation Anticancer Therapy. 8th Meeting of the Australasian-Gene-Therapy-Society, Sydney Australia, 08-10 May 2013. Hoboken, NJ United States: Jossey Bass, Ed. and Pub.. doi: 10.1002/jgm.2740
Dredge, K, Davis, K, Liu, L, Johnstone, K, Handley, P, Wimmer, N, Bytheway, I, Hammond, E, Li, CP, Rowley, J, Ferro, V and Gautam, A (2007). Heparan sulfate mimetics - potent angiogenesis inhibitors for cancer therapy. AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics, San Francisco, CA, United States, 22-26 October 2007. Philadelphia, PA, United States: American Association for Cancer Research.
Gautam, AM, Ferro, V, Wilson, EA, Freeman, C and Parish, C (2005). PI-88, a heparanase inhibitor showing promising evidence of patient benefit in phase II clinical trials.. AACR/NCI/EORTC International Conference on Molecular Targets and Cancer Therapeutics, Philadelphia Pa, Nov 14-18, 2005. PHILADELPHIA: AMER ASSOC CANCER RESEARCH.
Creese, B., Ferro, V., King, A. R., Mardon, K. M., Dickinson, R. G., Punler, M.J. and Dodds, H. (2001). Pharmacokinetics of [35s] PI-88 in rats. Annual Scientific Meeting of ASCEPT, Dunedin NZ, 3-5 December 2001. Melbourne: ASCEPT.

Patents

Ferro, V., Karoli, T., Liu, L., Handley, P.N., Johnstone, K.D., Wimmer, N. and Hammond, E.T. (2009). Novel sulfated oligosaccharide derivatives. WO/2009/049370.
Banwell, M. G., Bonnet, M., Ferro, V., Kreipl, A., Renner, J. and Offermann, D. A. (2006). Small molecule glycosaminoglycan mimetics. WO/2006/135973.
Ferro, Vito, Fairweather, Jon, Karoli, Tomislav and Liu, Ligong (2005). Sulfated oligosaccharide derivatives. WO/2005/085264.
Don, Robert Hugh, Ferro, Vito, Bytheway, Ian, Cochran, Siska, Fairweather, Jon Krueger, Hammond, Edward Timothy, Karoli, Tomislav, Li, Cai Ping and Liu, Ligong (2005). Glycosaminoglycan (GAG) mimetics. WO/2005/061523.

Areas of research

Biomolecular chemistry theme
Biotechnology discipline
Medicinal chemistry theme
Organic chemistry discipline