Prof Steven L. Castle from the Chemistry & Biochemistry Department, Brigham Young University / Provo, UTAH, USA, will present results from his teams synthetic efforts targeting the peptide yaku’amide A and related analogs, and the anticancer activity of these compounds will be discussed. In addition, efforts to use the methodology developed in this endeavor to evaluate the ability of dehydroamino acids to increase the proteolytic stability of peptides will be described.