Lipid droplets (LDs) are increasingly becoming recognized as critical organelles in signaling events, transient protein sequestration and inter-organelle interactions in multiple signalling pathways. However, the role LDs play in anti-viral innate immune pathways remains largely unknown. We believe that LDs play vital roles in facilitating the magnitude of the early anti-viral immune response, in particular the production of IFN following viral infection, and control of viral replication. Our group has characterised the the lipidome, proteome and trafficking patterns of LDs during an early antiviral response, and can demonstrate that these critical organelles play a vital role in the control of viral replication.